Gerd Bayer

Aims: The purpose of the present study was to examine the comparative vascular healing response to stents coated with permanent or biodegradable polymer and uncoated stents in a porcine model of coronary artery stenting. Methods and results: Juvenile pigs were randomly allocated to implantation of stents coated with permanent polymer (PP, methac...

Biodegradable stent coatings were recently introduced as a potential solution to overcome sustained inflammatory responses observed with permanent polymer-based drug-eluting stents. In a preliminary study, selected biodegradable or permanent polymer-based sirolimus-eluting stent (SES) formulations were screened for effectiveness in comparison to ba...

The vascular effects of drug- eluting balloon (DEB) deployment in the absence of coronary stents have not been characterised. This study evaluated potential vascular effects of paclitaxel-coated angioplasty balloons using different excipients in the absence of additional stents. A total 45 porcine arteries were treated with paclitaxel-coated DEBs u...

The advent of drug-eluting balloon (DEB) therapy has represented an important development in interventional cardiology. Nevertheless, preclinical data with this technology remain scant, and comparative studies have not previously been published. Bare metal stents were implanted in the coronary arteries of 15 pigs followed by balloon angioplasty. An...

The irreversible conversion of the plasma protein fibrinogen to fibrin is an important step within the coagulation process. Contact activation may be stimulated by an electron transfer from the fibrinogen molecule to an alloplastic material. Structure and electronic properties of fibrinogen and material are therefore determining the hemocompatibili...