Giampaolo Arcamone

• Medical Doctor at Policlinico di Bari

The purpose of the study was to examine safety and efficacy of non-activated Protein C (PC) supplementation in our cohort of septic pediatric hematological patients. We conducted a retrospective study of 22 septic patients receiving human plasma-derived PC concentrate from 2008 to 2015 at our Pediatric Oncology Center (Bari, Italy). The Surviving s...

Metastases in the bone marrow (BM) are grim prognostic factors in patients with neuroblastoma (NB). In spite of extensive analysis of primary tumor cells from high- and low-risk NB patients, a characterization of freshly isolated BM-infiltrating metastatic NB cells is still lacking. Our aim was to identify proteins specifically expressed by metasta...

Transcripts differentially expressed between BM-infiltrating GD2 positive cells and primary tumors from i) patients dead of stage 4 NB, ii) patients with stage 4 NB alive at 5 year follow-up, and iii) patients with stage 4 NB, irrespective of outcome, selected by SAM analysis. (PDF)

Box-and-Whisker plots of AGT, ATP1A2, BLK, CX3CL1, IGSF1, IGFBP3, and TNC gene expression values by qPCR (normalized to ATP5B, and after logarithmic transformation of original measures) in 5 GD2 positive cells (GD2+) and 5 primary tumors from patients dead of disease (NB_dead), previously hybridized to microarrays. Each box represents the values fr...

Box-and-Whisker plots of AGT, ATP1A2, BLK, CX3CL1, IGSF1, IGFBP3, and TNC gene expression values by qPCR (normalized to ATP5B, and after logarithmic transformation of original measures) in 5 GD2 positive cells (GD2+) and 5 primary tumors from alive patients (NB_alive), previously hybridized to microarrays. Each box represents the values from the 25...

Box-and-Whisker plots of AGT, ATP1A2, CX3CL1, and IGSF1 gene expression values by qPCR (normalized to ATP5B, and after logarithmic transformation of original measures) in 5 GD2 positive cells (GD2+) and 5 primary tumors from alive stage 4 patients (NB_alive) (independent sample set). Each box represents the values from the 25th to 75th percentile,...

The most significantly (P≤0.05) enriched Gene Ontology Biological Process (GOBP) terms in gene signatures of BM-infiltrating GD2 positive cells and primary NB tumors from stage 4 patients. (XLS)

Box-and-Whisker plots of AGT, ATP1A2, CX3CL1, and IGSF1 gene expression values by qPCR (normalized to ATP5B, and after logarithmic transformation of original measures) in 5 GD2 positive cells (GD2+) and 5 primary tumors from stage 4 patients (NB) (independent sample set). Each box represents the values from the 25th to 75th percentile, the middle l...

Box-and-Whisker plots of AGT, ATP1A2, CX3CL1, and IGSF1 gene expression values by qPCR (normalized to ATP5B, and after logarithmic transformation of original measures) in 5 GD2 positive cells (GD2+) and 5 primary tumors from stage 4 patients dead of disease (NB_dead) (independent sample set). Each box represents the values from the 25th to 75th per...

Box-and-Whisker plots of AGT, ATP1A2, BLK, CX3CL1, IGSF1, IGFBP3, and TNC gene expression values by qPCR (normalized to ATP5B, and after logarithmic transformation of original measures) in 5 GD2 positive cells (GD2+) and 5 primary tumors (NB) previously hybridized to microarray. Each box represents the values from the 25th to 75th percentile, the m...

We report an uncommon severe soft-tissue infection of the thighs in a male child with acute lymphoblastic leukemia. Early and aggressive medical treatment and the conservative surgical approach were successful. Necrotizing fasciitis should be suspected in any soft-tissue infection until it can be definitely ruled out, since prompt deliver of medica...

Patients with ataxia-telangiectasia (A-T) have an increased risk of developing malignancies and are prone to severe early or late toxicity owing to chemotherapy. Leukemia and lymphoma account for about 85% of malignancies, but solid tumors have also been reported. We describe an unusual case of an 8-year-old child affected by A-T, who presented a p...

To describe treatment, clinical course, and survival of a cohort of Italian patients with neuroblastoma. The study includes data from 2,216 children (age 0 to 14 years) diagnosed between 1979 and 2005. Overall survival (OS) was analyzed by clinical and biologic features at presentation and periods of diagnosis: 1979 to 1984, 1985 to 1991, 1992 to 1...

Lymphoblastic lymphoma (LBL) is the second most frequent lymphoma subtype in childhood. It is commonly treated according to therapy strategies for lymphoblastic leukemia. The AIEOP LNH-92 protocol was a modified LSA2-L2 therapy used for both T- and B-cell precursor LBL and included Induction, Consolidation, and Maintenance treatment with a total du...

The RMS4.99 study was designed to explore the role of early sequential intensified chemotherapy (SICT) with PBSC rescue in patients with soft tissue sarcoma with a poor prognosis. Fourteen patients with desmoplastic small round-cell tumor (DSRCT) were included in this study. Initial chemotherapy was followed by a course of CY and etoposide with sub...

Here we report a case of administration of defibrotide in an 11 months old infant with hepatic veno-occlusive disease during chemotherapy for nephroblastoma. He presented with abdominal distension, a weight gain of 15%, ascites, hepatomegaly with right upper quadrant pain, thrombocytopenia and hypertransaminasemia. Despite therapy, his clinical con...

10031 Background: Children with metastases at diagnosis for Wilms tumor (WT) still display a worse prognosis compared to localized disease. Methods: We analyzed survival results in patients with stage IV WT enrolled in the AIEOP CNR92 and TW2003 clinical trials (3/1992–3/2008). Treatment strategy across these trials evolved in terms of sparing whol...

Febrile Neutropenia (FN) is a complication of chemotherapy in childhood cancer and at the same time secondary deficit of Protein C (PC) is often present during sepsis in children with cancer. In this study we have compared the clinical outcome of two different groups. At the onset of FN during chemotherapy the first group (patients with a secondary...

An 11-year-old girl presented with a skin nodule of the face. Its clinical features and pathological findings were not able to differentiate between a malignant lesion as cutaneous lymphoma type B and a benign lesion as pseudolymphoma. Thirty months after surgery, no evidence of recurrence was observed, either locally and/or at a distance, thus sug...

Objective. From 1999 to 2004 the SIOP Europe Neuroblastoma Group conducted a study on children with neuroblastoma diagnosed in the first year of life. The object of this report is to describe the characteristics at diagnosis of the Italian cases enrolled in this study. Methods. Patients were diagnosed in 22 Italian institutions of Paediatric Oncolo...

Irinotecan (CPT-11) is a novel antineoplastic agent that takes effect by inhibiting topoisomerase I. The Italian Soft Tissue Sarcoma (STS) Committee performed a multiinstitutional Phase II study to evaluate its effect on STS. Over a 2-year period between 2002 and 2004, 32 heavily pretreated patients were administered 60-minute infusions of irinotec...

Elevated plasma concentrations of endogenous thrombin generation markers and thrombotic events have been reported in children with leukemia. The aim of this study was to evaluate the effects of cancer and its treatment on thrombin generation (TAT levels) in children with acute lymphoblastic leukemia (ALL). The authors evaluated 32 children (23 M, 9...

Selected hemostatic parameters of 23 children affected by beta-thalassemia major were studied and compared to an age- and sex-matched group. Plasma prekallikrein level was reduced in all patients, splenectomized or not. In splenectomized patients, platelet count and in vitro platelet aggregability were significantly increased and Protein C was slig...