Georgios Nikolopoulos

Georgios Nikolopoulos
University of Cyprus · Medical School

About

136
Publications
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Publications

Publications (136)
Presentation
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Our presentation on the psychosocial impact and coping in healthcare professionals during the COVID-19 pandemic, during the EHPS 2021 conference
Conference Paper
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The present study aims to address the gap in the literature by examining the psychosocial impact and self-regulation skills in healthcare professionals during the COVID-19 pandemic in Cyprus. It is hoped that the study will provide the basis for a short- and long-term national strategy to support healthcare professionals during the COVID-19 pandemi...
Article
Background Hypofibrinolysis has been demonstrated in several studies in adult sepsis. Although fibrinolysis is an important and integral part of the hemostatic system, few data are available regarding its role in neonatal sepsis. Our purpose was to define fibrinolytic profiles across neonatal sepsis spectrum using rotational thromboelastometry (ROT...
Article
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Community pharmacists can play an important role by supplying EAI, offering instructions on its correct use and storage, and assisting patients who are experiencing anaphylaxis (4,5). However, it has been reported that there are gaps in pharmacists' knowledge on anaphylaxis and on EAI use (6-9). Therefore, it has been proposed that they should be a...
Article
Linked Content This article is linked to Bonovas et al and Tsai papers. To view these articles visit https://doi.org/10.1111/apt.14449 and https://doi.org/10.1111/apt.14480.
Article
Background: Biological therapies have improved the care of patients with ulcerative colitis (UC). Tofacitinib, an oral small-molecule Janus kinase inhibitor, is potentially a new treatment option. Aim: To comparatively assess efficacy and harm of tofacitinib and biologics (infliximab, adalimumab, golimumab and vedolizumab) in adult patients not...
Article
Aims: Oral systemic corticosteroids have been used to induce remission in patients with active inflammatory bowel disease (IBD) for over 50 years; however, the wide array of adverse events (AEs) associated with these drugs prompted the development of steroid compounds with targeted delivery and low systemic bioavailability. This study assessed cor...
Article
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Attacks on peoples’ dignity help to produce and maintain stigmatization and interpersonal hostility. As part of an effort to develop innovative measures of possible pathways between structural interventions or socially-disruptive Big Events and HIV outbreaks, we developed items to measure dignity denial. These measures were administered to 300 peop...
Article
Background: High numbers of HIV-1 infections among people who inject drugs (PWID) have been diagnosed in Athens, Greece since 2011. We aimed to trace the geographic origin of HIV-1 infection for migrant who inject drugs and to investigate whether transmissions occur more frequently among migrants than among Greek nationals. Methods: Multiple cro...
Article
Background: The prevalence of HIV-1 drug resistance among treatment-naïve patients ranges between 8.3% and 15% in Europe and North America. Previous studies showed that subtypes A and B were the most prevalent in the Greek HIV-1 epidemic. Our aim was to estimate the prevalence of resistance among drug naïve patients in Greece and to investigate th...
Article
en Linked Content This article is linked to Bonovas et al papers. To view these articles visit https://doi.org/10.1111/apt.14023 and https://doi.org/10.1111/apt.14072.
Article
Full-text available
Background.: A "seek-test-treat" intervention (ARISTOTLE) was implemented in response to an outbreak of human immunodeficiency virus (HIV) infection among persons who inject drugs (PWID) in Athens. We assess trends in HIV incidence, prevalence, risk behaviors and access to prevention/treatment. Methods.: Methods included behavioral data collecti...
Article
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This article describes two sets of data on multiple body parameters of five participants, on microclimatic variables, and on self-reported assessment of thermal responses, all monitored in the same outdoor urban environment. Data were collected during three seasons, summer, autumn and winter 2010–2011, in the city of Athens, Greece. Part of these d...
Article
HIV remains an important public health issue worldwide. However, new prevention approaches have recently been developed and are very promising. Antiretroviral treatment as prevention, or as a prophylaxis after exposure to HIV, has been shown to reduce the likelihood of HIV acquisition. Over the last years, animal studies and randomized clinical tri...
Article
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Background: UNAIDS has set a 90-90-90 target to curb the HIV epidemic by 2020, but methods used to assess whether countries have reached this target are not standardised, hindering comparisons. Methods: Through a collaboration formed by the European Centre for Disease Prevention and Control (ECDC) with European HIV cohorts and surveillance agenc...
Article
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The Joint United Nations Programme on HIV/AIDS (UNAIDS) has set a "90-90-90" target to curb the human immunodeficiency virus (HIV) epidemic by 2020, but methods used to assess whether countries have reached this target are not standardized, hindering comparisons. Through a collaboration formed by the European Centre for Disease Prevention and Contr...
Article
Background: The relationship of 5-aminosalicylates' use with the risk of colorectal neoplasia in patients with inflammatory bowel disease (IBD) has been the focus of a growing body of research. Aim: To investigate this association through an updated meta-analysis of observational studies. Methods: PubMed, Scopus and major conference proceeding...
Article
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This article describes data on the intensity of ultraviolet B (UVB) radiation collected during field questionnaire-based surveys in Athens, Greece. The surveys were conducted over 11 days of July and October 2010 at three different urban, outdoor sites. A total of 1104 interviews were conducted. The participants were asked to report whether they fe...
Article
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Background Rotational thromboelastometry (ROTEM) is an attractive method for rapid evaluation of hemostasis in neonates. Currently, no reference values exist for ROTEM assays in full-term and pre-term neonates. Our aim was to establish reference ranges for standard extrinsically activated ROTEM assay (EXTEM) in arterial blood samples of healthy ful...
Article
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Early treatment, soon after infection, reduces HIV transmissions and benefits patients. The Transmission Reduction Intervention Project (TRIP) evaluated a network intervention to detect individuals recently infected (in the past 6 months). TRIP was conducted in Greece (2013–2015) and focused on drug injector networks. Based on HIV status, testing h...
Data
A. Means of observed migration events across all bootstrap trees between the European countries.B. Ratio of mean of observed over mean of expected migration events between the European countries.
Data
Number of sequences per country. The Initial Dataset describes the number of sequences per country downloaded after the bibliographic search. Datasets I and II were used in the analyses.
Data
A. Means of observed migration events across all bootstrap trees between large geographic regions and European countries.B. Ratio of mean of observed over mean of expected migration events between large geographic regions and European countries.
Article
This analysis assessed the utility of the limiting antigen avidity assay (LAg). Samples of people who inject drugs (PWID) in Greece with documented duration of HIV-1 infection were tested by LAg. A LAg-normalized optical density (ODn) ⩽1·5 corresponds to a recency window period of 130 days. The proportion true recent (PTR) and proportion false rece...
Article
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Macro-social/structural events (“big events”) such as wars, disasters, and large-scale changes in policies can affect HIV transmission by making risk behaviors more or less likely or by changing risk contexts. The purpose of this study was to develop new measures to investigate hypothesized pathways between macro-social changes and HIV transmission...
Article
HIV is responsible for one of the largest viral pandemics in human history. Despite a concerted global response for prevention and treatment, the virus persists. Thus, urgent public health action, utilizing novel interventions, is needed to prevent future transmission events, critical to eliminating HIV. For public health planning to prove effectiv...
Article
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Human immunodeficiency virus type 1 (HIV-1) was discovered in the early 1980s when the virus had already established a pandemic. For at least three decades the epidemic in the Western World has been dominated by subtype B infections, as part of a sub-epidemic that traveled from Africa through Haiti to United States. However, the pattern of the subs...
Article
HIV strains continuously evolve, tend to recombine and new circulating variants are being discovered. Novel strains complicate efforts to develop a vaccine against HIV and may exhibit higher transmission efficiency and virulence, and elevated resistance to antiretroviral agents. The United Nations Joint Programme on HIV/AIDS (UNAIDS) set an ambitio...
Conference Paper
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O1 HIV-1 diversity in Bulgaria (current molecular epidemiological picture) Ivailo Alexiev, Reneta Dimitrova, Anna Gancheva, Asya Kostadinova, Mariyana Stoycheva, Daniela Nikolova, Ivaylo Elenkov O2 Knowledge, attitudes and practices of the general population on HIV/AIDS, hepatitis B and C in Romania Cătălin Tilișcan, Mioara Predescu, Bogdan Păunesc...
Article
Background & aims: Safety issues are a major concern for patients considering treatments for inflammatory bowel disease (IBD). We performed a systematic review and meta-analysis to determine whether biologic agents affect the risk of infection or malignancy in adults with IBD. Methods: We searched PubMed, Embase, Scopus, Cochrane IBD Group Speci...
Article
Objectives: The aim of our study was to validate the Genscreen HIV ½ version 2 (BIO-RAD) for detecting HIV antibodies in oral fluid specimens (OF). Background: The advantage of assays to detect HIV infection in OF lies in the on-site easy access and noninvasive sample collection. Methods: Paired serum and OF were collected from 496 subjects (2...
Article
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Human immunodeficiency virus (HIV) transmission remains significant in Europe. Rates of acquired immunodeficiency syndrome (AIDS) have declined, but not in all countries. New HIV diagnoses have increased among native and foreign-born men who have sex with men. Median CD4+ T-cell count at diagnosis has increased, but not in all groups, and late diag...
Article
Mild heat-related health effects and their potential association with meteorological and personal parameters in relation to subjective and objective thermal sensation were investigated. Micrometeorological measurements and questionnaire surveys were conducted in an urban Mediterranean environment during a warm, cool, and a transitional season. The...
Article
Objective: This systematic review and meta-analysis aimed to reassess the effectiveness of condoms in reducing heterosexual transmission of HIV. Methods: Medline, Scopus, and the ISI Web of Science databases were searched up to June 2014. Eligible studies were synthesized using random-effects models. Results: Twenty-five studies with 10,676 HI...
Article
A significant increase in HIV-1 diagnoses was reported among Injecting Drug Users (IDUs) in the Athens (17-fold) and Bucharest (9-fold) metropolitan areas starting 2011. Molecular analyses were conducted on HIV-1 sequences from IDUs comprising 51% and 20% of the diagnosed cases among IDUs during 2011-2013 for Greece and Romania, respectively. Phylo...
Article
Greece experienced an unprecedented increase in HIV cases among drug injectors in 2011 after economic crisis. Network-level factors are increasingly understood to drive HIV transmission in emerging epidemics. We examined the relationship between networks, risk behaviors, and HIV serostatus among 1404 people who inject drugs in Athens, Greece. We ge...
Article
Background The coinfection of Hepatitis B Virus (HBV) and Human Immunodeficiency Virus (HIV) has been associated with increased death rates. However, the relevant research has mostly relied on serologic HBV testing [HBV surface Antigen (HBsAg)]. The aim of this work was to explore the relationship of HBV viraemia with overall mortality among HIV/HB...
Article
The altruism and/or solidarity of people who inject drugs (PWID) helps protect sex and drug partners from HIV. Research has been hindered by lack of measures. We developed and administered scales to assess these variables to 300 PWID. Both the Altruism Scale and the Solidarity Scale were internally consistent. Each correlated significantly with mea...
Article
Full-text available
Aims: To (i) describe an intervention implemented in response to the HIV-1 outbreak among people who inject drugs (PWIDs) in Greece (ARISTOTLE programme), (ii) assess its success in identifying and testing this population and (iii) describe socio-demographic characteristics, risk behaviours and access to treatment/prevention, estimate HIV prevalen...
Article
Full-text available
Background: There is sparse evidence that demonstrates the association between macro-environmental processes and drug-related HIV epidemics. The present study explores the relationship between economic, socio-economic, policy and structural indicators, and increases in reported HIV infections among people who inject drugs (PWID) in the European Ec...
Article
Over the eight months following Hurricane Sandy, of October 2012, we interviewed 300 people who inject drugs in New York City. During the week after the storm, 28% rescued others or volunteered with aid groups; 60% experienced withdrawal; 27% shared drug injection or preparation equipment, or injected with people they normally would not inject with...
Article
Systematic reviews and meta-analyses are a valuable tool to answer research questions, generate recommendations and influence health policy in an evidence-based manner [1]. However, flaws in the design, conduct, analysis, and reporting of the studies that are included in a systematic review may distort estimates of the true intervention effect in t...
Article
Big Events are processes like macroeconomic transitions that have lowered social well-being in various settings in the past. Greece has been hit by the global crisis and experienced an HIV outbreak among people who inject drugs. Since the crisis began (2008), Greece has seen population displacement, inter-communal violence, cuts in governmental exp...
Article
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Our aim was to identify laboratory assays in order to assess the anticoagulant effects of dabigatran etexilate (DE). Twenty patients with nonvalvular atrial fibrillation treated on DE (110 mg per os twice daily) and 20 on acenocoumarol were studied. Conventional coagulation tests, endogenous thrombin potential (ETP), thromboelastometry (ROTEM), epi...
Conference Paper
Full-text available
Issues: HIV/AIDS researchers have called for new measurements to enable studies of how large-scale social structural factors may affect HIV epidemics. Few measures exist at the individual level that could be used to assess structural influences or potential effects of future structural interventions. Description: Through extensive qualitative int...
Conference Paper
Stigma against people with HIV, including those who are recently infected and thus more likely to transmit the virus, can deter participation in community-based interventions and possibly lead to harms against those who do participate. We use baseline data from an HIV intervention project to assess community-level stigma and its relationship to per...
Article
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Background: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found to affect both atheroma and thrombosis. However, the association between PAI-1 levels and the incidence of myocardial infarction...
Article
Full-text available
Background: The cost-effectiveness of universal leucoreduction of blood components remains unclear. When using leucoreduced red blood cells, the decrease in the rate of febrile non-haemolytic transfusion reactions (FNHTR) is the only proven, meaningful clinical benefit, whose relationship to costs can be calculated relatively easily. The aim of th...
Article
To investigate the association between statin use and colorectal cancer risk, we conducted an updated meta-analysis of published studies. We performed a comprehensive search for studies published up to July 2013. Eligible studies for this meta-analysis were either randomized controlled trials (RCTs) or observational studies (case-control or cohort)...
Article
Full-text available
Objectives. We examined HIV prevalence and risk factors among injection drug users (IDUs) in Athens, Greece, during an HIV outbreak. Methods. We used respondent-driven sampling (RDS) to recruit 1404 IDUs to the Aristotle intervention in August to October 2012. We interviewed participants and tested for HIV. We performed bivariate and multivariate a...
Article
Full-text available
During 2011, a dramatic increase (1600%) of reported HIV-1 infections among injecting drug users (IDUs) was noted in Athens, Greece. We herein assess the potential causal pathways associated with this outbreak. Our study employed high resolution HIV-1 phylogenetic and phylogeographic analyses. We examined also longitudinal data of ecological variab...
Article
Current ideas about HIV prevention include a mixture of primarily biomedical interventions, socio-mechanical interventions such as sterile syringe and condom distribution, and behavioral interventions. This article presents a framework for socially-integrated transdisciplinary HIV prevention that may improve current prevention efforts. It first des...
Article
Co-infection of human immunodeficiency virus (HIV) with hepatitis C virus (HCV) is rather common. In the era of highly active antiretroviral therapy (HAART), viral hepatitis could result in adverse outcomes in HIV+ patients. The current meta-analysis aims to evaluate the impact of HCV on immunological and virological responses after HAART initiatio...
Conference Paper
INTRODUCTION. Circulating levels of Plasminogen Activator Inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found to affect both atheroma and thrombosis. However, the association between PAI-1 levels and the incidence of Myocardial Infarction (M...
Article
TO THEEDITOR: The population-based cohort study by Tsan et al 1 showed that statin use was associated with a significantly reduced risk of hepatocellular carcinoma (HCC) in patients with hepatitis C virus infection (adjusted hazard ratio, 0.53; 95% CI, 0.49 to 0.58). However, we would like to raise a significant issue. As the authors acknowledge, n...
Article
Background The incidence of HIV/AIDS in Greece along of the migrants’ influx, challenges policy makers and NGOs working in the field to plan prevention efforts in mobile populations. Methods A total of 149 participants (81.21% men and 18.79% women) with mean age 29.0 ± 7.66 years old, have completed an anonymous and self report questionnaire in ord...
Article
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Background: The role of the D allele of the angiotensin-converting enzyme (ACE) gene I/D polymorphism in the clinical outcomes of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains controversial. Our aim was to assess simultaneously the effect of the ACE I/D polymorphisms as well as the serum and BALF ACE le...
Conference Paper
Full-text available
Having approximately 34% of its population at risk of malaria, Bangladesh is one of the four major malaria-endemic countries in South-East Asia. Most of the malarial cases come from 13 endemic districts of the country. Plasmodium falciparum is the predominant malarial parasite in Bangladesh; however, P. vivax, P. malariae, and P. ovale have also be...
Article
Aim: A growing body of evidence suggests that bisphosphonates may have chemopreventive potential against colorectal cancer. Our aim was to examine this association through a meta-analysis of observational studies. Methods: A comprehensive search for relevant articles published up to October 2012 was performed, reviews of each study were conducte...
Article
Decreased expression of E-cadherin has been associated with poorly differentiated endometrial carcinomas and poorer outcomes. The purpose of this study was to examine the distribution of E-cadherin immunohistochemical expression in specimens from primary endometrial carcinomas and its relation to classical clinicopathological prognostic factors. Su...
Article
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Bangladesh is one of the four major malaria-endemic countries in South-East Asia having approximately 34% of its population at risk of malaria. This paper aims at providing an overview of the malaria situation in this country. Relevant information was retrieved from published articles and reports in PubMed and Google Scholar. Malaria in Bangladesh...