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Gillian Coughlan

Gillian Coughlan
Harvard Medical School, Massachusetts General Hospital · Department of Neurology

Ph.D. Biomedical Science

About

37
Publications
10,067
Reads
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327
Citations

Publications

Publications (37)
Article
Full-text available
Subject-level independent component analysis (ICA) is a well-established and widely used approach in denoising of resting-state functional magnetic resonance imaging (fMRI) data. However, approaches such as ICA-FIX and ICA-AROMA require advanced setups and can be computationally intensive. Here, we aim to introduce a user-friendly, computationally...
Preprint
Cognitive tests sensitive to the integrity of the medial temporal lobe (MTL), such as mnemonic discrimination of perceptually similar stimuli, may be useful early markers of risk for cognitive decline in older populations. Perceptual discrimination of stimuli with overlapping features also relies on MTL, but remains relatively unexplored in this co...
Preprint
Full-text available
Path integration changes may precede a clinical presentation of Alzheimer disease by several years. Studies to date have focused on how grid cell changes affect path integration in preclinical AD. However, vestibular input is also critical for intact path integration. Here, we developed a naturalistic vestibular task that requires individuals to ma...
Article
Background: Spatial disorientation is one of the earliest and most distressing symptoms seen in patients with Alzheimer disease (AD) and can lead to them getting lost in the community. Although it is a prevalent problem worldwide and is associated with various negative consequences, very little is known about the extent to which outdoor navigation...
Article
The apolipoprotein E (APOE)‐ε4 allele represents the greatest genetic risk factor for late‐onset Alzheimer’s disease (AD). Identifying a resilience profile that might mitigate medial temporal lobe atrophy in enriched genetic risk may explain differences between individuals’ susceptibility to AD pathology. 742 older adults from OASIS‐3 were stratifi...
Article
Background: Docosahexaenoic acid (DHA) is the main long chain omega-3 polyunsaturated fatty acids in the brain and accounts for 30% to 40% of fatty acids in the grey matter of the human cortex. Although the influence of circulating DHA levels on memory function is widely researched, its association with brain volumes is under investigated and its...
Preprint
Full-text available
Subject-level independent component analysis (ICA) is a well-established and widely used approach in denoising of resting-state functional magnetic resonance imaging (fMRI) data. However, approaches such as ICA-FIX and ICA-AROMA require advanced setups and/or are computationally intensive. Here, we aim to introduce a user-friendly, computationally...
Article
Objective: Structural neuroimaging findings in younger and older adults with major depressive disorder (MDD) are highly heterogeneous, possibly as a result of methodological limitations, lack of distinction between MDD and late-life depression (LLD), or clinical moderators. Using a novel meta-analytic network mapping approach, the authors sought t...
Conference Paper
Background: Docosahexaenoic acid (DHA) is the main long chain omega-3 polyunsaturated fatty acids in the brain and accounts for 30% to 40% of fatty acids in the grey matter of the human cortex. Although the influence of circulating DHA levels on memory function is widely researched, its association with brain volumes is under investigated and its a...
Conference Paper
Background: The apolipoprotein E (APOE)-ε4 allele represents the greatest genetic risk factor for late-onset Alzheimer’s disease (AD). Identifying a resilience profile that might mitigate medial temporal lobe atrophy in enriched genetic risk may explain differences between individuals’ susceptibility to AD pathology. Method: 742 older adults from...
Article
Full-text available
Introduction: The apolipoprotein E (APOE) ε4 allele is the greatest genetic risk factor for Alzheimer's disease (AD). Our aim was to identify the structural brain measures that mitigate the negative effect of APOE ε4 on cognition, which would have implications for AD diagnosis and treatment trial selection. Methods: A total of 742 older adults (...
Article
Full-text available
Docosahexaenoic acid is the main long-chain omega-3 polyunsaturated fatty acids in the brain and accounts for 30-40% of fatty acids in the grey matter of the human cortex. Although the influence of docosahexaenoic acid on memory function is widely researched, its association with brain volumes is under investigated and its association with spatial...
Article
Full-text available
Research suggests that tests of memory fidelity, feature binding and spatial navigation are promising for early detection of subtle behavioural changes related to Alzheimer’s disease. In the absence of longitudinal data, one way of testing the early detection potential of cognitive tasks is through the comparison of individuals at different genetic...
Preprint
BACKGROUND Spatial disorientation is one of the earliest and most distressing symptoms seen in patients with Alzheimer disease (AD) and can lead to them getting lost in the community. Although it is a prevalent problem worldwide and is associated with various negative consequences, very little is known about the extent to which outdoor navigation p...
Preprint
Full-text available
Research suggests that tests of memory fidelity, feature binding and spatial navigation are promising for early detection of subtle behavioural changes related to Alzheimer's disease (AD). In the absence of longitudinal data, one way of testing the early detection potential of cognitive tasks is through the comparison of individuals at different ge...
Article
Path integration spatial navigation processes are emerging as promising cognitive biomarkers for prodromal and clinical Alzheimer’s disease (AD). However, such path integration changes have been little explored in Vascular Cognitive Impairment (VCI),despite neurovascular change being a major contributing factor to dementia and potentially AD. In pa...
Article
Cognitive decline is a common complaint in menopause. Alzheimer disease(AD) has higher incidence in women and early menopause increases risk for AD. Studies of cognitive change at menopause have had mixed results. Navigational ability declines early in the course of AD. No studies have looked at changes in navigational ability around menopause. Obj...
Article
Full-text available
The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At ba...
Article
Full-text available
Path integration spatial navigation processes are emerging as promising cognitive markers for prodromal and clinical Alzheimer’s disease (AD). However, such path integration changes have been less explored in Vascular Cognitive Impairment (VCI), despite neurovascular change being a major contributing factor to dementia and potentially AD. In partic...
Article
Objective: With the rising burden of dementia globally, there is a need to harmonize dementia research across diverse populations. The Addenbrooke's Cognitive Examination-III (ACE-III) is a well-established cognitive screening tool to diagnose dementia. But there have been few efforts to standardize the use of ACE-III across cohorts speaking diffe...
Preprint
Full-text available
Path integration spatial navigation processes are emerging as promising cognitive markers for prodromal and clinical Alzheimer's disease (AD). However, such path integration changes have been little explored in Vascular Cognitive Impairment (VCI), despite neurovascular change being a major contributing factor to dementia and potentially AD. In part...
Article
Navigation processes that are selectively mediated by functional activity in the entorhinal cortex may be a marker of preclinical Alzheimer's disease (AD). Here, we tested if a short path integration paradigm can detect the strongest genetic-risk phenotype of AD in large sample of apolipoprotein E (APOE)-genotyped individuals. We also examined the...
Article
Background: Neuroimaging findings in younger and older adults with major depressive disorder (MDD) are highly heterogeneous. It is unclear whether this heterogeneity is due to methodological limitations, lack of distinction between MDD and late-life depression (LLD), or clinical moderators. Methods: We identified all voxel-based and surface-based...
Article
Full-text available
There is increasing evidence that menopausal changes can have an impact on women's cognition and potentially, the future development of dementia. In particular, the role of reduced levels of estrogen in postmenopausal changes has been linked to an increased risk of developing dementia in observational studies. Not surprisingly, this has led to seve...
Preprint
Navigation processes mediated selectively by the entorhinal cortex (EC) may be impaired in individuals with suspected preclinical Alzheimers disease (AD) but the clinical utility of navigation tests to detect such impairments remains to be established. In a sample of 64 individuals (32 e3e3 and 32 e3e4) we tested whether an existing paradigm the Vi...
Article
Background: Dementia-related missing incidents are highly prevalent but still poorly understood. This is particularly true for environmental/geospatial risk factors, which might contribute to these missing incidents. Objective: The study aimed to conduct a retrospective, observational analysis on a large sample of missing dementia patient case r...
Data
This PDF file includes: Supplementary text Tables S1 to S3 Fig S1 to S5 References for SI reference citations S RESULTS Supplementary Text The effect of homozygote genotype status on navigation in SHQ We tested the effect of genotype on Wayfinding Distance and duration with the inclusion of the e4e4 carriers, which resulted in strong effect of geno...
Article
Full-text available
Spatial navigation is emerging as a critical factor in identifying preclinical Alzheimer’s disease (AD). However, the impact of interindividual navigation ability and demographic risk factors (e.g., APOE, age, and sex) on spatial navigation make it difficult to identify persons “at high risk” of AD in the preclinical stages. In the current study, w...
Article
Full-text available
Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify preclinical individuals and target potentially disease-modifying therapies towards them. Current neuroimaging and biomarker research is strongly focused in this direction, with the aim of establishing AD fingerprints to identify individuals at high risk of develop...
Preprint
Full-text available
INTRODUCTION Spatial navigation is emerging as a critical factor in identifying pre-symptomatic Alzheimer pathophysiology, with the impact of sex and APOE status on spatial navigation yet to be established. METHODS We estimate the effects of sex on navigation performance in 27,308 individuals (50-70 years [benchmark population]) by employing a nov...
Article
Full-text available
Spatial orientation is emerging as an early and reliable cognitive biomarker of Alzheimer’s disease (AD) pathophysiology. However, no evidence exists as to whether spatial orientation is also affected in vascular dementia (VaD). Objective To examine allocentric (map-based) and egocentric (viewpoint-based) spatial orientation in an early stage VaD...
Article
Full-text available
We propose that boredom, a state associated with a sense of meaninglessness, leads to a psychological search for meaning in life, which, in turn, elevates affirmation of heroes. This hypothesis builds on the notion that heroes function, in part, as sources of meaning in life. Using a correlational model, we found that boredom proneness predicted mo...

Network

Cited By

Projects

Projects (4)
Project
This is a collection of articles linked to the research game app Sea Hero Quest, used to test over 4 million people across different countries.
Archived project
Path integration spatial navigation processes are currently emerging as promising cognitive biomarkers for clinical and prodromal Alzheimer’s disease (AD). However, such path integration changes have yet to be characterised in Vascular Cognitive Impairment (VCI). It is currently therefore not clear whether VCI has specific or similar path integration processes as AD. In the current study we explore path integration performance in AD and VCI groups.
Project
1. Increase sensitivity of diagnostic tools by personalising assessment methods 2. Understand the neuropathological mechanisms that lead to spatial navigation impairments in preclinical Alzheimer's disease 3. Idenitify a clinically feasible diagnostic test