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Georgios Benetos

Georgios Benetos
National and Kapodistrian University of Athens, Faculty of Medicine · First Department of Cardiology

MD, PhD

About

132
Publications
4,975
Reads
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445
Citations
Introduction
Cardiac CT: coronary volume index, artificial intelligence reconstruction algorithms, structural valve disease ct imaging Cardio-oncology: role of calcium score in cardio-oncology patients Structural valve disease: role of pre-dilatation in TAVI
Additional affiliations
December 2019 - present
National and Kapodistrian University of Athens
Position
  • Academic Scholar
Description
  • Cardio-oncology outpatient clinic Research in Cardio-oncology Research in TAVI and structural valve disease
October 2019 - present
Lefkos Stavros Athens Clinic
Position
  • Cardiac CT specialist
September 2018 - August 2019
University Hospital Zürich
Position
  • Assistenzartzt
Description
  • Cardiac CT level 3 accreditation SPECT, PET cardiac imaging Research in cardiac CT Research protocols: deep learning reconstruction algorithms validation, coronary artery volume index, PET/MR
Education
August 2019 - September 2020
University of Zurich
Field of study
  • Deep Learning Reconstruction Algorithms in Cardiac CT
September 2014 - September 2016
January 2013 - March 2017
National and Kapodistrian University of Athens
Field of study
  • Carotid atherosclerotic plaques

Publications

Publications (132)
Article
Full-text available
We describe a patient with symptomatic severe mitral regurgitation, due to a failed 33‐mm Epic (St. Jude Medical, St. Paul, MN) bioprosthetic heart valve surgically implanted 10‐year before. For this specific purpose, we implanted a novel balloon‐expandable transcatheter heart valve, the MyVal (Meril Life Science, Vapi, India). To the best of our k...
Article
The ACURATE neo transcatheter aortic valve is a self-expanding device. Several studies have investigated safety and efficacy, but meta-analysis and pooled data are lacking. We aimed to provide a comprehensive systematic review and meta-analysis on the clinical outcomes of transcatheter aortic valve implantation with the ACURATE neo valve. A systema...
Article
Full-text available
Introduction Myocardial infarction with non-obstructive coronary arteries (MINOCA) occurs in 5%–15% of all patients with acute myocardial infarction. Cardiac MR (CMR) and optical coherence tomography have been used to identify the underlying pathophysiological mechanism in MINOCA. The role of cardiac CT angiography (CCTA) in patients with MINOCA, h...
Article
Full-text available
Purpose To assess the prognostic value of regional quantitative myocardial flow measures as assessed by ¹³ N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI) in patients with suspected coronary artery disease (CAD). Methods We retrospectively included 150 consecutive patients with suspected CAD who underwent clinically...
Article
Full-text available
Background: Microwave radiometry (MWR) assesses non-invasive carotid artery temperatures reflecting inflammation. In the present study, we aimed to investigate the impact of hypolipidemic therapy either with simvastatin or with combination simvastatin plus ezetimibe on carotid artery temperatures of patients with familial hyperlipidemia syndromes...
Article
Introduction Transcatheter aortic valve implantation is the treatment of choice in a consistently expanding group of patients with severe aortic valve stenosis. Tricuspid and mitral annular dilatation with consequent valvular regurgitation are associated with adverse outcome. Computed tomography angiography (CTA) is routinely performed for preproce...
Article
Background/Introduction Arterial stiffness and aortic hemodynamics are independent predictors of adverse cardiovascular events. Indications for transcatheter aortic valve implantation (TAVI) are expanding and aortic valve calcifications (AVC) are an important prognostic factor of the success of TAVI. Purpose We sought to investigate the associatio...
Article
Aims Paravalvular leak (PVL) remains a frequent complication after transcatheter aortic valve implantation (TAVI) and seems to affect short- and long-term survival. Purpose The aim of this study was: 1) to identify anatomical predictors of PVL after TAVI and 2) assess the impact of PVL on cumulative survival. Methods and results Patients with sev...
Article
Full-text available
PurposeMisalignment between positron emission tomography (PET) datasets and attenuation correction (AC) maps is a potential source of artifacts in myocardial perfusion imaging (MPI). We assessed the impact of adenosine on the alignment of AC maps derived from magnetic resonance (MR) and PET datasets during MPI on a hybrid PET/MR scanner.Methods Twe...
Article
Transcatheter aortic valve implantation (TAVI) is an established method for treating patients with aortic valve stenosis. We sought to determine the long-term clinical outcomes and performance of a self-expanding bioprosthesis beyond 5 years. Consecutive patients scheduled for TAVI were included in the analysis. Primary end points were all-cause an...
Article
Full-text available
Background: Chemotherapy regimens for breast cancer treatment can promote vascular dysfunction and lead to high cardiovascular risk. Purpose: To investigate the cardiovascular burden and vascular inflammation in metastatic breast cancer patients receiving CDK 4/6 inhibitors or everolimus in addition to standard hormonal treatment. Methods: 22 conse...
Article
Background: The role of adipose tissue (AT) in arterial inflammation in familial dyslipidaemias is poorly studied. We investigated the relationship between AT and arterial inflammation in patients with heterozygous familial hypercholesterolemia (heFH) and familial combined hyperlipidemia (FCH). Methods and results: A total of 40 patients (20 heF...
Article
Full-text available
The GREECE trial (NCT04631809) aims to compare CCTA-guided ICA (CTgICA) versus the ICA alone. It is a multicenter, randomized, controlled study which will be conducted in 9 Greek hospitals for 24 months. Our aim is to investigate whether the information obtained by CCTA will guide ICA in everyday clinical practice, targeting on decision-making with...
Article
Full-text available
Objectives Coronary artery volume indexed to left myocardial mass (CAVi), derived from coronary computed tomography angiography (CCTA), has been proposed as an indicator of diffuse atherosclerosis. We investigated the association of CAVi with quantitative flow parameters and its ability to predict ischemia as derived from ¹³ N-ammonia positron emis...
Article
Full-text available
Background No methodology is available to distinguish truly reduced myocardial flow reserve (MFR) in positron emission tomography myocardial perfusion imaging (PET MPI) from seemingly impaired MFR due to inadequate adenosine response. The adenosine-induced splenic switch-off (SSO) sign has been proposed as a potential marker for adequate adenosine...
Article
Objective To present 1 year clinical and echocardiographic outcomes of the randomized DIRECT (Pre‐dilatation in Transcatheter Aortic Valve Implantation Trial) trial. Background Intermediate‐term data from randomized studies investigating the safety and efficacy of direct implantation are lacking. Methods DIRECT trial randomized 171 consecutive pa...
Article
Full-text available
Introduction Transcatheter aortic valve implantation (TAVI) has become the standard of care for high-risk and inoperable surgical patients and a valid alternative in intermediate-risk patients with severe aortic stenosis.The DIRECT trial (Predilatation in Transcatheter Aortic Valve Implantation Trial) was a multicenter, randomized, clinical trial d...
Article
Full-text available
Introduction The DIRECT trial (Predilatation in Transcatheter Aortic Valve Implantation (TAVI) Trial) was a multicenter, randomized, clinical trial designed to evaluate the safety and efficacy of TAVI with or without balloon aortic valvuloplasty (BAV) in patients with symptomatic, severe aortic valve stenosis. Purpose To investigate by echocardiog...
Article
Background Familial hypercholesterolemia (FH) syndromes constitute an important risk factor for premature atherosclerosis. Microwave radiometry (MWR) assess non-invasively carotid artery temperatures reflecting inflammation. Recent data support that statin therapy, that constitutes the cornerstone for the treatment of FH, reduces systemic inflammat...
Article
Background Positron emission tomography myocardial perfusion imaging (PET MPI) is a robust and excellent tool for assessing ischemia. So far, however, no methodology has been established to distinguish truly reduced MFR due to microvascular dysfunction or three-vessel coronary disease (CAD) from seemingly impaired MFR due to inadequate adenosine re...
Article
Full-text available
Introduction The DIRECT trial (Predilatation in Transcatheter Aortic Valve Implantation Trial) evaluated in a randomized fashion the safety and efficacy of direct (without balloon pre-dilatation) implantation of a self-expanding valve in all comers undergoing TAVI. Purpose To investigate the impact of direct implantation of a self-expanding valve...
Article
Objectives: The aim of this study was to investigate the prognostic and clinical value of quantitative positron emission tomographic (PET) metrics in patients with ischemic heart failure. Background: Although myocardial flow reserve (MFR) is a strong predictor of cardiac risk in patients without heart failure, it is unknown whether quantitative PET...
Article
Background Coronary computed tomography angiography (CCTA)-based transluminal attenuation gradient (TAG) was suggested to determine the functional significance of a stenosis. However, evidence that TAG acquired by wide-volume scanners can assess the hemodynamic significance of stenosis assessed by single-photon emission computed tomography (SPECT)...
Article
Full-text available
Coronary computed tomography angiography (CCTA) provides critical prognostic information on plaque burden and stenosis severity of coronary arteries. We aimed to investigate the long-term prognostic value of coronary artery volume per myocardial mass as a potential new imaging parameter. Consecutive patients with suspected coronary artery disease (...
Article
Objective: The purpose of this study was to quantify the reduction in radiation dose achievable by using the optimal z-axis coverage in coronary computed tomography (CT) angiography (CCTA) on a latest-generation 256-slice scanner. Methods: A total of 408 scans were reviewed that were performed on a wide-range detector scanner allowing up to 16-c...
Article
Full-text available
Purpose/Background/Objectives: Aortic stiffness and hemodynamics are independent predictors of adverse cardiovascular events. Transcatheter aortic valve implantation (TAVI) is growingly used in high surgical risk patients with aortic valve stenosis. We sought to investigate the effect of TAVI on aortic stiffness. Methods: Fifty-five high-risk patie...
Poster
Introduction: To accomplish further decrease in radiation exposure and/or improvement in assessment of coronary computed tomography angiography (CCTA), advances in image reconstruction are necessary. While iterative reconstruction algorithms resulted in plastic appearance at high strength, deep-learning image reconstruction (DLIR) offers unique opp...
Article
Background: Advances in image reconstruction are necessary to decrease radiation exposure from coronary CT angiography (CCTA) further, but iterative reconstruction has been shown to degrade image quality at high levels. Deep-learning image reconstruction (DLIR) offers unique opportunities to overcome these limitations. The present study compared t...
Article
Full-text available
Purpose The human pathophysiology of stunned, hibernating and scarred myocardium in ischemic cardiomyopathy is a subject of controversy. While the “smart heart” theory postulates that reduced myocardial blood flow (MBF) at rest is responsible for myocytes switching to a state of hibernation, other theories suggest that a reduced myocardial flow res...
Article
Introduction The association of carotid plaque inflammation with cerebrovascular events is a matter of rigorous research. Microwave Radiometry (MWR) allows in vivo noninvasive measurement of the internal temperatures of tissues, reflecting inflammation. Purpose To investigate whether increased carotid temperatures in patients with documented coron...
Article
Background Adipose tissue regulates energy balance and glucose homeostasis via the secretion of circulating molecules, termed adipokines, such as leptin and adiponectin. Excess adiposity and adipose tissue dysfunction have been involved in the pathogenesis of dyslipidemias. Positron emission tomography/computed tomography (PET/CT) with F-18-Fluorod...
Article
Background The adipose tissue is now established as a major regulator of cardiovascular status, mediated by the secretion of several bioactive molecules, including adipocytokines. Individuals with genetic dyslipidaemias of either familial combined hyperlipidemia (FCH) or heterozygous familial hypercholesterolemia (heFH) subtype are characterized by...
Poster
Aim/Introduction: Misalignment of positron emission tomography (PET) datasets and maps for attenuation correction (AC) is a well-known potential source of artifacts in myocardial perfusion imaging (MPI). A hybrid PET/MR scanner offers inherent spatial co-registration of the PET dataset an AC-maps from MRI (MRAC). Therefore, occurrence of misalignme...
Article
Background Coronary computed tomography angiography (CCTA) provides incremental prognostic information over traditional risk factors in patients with suspected coronary artery disease. However, little is known about the long-term predictive performance of CCTA-derived coronary volumes and mid-diastolic left ventricular (LV) mass. Purpose To assess...
Article
Full-text available
Objectives: The aim of this study was to compare the implantation of a self-expanding valve with or without balloon aortic valvuloplasty (BAV) in an open-label, noninferiority, randomized trial. Background: There are no randomized studies comparing the implantation of a self-expanding valve with (pre-BAV) or without BAV. Methods: Consecutive p...
Article
Aims: To test the hypothesis that virtual functional assessment index (vFAI) is related with regional flow parameters derived by quantitative positron emission tomography (PET) and can be used to assess abnormal vasodilating capability in coronary vessels with stenotic lesions at coronary computed tomography angiography (CCTA). Methods and result...
Article
Full-text available
Background: Microwave Radiometry (MWR) is a new validated method, which allows evaluation of thermal heterogeneity of carotid arteries and is associated with inflammation.Purpose: The aim of this pilot study was to determine if thermal heterogeneity in the carotid arteries is associated with aortic elastic properties in patients with dyslipidemia a...
Article
Full-text available
Purpose/Background/Objectives: Aortic stiffness and central hemodynamics are established vascular biomarkers. Transcatheter aortic valve implantation (TAVI) is a promising new technique for the treatment of aortic valve stenosis in elderly patients. We examined the effect of TAVI on the elastic properties of the aorta and on central hemodynamics. M...
Article
Background: Vulnerable plaque plays crucial role in prognosis of diabetes mellitus (DM). Microwave radiometry (MWR) allows measurement of the temperature of tissues, thus indirectly reflecting inflammation, a characteristic of atherosclerotic plaque stability. Aim of the study was to evaluate the relation of carotid artery inflammation with glycem...
Article
Background Familial dyslipidemias of either heterozygous (heFH) or combined (FCH) type lead to accelerated atherogenesis and increased cardiovascular risk. Objective The aim of this study was to investigate in statin-naïve adult patients with familial dyslipidemias whether inflammatory activation and liver, spleen and bone marrow metabolic activit...