Geunhyuk Jang- Ph.D
- Professional at Amorepacific Corporation
Geunhyuk Jang
- Ph.D
- Professional at Amorepacific Corporation
Professional, AMOREPACIFIC
About
6
Publications
347
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9
Citations
Introduction
PhD. Organic chemistry/
Process chemist/
Pharmaceutical R&D/
Artificial peptide/
Designed nucleotide/
Microneedle
Current institution
Additional affiliations
September 2021 - present
January 2018 - August 2021
March 2012 - November 2016
Publications
Publications (6)
The exposome encompasses all factors people encounter through life, with the skin constantly exposed. While particulate matter (PM) and sleep deprivation are known to contribute to barrier dysfunction, their combined effects remain unclear.
Matrix metalloproteinases-2 (MMP-2) is crucial for collagen degradation at the dermal-epidermal junction, contributing to skin aging and photoaging. This study presents a series of hydroxamate-based inhibitors selectively targeting MMP-2. Through structure-activity relationship analysis, we systematically modified the N-arylsulfonyl group and amino...
The inherent conformational preferences of the neutral β-peptide foldamer series, Ac-(ACHC)
n
-NHBn, n = 2-4, are studied in the gas phase using conformation-specific IR-UV double resonance methods. The cyclically constrained chiral β-amino acid cis-2-aminocyclohexane carboxylic acid (ACHC) is designed to bring both right- and left-handed helices i...
α/β-Peptide 11/9-helix is an unconventional helical structure in which 11- and 9-membered ring hydrogen bonds alternate along the helical axis. We have examined the interplay and the relative strength of these two hydrogen bonding types by IR, NMR, and X-ray crystallographic methods. A pair of two adjacent hydrogen bonds with opposite directionalit...
Short α/β-peptides that consist of alternating l-α-amino acids and trans-2-aminocyclopentanecarboxylic acid are known to adopt both 11- and 14/15-helical conformations in solution. We report short α/β-depsipeptides containing (S)-lactic acid as the third residue from the N-terminus. The α/β-depsipeptide pentamers and heptamers adopt 14/15-helical c...
