Gernot Roessler

University Hospital RWTH Aachen · Ophthalmology

Purpose To determine differing outcomes among either phakic or pseudophakic patients who received standalone XEN45 Gel Stent (Allergan, an AbbVie Company, CA, USA) implantation and patients who underwent combined surgery with phacoemulsification. Methods This retrospective single-center study involved 180 eyes of 180 participants who underwent XEN...

Background: To investigate in combined iStent inject implantation with phacoemulsification carried out bilaterally, whether intraocular pressure (IOP)-lowering effectiveness in the first eye has a predictive potential for the outcome of the second eye in primary open-angle glaucoma (POAG). Methods: This retrospective study included 72 eyes from...

Background and aim: The continuous recording of eye injuries caused by fireworks around New Year's Eve over 6 years allows us to investigate injury numbers, injury patterns, and accident histories in a year to year comparison. In order to relieve the burden on hospitals during the COVID-19 pandemic, a ban on the sale of firework articles was imple...

Purpose: To determine anatomical success and best corrected visual acuity (BCVA) after secondary surgery with heavy silicone oil (HSO) tamponade in patients with persistent full-thickness macular holes (FTMH).Material & Methods: In this retrospective study 63 eyes with persistent FTMH after primary pars plana vitrectomy (ppV) and internal limiting...

Purpose To determine the predictability of success and the risk of open conjunctival revision in the subsequent eye after XEN45 Gel Stent implantation according to lens status. Methods This was a retrospective single-centre study involving 132 eyes of 66 participants who had undergone intraocular pressure (IOP)-lowering XEN45 Gel Stent implantatio...

The BioAdhere study: biocompatible, tailor-made bioadhesive peptides (peptesives) fixating macroscopic objects on the retinal surface.

Purpose To determine the impact of failed ab-interno trabeculectomy on the postoperative outcome of subsequent XEN45 gel stent (Allergan, CA, USA) implantation in pseudophakic eyes. Methods In this retrospective single-center study, we included 60 pseudophakic eyes from 60 participants who underwent XEN45 gel stent implantation. Thirty eyes each u...

Introduction: We report a case of endophthalmitis and endocarditis that developed after stent perforation following a XEN45 Gel Stent implantation 10 months ago. Case report: A 79-year-old man was referred to our hospital because of endophthalmitis of the right eye. The patient had undergone XEN45 Gel Stent implantation in the same eye 10 months...

Purpose We assessed the accuracy of lens power calculation in highly myopic patients implanting plus and minus intraocular lenses (IOL). Methods We included 58 consecutive, myopic eyes with an axial length (AL) > 26.0 mm, undergoing phacoemulsification and IOL implantation following biometry using the IOLMaster 500. For lens power calculation, the...

Background To determine whether the outcome of the first eye may serve as a predictor for intraocular pressure (IOP)‐lowering effectiveness in the second eye following bilateral ab‐interno trabeculectomy. Methods This retrospective single‐centre study included 168 eyes from 84 participants, who underwent combined Trabectome surgery with phacoemuls...

PurposeWe conducted a retrospective study to evaluate the intraocular pressure (IOP) lowering effect, the success rates, and the risk of bleeding events of patients receiving an iStent inject combined with phacoemulsification under anticoagulation therapy compared with a matched control group.Methods In this retrospective study, sixty-four eyes und...

The published online version contains mistake as the author's first name and last name have been interchanged as "Hild Matthias" instead of "Matthias Hild".

Purpose This study investigates the long-term intraocular pressure (IOP) lowering potential, risk profile and success rate of a triple procedure comprising phacoemulsification, trabecular aspiration and trabectome (Microsurgical Technology, Redmond, WA, USA) for treating exfoliation glaucoma. Methods A total of 117 eyes of 117 patients with exfoli...

PRéCIS:: The XEN45 Gel Stent can be implanted after failed trabeculectomy without disadvantages compared with primary implantation. Purpose: We aimed to compare the outcomes of XEN45 Gel Stent (Allergan, CA, USA) implantation in pseudophakic eyes after failed trabeculectomy and in pseudophakic eyes without other previous surgeries. Patients and...

Background: After implantation of a XEN gel stent scarring of the conjunctiva with elevation of the intraocular pressure (IOP) is a frequent occurrence. This article describes a surgical revision technique with opening of the conjunctiva and removal of scar tissue. In order to standardize the technique the surgical procedure was divided into nine...

Background: The restoration of vision in blind patients suffering from degenerative retinal diseases like retinitis pigmentosa (RP) may be obtained by local electrical stimulation with retinal implants. In this study, a very large electrode array for retinal stimulation (VLARS) was introduced and tested regarding its safety in implantation and bio...

Introduction: We report a case of XEN45 Gel Stent removal three years after its implantation. The stent had degraded with a closed lumen, so a new stent was implanted. Case report: A 63-year-old woman was scheduled for XEN45 Gel Stent implantation. Three years after the primary surgery and two years after a surgical revision, a second revision s...

Purpose: Most studies about retinal detachment cover a limited follow-up period. The purpose of this research is to assess the long-term results after pars plana vitrectomy (PPV) and scleral buckle (SB) surgery in patients with rhegmatogenous retinal detachment (RRD). Methods: 155 patients with RRD are treated either with SB or PPV with a mean f...

Background: Trabectome surgery combined with phacoemulsification is effective in lowering (intraocular pressure) IOP in pseudoexfoliation glaucoma. Trabectome surgery usually aims to remove two to four clock hours of the trabecular meshwork. When adding trabecular aspiration, the remaining meshwork can be treated as well, and therefore 360 degrees...

Purpose: To determine ocular side effects of vardenafil with special regard to color vision and retinal function. Methods: This was a single center, randomized, double-blind, placebo-controlled, twofold crossover study with an administration of a single oral dose of two 20 mg tablets of BAY 38-9456 (vardenafil hydrochloride) or corresponding pla...

Purpose: The XEN45 Gel Stent is a flexible hydrophilic tube placed under the conjunctiva via the anterior chamber. This study investigates the IOP (intraocular pressure)-lowering potential, the risk profile, and the success rate of the XEN45 Gel Stent. Methods: Two hundred and sixty-one eyes underwent surgery. The mean follow-up time was 8.5 mon...

Importance: To investigate the long-term safety of a novel intraocular telemetric pressure sensor. Background: Acquisition of accurate intraocular pressure (IOP) data is vital for sufficient medical care of glaucoma patients. Non-invasive self-tonometry with a telemetric IOP sensor can provide important information regarding the individual IOP p...

Background It is unclear whether or not an additional encircling band improves outcome in vitrectomy for pseudophakic retinal detachment (PRD). Also unclear is whether small gauge transconjunctival trocar-guided vitrectomy is as successful as conventional 20 gauge (G) vitrectomy. Methods 257 adult patients with uncomplicated PRD were enrolled in 1...

Epiretinal visual prostheses have already been implanted in blind retinitis pigmentosa (RP) patients. Here we report on clinical experience with the Argus® II device and the EPIRET 3 device, on the basis of data from patients operated in Germany. Twenty-eight patients were implanted with the Argus II device and followed for up to three years. EPIRE...

Purpose: Intensive postoperative care is essential for the outcome of trabeculectomy. However, in a rural setting, repeated visits to the operating theatre are often not requested or possible. The objective of this study was to examine the outcome of trabeculotomy combined with cataract surgery in patients with glaucoma. Patients and Methods: 142 p...

Purpose: The aim of the study was to investigate the agreement of intraocular pressure (IOP) measurement using dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) in eyes after vitrectomy with intraocular gas endotamponade, in eyes after vitrectomy with no tamponade, and in controls. Methods: In this prospective comparative...

Purpose: The number of outpatient operations in Germany is not registered in a centralised manner. To estimate the development of the outpatient intraocular surgery especially since the implementation of the intravitreal injections, surveys among ophthalmic surgeons were analysed. Methods: Between 2006 and 2013 surveys were done among ophthalmic su...

Purpose: We investigated the safety of a telemetric IOP sensor and the accuracy of its IOP measurements in six patients with open-angle glaucoma and cataract. Methods: The study design was a prospective, single-center clinical trial. Here we present 1-year follow-up data. A ring-shaped telemetric IOP sensor was implanted in the ciliary sulcus af...

Introduction In addition to measurement errors, individual anatomical conditions could be made responsible for unexpected prediction errors in the determination of the correct intraocular lens power for cataract surgery. Obviously, such anatomical conditions might be relevant for both eyes. The purpose of this study was to evaluate whether the post...

Background The purpose of this study was to examine retinal recovery processes to pographically by the application of three flash sequences with specific interstimulus intervals. Methods Twelve healthy subjects underwent multifocal electroretinography with a light-emitting diode stimulator. Every flash sequence consisted of three flashes with 25 m...

Purpose: Blue-yellow visual-evoked potentials (BY-VEPs) may be used for diagnostics of functional ganglion cell damage in glaucoma and other ocular diseases. In this study we investigated the impact of lenticular opacities on BY- and standard pattern reversal VEPs by examining patients before and after cataract surgery. Methods: Eighteen patient...

Purpose.The relationship between number of laser burns of cyclophotocoagulation (CPC) and intraocular pressure (IOP) reduction is unknown. This animal model was established to reveal a possible dose-response-relationship between the number of applied laser burns and the IOP lowering effect. Methods. 30 chinchilla bastard rabbits were divided into 5...

Purpose: To demonstrate development and complications in heavy silicone oil (HSO) surgery in 100 eyes following primary vitreoretinal surgery. Methods: 100 eyes were included in this retrospective study that underwent vitreoretinal surgery using HSO as endotamponade. Indication diagnoses were retinal detachments (n = 76), complicated macular hol...

Purpose To investigate the reliability of partial coherence laser interferometry for optical biometry in highly myopic eyes. Methods Axial length measurements by the IOLMaster (Carl Zeiss Meditec, Germany) with signal-to-noise ratio (SNR) ≥2 were performed in 52 consecutive myopic subjects with axial length ≥26.5 mm and 45 emmetropic patients bef...

Retinal implants have been developed to treat blindness causing retinal degenerations such as Retinitis pigmentosa (RP). The retinal stimulators are covering only a small portion of the retina usually in its center. To restore not only central vision but also a useful visual field retinal stimulators need to cover a larger area of the retina. Howev...

Multiple sclerosis (MS) is the most common chronic disease of the central nervous system in Germany. In 80 % of patients early stages of the disease are characterized by a clinically isolated episodic course. Ocular manifestations are common and mostly affect the optic nerve or the uvea and in some cases the retinal vessels. Here we report on a bil...

The purpose of this study was to test the effect of ethyl alcohol on the koniocellular and magnocellular pathway of visual function and to investigate the relationship between such visual field changes and retrobulbar blood flow in healthy subjects. In 12 healthy subjects (mean age 32 ± 4 years), color Doppler imaging, short-wavelength automated pe...

Retina degeneration is one of the leading causes of blindness nowadays and cannot be cured in most cases. It has been shown that electrical stimulation of retinal ganglion cells can generate visual perceptions and therefore implantable electrode arrays can be possible treatment for these patients. Most implants developed for that purpose use electr...

Schwere Augenverletzungen stellen fur den Betroffenen meist eine erhebliche Beeintrachtigung des Alltagslebens dar. Augenverletzungen mit Beteiligung des hinteren Augenabschnitts sind zumeist schwere Augenverletzungen mit einer unsicheren Prognose. Nicht selten ist nach der akuten Behandlungsphase mit ggf. mehrfachen operativen Rekonstruktionen ein...

Ziel ist die Untersuchung der Effektivität und der Sicherheit bei der Behandlung von therapierefraktären Glaukomen mithilfe von Ahmed Glaucoma Valve (AGV)-Implantaten über Pars-plana-Zugang nach Vitrektomie.Bei 27 Augen von 22 Patienten mit komplexen therapierefraktären Sekundärglaukomen wurde eine AGV-Implantation über Pars-plana-Zugang durchgefüh...

BACKGROUND: Aim of this study is the presentation of long-term results regarding the effectiveness and safety of the implantation of Ahmed glaucoma valve (AGV) devices using a pars plana approach after vitrectomy in the treatment of therapy refractive glaucoma. METHODS: The implantation of AGV devices using a pars plana approach after vitrectomy w...

Hintergrund Ziel ist die Untersuchung der Effektivität und der Sicherheit bei der Behandlung von therapierefraktären Glaukomen mithilfe von Ahmed Glaucoma Valve (AGV)-Implantaten über Pars-plana-Zugang nach Vitrektomie. Methoden Bei 27 Augen von 22 Patienten mit komplexen therapierefraktären Sekundärglaukomen wurde eine AGV-Implantation über Par...

Ultrasound-A-scan-biometry intraocular lens power calculation for cataract surgery sometimes shows lack of accuracy in patients with high myopia. The purpose of this retrospective study was to assess the accuracy of lens power calculation with optical biometry using the Zeiss IOLMaster across a large range of myopia levels. We included 37 consecuti...

The EPIRET3 retinal prosthesis was implanted in six volunteers legally blind from retinitis pigmentosa (RP) and removed after 4 weeks. Two years later, these subjects were re-examined to investigate ocular side effects and potential changes to quality of life. Vision-related quality of life was recorded using the NEI-VFQ-25 questionnaire. Clinical...

To compare hyperbaric oxygen treatment combined with hemodilution with hemodilution only in central retinal artery obstruction. Retrospective, nonrandomized case series. We reviewed records of all our patients diagnosed with central retinal artery obstruction between 1997 and 2010. In these patients, hyperbaric oxygen and hemodilution therapy had b...

To investigate the impact of cataract surgery on the association of the ocular pulse amplitude (OPA) and intraocular pressure (IOP) with respect to the interpretation of OPA as an estimate of ocular blood flow. Twenty-four patients with cataract were included in a clinical study. OPA was measured using dynamic contour tonometry (DCT, Pascal(®), SMT...

To examine the relationship between surgeon experience and success rates in retinal detachment surgery. Success rates during a follow-up of 11 months of 8 surgeons who performed in total 375 retinal detachment procedures ranging from 14 to 115 cases between December 1997 and January 2002 were correlated to the total number of vitreoretinal procedur...

To determine the threshold charges needed for eliciting visual perceptions through acute electrical stimulation of the human retina in patients suffering from retinitis pigmentosa, using an epiretinal microelectrode array. In a multicentre study, 20 patients (average age 55 years) with visual acuities ranging from 4/200 to no light perception were...

The aim of this study was to develop surgical methods for the implantation of a wireless intraocular epiretinal retina implant (EPI RET3) in Göttingen minipigs. This animal model resembles closely the anatomical conditions in humans, and is thus suitable for investigating the EPI RET3 implant as designed for the application in humans. Phacoemulsifi...

To introduce a method for improvement of multifocal VEP (mfVEP) recordings by prediction of waveforms at multiple positions on the surface of the skull. Fifteen healthy participants (mean age 24 ± 3.8 years) underwent mfVEP recordings from 3 surface positions. Two methods of a best-of-mfVEP approach were used and compared. In the first, a standard...

Aims: For the purpose of visual rehabilitation of subjects with photoreceptor degeneration, an implantable microelectronic device for epiretinal stimulation was developed. Our study aimed to show whether implantation and explantation could be conducted safely and to investigate tissue compatibility. Methods: The device was implanted in 5 Götting...

The fixation of polyimide stimulator foils as the basic substrate of epiretinal prostheses by using retinal tacks may cause retinal or choroidal alterations such as retinal proliferations or choroidal neovascularizations. During the prospective trial for the semichronical testing of a wireless intraocular retinal implant (EPIRET3) we investigated a...

In acute retinal stimulation experiments retinal stimulators are inserted into the eye, activated, and responses from patients to electrical stimulation are recorded. These tests were done to obtain evidence that the principle of electrical stimulation of the retina works in terms of elicitation of phosphenes or visual perception, respectively. The...

To assess the accuracy and signal quality of axial length measurements by partial coherence laser interferometry (PCI) for optical biometry in eyes with conventional silicone oil (SO) or heavy silicone oil (HSO) as endotamponade. We included 26 eyes with SO endotamponade (SO, n = 15; HSO, n = 11) using a Zeiss IOLMaster for measurement of axial len...

Visual sensations in patients with blindness and retinal degenerations may be restored by electrical stimulation of retinal neurons with implantable microelectrode arrays. A prospective trial was initiated to evaluate the safety and efficacy of a wireless intraocular retinal implant (EPIRET3) in six volunteers with blindness and RP. The implant is...

Our aim was to identify different states of energy metabolism in the perfused isolated vertebrate retina by simultaneous recordings of light-evoked changes of transretinal potential (TRP) and spectroscopic changes related to oxidation of pyridine nucleotides. Isolated retinas were obtained from R.esc. and superfused. For each setting, three experim...

Degenerations of the outer retina such as retinitis pigmentosa (RP) lead to blindness due to photoreceptor loss. There is a secondary loss of inner retinal cells but significant numbers of bipolar and ganglion cells remain intact for many years. Currently, no therapeutic option to restore vision in these blind subjects is available. Short-term patt...

Syphilis is a dangerous sexually transmitted infection which can be effectively treated with penicillin to avoid late-onset diseases. Even if syphilis is diagnosed an HIV infection should be excluded. A 32-year-old homosexual man complained about a decreased bilateral visual acuity after a feverish infection with lymphadenitis colli. With slit-lamp...

Einleitung: Die Lues (Syphilis) bezeichnet eine gefährliche zyklische Infektionskrankheit, welche meist durch Geschlechtsverkehr übertragen wird. Durch eine rechtzeitige und ausreichende Behandlung mit Penicillin kann das Auftreten von syphilitischen Späterscheinungen völlig vermieden werden. Bei serologischem Nachweis einer Lues sollte ebenfalls e...

To assess the practical feasibility and signal quality of axial length measurements by partial coherence laser interferometry in silicone oil-filled eyes with previous complicated vitreoretinal surgery. Department of Ophthalmology, University Cologne, Cologne, Germany. Using a Zeiss IOLMaster, axial length measurements and signal-to-noise ratios of...

To demonstrate local cortical activations in the primary visual cortex of the cat as a result of retinal electrical stimulation by means of a completely wireless-controlled, implantable retinal prosthesis in a series of acute experiments. The transfer of energy to drive the device and signals to activate any combination of 25 retinal electrodes was...

This paper reports on methods and technical equipment to investigate the epiretinal stimulation of the retina in blind human subjects in acute trials. Current is applied to the retina through a thin, flexible microcontact film (microelectrode array) with electrode diameters ranging from 50 to 360 microm. The film is mounted in a custom-designed sur...

Currently, no treatment is available for degenerative diseases of retinal photoreceptors. The patients are faced with a high risk of blindness. Biological approaches failed to prove efficacy. A new concept for the treatment of disorders like retinitis pigmentosa is electrical stimulation at various levels of the visual system. Therefore, devices we...

Retinal artery occlusion (RAO) is an ophthalmological emergency that causes a major decrease of visual parameters in most of the cases. Purpose of this pilot study was to evaluate the effect of adjunctive hyperbaric oxygen therapy (HBO) on visual acuity (VA). Patients with acute central or branch artery occlusion (CRAO/BRAO) consecutively admitted...

We performed a retrospective clinicopathologic study on sequential biopsy specimens from 90 patients with Philadelphia chromosome-positive chronic myelogenous leukemia to study therapy-specific effects of busulfan (28 patients), hydroxyurea (32 patients), and interferon-alfa (IFN-alfa; 30 patients). Bone marrow specimens were evaluated by morphomet...

Retinal artery occlusion (RAO) is an ophthalmological emergency that causes a major decrease of visual parameters in most of the cases. Purpose of this pilot study was to evaluate the effect of adjunctive hyperbaric oxygen therapy (HBO) on visual acuity (VA). Patients and Methods. Patients with acute central or branch artery occlusion (CRAO/ BRAO)...

Retinal laser coagulation (LC) of extrafoveal subretinal neovascularization (SRN) due to age-related macular degeneration (AMD) is the only sure therapy. Diagnostics, therapy and follow-up are presented in a case report. A 55-year-old woman had suffered from progressive reduction of visual acuity (with metamorphopsia) in both eyes (LE > RE) for 3 y...