Gesa Hartwigsen

Gesa Hartwigsen
Max Planck Institute for Human Cognitive and Brain Sciences | CBS · Lise Meitner Research Group Cognition and Plasticity

PhD

About

192
Publications
36,031
Reads
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3,542
Citations
Citations since 2016
139 Research Items
2947 Citations
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20162017201820192020202120220200400600
20162017201820192020202120220200400600
Additional affiliations
April 2013 - present
Christian-Albrechts-Universität zu Kiel
Position
  • University of Kiel
April 2013 - present
Christian-Albrechts-Universität zu Kiel
Position
  • University of Kiel
July 2010 - March 2013
University of Leipzig

Publications

Publications (192)
Poster
Full-text available
Conceptual knowledge is central to human cognition. Previous neuroimaging studies suggest that conceptual processing relies on the joint contribution of modality-specific perceptual-motor and multimodal brain regions. In particular, multimodal inferior parietal cortex (IPL) coupled with somatomotor cortex during action knowledge retrieval and with...
Code
Here, we provide an example dataset for our *Precise motor mapping with transcranial magnetic stimulation* protocol. All scripts, installation instructions, etc. to conduct the mapping are made accessible in a code repository.
Article
We describe a routine to precisely localize cortical muscle representations within the primary motor cortex with transcranial magnetic stimulation (TMS) based on the functional relation between induced electric fields at the cortical level and peripheral muscle activation (motor-evoked potentials; MEPs). Besides providing insights into structure–fu...
Data
Supplementary Material to Kuhnke et al. (2022) "Meta-analytic evidence for a novel hierarchical model of conceptual processing" https://www.researchgate.net/publication/365162594_Meta-analytic_evidence_for_a_novel_hierarchical_model_of_conceptual_processing
Preprint
Full-text available
Conceptual knowledge plays a pivotal role in human cognition. Grounded cognition theories propose that concepts consist of perceptual-motor features represented in modality-specific perceptual-motor cortices. However, it is unclear whether conceptual processing consistently engages modality-specific areas. Here, we performed an activation likelihoo...
Article
Full-text available
Categorical predictions have been proposed as the key mechanism supporting the fast pace of syntactic composition in language. Accordingly, grammar-based expectations are formed-e.g., the determiner "a" triggers the prediction for a noun-and facilitate the analysis of incoming syntactic information, which is then checked against a single or few oth...
Preprint
Full-text available
Semantic cognition is central to communication and our understanding of the world. It is usually well preserved in healthy aging. However, semantic control processes, which guide semantic access and retrieval, decline with age. The present study explored the potential of intermittent theta burst stimulation (iTBS) to enhance semantic cognition in h...
Article
Full-text available
Auditory sentence comprehension involves processing content (semantics), grammar (syntax), and intonation (prosody). The left inferior frontal gyrus (IFG) is involved in sentence comprehension guided by these different cues, with neuroimaging studies preferentially locating syntactic and semantic processing in separate IFG subregions. However, this...
Article
Full-text available
Cognitive aging is associated with widespread neural reorganization processes in the human brain. However, the behavioral impact of such reorganization is not well understood. The current neuroimaging study investigated age differences in the functional network architecture during semantic word retrieval in young and older adults. Combining task-ba...
Preprint
The neuromodulatory effects of transcranial magnetic stimulation (TMS) on language competence in healthy participants was meta-analyzed by a random-effect model. TMS showed a significant overall effect, thus demonstrating its efficacy on healthy participants’ language competence. TMS neuromodulatory effects were moderated by tasks, brain regions, s...
Article
Noninvasive brain stimulation (NIBS) techniques are widely used tools for the study and rehabilitation of cognitive functions. Different NIBS approaches aim to enhance or impair different cognitive processes. The methodological focus for achieving this has been on stimulation protocols that are considered either inhibitory or facilitatory. However,...
Article
Objective Alpha oscillations are linked to inhibitory capabilities in higher cognitive processing. Transcranial alternating current stimulation (tACS) at 10 Hz can enhance alpha oscillations and modulate behaviour. One possibility to increase the efficacy of tACS may be stimulating at the individual alpha frequency (IAF). The present work addresses...
Article
Speech comprehension is often challenged by increased background noise, but can be facilitated via the semantic context of a sentence. This predictability gain relies on an interplay of language-specific semantic and domain-general brain regions. However, age-related differences in the interactions within and between semantic and domain-general net...
Preprint
Full-text available
Semantic memory is a fundamental human ability which is central to communication. Although it is usually well preserved in healthy aging, memory problems in verbal communication due to slowed access and retrieval processes are a common complaint with increasing age. So far, the neural bases of this paradox remain poorly understood. The current neur...
Article
Full-text available
Semantic knowledge is central to human cognition. The angular gyrus (AG) is widely considered a key brain region for semantic cognition. However, the role of the AG in semantic processing is controversial. Key controversies concern response polarity (activation vs. deactivation) and its relation to task difficulty, lateralization (left vs. right AG...
Article
Full-text available
Human cognition is organized in distributed networks in the brain. Although distinct specialized networks have been identified for different cognitive functions, previous work also emphasizes the overlap of key cognitive domains in higher level association areas. The majority of previous studies focused on network overlap and dissociation during re...
Article
Full-text available
Low-intensity transcranial electrical stimulation (tES), including alternating or direct current stimulation, applies weak electrical stimulation to modulate the activity of brain circuits. Integration of tES with concurrent functional MRI (fMRI) allows for the mapping of neural activity during neuromodulation, supporting causal studies of both bra...
Article
Full-text available
Language is a cognitive function that is asymmetrically distributed across both hemispheres, with left dominance for most linguistic operations. One key question of interest in cognitive neuroscience studies is related to the contribution of both hemispheres in bilingualism. Previous work shows a difference of both hemispheres for auditory processi...
Article
The cerebellum and its interaction with cortical areas play a key role in our ability to flexibly adapt a motor program in response to sensory input. Current knowledge about specific neural mechanisms underlying the process of visuomotor adaptation is however lacking. Using a novel placement of EEG electrodes to record electric activity from the ce...
Article
Diaschisis is a phenomenon observed in stroke that is defined as neuronal dysfunction in regions spared by the infarction but connected to the lesion site. We combined lesion network mapping and task-based functional MRI in 71 patients with post-stroke aphasia to investigate, whether diaschisis and its resolution contribute to early loss and recove...
Preprint
Full-text available
Ischemic cerebrovascular events often lead to aphasia. Previous work provided hints that such strokes may affect women and men in distinct ways. Women tend to suffer strokes with more disabling language impairment, even if the lesion size is comparable to men. In 1,401 patients, we isolated data-led representations of anatomical lesion patterns and...
Preprint
Full-text available
We describe a routine to precisely localize cortical muscle representations within the primary motor cortex with transcranial magnetic stimulation (TMS). This allows for an accurate and experimenter-independent determination of motor thresholds and enables TMS dosing based on individual field thresholds. Motor evoked potentials (MEPs) for different...
Preprint
Full-text available
We describe a routine to precisely localize cortical muscle representations within the primary motor cortex with transcranial magnetic stimulation (TMS) based on the functional relation between induced electric fields at the cortical level and motor evoked potentials. Besides insights into structure-function relationships, this lays the foundation...
Preprint
Full-text available
Semantic knowledge is central to human cognition. The angular gyrus (AG) is widely considered a key brain region for semantic cognition. However, the role of the AG in semantic processing is controversial. Key controversies concern response polarity (activation vs. deactivation) and its relation to task difficulty, lateralization (left vs. right AG...
Preprint
Full-text available
Semantic knowledge is central to human cognition. The angular gyrus (AG) is widely considered a key brain region for semantic cognition. However, the role of the AG in semantic processing is controversial. Key controversies concern response polarity (activation vs. deactivation) and its relation to task difficulty, lateralization (left vs. right AG...
Article
How do predictions in the brain incorporate the temporal unfolding of context in our natural environment? We here provide evidence for a neural coding scheme that sparsely updates contextual representations at the boundary of events. This yields a hierarchical, multilayered organization of predictive language comprehension. Training artificial neur...
Preprint
Full-text available
Speech comprehension is often challenged by increased background noise, but can be facilitated via the semantic context of a sentence. This predictability gain relies on an interplay of language-specific semantic and domain-general brain regions. However, age-related differences in the interactions within and between semantic and domain-general net...
Poster
Full-text available
Neural plasticity is a critical process underlying our ability to successfully adapt to everyday challenges. Repetitive transcranial magnetic stimulation (rTMS) provides a means to induce plasticity in distributed neural net-works. Combining rTMS with fMRI allows to map the consequences of stimulation-induced plasticity within and across specialize...
Article
Full-text available
Transcranial magnetic stimulation (TMS) is a powerful tool to investigate causal structure-function relationships in the human brain. However, a precise delineation of the effectively stimulated neuronal populations is notoriously impeded by the widespread and complex distribution of the induced electric field. Here, we propose a method that allows...
Article
Full-text available
Noninvasive brain stimulation (NIBS) allows to actively and noninvasively modulate brain function. Aside from inhibiting specific processes, NIBS may also enhance cognitive functions, which might be used for the prevention and intervention of learning disabilities such as dyslexia. However, despite the growing interest in modulating learning abilit...
Preprint
Auditory language comprehension involves processing the content (semantics), grammar (syntax), and intonation (prosody) of a sentence. Sentence processing guided by prosody has been shown to involve the left inferior frontal gyrus (IFG). Prosodic cues are known to interact closely with both syntax and semantics, yet, whether these two processing do...
Article
Full-text available
Aging is characterized by a decline of cognitive control. In semantic cognition, this leads to the paradox that older adults usually show poorer task performance than young adults despite their greater semantic knowledge. So far, the underlying neural changes of these behavioral differences are poorly understood. In the current neuroimaging study,...
Article
Full-text available
The role of the motor cortex in perceptual and cognitive functions is highly controversial. Here, we investigated the hypothesis that the motor cortex can be instrumental for translating foreign language vocabulary. Human participants of both sexes were trained on foreign language (L2) words and their native language translations over four consecut...
Article
Full-text available
Transcranial direct current stimulation (tDCS) is widely used to explore the role of various cortical regions for reactive response inhibition. In recent years, tDCS studies reported polarity-, time- and stimulation-site dependent effects on response inhibition. Given the large parameter space in which study designs, tDCS procedures and task proced...
Article
Full-text available
The language system uses syntactic, semantic, as well as prosodic cues to efficiently guide auditory sentence comprehension. Prosodic cues, such as pitch accents, can build expectations about upcoming sentence elements. This study investigates to what extent syntactic and semantic expectations generated by pitch accents can be dissociated and if so...
Article
Uniquely human cognitive faculties arise from flexible interplay between specific local neural modules, with hemispheric asymmetries in functional specialization. Here, we discuss how these computational design principles provide a scaffold that enables some of the most advanced cognitive operations, such as semantic understanding of world structur...
Article
Word category information (WCI) is proposed to be fundamental for syntactic learning and processing. However, it remains largely unclear how left-hemispheric key regions for language, including BA 44 in the inferior frontal gyrus (IFG) and superior temporal gyrus (STG), interact with their right-hemispheric homologues to support the WCI-based synta...
Article
Full-text available
Non-invasive brain stimulation (NIBS) has gained increasing popularity as a modulatory tool for drawing causal inferences and exploring task-specific network interactions. Yet, a comprehensive synthesis of reading-related NIBS studies is still missing. We fill this gap by synthesizing the results of 78 NIBS studies investigating the causal involvem...
Preprint
Full-text available
Categorical predictions have been proposed as the key mechanism supporting the fast pace of syntactic composition in human language. Accordingly, grammar-based expectations facilitate the analysis of incoming syntactic information - e.g., hearing the determiner 'the' enhances the prediction of a noun - which is then checked against a single or few...
Article
Full-text available
Semantic composition is the ability to combine single words to form complex meanings and is an essential component for successful communication. Evidence from neuroimaging studies suggests that semantic composition engages a widely distributed left-hemispheric network, including the anterior temporal lobe, the inferior frontal gyrus and the angular...
Preprint
Full-text available
Background: The precise cortical origins of the electrophysiological and behavioral effects of transcranial magnetic stimulation (TMS) remain largely unclear. Addressing this question is further impeded by substantial inter-individual response variability to TMS. Objective: We present a novel method to reliably and user-independently determine the...
Article
The left posterior inferior frontal gyrus in the prefrontal cortex is a key region for phonological aspects of language processing. A previous study has shown that alpha-tACS over the prefrontal cortex applied before task processing facilitated phonological decision-making and increased task-related theta power. However, it is unclear how alpha-tAC...
Data
Supplementary Material to Kuhnke et al. (2021) Cerebral Cortex "Task-Dependent Functional and Effective Connectivity during Conceptual Processing".
Article
Full-text available
Conceptual knowledge is central to cognition. Previous neuroimaging research indicates that conceptual processing involves both modality-specific perceptual-motor areas and multimodal convergence zones. For example, our previous functional magnetic resonance imaging (fMRI) study revealed that both modality-specific and multimodal regions respond to...
Preprint
Full-text available
The inferior parietal lobe (IPL) is a key neural substrate underlying diverse mental processes, from basic attention to language and social cognition, that define human interactions. Its putative domain-global role appears to tie into poorly understood differences between cognitive domains in both hemispheres. Across attentional, semantic, and soci...
Article
Full-text available
The inferior parietal lobe (IPL) is a key neural substrate underlying diverse mental processes, from basic attention to language and social cognition, that define human interactions. Its putative domain-global role appears to tie into poorly understood differences between cognitive domains in both hemispheres. Across attentional, semantic, and soci...
Article
Full-text available
Semantic composition, the ability to combine single words to form complex meanings, is a core feature of human language. Despite growing interest in the basis of semantic composition, the neural correlates and the interaction of regions within this network remain a matter of debate. We designed a well-controlled two-word fMRI paradigm in which phra...
Data
Unthresholded group-level activation maps for Kuhnke et al. (2020) Cerebral Cortex: https://neurovault.org/collections/9490/
Article
Full-text available
Motor and cognitive functions are organized in large-scale networks in the human brain that interact to enable flexible adaptation of information exchange to ever-changing environmental conditions. In this review, we discuss the unique potential of the consecutive combination of repetitive transcranial magnetic stimulation (rTMS) and functional neu...
Preprint
Full-text available
Background Low intensity transcranial electrical stimulation (tES), including alternating or direct current stimulation (tACS or tDCS), applies weak electrical stimulation to modulate brain circuits. Integration of tES with concurrent functional magnetic resonance imaging (fMRI) allows neuromodulation of brain regions while mapping network function...
Preprint
Full-text available
How can anticipatory neural processes structure the temporal unfolding of context in our natural environment? We here provide evidence for a neural coding scheme that sparsely updates contextual representations at the boundary of events and gives rise to a hierarchical, multi-layered organization of predictive language comprehension. Training artif...
Article
Full-text available
Word-production theories argue that during language production, a concept activates multiple lexical candidates in left temporal cortex, and the intended word is selected from this set. Evidence for theories on spoken-word production comes, for example, from the picture-word interference task, where participants name pictures superimposed by congru...
Poster
Full-text available
The precise cortical location underlying the physiological and behavioral TMS effects are still only coarsely known. So far, mapping strategies rely on center of gravity approaches and therefore localize the stimulated cortical site only approximately and indirectly. Such mappings have practical clinical relevance, for example in the context of pre...
Preprint
Full-text available
Aging is characterized by a decline of cognitive control. In semantic cognition, this leads to the paradox that older adults usually show poorer task performance than young adults despite their greater semantic knowledge. So far, the underlying neural changes of these behavioral differences are poorly understood. In the current neuroimaging study,...
Article
Full-text available
When speech intelligibility is reduced, listeners exploit constraints posed by semantic context to facilitate comprehension. The left angular gyrus (AG) has been argued to drive this semantic predictability gain. Taking a network perspective, we ask how the connectivity within language-specific and domain-general networks flexibly adapts to the pre...
Article
Full-text available
Despite a rise in the use of "learning by doing" pedagogical methods in praxis, little is known as to how the brain benefits from these methods. Learning by doing strategies that utilize complementary information ("enrichment") such as gestures have been shown to optimize learning outcomes in several domains including foreign language (L2) training...
Article
Full-text available
Previous studies in healthy populations have provided equivocal evidence whether the application of anodal transcranial direct current stimulation (tDCS) over the left prefrontal cortex (PFC) can improve performance in verbal fluency tasks. In this double-blind, randomised within-participant study, we investigated whether anodal tDCS over the left...
Article
Full-text available
Language comprehension depends on tight functional interactions between distributed brain regions. While these interactions are established for semantic and syntactic processes, the functional network of speech intonation - the linguistic variation of pitch - has been scarcely defined. Particularly little is known about intonation in tonal language...
Article
Full-text available
Resolving cognitive interference is central for successful everyday cognition and behavior. The Stroop task is a classical measure of cognitive interference. In this task, participants have to resolve interference on a trial-by-trial basis and performance is also influenced by the trial history, as reflected in sequence effects. Previous neuroimagi...
Article
Full-text available
Have you ever tried to remember a word in a foreign language? What strategy did you use? In several studies, we examined the beneficial effects of viewing pictures and performing gestures while learning foreign language words. Both pictures and gestures helped primary school kids and adults to better remember the meanings of foreign language words...
Poster
Full-text available
The inferior parietal lobe (IPL) is a heteromodal convergence zone that has been implicated in a variety of key cognitive domains in the human brain. Despite intensive research on hemispheric specialization of the IPL, task-driven differences of whole-brain connectivity patterns are unclear. The present study sheds light on the functional specifici...
Article
Full-text available
Noninvasive brain stimulation (NIBS) techniques, such as transcranial magnetic stimulation or transcranial direct and alternating current stimulation, are advocated as measures to enable causal inference in cognitive neuroscience experiments. Transcending the limitations of purely correlative neuroimaging measures and experimental sensory stimulati...
Data
Supplementary Material for Kuhnke et al. (2020) NeuroImage "Left posterior inferior parietal cortex causally supports the retrieval of action knowledge".
Preprint
Semantic composition, i.e. the ability to combine single words to form complex meanings, is a core feature of human language. Despite growing interest in the basis of semantic composition, the neural correlates and the interaction of regions within this network remain a matter of debate. In the present fMRI study, we designed a well controlled two-...
Article
Full-text available
Conceptual knowledge is central to human cognition. The left posterior inferior parietal lobe (pIPL) is implicated by neuroimaging studies as a multimodal hub representing conceptual knowledge related to various perceptual–motor modalities. However, the causal role of left pIPL in conceptual processing remains unclear. Here, we transiently disrupte...
Preprint
The role of the motor cortex in perceptual and cognitive functions is highly controversial. Here, we investigated the hypothesis that the motor cortex can be instrumental for translating foreign language vocabulary. Participants were trained on foreign language (L2) words and their native language translations over four consecutive days. L2 words w...
Chapter
Transcranial magnetic stimulation (TMS) is a noninvasive and painless tool for the electrical stimulation of the human cortex. TMS depolarizes cortical neurons and can evoke measurable electrophysiological and behavioral effects. TMS is usually applied to one cortical area but can also be given to two or more areas (i.e., multisite TMS). Single or...
Article
Full-text available
Background The COVID-19 pandemic has broadly disrupted biomedical treatment and research including non-invasive brain stimulation (NIBS). Moreover, the rapid onset of societal disruption and evolving regulatory restrictions may not have allowed for systematic planning of how clinical and research work may continue throughout the pandemic or be rest...