German Alberto Tellez

German Alberto Tellez
Corporacion Universitaria Empresarial Alexander von Humboldt

MD, PhD

About

36
Publications
9,866
Reads
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172
Citations
Additional affiliations
January 2010 - present
University of Quindio
Position
  • Researcher
Description
  • Research leader of the antimicrobial peptides Research line. Principal investigator of projects related to the identification, design, production, and evaluation of antimicrobial peptides. Tutor of PhD, MSc, and undergraduate students.
Education
January 2000 - December 2007
University of Quindio
Field of study
  • Medicine

Publications

Publications (36)
Article
Trypanosoma cruzi is an obligate parasite that uses glucose as one of the main resources to maintain its survival and proliferation. In eukaryotic cells glucose transport across membranes is mediated by facilitated transport through a variety of transporters. Herein, genes from the recently described SWEET family of carbohydrate transporters were i...
Article
Full-text available
Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Objectives Host defense peptides (HDP) are produced by a diversity of beetles. The aims of this work were (1) to find new promising peptides from the Coleoptera family Scarabaeidae with potential biomedical applications, (2) to modify physicochemical and structural characteristics of one of...
Article
Antibiotic resistance is an increasing global problem and therapeutic alternatives to traditional antibiotics are needed. Antimicrobial and host defense peptides represent an attractive source for new therapeutic strategies, given their wide range of activities including antimicrobial, antitumoral and immunomodulatory. Insects produce several famil...
Article
Full-text available
The Coleoptera Scarabaeidae family is one of the most diverse groups of insects on the planet, which live in complex microbiological environments. Their immune systems have evolved diverse families of Host Defense Peptides (HDP) with strong antimicrobial and immunomodulatory activities. However, there are several peptide sequences that await discov...
Preprint
Full-text available
Introduction: The Coleoptera Scarabaeidae family is one of the most diverse groups of insects on the planet, living in complex microbiological environments. Their immune systems have evolved with the generation of host defense peptides but only a small number of these peptides have been characterized. Methods: In this work two sources of informatio...
Preprint
Este método es basado en el método clásico de micro-dilución en placa de NCLSS (National Committee of Laboratory Safety and Standards (NCLSS) como fue publicado en Amsterdam, D. 1996. Susceptibility testing of Antimicrobials in liquid media.In'Antibiotics in Laboratory Medicine', Lorian, V., ed. Fourth Edition, pp.52-111. Williams and Wilkins, Balt...
Article
Full-text available
Maggots from the Lucilia sp. genus are used for debridement of infected and necrotic wounds. Broad-spectrum antimicrobial activity has been described in the excretion/secretions (ES 1) of these larvae. This study identifies the genetic sequence of a cecropin-like antimicrobial peptide from Lucilia eximia. Total RNA was extracted and used for PCR-RA...
Article
Full-text available
Dung beetles are exposed to a complex microbiological ecosystem during their life cycle. Characterization of novel host-defense peptides (HDP) is essential to understanding the host innate immune response in insects. It constitutes a promising alternative to look for new therapeutic agents against pathogenic microbes. We identified four new HDP, Ox...
Data
Antibiotic resistance profile. The antibiotic resistant profile of the bacterial strains. (DOCX)
Data
Oxysterlins genetic sequences. The genetic sequences of the Oxysterlins with the codes reported in the NCBI database. (DOCX)
Data
Ramachandran plots of the oxysterlins. Ramachandran plots for the structural models of the Oxysterlins 1 to 4 in the figures A-D. (DOCX)
Preprint
El ensayo de herida o ruptura in vitro, es un método fácil, de bajo costo y bien desarrollado para medir migración celular in vitro. Los pasos básicos implican la creación de una “herida” en una monocapa celular, capturando las imágenes al principio y en intervalos regulares de tiempo durante la migración celular para cerrar la herida y comparar la...
Preprint
Full-text available
Evaluación de la capacidad de neutralización del efecto del Lipopolisacarido (LPS) de inducir la producción de Factor de Necrosis Tumoral (TNFalfa) en Células Mononucleares de Sangre Periférica (PBMCs)tratadas con peptidos cationicos. La realizacion de este protocolo fue posible gracias al apoyo del departamento administrativo deciencia tecnología...
Preprint
Full-text available
Este método es basado en el método clásico de micro-dilución en placa de NCLSS (National Committee of Laboratory Safety and Standards (NCLSS) como fue publicado en Amsterdam, D. 1996. Susceptibility testing of Antimicrobials in liquid media.In'Antibiotics in Laboratory Medicine', Lorian, V., ed. Fourth Edition, pp.52-111. Williams and Wilkins, Balt...
Preprint
Full-text available
Procedimiento basado en la sedimentación a través de una barrera de densidad de 1,077g/ml dejando en la interfase los PBMCs. La realizacion de este protocolo fue posible gracias al apoyo del departamento administrativo deciencia tecnología e innovacion, Colciencias a traves del proyecto 111356933173convocatoria569-2012.
Preprint
Full-text available
Procedimiento basado en la sedimentación a través de una barrera de densidad de 1,077g/ml dejando en la interfase los PBMCs.
Preprint
Full-text available
Angionesis in vitro: Es la formación In vitro de tubos capilares por células endoteliales en la matriz de una membrana basal, es un metodo in vitro poderoso para evaluar varios factores que promueven o inhiben angiogenesis. Es para definir las rutas de señalización en angiogenesis, identificando los genes reguladores de angiogenesis y caracterizand...
Preprint
Full-text available
Esta prueba evalúa la actividad hemolítica de péptidos o moleculas sobre eritrocitos humanos como criterio de selectividad ante las células eucariotas. La realizacion de este protocolo fue posible gracias al apoyo del departamento administrativo de ciencia tecnología e innovacion, Colciencias a traves del proyecto 111356933173 convocatoria569-2012.
Preprint
Evaluación de la capacidad de neutralización del efecto del Lipopolisacarido (LPS) de inducir la producción de Factor de Necrosis Tumoral (TNFalfa) en Células Mononucleares de Sangre Periférica (PBMCs)tratadas con peptidos cationicos.
Preprint
Full-text available
El ensayo de herida o ruptura in vitro, es un método fácil, de bajo costo y bien desarrollado para medir migración celular in vitro. Los pasos básicos implican la creación de una “herida” en una monocapa celular, capturando las imágenes al principio y en intervalos regulares de tiempo durante la migración celular para cerrar la herida y comparar la...
Preprint
Este método es basado en el método clásico de micro-dilución en placa de NCLSS (National Committee of Laboratory Safety and Standards (NCLSS) como fue publicado en Amsterdam, D. 1996. Susceptibility testing of Antimicrobials in liquid media.In'Antibiotics in Laboratory Medicine', Lorian, V., ed. Fourth Edition, pp.52-111. Williams and Wilkins, Balt...
Chapter
Full-text available
The NS5 protein form Dengue virus 2 (DENV2) has an ARN dependant ARN polymerase activity (RdRp) and it is an important target to develop new treatments against dengue. We had amplified by PCR and cloned in the plasmid pGEX-5X-1 the genetic sequence of the polymerase domain from NS5 of DENV2. This domain was expressed as a fusion protein with Glutat...
Article
Full-text available
Introduction: Chronic leg ulcers are a burden for the health system and impact quality of life. The infections, the necrotic tissue and the difficult treatment affects the prognosis and healing time. Maggot therapy is presented as an acceptable alternative for the debridement and treatment of this pathology. Objective: The larval therapy was ass...
Article
Full-text available
Introducción. Las úlceras crónicas son una afección con un impacto negativo importante en la calidadde vida de los pacientes y en el sistema de salud; la aparición de infecciones y su difícil manejo, asícomo la presencia de tejido necrótico, afectan el pronóstico de curación. La larvaterapia se presentacomo una opción para el desbridamiento y el ma...
Article
Full-text available
Introduction: Mammomonogamus laryngeus is a nematode parasite that is usually found in the larynx of mammals in the tropics, especially in cattle, sheep and cats. Objective: The prevalence of M. laryngeus was determined in cattle brought to an abattoir as an indicator of its prevalence in the general population. Materials and methods. The presen...
Article
Full-text available
p>Introduction. Mammomonogamus laryngeus is a nematode parasite that is usually found in the larynx of mammals in the tropics, especially in cattle, sheep and cats. Objective. The prevalence of M. laryngeus was determined in cattle brought to an abattoir as an indicator of its prevalence in the general population. Materials and methods. The present...
Article
Full-text available
The antimicrobial peptides (AMP) are the effectors molecules of the innate immune system, finding groups of this kind of substances in almost all living organisms from bacteria to mammals. They are a family of versatile substances with complexes action mechanisms in the pathogen they interact with membrane, DNA synthesis and protein synthesis and f...
Article
Full-text available
Resumen Los péptidos antimicrobianos son las molé-culas efectoras del sistema inmune innato, cuyas familias se encuentran en casi todos los organismos, desde bacterias hasta ma-míferos. Son una familia de sustancias po-lifacéticas con complejos mecanismos de acción relacionados con la interacción con el patógeno a través de su membrana, o afectando...
Article
Full-text available
First case report of Mammomonogamus (Syngamus) laryngeus human infection in Colombia Parasitic nematodes of the genus Mammomonogamus affect the respiratory tract of domestic mammals. The male and female of M. laryngeus remain in permanent copula so that the pair appears as a "Y'. To date, a few more than 100 cases of human infections by this parasi...
Article
Full-text available
Monoclonal antibodies are specialized glucopro- teins that belong to the immune system, produced by the B cells which have the ability to recognize other molecules (antigens). They are important tools in clinical practice and biotechnology and have been useful in the diagnosis and treatment of infectious, inflammatory, immunological and neoplasic d...
Article
Full-text available
Parasitic nematodes of the genus Mammomonogamus affect the respiratory tract of domestic mammals. The male and female of M. laryngeus remain in permanent copula so that the pair appears as a "Y'. To date, a few more than 100 cases of human infections by this parasite have been reported in the biomedical literature. This report describes the first i...
Article
Full-text available
Los anticuerpos monoclonales son glucoproteínas especializadas que hacen parte del sistema inmune, producidas por las células B, con la capacidad de reconocer moléculas específicas (antígenos). Los anticuerpos monoclonales son herramientas esenciales en el ámbito clínico y biotecnológico, y han probado ser útiles en el diagnóstico y tratamiento de...

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