Gerda K Pot

Louis Bolk Instituut | louisbolk · Nutrition and Health

Chrono-nutrition is an emerging field of research that includes three aspects of time: (1) regularity, (2) frequency, and (3) clock time. Due to the COVID-19 pandemic and the implemented lockdown, daily routines were disrupted, which presented a unique opportunity to investigate chrono-nutrition, in particular in adolescents. A nested case-control...

Background: Lifestyle intervention studies to treat type 2 diabetes (T2D) are on the rise. However, in-depth research is lacking into the dietary changes that participants make. Methods: The present study aimed to observe the dietary intake of participants following the group program 'Reverse Diabetes2 Now' (RD2N) over 12 months. The web-based 2...

Leefstijlinterventies bij diabetes type 2 (DM2) blijken op de korte termijn goed te werken. Of ze ook op de langere termijn in ‘real life’-omstandigheden effect hebben is echter nog niet zo duidelijk. De intensieve leefstijlbehandeling Keer Diabetes2 Om van Voeding Leeft blijkt een duurzame gedragsverandering teweeg te brengen. Na 24 maanden gebrui...

The circadian timing system governs daily biological rhythms, synchronising physiology and behaviour to the temporal world. External time cues, including the light‐dark cycle and timing of food intake, provide daily signals for entrainment of the central, master circadian clock in the hypothalamic suprachiasmatic nuclei (SCN), and of metabolic rhyt...

Background Eating problems are highly prevalent in older patients with dementia and as a consequence, these patients are at greater risk of becoming malnourished. Fingerfoods, snacks that can be picked with thumb and forefinger, could be used to counteract malnutrition in patients with dementia. The aim of this feasibility study was to evaluate whe...

Introduction A wealth of evidence supports short-term efficacy of lifestyle interventions in type 2 diabetes (T2D). However, little is known about long-term effects of lifestyle interventions in real-life settings. Methods This observational, single-arm study evaluated long-term impact of ‘Voeding Leeft: Reverse-Diabetes2-Now’, a 6-month multicomp...

This study investigates the relationship between the consumption of foods and eating locations (home, school/work and others) in British adolescents, using data from the UK National Diet and Nutrition Survey Rolling Program (2008–2012 and 2013–2016). A cross-sectional analysis of 62,523 food diary entries from this nationally representative sample...

Background: Antibiotic-associated diarrhea (AAD) occurs in 2-25% of nursing home residents, which may lead to dehydration, malnutrition, severe complications and hospitalizations. Research shows that probiotics can be effective and safe in reducing AAD. However, probiotics are not routinely used in Dutch nursing homes. The objectives of this evalu...

Objectives To examine associations of tree nut snack (TNS) consumption with diet quality and cardiovascular disease (CVD) risk in UK adults from National Diet and Nutrition Survey (NDNS) 2008–2014. Design Cross-sectional analysis using data from 4-d food diaries, blood samples and physical measurements for CVD risk markers. To estimate diet qualit...

Background: Delayed sleep-wake phase disorder (DSPD), characterized by delayed sleep-onset and problems with awakening in the morning, is mostly prevalent in adolescents. Several studies have suggested chrono-nutrition could present a possible modifiable risk factor for DSPD. Objective: To describe differences in chrono-nutrition and diet quality i...

Background Eating problems are highly prevalent in older patients with dementia and as a consequence, these patients are at greater risk of becoming malnourished. Fingerfoods, snacks that can be picked with thumb and forefinger, could be used to counteract malnutrition in patients with dementia. The aim of this feasibility study was to evaluate whe...

Background Eating problems are highly prevalent in older patients with dementia and as a consequence, these patients are at greater risk of becoming malnourished. Fingerfoods, snacks that can be picked with thumb and forefinger, could be used to counteract malnutrition in patients with dementia. The aim of this feasibility study was to evaluate whe...

Background Eating problems are highly prevalent in older patients with dementia and as a consequence, patients are at greater risk of becoming malnourished. Fingerfoods, snacks that can be picked with thumb and forefinger, could be used to counteract malnutrition in patients with dementia. The aim of this feasibility study was to evaluate whether p...

Background Eating problems are highly prevalent in older patients with dementia and as a consequence, these patients are at greater risk of becoming malnourished. Fingerfoods, snacks that can be picked with thumb and forefinger, could be used to counteract malnutrition in patients with dementia. The aim of this feasibility study was to evaluate whe...

Individuals increasingly consume their meals away from home. This article describes a series of studies that examined the effects of meals with reduced amounts of meat and increased amounts of vegetables on food consumption, waste and guest satisfaction in four real-life restaurant settings in the Netherlands: an a-la-carte restaurant, six company...

Low fruit and vegetable consumption is associated with poor outcomes after renal transplantation. Insufficient fruit and vegetable consumption is reported in the majority of renal transplant recipients (RTR). The aim of this study was to identify barriers and facilitators of fruit and vegetable consumption after renal transplantation and explore if...

Introduction Prevalence of type 2 diabetes (T2D) is increasing rapidly and lifestyle interventions to reverse diabetes are seen as a possible solution to stop this trend. New practice-based evidence is needed to gain more insight in the actual, and above all scientific, basis for these claims. Methods This observational study with a pretest post-t...

Objectives To test the methodology of recruitment, retention and data completeness in a prospective cohort recruited after a hospitalised episode of acute kidney injury (AKI), to inform a future prospective cohort study examining the effect of obesity on AKI outcomes. Design Feasibility study. Setting Single centre, multi-site UK tertiary hospita...

Objective Evidence suggests that the rate of glucose release following consumption of carbohydrate-containing foods, defined as the glycaemic index (GI), is inversely associated with cognitive function. To date, most of the evidence stems from either single-meal studies or highly heterogeneous cohort studies. We aimed to study the prospective assoc...

Objective To evaluate the internal validity and reliability of an index developed to assess the nutritional quality of meals. Methods The Main Meal Quality Index is composed of ten components. The final scores range from 0-100 points. The index performance was measured using strategies for assessing content validity, construct validity, discrimina...

Background: Evidence suggests that short sleep duration may be a newly identified modifiable risk factor for obesity, yet there is a paucity of studies to investigate this. Objective: We assessed the feasibility of a personalized sleep extension protocol in adults aged 18-64 y who are habitually short sleepers (5 to <7 h), with sleep primarily m...

Associations between tree nut consumption and cardiovascular disease risk markers in the UK adult population based on National Diet and Nutrition Survey (NDNS) rolling programme 2008–2014 - Volume 76 Issue OCE4 - V. Dikariyanto, S.E.E. Berry, G.K. Pot, W.L. Hall

Associations between tree nut consumption and diet quality in the UK adult population based on National Diet and Nutrition Survey (NDNS) rolling programme 2008–2014 - Volume 76 Issue OCE4 - V. Dikariyanto, W.L. Hall, S.E.E. Berry, G.K. Pot

The feasibility of lengthening sleep in habitually short sleepers and its effect on dietary intake, energy balance, and metabolic risk factors: A randomised controlled trial - Volume 76 Issue OCE4 - H.K. Al Khatib, W.L. Hall, A. Creedon, E. Ooi, T. Masri, S.V. Harding, L. McGowan, J. Darzi, G.K. Pot

The urban environment has changed vastly over past decades, which also has had an impact on our sleep and dietary patterns and possibly health outcomes. Some studies have shown that sleep duration and sleep quality has declined over past decades, especially in children. In parallel, our lifestyle and dietary patterns have also changed including mor...

Background: Although growing evidence suggests that dietary patterns associated with noncommunicable diseases in adulthood may develop early in life, when these are established, as well as their determinants, remains unclear. Methods: We examined determinants and tracking of a dietary pattern (DP) associated with metabolic risk and its key food...

Although breakfast consumption is widely considered to be an important component of a healthy lifestyle, few UK studies have examined differences in nutrient intakes between breakfast consumers and breakfast skippers among children and adolescents. We investigated associations between breakfast skipping in 4–18-year-olds and their nutrient intakes...

This article provides an update on the project ‘Sleep patterns in relation to dietary patterns and cardio-metabolic risk’, which received funding from the British Nutrition Foundation (BNF) Drummond Pump Priming Award. Studying the relationship between sleep, the biological clock, timing of eating and nutrition is part of a new research area termed...

Investigating the relationship between foods consumed and eating location for UK adolescents using the NDNS - Volume 76 Issue OCE1 - A.N. Chapman, E. Almiron-Roig, G.K. Pot, L. Palla

Consumption of fast food and ready-to-eat meals has been positively associated with obesity. In the UK, ready-made meals are more often consumed than in Brazil, a country in which nutrition transition is relatively low. This study aimed to compare the nutritional quality of the main meal consumed by adults in Brazil and UK. Food record data was obt...

Dietary glycaemic index and cognitive function: associations in adults aged 53y of the 1946 British birth cohort - Volume 76 Issue OCE1 - E. Philippou, G.K. Pot, A. Heraclides, R. Bendayan, M. Richards

The increasing rate in obesity amongst young people is a national concern. Recently the location of eating has been implicated in changes in diet quality in adolescents (1). Data from four day food diaries from 884 teenagers aged 11–18 years participating in the 2008–2012 UK National Dietary and Nutrition Survey Rolling Programme (NDNS RP) were use...

Background: Interventions to increase cooking skills (CS) and food skills (FS) as a route to improving overall diet are popular within public health. This study tested a comprehensive model of diet quality by assessing the influence of socio-demographic, knowledge- and psychological-related variables alongside perceived CS and FS abilities. The cor...

Background/objectives: The aim of this study was to evaluate the validity and reliability of the Main Meal Quality Index when applied on the UK population. Subjects/methods: The indicator was developed to assess meal quality in different populations, and is composed of 10 components: fruit, vegetables (excluding potatoes), ratio of animal protei...

Background: It is unknown whether short sleep duration causatively contributes to weight gain. Studies investigating effects of partial sleep deprivation (PSD) on energy balance components report conflicting findings. Our objective was to conduct a systematic review and meta-analysis of human intervention studies assessing the effects of PSD on ene...

The importance of the circadian rhythm in regulating human food intake behaviour and metabolism has long been recognised. However, little is known as to how energy intake is distributed over the day in existing populations, and its potential association with obesity. The present review describes global trends in time-of-day of energy intake in the...

Studying irregular meal patterns fits in with the latest research focusing not only on what people eat but also when they eat, also called chrono-nutrition. Chrono-nutrition involves studying the impact of nutrition on metabolism via circadian patterns, including three aspects of time: (ir)regularity, frequency and clock time. The present paper aim...

This systematic review aimed to synthesise information on indices developed to evaluate nutritional quality of meals. A strategy for systematic search of the literature was developed using keywords related to assessment of meal quality. Databases searched included ScienceDirect, PubMed, Lilacs, SciELO, Scopus, Cochrane, Embase and Google Scholar. T...

There is some evidence from studies in adults and limited evidence from studies in children that eating later in the day may increase the risk of overweight and obesity. In this cross-sectional study, we investigated associations between evening meal timing in children and their weight status and energy intake. Dietary data obtained from the UK's N...

Background/objectives: Nutrition and dietary supplementation may modulate outcomes in colorectal cancer (CRC) survivors. However, no recent systematic review has focused on randomised controlled trials (RCTs). The aim of this systematic review was to examine the effects of nutritional RCTs in survivors of colorectal adenomas and cancer. Subjects/...

Short sleep duration (⩽5–6 h/night) has been associated with an increased risk of weight gain (1,2) and non-communicable disease (3). Recently, through a systematic review and meta-analysis, we identified that short sleep duration may induce positive energy balance and have implications on weight gain over the long term (Al Khatib et al, unpublishe...

div class="title">Sleep duration, nutrient intake and nutritional status in UK adults - Volume 75 Issue OCE3 - G.K. Pot, H.K. Al Khatib, M. Perowicz, W.L. Hall, S.V. Harding, J. Darzi

Irregularity in eating patterns could be a potential cardiometabolic risk factor. We aimed to study the associations of irregular intake of energy at meals in relation to cardiometabolic risk factors 10 and 17 years later. Variability of energy intake data – derived from 5-d estimated diet diaries of cohort members of the National Survey for Health...

Background: It is well known that fish is the major natural source of vitamin D in the diet; therefore, this meta-analysis investigated the influence of fish consumption in randomized controlled trials (RCTs) on serum 25-hydroxyvitamin D [25(OH)D] concentrations. Objective: A literature search was carried out in Medline, Embase, Web of Science,...

Energy dense, high fat, low fibre diets may contribute to obesity in young people, however their relationships with other cardiometabolic risk factors are unclear. We examined associations between an 'energy-dense, high-fat and low-fibre' dietary pattern (DP) and cardiometabolic risk factors, and the tracking of this DP in adolescence. Data was sou...

Background/objectives: As populations are ageing, more emphasis is placed on healthy ageing. Over the past decades, food consumption patterns and food availability have also changed drastically, and therefore this study aimed to describe these changes in an ageing population. Subjects/methods: Food consumption of participants from the Medical Re...

Despite the increasing use of dietary patterns (DP) to study diet and health outcomes, relatively few studies have examined the reliability of DP using different dietary assessment methods. Reduced-rank regression (RRR) is an emerging statistical method that incorporates a priori information to characterise DP related to specific outcomes of intere...

Background/objectives: In spite of several studies relating dietary patterns to breast cancer risk, evidence so far remains inconsistent. This study aimed to investigate associations of dietary patterns derived with three different methods with breast cancer risk. Subjects/methods: The Mediterranean Diet Score (MDS), principal components analyse...

Background/objectives: A potential risk factor for cardiometabolic diseases is irregular or inconsistent eating, however, research on this topic is scarce. We aimed to study associations between irregular consumption of energy intake in meals and cardiometabolic risk factors. Subject and methods: Dietary intake data were derived from 5-day estim...

Current indices of diet quality generally include intakes of specific foods or nutrients. We sought to develop an index that discriminates healthy and unhealthy eating choices for use in large surveys as a short questionnaire and as a measure in existing studies with adequate dietary data. The Eating Choices Index (ECI) score included four componen...

In animal models, excess luminal iron exacerbates colonic inflammation and cancer development. Moreover, in inflammatory bowel disease (IBD) patients with mild to moderate disease activity dietary fortificant iron intake is inversely related to quality of life. Here we sought to determine whether dietary iron intakes were also related to quality of...

Pathway analysis of gene expression data from colonic biopsies distinguishes salmon from cod consumers - Volume 72 Issue OCE2 - G. Majsak-Newman, G. Hooiveld, G. K. Pot, L. J. Harvey, J. F. Doleman, E. K. Lund

The alcohol-breast cancer association has been established using alcohol intake measurements from Food Frequency Questionnaires (FFQ). For some nutrients diet diary measurements are more highly correlated with true intake compared with FFQ measurements, but it is unknown whether this is true for alcohol. A case-control study (656 breast cancer case...

High saturated fat intake is an established risk factor for several chronic diseases. The objective of the present study is to report dietary intakes and main food sources of fat and fatty acids (FA) from the first year of the National Diet and Nutrition Survey (NDNS) rolling programme in the UK. Dietary data were collected using 4 d estimated food...

The National Diet and Nutrition Survey (NDNS) is a cross-sectional survey designed to gather data representative of the UK population on food consumption, nutrient intakes and nutritional status. The objectives of the present paper were to identify and describe food consumption and nutrient intakes in the UK from the first year of the NDNS rolling...

IntroductionThe role of the commensal flora in the maintenance of a healthy mucosa is now recognized1 but there remains a lack of data in relation to the healthy human colon. Array analyses by us, comparing paired samples from 28 patients taken at colonoscopy and sigmoidoscopy, have highlighted innate immune responses to be of particular interest....

Introduction The authors have previously shown that both mRNA and protein profiles of IL-1β and IL-8 in biopsies taken from macroscopically normal colon tissue during colonoscopy are significantly different to those taken during sigmoidoscopy. The former procedure involves emptying of the bowel 24 h prior to sample collection while in the latter ca...

Television use and nutrient intakes in young children from the first year of the National Diet and Nutrition Survey rolling programme - Volume 70 Issue OCE1 - N. Ziauddeen, G. K. Pot, C. J. Prynne, B. Bates, H. Henderson, S. Pigott, C. Deverill, A. M. Stephen

Fish consumption is associated with a reduced colorectal cancer risk. A possible mechanism by which fish consumption could decrease colorectal cancer risk is by reducing inflammation. However, thus far, intervention studies investigating both systemic and local gut inflammation markers are lacking. Our objective in this study was to investigate the...

National Diet and Nutrition Survey: fat and fatty acid intakes from the first year of the rolling programme - Volume 69 Issue OCE6 - G. K. Pot, C. J. Prynne, C. Roberts, B. Teucher, E. Fitt, D. Cole, B. Bates, H. Henderson, S. Pigott, C. Deverill, G. Swan, A. M. Stephen

Fish consumption is associated with a reduced colorectal cancer risk. A possible mechanism by which fish consumption could decrease colorectal cancer risk is by reducing inflammation. However, thus far, intervention studies investigating both systemic and local gut inflammation markers are lacking. Our objective in this study was to investigate the...

Observational studies suggest that fish consumption is associated with a decreased colorectal cancer (CRC) risk. A possible mechanism by which fish could reduce CRC risk is by decreasing colonic genotoxicity. However, concerns have also been raised over the levels of toxic compounds found in mainly oil-rich fish, which could increase genotoxicity....

A high intake of n-3 polyunsaturated fatty acids (PUFAs), mainly present in fish, may be associated with decreased inflammation. Previous intervention studies on fish PUFA and inflammatory markers in healthy individuals did not analyze a broad spectrum of inflammatory cytokines, chemokines and cell adhesion molecules, or their interrelationships. T...

Diet is a major factor in the etiology of colorectal cancer, with high fish consumption possibly decreasing colorectal cancer risk, as was shown in several observational studies. To date, no intervention trials have examined the possible beneficial effects of fish intake on colorectal cancer risk. The objective was to investigate the effects of a 6...

Several observational studies have indicated that fish consumption is inversely associated with the occurrence of colorectal adenomas and progression of ulcerative colitis (UC), both risk factors for colorectal cancer. N-3 fatty acids in oily fish may favourably influence inflammatory processes involved in colorectal carcinogenesis. Also, other con...

Several human and animal studies have shown that n-3 polyunsaturated fatty acids (PUFA) might be associated with a decreased risk, whereas other studies showed that n-6 PUFA may be associated with an increased risk of colorectal cancer. However, results from these studies are not consistent. We evaluated the associations between serum n-3 and n-6 P...