Gil Fraqueza

Gil Fraqueza
Universidade do Algarve | UALG · Centro de Ciências do Mar (CCMAR)

Professor

About

18
Publications
1,435
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256
Citations
Citations since 2016
12 Research Items
203 Citations
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Introduction
Gil Fraqueza currently works at the Centro de Ciências do Mar (CCMAR), Universidade do Algarve. Gil does research in Inorganic Chemistry, Chemical Kinetics and Biochemistry. Their current project is 'Biological applications of polyoxometalates and metal complexes'.
Skills and Expertise

Publications

Publications (18)
Article
Decavanadate is a polyoxometalate (POMs) that has shown extensive biological activities, including antidiabetic and anticancer activity. Importantly, vanadium-based compounds as well as antidiabetic biguanide drugs, such as metformin, have shown to exert therapeutic effects in melanoma. A combination of these agents, the metformin-decavanadate comp...
Article
Full-text available
Plasma membrane calcium ATPases (PMCA) and sarco(endo) reticulum calcium ATPases (SERCA), are key proteins in the maintenance of calcium homeostasis. Herein, we compare for the first time the inhibition of SERCA and PMCA calcium pumps by several polyoxotungstates (POTs), namely by Wells-Dawson phosphotungstate anions [P2W18O62]⁶⁻ (intact, {P2W18}),...
Article
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The therapeutic applications of gold are well-known for many centuries. The most used gold compounds contain Au(I). Herein, we report, for the first time, the ability of four Au(I) and Au(III) complexes, namely dichloro (2-pyridinecarboxylate) Au(III) (abbreviated as 1), chlorotrimethylphosphine Au(I) (2), 1,3-bis(2,6-diisopropylphenyl) imidazole-2...
Chapter
Golf is a key sector for tourism in Portugal and particularly in the Algarve, which has been recognized, on several occasions, as the best golf destination in the world. Beyond to the economic and social outputs, golf courses can have a positive impact in local environment, promoting habitats and local biodiversity. Today’s societies face the chall...
Article
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Polyoxometalates (POMs) are promising inorganic inhibitors for P-type ATPases. The experimental models used to study the effects of POMs on these ATPases are usually in vitro models using vesicles from several membrane sources. Very recently, some polyoxotungstates, such as the Dawson anion [P2W18O62]6−, were shown to be potent P-type ATPase inhibi...
Article
Full-text available
Recently, a global analysis of the structure-activity-relationship of a series of polyoxometalates (POMs) referred that the most active POMs were ascribed to be polyoxovanadates (POVs), especially decavanadate (V10), which was very active against certain bacteria (Bijelic et al, Chem Comm, 2018). The present study explores this observation and comp...
Article
Full-text available
Polyoxometalates are transition metal complexes that exhibit a broad diversity of structures and properties rendering them promising for biological purposes. They are able to inhibit a series of biologically important enzymes including various phosphatases, thus affecting many biochemical processes. In the present study, we analyzed and compared th...
Article
Full-text available
The putative applications of poly-, oligo- and mono-oxometalates in biochemistry, biology, pharmacology and medicine are rapidly attracting interest. In particular, these compounds may act as potent ion pump inhibitors and have the potential to play a role in the treatment of e.g. ulcers, cancer and ischemic heart disease. However, the mechanism of...
Article
Full-text available
Recently we demonstrated that the decavanadate (V(10)) ion is a stronger Ca(2+)-ATPase inhibitor than other oxometalates, such as the isoelectronic and isostructural decaniobate ion, and the tungstate and molybdate monomer ions, and that it binds to this protein with a 1 : 1 stoichiometry. The V(10) interaction is not affected by any of the protein...
Article
Over the last few decades there has been increasing interest in oxometalate and polyoxometalate applications to medicine and pharmacology. This interest arose, at least in part, due to the properties of these classes of compounds as anti-cancer, anti-diabetic agents, and also for treatment of neurodegenerative diseases, among others. However, our u...

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Projects

Project (1)
Project
We apply the versatile interactions of polyoxometalates with biomolecules in the fields of cytotoxicity, enzyme inhibition and biomembranes.