Gilles Allali

Gilles Allali
Lausanne University Hospital | CHUV · Département des neurosciences cliniques

Head of the Leenaards Memory Center, Lausanne University Hospital (CHUV)

About

278
Publications
45,566
Reads
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6,157
Citations
Introduction
Gilles Allali currently leads the Leenaards Memory Center at Lausanne University Hospital (CHUV). Gilles does research in Behavioural Science, focusing on the relationship between motor and cognitive function.
Additional affiliations
July 2013 - July 2015
Albert Einstein College of Medicine
Position
  • Senior Researcher

Publications

Publications (278)
Article
Full-text available
Objective To assess whether gait, neuropsychological, and multimodal MRI parameters predict short-term symptom reversal after cerebrospinal fluid (CSF) tap test in idiopathic normal pressure hydrocephalus (iNPH). Methods Thirty patients (79.3 ± 5.9 years, 12 women) with a diagnosis of probable iNPH and 46 healthy controls (74.7 ± 5.4 years, 35 wom...
Article
Full-text available
Objective Several studies have reported poor long-term neuropsychological performances in patients following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but none has yet considered the effect of administering multiple intercorrelated neuropsychological tests and assessed the frequency of cognitive deficits in a normative...
Article
Background This study examines and compares CARE and Cardiovascular Health Study (CHS) frailty states (i.e., robust, prefrail and frail) for their association with incident adverse health outcomes, including falls, depression, cognitive and functional decline, major neurocognitive disorders, hospitalization and mortality in community-dwelling older...
Article
Background: Cerebro-spinal fluid (CSF) tap test is one common procedure to predict the efficiency of ventriculo-peritoneal (VP) shunt for idiopathic normal pressure hydrocephalus(iNPH). Objective tests after CSF tap test were used to establish the surgical indication, but subjective improvements may also be important in the selection of surgical c...
Article
Background and purpose: Cognitive and motor impairments are risk factors of major neurocognitive disorders (MNCD). Inability to name the date and use of a walking aid and/or history of falls are two items which are surrogate measures of cognitive and motor impairments. This study aims to examine the association of inability to name the date (i.e.,...
Article
Background: Recent advances occurred in the field of Alzheimer's disease (AD) biomarkers and the introduction of a research framework grounded on a biomarker-based definition of AD might have fostered an increased clinical use of AD biomarkers. For this reason, an up-to-date depiction of the clinical use of AD biomarkers is needed. Objective: To...
Article
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Healthcare workers have potentially been among the most exposed to SARS-CoV-2 infection as well as the deleterious toll of the pandemic. This study has the objective to differentiate the pandemic toll from post-acute sequelae of SARS-CoV-2 infection in healthcare workers compared to the general population. The study was conducted between April and...
Article
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Background “Emergency Room Evaluation and Recommendations” (ER ² ) risk levels (i.e., low, moderate and high) may be used to screen for major neurocognitive disorders (MNCD) in older emergency department users, as a high ER ² risk level is associated with MNCD diagnosis. This study aims to examine the association of ER ² risk levels with incident M...
Article
Full-text available
Aim The aim of this cross-sectional study was to measure the effect of dual tasks on gait stability in ambulant children with cerebral palsy (CP) compared to typically developing (TD) children. Methods The children of the CP (n = 20) and TD groups (n = 20) walked first without a dual task, then while counting forward and finally while alternativel...
Article
Introduction: Older people with major neurocognitive disorders (MNCDs) visiting the emergency department (ED) are at high risk of hospital admissions. The "Emergency Room Evaluation and Recommendations" (ER2) tool decreases the length of stay (LOS) in the hospital when older people visiting ED are hospitalized after an index ED visit, regardless o...
Article
Full-text available
There is growing awareness that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, even in its mild or moderate respiratory forms, can include long-term neuropsychological deficits. Standardized neuropsychological, psychiatric, neurological, and olfactory tests were administered to 45 patients 236.51 ± 22.54 days after hospital...
Article
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Background: Persistent symptoms of SARS-CoV-2 are prevalent weeks to months following the infection. To date, it is difficult to disentangle the direct from the indirect effects of SARS-CoV-2, including lockdown, social, and economic factors. Objective: The study aims to characterize the prevalence of symptoms, functional capacity, and quality o...
Article
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Lack of awareness of cognitive impairment (i.e., anosognosia) could be a key factor for distinguishing between neuropsychological post-COVID-19 condition phenotypes. In this context, the twofold aim of the present study was to i) establish the prevalence of anosognosia for memory impairment, according to the severity of the infection in the acute p...
Article
Full-text available
Background and Purpose Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with several complications of the central nervous system (CNS), including acute encephalopathy. Methods In this pilot study, we report a series of 39 patients (66.5 ± 9.2 years; 10.3% female) with acut...
Preprint
Aim The aim of this prospective cross-sectional study with matched controls was to measure the effect of dual tasks on gait stability in ambulant children with cerebral palsy (CP) compared to typically developing (TD) children. Methods The children of the CP (n= 20) and TD groups (n=20) walked first without a dual task, then while counting and fin...
Article
La dificultad respiratoria, también conocida como disnea, es un síntoma frecuente que causa debilidad. Varios reportes han destacado la ausencia de disnea en un subgrupo de pacientes que padecen COVID-19, en la llamada hipoxemia «silenciosa» o «feliz». Los reportes también han mencionado la falta de una relación clara entre la gravedad clínica de l...
Article
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In 2021, we assisted to the publication of new diagnostic criteria, classifications, and guidelines (CIDP, brain tumors, auto-immune encephalitis). Several studies helped to define the pharmacological management of focal and generalized epileptic seizures and epilepsy in pregnant women. The availability of biomarkers and the approval of immunothera...
Article
Atemnot, auch als Dyspnoe bezeichnet, ist ein häufiges und lähmendes Symptom. In mehreren Berichten wurde die Abwesenheit von Atemnot bei einer Untergruppe von Patienten mit COVID-19 hervorgehoben, die manchmal als «stille» oder «glückliche Hypoxie» bezeichnet wird. Ebenfalls wurde in Berichten erwähnt, dass es an einem klaren Zusammenhang zwischen...
Article
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Purpose: The Emergency Room Evaluation and Recommendation (ER ² ) is an application in the electronic medical file of patients visiting the Emergency Department (ED) of the Jewish General Hospital (JGH; Montreal, Quebec, Canada). It screens for older ED visitors at high risk of undesirable events. The aim of this study is to examine the performance...
Article
The Memory Centres of several Swiss hospitals have set up a national online registry for Alzheimer's research, called www.BHR-suisse.org. This type of registry already exists in the United States (www.brainhealthregistry.org/) and the Netherlands (https://hersenonderzoek.nl/). It contributes, as do these initiating sites, to the creation of a globa...
Article
Les centres de la mémoire de plusieurs hôpitaux suisses ont créé un Registre national suisse en ligne pour la recherche sur Alzheimer, intitulé www.bhr-suisse.org. Ce type de registre existe déjà aux États-Unis (www.brainhealthregistry.org/) et aux Pays-Bas (hersenonderzoek.nl/). Il contribue, au même titre que ces sites initiateurs, à constituer u...
Article
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Encephalopathy is a neurological complication of COVID-19. The objective of this exploratory study is to investigate the link between systemic inflammation and brain microstructural changes (measured by diffusion-weighted imaging) in patients with COVID-19 encephalopathy. 20 patients with COVID-19 encephalopathy (age: 67.3 $$\pm$$ ± 10.0 years; 90%...
Article
Background The role of vitamin D supplementation in improving cognition and slowing the incidence of minor and major neurocognitive disorders is a matter of debate. To our knowledge, no systematic review of randomized controlled trials (RCTs) has examined this question in adults.Objectives The purpose of this systematic review is to synthesize the...
Article
Many reports have described pain appearance or an increase of chronic pain concomitant to SARS-CoV-2 infection. Here, we describe the cases of three patients with chronic cancer pain, in which COVID-19 was associated with a dramatic reduction/disappearance of pain. Pain reappeared following recovery from COVID-19. Neurological imaging and pathologi...
Article
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Background. The Motoric Cognitive Risk (MCR) syndrome is defined in non-demented older adults by cognitive complaints and slow gait. Individuals with MCR are at higher risk of dementia and other poor clin- ical outcomes, such as falls. However, no data are available as regards functional mobility alterations associated with MCR. The main purpose of...
Article
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Background: Late-life depressive symptomatology and motoric cognitive risk syndrome (MCR) have independently been associated with an increased risk for incident dementia. This study aimed to examine the association of late-life depressive symptomatology, MCR, and their combination on incident dementia in community-dwelling older adults living in Qu...
Article
Background: Alzheimer's disease (AD) pathology impacts the response to treatment in patients with idiopathic normal pressure hydrocephalus (iNPH), possibly through changes in resting-state functional connectivity (rs-FC). Objective: To explore the relationship between cerebrospinal fluid biomarkers of AD and the default mode network (DMN)/hippoc...
Article
Breathlessness, also known as dyspnoea, is a debilitating and frequent symptom. Several reports have highlighted the lack of dyspnoea in a subgroup of patients suffering from COVID-19, sometimes referred to as “silent” or “happy hyp­oxaemia.” Reports have also mentioned the absence of a clear relationship between the clinical severity of the diseas...
Article
Full-text available
Purpose Assess the individual and combined diagnostic value of amyloid-PET and tau-PET in a memory clinic population. Methods Clinical reports of 136 patients were randomly assigned to two diagnostic pathways: AMY-TAU, amyloid-PET is presented before tau-PET; and TAU-AMY, tau-PET is presented before amyloid-PET. Two neurologists independently asse...
Article
Progressive loss of walking ability in amyotrophic lateral sclerosis (ALS) has been scarcely studied as a potential predictive factor for survival in motor neuron disease. We aimed to assess the progression of gait decline and its association with mortality in ALS using the Timed Up and Go test (TUG). Patients were followed up prospectively at the...
Preprint
Full-text available
Background. This study aims to investigate the clinical use of the main Alzheimer’s disease (AD) biomarkers in patients with mild cognitive impairment (MCI) by examining the beliefs and preferences of clinicians and biomarker experts of the European Alzheimer’s Disease Consortium (EADC). Methods. Out of 306 contacted EADC professionals, 150 (101 cl...
Article
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The current SARS-CoV-2/COVID-19 pandemic has led to a global health crisis. The clinical spectrum of SARS-CoV-2 infection ranges from asymptomatic infection to critical illness affecting almost every organ including the central and peripheral nervous systems. Myoclonus, a less expected and relatively unusual neurological complication, together with...
Article
A significative proportion of patients with pulmonary-related COVID-19 initially present with « silent » or « happy » hypoxemia, a term denoting an absence of dyspnea or other respiratory distress symptoms in face of profound hypoxemia. COVID-19 is a multisystemic disease characterized by the diffusion of SARS-COV-2 through the blood and a widespre...
Article
Background: The motoric cognitive risk (MCR) syndrome is a pre-clinical stage of dementia characterized by slow gait and cognitive complaint. Yet, the brain substrates of MCR are not well established. Objective: To examine cortical thickness, volume, and surface area associated with MCR in the MCR-Neuroimaging Consortium, which harmonizes image...
Article
COVER ILLUSTRATION Idiopathic Normal Pressure Hydrocephalus (iNPH), the leading cause of reversible dementia in ageing, is currently underdiagnosed and poorly understood. Using functional brain imaging and molecular data, Griffa et al. demonstrate an alteration of Default Mode Network resting‐state dynamics in iNPH patients compared to healthy cont...
Preprint
Full-text available
Background: There is growing awareness that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can include long-term neuropsychological deficits, even in its mild or moderate respiratory forms. Methods: Standardized neuropsychological, psychiatric, neurological and olfactory tests were administered to 45 patients (categorized ac...
Article
Background: Motoric cognitive risk syndrome (MCR) and mild cognitive impairment (MCI) are two pre-dementia stages with an overlap, which may influence the risk for dementia. Objective: The study aims to examine the association of MCR, MCI, and their combination with incident dementia in Quebec community-dwelling older adults. Methods: 1,063 ol...
Article
Background The severe acute respiratory coronavirus 2 (SARS‐CoV‐2) has been associated with neurological complications, including acute encephalopathy. In order to better understand the neuropathogenesis of this acute encephalopathy, we describe a series of patients with COVID‐19 encephalopathy, highlighting its phenomenology and its neurobiologica...
Preprint
Full-text available
Background: There is growing awareness that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can include long-term neuropsychological deficits, even in its mild or moderate respiratory forms. Methods: Standardized neuropsychological, psychiatric, neurological and olfactory tests were administered to 45 patients (categorized ac...
Article
In our response to Li Y C et al.¹ and Chigr F et al.², we suggested that asymptomatic hypoxemia in COVID‐19 could be due to the propagation of severe acute respiratory syndrome (SARS‐CoV‐2) toward cortical regions, particularly the insula.³ This article is protected by copyright. All rights reserved.
Article
Full-text available
Idiopathic Normal Pressure Hydrocephalus (iNPH)-the leading cause of reversible dementia in aging-is characterized by ventriculomegaly and gait, cognitive and urinary impairments. Despite its high prevalence estimated at 6% among the elderlies, iNPH remains underdiagnosed and undertreated due to the lack of iNPH-specific diagnostic markers and limi...
Article
The motoric cognitive risk (MCR) syndrome is characterized by slow gait and cognitive complaint, and increases the risk for both Alzheimer’s disease and vascular dementia. Our recently established MCR neuroimaging consortium aims to identify the brain substrates and pathologies in MCR – and consists of > 3,000 MRIs from 6 different older adult coho...
Article
Full-text available
Background: Idiopathic normal pressure hydrocephalus (iNPH) presents typical radiological signs that have been summarised in a semi-quantitative scale named the iNPH Radscale. However, the iNPH Radscale's predictive value for response to cerebrospinal uid (CSF) tap test has never been studied. This study aims to investigate if the iNPH Radscale can...
Article
Background: The co-occurrence of slow walking speed and subjective cognitive complaint (SCC) in non-demented individuals defines motoric cognitive risk syndrome (MCR), which is a pre-dementia stage. There is no information on the association between MCR and incident dementia in Québec's older population. Objective: The study aims to examine the as...
Article
With about one third of adults aged 65 years and older being reported worldwide to fall each year, and an even higher prevalence with advancing age, aged-related falls and the associated disabilities and mortality are a major public health concern. In this context, identification of fall risk in healthy older adults is a key component of fall preve...
Presentation
Full-text available
Le 15 décembre 2020 (9.15 à 13.00) aura lieu aux Hôpitaux Universitaires de Genève le 5ème symposium HUG-CHUV, qui abordera les différentes complications neurologiques du virus, parmi lesquelles les troubles neurocomportementaux, les complications neuroimmunologiques, les accidents vasculaires cérébraux, les atteintes du système nerveux périphériqu...
Article
Full-text available
This study compared gait speed changes after CSF tap test in patients with idiopathic normal pressure hydrocephalus presenting with various gait phenotypes (frontal, parkinsonian, normal, or other). All patients improved, except those with parkinsonian gait.
Article
Full-text available
Objective: This cross-sectional study aims to assess the association between neuroaxonal damage assessed by serum neurofilament light chain (sNfL) and the Timed Up and Go (TUG)-a reliable and rapid measure of global neurologic disability-in patients with MS. Methods: A total of 41 consecutive patients with MS (38.0 ± 10.4 years; 57% women) with lo...
Article
Full-text available
The main purpose of the present study was to compare the smoothness of gait in older adults with and without cognitive impairments, using the harmonic ratio (HR), a metric derived from trunk accelerations. Ninety older adults aged over 65 (age: 78.9 ± 4.8 years; 62% female) underwent instrumental gait analysis, performed using a wearable inertial s...
Article
Full-text available
Since December 2019, the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has rapidly spread worldwide, challenging the clinician and focusing the entire globe on critical illness high mortality. This article is protected by copyright. All rights reserved.
Article
Full-text available
Objectives Death or hospital readmission are frequent among patients surviving acute hypercapnic respiratory failure (AHRF). Severity scores are not valid to predict death or readmission after AHRF. Gait speed, a simple functional parameter, has been associated with hospital admission and death in the general population. The purpose of this study i...
Article
Background Motoric cognitive risk syndrome (MCR), which combines subjective cognitive complaint (SCC) and slow gait speed in individuals free of dementia and gait disability, is associated with cardiovascular risk factors and disease as well as incident cognitive impairment. Little information on MCR exists in the Canadian population. This study ai...
Article
Patients with coronavirus disease 2019 (COVID‐19) seldom complain of dyspnea. It has been suggested that the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) targets the brainstem and plays a role COVID‐19 respiratory failure. We hypothesise that asymptomatic hypoxemia presented by COVID‐19 patients with severe pneumonia is related to a...
Article
Background Chronic respiratory diseases are associated with cognitive dysfunction, but whether dyspnea by itself negatively impacts on cognition has not been demonstrated. Cortical networks engaged in subjects experiencing dyspnea are also activated during other tasks that require cognitive input and may provoke a negative impact through interferen...
Article
Background Chronic respiratory diseases are associated with cognitive dysfunction, but whether dyspnea by itself negatively impacts on cognition has not been demonstrated. Cortical networks engaged in subjects experiencing dyspnea are also activated during other tasks that require cognitive input and may provoke a negative impact through interferen...
Conference Paper
Full-text available
Objective: To investigate the prevalence of small vessel disease (SVD) and cerebral amyloid angiopathy (CAA) biomarkers in patients with idiopathic normal pressure hydrocephalus (iNPH) and the 1-year post-shunt outcome. Background: iNPH is the leading cause of reversible dementia in older adults and frequently associated with Alzheimer’s disease a...
Article
Introduction Central neurological gait abnormalities (CNGA; i.e. frontal or parkinsonian) are frequently associated with neurodegenerative conditions in older adults, but their pathophysiological substrates remain poorly described. This cross-sectional study aims to assess the association between cerebrospinal fluid (CSF) Alzheimer's biomarkers and...
Article
Full-text available
Idiopathic normal pressure hydrocephalus (iNPH) is a prevalent reversible neurological disorder characterized by impaired locomotion, cognition and urinary control with ventriculomegaly. Symptoms can be relieved with cerebrospinal fluid drainage, which makes iNPH the leading cause of reversible dementia. Because of a limited understanding of pathop...
Article
Full-text available
Individuals with mild cognitive impairment (MCI) have worse gait performance compared to cognitive healthy individuals (CHI). The discrepancy between imagined and performed timed up and go test (TUG), known as the TUG delta time, is a marker of brain gait control impairment in individuals with MCI. The study aims to examine the association between...
Chapter
Falls are very prevalent in older adults with cognitive impairment: older adults with dementia are 2–3 times more likely to fall than older adults without cognitive deficits. Social isolation, impaired mobility, injury and increased mortality represent the major consequences of falls in aging. Although older adults with cognitive impairment share s...