Gianluigi Rossi

Gianluigi Rossi
The University of Edinburgh | UoE · Roslin Institute

PhD
Livestock epidemiology - Disease ecology - Covid modelling

About

39
Publications
4,409
Reads
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300
Citations
Additional affiliations
February 2015 - June 2015
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna
Position
  • Temporary scholarship
January 2012 - March 2015
Università di Parma
Position
  • PhD Student

Publications

Publications (39)
Article
Full-text available
Assessing the performance of a surveillance system for infectious diseases of domestic animals is a challenging task for health authorities. Therefore, it is important to assess what strategy is the most effective in identifying the onset of an epidemic and in minimizing the number of infected farms. The aim of the present work was to evaluate the...
Article
Full-text available
Animals' exchanges are considered the most effective route of between-farm infectious disease transmission. However, despite being often overlooked, the infection spread due to contaminated equipment, vehicles, or personnel proved to be important for several livestock epidemics. This study investigated the role of indirect contacts in a potential i...
Presentation
Full-text available
Although live animals exchange is considered the most effective route of disease transmission between farms, the spread through contaminated equipment, vehicles, or personnel proved to be crucial for many epidemics, included the 2001 foot-and-mouth disease in the UK or the worldwide spread of avian flu in 2000s decade. Among farm professional visit...
Article
Full-text available
Rift Valley fever (RVF) is an important emerging zoonoses causing abortion and neonatal deaths in livestock and hemorrhagic fever in humans. It is typically characterized by acute epidemics with abortion storms often preceding human disease and these events have been associated with the El Niño weather cycles. Outside of areas that experience epide...
Article
Background : Mobility restrictions prevent the spread of infections to disease-free areas, and early in the coronavirus disease 2019 (COVID-19) pandemic, most countries imposed severe restrictions on mobility as soon as it was clear that containment of local outbreaks was insufficient to control spread. These restrictions have adverse impacts on th...
Article
Wastewater based epidemiology (WBE) has become an important tool during the COVID-19 pandemic, however the relationship between SARS-CoV-2 RNA in wastewater treatment plant influent (WWTP) and cases in the community is not well-defined. We report here the development of a national WBE program across 28 WWTPs serving 50% of the population of Scotlan...
Article
Full-text available
Understanding how emergent pathogens successfully establish themselves and persist in previously unaffected populations is a crucial problem in disease ecology, with important implications for disease management. In multi‐host pathogen systems this problem is particularly difficult, as the importance of each host species to transmission is often po...
Preprint
Full-text available
Background COVID-19 patients shed SARS-CoV-2 RNA in their faeces. We hypothesised that detection of SARS-CoV-2 RNA in wastewater treatment plant (WWTP) influent could be a valuable tool to assist in public health decision making. We aimed to rapidly develop and validate a scalable methodology for the detection of SARS-CoV-2 RNA in wastewater that c...
Article
Full-text available
Introduction The objective of this study is to show the importance of interspecies links and temporal network dynamics of a multi-species livestock movement network. Although both cattle and sheep networks have been previously studied, cattle-sheep multi-species networks have not generally been studied in-depth. The central question of this study i...
Preprint
Full-text available
The second SARS virus, SARS-CoV-2, emerged in December 2019, and within a month was globally distributed. It was first introduced into Scotland in February 2020 associated with returning travellers and visitors. By March it was circulating in communities across the UK, and to control COVID-19 cases, and prevent overwhelming of the National Health S...
Article
Full-text available
Established methods for whole-genome-sequencing (WGS) technology allow for the detection of single-nucleotide polymorphisms (SNPs) in the pathogen genomes sourced from host samples. The information obtained can be used to track the pathogen’s evolution in time and potentially identify ‘who-infected-whom’ with unprecedented accuracy. Successful meth...
Preprint
Full-text available
Restrictions on mobility are a key component of infectious disease controls, preventing the spread of infections to as yet unexposed areas, or to regions which have previously eliminated outbreaks. However, even under the most severe restrictions, some travel must inevitably continue, at the very minimum to retain essential services. For COVID-19,...
Preprint
Understanding how an emergent pathogen successfully establishes itself and persists in a previously unaffected population is a crucial problem in disease ecology. In multi-host pathogen systems this problem is particularly difficult, as the importance of each host species to transmission is often poorly characterised, and the epidemiology of the di...
Article
Full-text available
Contact network analysis has become a vital tool for conceptualizing the spread of pathogens in animal populations and is particularly useful for understanding the implications of heterogeneity in contact patterns for transmission. However, the transmission of most pathogens cannot be simplified to a single mode of transmission and, thus, a single...
Article
Control of bovine tuberculosis (bTB), caused by Mycobacterium bovis , in the Republic of Ireland costs €84 million each year. Badgers are recognized as being a wildlife source for M. bovis infection of cattle. Deer are thought to act as spillover hosts for infection; however, population density is recognized as an important driver in shifting their...
Preprint
Full-text available
Established methods for whole-genome-sequencing (WGS) technology allow for the detection of single-nucleotide polymorphisms (SNPs) in the pathogen genomes sourced from host samples. The information obtained can be used to track the pathogen’s evolution in time and potentially identify ‘who-infected-whom’ with unprecedented accuracy. Successful meth...
Article
Full-text available
Livestock movements are an important mechanism of infectious disease transmission. Where these are well recorded, network analysis tools have been used to successfully identify system properties, highlight vulnerabilities to transmission, and inform targeted surveillance and control. Here we highlight the main uses of network properties in understa...
Article
Obesity is a risk factor for postmenopausal estrogen receptor alpha positive (ER(+)) breast cancer. Molecular mechanisms underlying factors from plasma that contribute to this risk and how these mechanisms affect ERα signaling have yet to be elucidated. To identify such mechanisms, we performed whole metabolite and protein profiling in plasma sampl...
Article
Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is a chronic disease typical of cattle. Nonetheless, it can affect many mammals including humans, making it one of the most widespread zoonotic diseases worldwide. In industrialized countries, the main pathways of introduction of bTB into a herd are animal trade and contact with infected wil...
Article
Since the 1970s, mosquito-borne pathogens have spread to previously disease-free areas, as well as causing increased illness in endemic areas. In particular, dengue and chikungunya viruses, transmitted primarily by Aedes aegypti and secondarily by Aedes albopictus mosquitoes, represent a threat for up to a third of the world population, and are a g...
Article
Full-text available
Conjugated estrogens (CE) and Bazedoxifene (BZA) combination is used to alleviate menopause-associated symptoms in women. CE+BZA undergo first-pass-metabolism in the liver and deconjugation by gut microbiome via β-glucuronidase (GUS) enzyme inside the distal gut. To date, the impact of long-term exposure to CE+BZA on the gut microbiome or GUS activ...
Article
Endemic diseases can be counted among the most serious sources of losses for livestock production. In dairy farms in particular, one of the most common diseases is Johne's disease, caused by Mycobacterium avium ssp. paratuberculosis (MAP). Infection with MAP causes direct costs because it affects milk production, but it has also been suspected to i...
Article
Full-text available
Obesity is a preventable risk factor for post-menopausal ERα-(+) breast cancer. We hypothesized that serum from obese post-menopausal women contain factors that would increase tumorigenicity of breast cancer cells and increase risk of ERα-(+) breast cancer. Using whole metabolite profiling and OLINK biomarker panel of about 400 proteins associated...
Poster
Full-text available
(alt. title: The effect of shared pastures on the spread of bovine tuberculosis)
Article
Full-text available
Infectious diseases in livestock can be transmitted through fomites: objects able to convey infectious agents. Between-farm spread of infections through fomites is mostly due to indirect contacts generated by on-farm visits of personnel that can carry pathogens on their clothes, equipment, or vehicles. However, data on farm visitors are often diffi...
Data
Supplementary analyses. Including: data descriptive statistics and analysis, sensitivity analysis on the contamination period, weighted network analysis, network structure and farm exposure to infection using different assumptions, infection chains and infection potential. (PDF)
Data
Dataset used in the study. This includes three CSV files reporting a configuration of the contacts list for the considered networks (cattle movement, veterinary officers, and veterinary practitioners). (ZIP)
Poster
Integrative -omics approach identifies novel roles for extranuclear ER alpha signaling in rewiring cancer cell metabolism during obesity-associated breast cancer
Poster
Full-text available
Highly infectious diseases typical of livestock, such as foot-and-mouth disease, classical swine fever, and influenza, can be transmitted through fomites: i.e. objects or substances able to carry infectious organisms and, thus, spread the infection. The between-farm spread of these fomites, or indirect contacts, is mostly due to on-farm visits by o...
Presentation
Full-text available
Although live animals exchange is considered the most effective route of disease transmission between farms, the spread through contaminated equipment, vehicles, or personnel proved to be crucial for many epidemics, included the 2001 foot-and-mouth disease in the UK or the worldwide spread of avian flu in 2000s decade. Among farm professional visit...
Presentation
Full-text available
Biosecurity measures have been developed to protect people, animals and plants against the transmission of infectious agents. The lack of these measures played an important role in several epidemics of highly contagious diseases. Farmed animals diseases such as porcine reproductive and respiratory syndrome, foot-and-mouth disease, and avian influen...
Presentation
Background / Purpose: Bovine tuberculosis (bTB) caused by Mycobacterium bovis is one of the major disease threats to wild and farmed animals worldwide. In order to protect livestock, most countries have developed surveillance systems. Emilia-Romagna (ER – Northern Italy) has been bTB-free since 2007. The aim of this work was to evaluate the bTB s...
Article
Full-text available
To understand the consequences of the invasion of the nonnative rainbow trout Oncorhynchus mykiss on the native marble trout Salmo marmoratus, we compared two distinct headwater sectors where marble trout occur in allopatry (MTa) or sympatry (MTs) with rainbow trout (RTs) in the Idrijca River (Slovenia). Using data from field surveys from 2002 to 2...

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