Georgios Kareliotis

National Technical University of Athens | NTUA · Department of Physics

In oncology, tremendous research has been conducted on the use of alternative minimally invasive techniques for cancer treatment and diagnosis. The use of biophotonic techniques as a standalone treatment or together with conventional imaging techniques has gained interest among researchers in recent years, while biophotonic therapies such as photot...

Plasmonic photothermal and photodynamic therapy (PPTT and PDT, respectively) are two cancer treatments that have the potential to be combined in a synergistic scheme. The aim of this study is to optimize the PPTT treatment part, in order to account for the PDT lack of coverage in the hypoxic tumor volume and in cancer areas laying in deep sites. Fo...

For the past three decades, laser use has been investigated, mainly on implant applications, as well as hard and soft tissue processing on orthopedics. However, despite significant technological advances and achievements in Biophotonics, lasers have yet to emerge as a successful tool for hard-tissue manipulation (e.g., osseous tissue). Indeed, a ca...

Photodynamic therapy (PDT) is a non-invasive procedure mainly used for treatment of malignancies. It is based on cytotoxic products generation after the excitation of absorbed photosensitizing drugs by non-ionizing radiation. The wavelength chosen is usually in the 620 - 700 nm region, resulting in limited tissue penetration depth. The relatively l...

The introduction of new upconverting nanoparticles (UPCNPs) in the tumor area is being investigated worldwide as a solution for deep tissue theranostics interventions. Moreover, as the development of biophotonics techniques permits bioimaging in nanoscale, both photodynamic and photothermal sensing should be achieved even at cellular level with min...

Background: Promising results for mammary carcinoma treatment with photodynamic therapy (PDT) presuppose a careful selection of irradiation light wavelength. Methods: 4T1 tumors implanted in NOD-SCID mice were treated with Metvix-PDT under 625 nm, 660 nm and their combination light, for a fixed radiant exposure. The therapeutic outcome was assessed...

Today, 60 years after the laser discovery, the long experience in refractive surgery, the evaluation of the accumulated clinical outcomes and the limitations of kerato-refractive surgery generated the demand to develop alternative methods for treating vision defects. In the frame of this new philosophy for vision correction, the use of polymeric in...

Purpose: Numerous studies focus on cancer therapy worldwide, and although many advances have been recorded, the complexity of the disease dictates thinking out of the box to confront it. This study reviews some of the currently available ionizing (IR) and non-ionizing radiation (NIR)-based treatment methods and explores their possible combinations...

The discovery of coherent laser light in 1960 shifted and expanded the biomedical applications of radiation to the non-ionizing part of the electromagnetic spectrum. As in the case of ionizing radiation, but considering the laser specific features, the effective, safe and ethically acceptable use of biomedical laser technology requires interdiscipl...

Background Photodynamic therapy (PDT) is an alternative treatment method for liver metastatic cancer worth exploring. Methods This study implements a computational model of metastatic rat liver tissue subjected to superficial irradiation, after administration of 5,10,15,20-Tetrakis(3-hydroxyphenyl)chlorine (mTHPC). Spatial and temporal distributio...

AAPM Permission

Μεταφρασμένη στα ελληνικά έκδοση του Πρωτοκόλλου Δοσιμετρίας στη Φωτοδυναμική Θεραπεία της AAPM. Μετάφραση και επιστημονική επιμέλεια: Καρελιώτης Γ. & Μακροπούλου Μ.

Background: In photodynamic therapy (PDT) oxygen plays vital role in killing tumor cells and therefore its dosimetry is being thoroughly studied. Methods: Light distribution into tissue is modelled for radiation-induced fibrosarcoma (RIF) and nodular basal cell carcinoma (nBCC), in order to study the influence of blood flow on singlet oxygen con...

It is well known, that Computed Tomography is one of the main exposure sources to X-ray radiation for diagnostic purposes; and according to the most recent publication of European Commission, contributes 60% of the collective effective dose by X-ray examinations, in EU and EFTA countries. Nevertheless, patient dose cannot be too decreased, as its r...