Georges Dellatolas

Georges Dellatolas
French Institute of Health and Medical Research | Inserm · Center for Research in Epidemiology and Population Health CESP

About

219
Publications
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Publications

Publications (219)
Article
Background: Childhood severe traumatic brain injury (TBI) is a leading cause of long-lasting acquired disability, but predicting long-term functional outcome remains difficult. Objectives: This study aimed to 1) describe the functional outcome at 1 and 7 years post-TBI; 2) determine the initial and concurrent factors associated with long-term ou...
Article
Objective: This study aimed to investigate the extent to which language-based bedtime routines (LBR) reported by parents before kindergarten were associated with early cognitive skills at kindergarten and subsequent academic achievement in typically developing children. Method: We followed a community-based sample of 664 French-speaking adolesce...
Article
Objective. To explore memory functioning 7 years after severe paediatric traumatic brain injury (TBI), associated factors, and relationships with other outcomes. Method. Children aged 0-15 years (n = 65), consecutively admitted over a 3-year period in a single trauma centre, who survived after severe non-inflicted TBI, were included in a prospecti...
Chapter
This chapter proposes a review of neuropsychologic and behavior findings in pediatric pathologies of the cerebellum, including cerebellar malformations, pediatric ataxias, cerebellar tumors, and other acquired cerebellar injuries during childhood. The chapter also contains reviews of the cerebellar mutism/posterior fossa syndrome, reported cognitiv...
Chapter
Childhood traumatic brain injury (TBI) commonly occurs during brain development and can have direct, immediately observable neurologic, cognitive, and behavioral consequences. However, it can also disrupt subsequent brain development, and long-term outcomes are a combination of preinjury development and abilities, consequences of brain injury, as w...
Article
Background: Childhood severe traumatic brain injury (TBI) is a leading cause of long-lasting acquired disability, but little is known about functional outcome. Objective: We aimed to 1) study clinical recovery and functional outcome over 24 months after severe childhood TBI, 2) identify early sociodemographic and severity factors influencing outcom...
Article
Full-text available
Purpose To investigate self- and parent-reported Health-Related Quality-of-Life (HRQoL) and their associations after severe childhood traumatic brain injury (TBI) in the Traumatisme Grave de l’Enfant (TGE) cohort. Methods Self- (n = 34) and/or parent-reports (n = 25) of HRQoL were collected for 38 participants (age 7–22 years) 7 years after severe...
Article
Full-text available
Based on a definition of time knowledge as the correct representation and use of the various time units, a validated questionnaire, the Time Knowledge Questionnaire (TKQ) has been developed with norms for typically developing children aged 6–11 years. The TKQ is a relatively short (10–45 min) and innovative tool, comprising 25 questions broken down...
Article
Introduction. – In France, most children aged 3 to 4 years old attend preschool but tools to measure their language are missing. Objective. – Our aim was to built a tool for teachers to evaluate children’s expressive language during the fourth year of life: the SELEFT4. Method. – It comprises a total of 65 items presented in four sections: vocabula...
Article
This chapter proposes a review of neuropsychologic and behavior findings in pediatric pathologies of the cerebellum, including cerebellar malformations, pediatric ataxias, cerebellar tumors, and other acquired cerebellar injuries during childhood. The chapter also contains reviews of the cerebellar mutism/posterior fossa syndrome, reported cognitiv...
Article
Childhood traumatic brain injury (TBI) commonly occurs during brain development and can have direct, immediately observable neurologic, cognitive, and behavioral consequences. However, it can also disrupt subsequent brain development, and long-term outcomes are a combination of preinjury development and abilities, consequences of brain injury, as w...
Article
Objectives: Severe childhood traumatic brain injury (TBI) leads to long-standing executive function and attention deficits, with negative consequences for participation, academic outcome and independence. This study aimed to assess executive function and attention 7 years after severe childhood TBI in comparison with a matched control group and to...
Article
The purpose of this study was to investigate language and cognitive outcomes following severe childhood stroke, and the role of age at stroke according to lesion lateralization. We retrospectively included children consecutively admitted to a physical medicine and rehabilitation department between 1992 and 2015 following childhood stroke (age at s...
Article
The aims of this study were (1) to prospectively measure memory functioning following severe childhood Traumatic Brain Injury (TBI), and its evolution over 2 years; (2) to assess demographic and medical factors associated with memory function and recovery; (3) to explore relations between memory and other TBI outcomes. Methods: Children (aged 0–15...
Article
Objective: To investigate presence of and factors associated with self- and parent-reported fatigue 7 years after severe childhood traumatic brain injury (TBI) in the prospective longitudinal study TGE (Traumatisme Grave de l'Enfant-severe childhood trauma). Methods: Self-reports and/or parent reports on the Multidimensional Fatigue Scale were c...
Poster
Background and aims: Few studies to date have explored memory functioning in the long term after severe childhood traumatic brain injury (TBI). The aims of this study were: 1) to assess memory functioning 7 years after severe childhood TBI; 2) to assess demographic and medical factors associated with memory function and recovery; and 3) to explore...
Poster
Introduction: The aims of this study were to assess executive functioning seven years after severe childhood traumatic brain injury (TBI), and factors associated with outcome. Patients and methods: Children (0-15 years; n=65) consecutively admitted in a single trauma center, who survived a severe non-inflicted TBI, were included in a prospective lo...
Conference Paper
Introduction: Participation in home, school, and community activities is considered the ultimate goal of rehabilitation. The aims of this study were to examine participation 7 years after severe childhood traumatic brain injury (TBI). Patients and Methods: Children (0–15y) consecutively admitted in a single trauma center following severe accidental...
Conference Paper
Introduction: To investigate Fatigue and Health-Related Quality-of-Life (HRQoL) seven years following severe childhood traumatic brain injury (TBI). Material and methods: Self- (n=34) and/or parent/proxy (n=25) reports on the Multidimensional Fatigue Scale and the Pediatric Quality-of-Life Inventory were collected seven years after severe childhood...
Conference Paper
Introduction: The aims of this study were to study functional outcome over 24 months following childhood severe traumatic brain injury (TBI); and to determine how initial functional status predicts 7-year intellectual and academic outcomes. Patients and Methods: Children (0–15y) consecutively admitted in a single trauma center, following severe acc...
Conference Paper
Introduction: Participation in home, school, and community activities is considered the ultimate goal of rehabilitation. The aims of this study were to examine participation 7 years after severe childhood traumatic brain injury (TBI). Patients and Methods: Children (0–15y) consecutively admitted in a single trauma center following severe accidental...
Conference Paper
Introduction: The aims of this study were to study functional outcome over 24 months following childhood severe traumatic brain injury (TBI); and to determine how initial functional status predicts 7-year intellectual and academic outcomes. Patients and Methods: Children (0–15y) consecutively admitted in a single trauma center, following severe acc...
Article
Purpose: Participation in home, school and community activities is considered as the ultimate aim of rehabilitation. The aims of this study were to examine participation seven years post-severe childhood traumatic brain injury and factors associated with participation. Materials and methods: Participants were enrolled in the Traumatisme Grave de l’...
Article
Objective: Studies on parental stress following childhood acquired brain injury (ABI-including brain tumours (BT) and other brain injuries) are scarce. The aim of this study was to assess maternal stress in a sample of children and adolescents diagnosed with severe paediatric ABI. Methods: Seventy-eight X-speaking mothers of 37 with BT and 41 with...
Presentation
Background and Aims: Severe childhood traumatic brain injury (TBI) leads to severe and long-standing executive functions deficits, with negative consequences on social participation, academic outcome and later independence and integration in the workforce. The aim of this study was to prospectively study executive functioning, 7-8 years after sever...
Presentation
Background and Aims: Childhood traumatic brain injury (TBI) is a leading cause of lifelong acquired disability. It remains difficult to predict long-term functional outcome. The aims of this study were (1) to study the evolution and factors associated to functional outcome over 24 months after childhood severe TBI; (2) to determine how functional s...
Presentation
Background and Aims: Severe Traumatic Brain Injury (TBI) is the main cause of death and acquired disability in childhood in developed countries. Among cognitive sequelae, memory impairment is frequent and impacts everyday functioning and academic achievement. The aims of this study were: (1) to prospectively measure memory functioning following sev...
Article
Objective: This longitudinal study examines school achievement in terms of grade failures among deaf children ten years after cochlear implantation according to the children's age, language skills, intelligibility and parental socio-educational status. Methods: The participants were 50 deaf children, the mean age at implantation was 3,7 years, with...
Article
Background and purpose: The cerebellum has a pivotal role in regulating human behavior; yet whether this function is mediated only through contralateral cerebro-cerebellar pathways is under-investigated. Thus, we examined feed-backward and feed-forward ipsilateral and contralateral cerebro-cerebellar connections using a detereministic diffusion te...
Conference Paper
Introduction/Background Severe Traumatic Brain Injury (TBI) is the main cause of children mortality and disability in developed countries. Among cognitive sequelae, memory impairment is frequent and impacts everyday functioning and academic achievement. The aims of this study were: (1) to measure memory functioning in children who sustained a sever...
Presentation
Acquisition of time knowledge (TK; the correct representation and use of time units) is associated with the development of numerical abilities. In a first study, 105 typically-developing children (mean age 8.7 years) were interviewed with the Time Knowledge Questionnaire (TKQ) and the Zareki-R, a battery for the evaluation of numerical abilities. T...
Article
Purpose: The purpose of this study was to evaluate the long-term cognitive sequelae and to describe the neuropsychological profile of patients with intracranial germ cell tumors according to tumor location (pineal or suprasellar site). Patients and methods: Forty-five children treated at Gustave Roussy between 1991 and 2010 were assessed with ne...
Article
Purpose: To investigate intellectual and situation-based social outcome and educational achievement in adult survivors of childhood medulloblastoma and analyse factors influencing outcome Methods: We collected demographic, medical and cognitive data, and social and educational outcome at a mean time since the end of treatments of 14.9 years in 58 a...
Article
In children treated for malignant cerebellar tumors, there are only a few studies investigating temporal skills, despite the role of the cerebellum in time processing being generally acknowledged. Children’s time knowledge has been defined as the correct representation and use of familiar time units. The present study compares time knowledge in 38...
Article
Background The relationship between direct assessments of cognitive performance and questionnaires assessing quality of survival (QoS) is reported to be weak-to-nonexistent. Conversely, the associations between questionnaires evaluating distinct domains of QoS tend to be strong. This pattern remains understudied. Methods In the HIT-SIOP PNET4 rand...
Article
Background: The relationship between direct assessments of cognitive performance and questionnaires assessing quality of survival (QoS) is reported to be weak-to-nonexistent. Conversely, the associations between questionnaires evaluating distinct domains of QoS tend to be strong. This pattern remains understudied. Methods: In the HIT-SIOP PNET4 ra...
Article
Objective Studies on language outcome following childhood stroke are rare. The aims of this study were to study language, cognitive and school outcomes following childhood stroke. Materials/patients and methods We retrospectively reviewed the files of children (1 month–15 years) consecutively admitted to a physical medicine and rehabilitation depar...
Article
Background Medulloblastoma is the most common malignant central nervous system tumor in children. Treatment most often includes surgical resection, craniospinal irradiation, and adjuvant chemotherapy. Although survival has improved dramatically, the tumor and its treatments have devastating long-term side effects that negatively impact quality of s...
Article
Background. Medulloblastoma is the most common malignant central nervous system tumor in children. Treatment most often includes surgical resection, craniospinal irradiation, and adjuvant chemotherapy. Although survival has improved dramatically, the tumor and its treatments have devastating long-term side effects that negatively impact quality of...
Conference Paper
Background: The relationship between direct assessments of cognitive performance and questionnaires assessing quality of survival (QoS) is reported to be weak-to-nonexistent. Conversely, the associations between questionnaires evaluating distinct domains of QoS tend to be strong. This pattern remains understudied. Methods: In the HIT-SIOP PNET4 ra...
Conference Paper
BACKGROUND: The relationship between direct assessments of cognitive performance and questionnaires assessing QoS is consistently reported to be weak-to-nonexistent. Conversely, the associations between questionnaires evaluating distinct domains of QoS tend to be strong. This equivocal pattern remains understudied. METHODS: In the HIT-SIOP PNET4 ra...
Article
In clinical outcome assessment, the relation between performance-based measures and questionnaire ratings of the same domain is weak, but correlations between questionnaires proposed for the evaluation of different domains are strong. The present study aims to illustrate these phenomena in a group of patients with neurofibromatosis type 1 (NF1) and...
Article
Acquisition of time knowledge (TK; the correct representation and use of time units) is linked to the development of numerical abilities, but this relationship has not been investigated in children. The current study examined the acquisition of TK and its association with numerical skills. A total of 105 children aged 6 to 11 years were interviewed...
Article
Neurofibromatosis type 1 (NF1) is an autosomal dominant multisystem disorder, with large inter and intrafamilial clinical variability and uncertain prognosis. In children with NF1 cognitive disorders, learning difficulties and behavioral problems are common. The present study aims to establish the neuropsychological and behavioral profiles of 78 pa...
Article
The persistence of academic difficulties from childhood through adulthood has led researchers to focus on the identification of the early factors influencing children's subsequent achievement in order to improve the efficient screening of children who might be at risk of school failure. The foundations of academic achievement can be accurately trac...
Article
There is a lack of studies assessing executive functions (EF) using ecologically valid tests in children with frontal lobe lesions. This study aimed to (1) evaluate EF in children, adolescents and young adults treated for childhood frontal lobe tumours, (2) identify factors influencing performance, such as age at diagnosis or type of treatment, and...
Article
Purpose/Objective(s) In the XXX-XXXX XXXXX European randomised controlled trial, children with standard risk medulloblastoma were allocated to hyperfractionated (HFRT arm, including a partially focussed boost) or standard radiation therapy (STRT arm) followed, in both arms, by maintenance chemotherapy. Event-free survival was similar in both arms....
Article
Full-text available
Unlabelled: Abstract Purpose: A number of studies report neurological and cognitive deficits and behavioural disorders in children after surgical treatment for a benign cerebellar tumour. The present study explores functional outcome in adolescents and adults treated for a low-grade cerebellar astrocytoma in childhood. Materials and methods: Par...
Article
It has been suggested that the cerebellum is involved in reading acquisition and in particular in the progression from automatic grapheme-phoneme conversion to the internalization of speech required for silent reading. This idea is in line with clinical and neuroimaging data showing a cerebellar role in subvocal rehearsal for printed verbalizable m...
Article
Full-text available
The aim of this study was to investigate the temporal abilities of children treated by surgery for a malignant tumor in the cerebellum, both in the perception and the production of rhythm. Children with a diagnosed medulloblastoma and age-matched control children were tested in a rhythm discrimination task and a sensorimotor synchronization task. T...
Conference Paper
BACKGROUND: In the PNET4 European randomised controlled trial, children with standard risk medulloblastoma were allocated to HFRT or to STRT. All received maintenance chemotherapy. Event-free survival was similar between the two treatment arms. HFRT was associated with worse growth and better questionnaire-based executive function 6.1 years postdia...
Conference Paper
BACKGROUND: In the PNET4 European randomised controlled trial, children with standard risk medulloblastoma were allocated to HFRT or to STRT. All received maintenance chemotherapy. Event-free survival was similar between the two treatment arms. HFRT was associated with worse growth and better questionnaire-based executive function 6.1 years post di...
Article
Full-text available
BACKGROUND: LMD in children with recurrent medulloblastoma and other PNETs carries a poor prognosis and novel therapies are urgently needed to improve disease control. Somatostatin receptor-2 (SSR-2)is overexpressed in medulloblastoma and other central PNETs and can serve as a target for radionuclide tagged somatostatin analogues like 177Lu-DOTA-TA...
Article
Full-text available
Primary objective: Conceptions of time in children having survived malignant cerebellar tumours (CT) and healthy children matched for chronological age (HCCA) were compared, knowing that the cerebellum has been involved in time perception. Methods and procedure: Study participants included 20 children with CT (13 boys) and 20 HCCA (10 boys) aged...
Article
Background: Studies on Attention-Deficit Hyperactivity Disorder (ADHD) show high comorbidity with learning disorders. This study examines the relationships between inattention, hyperactivity and reading performance in a non-referred sample of second grade schoolchildren in an Athenian borough.
Article
Full-text available
Dravet syndrome (DS) is currently considered as an epileptic encephalopathy, a condition in which epilepsy causes deterioration or developmental delay but preliminary data suggested that cognitive course may worsen independently from epilepsy. Our objective was to prospectively analyze the neuropsychological features in a large cohort of DS patient...
Article
To determine what epilepsy types occur after herpetic encephalitis and what are the determinant factors for subsequent infantile spasms. We analyzed retrospectively the clinical history of 22 patients, referred to Necker and Saint Vincent de Paul Hospitals (Paris) through the French pediatric epilepsy network from March 1986 to April 2010 and who d...
Article
IntroductionIn France, most children aged 3 to 4 years old attend preschool but tools to measure their language are missing.Objective Our aim was to built a tool for teachers to evaluate children's expressive language during the fourth year of life: the SELEFT4.Method It comprises a total of 65 items presented in four sections: vocabulary, grammar,...
Article
Full-text available
This study examined the relation between emergent literacy skills, teachers' reports of behavioral problems, and word reading achievement in a community sample of French students. Family background was investigated and included familial antecedents of reading difficulties (Fa/Rd) and parents' educational level. The analyses explored the pattern of...
Article
Aim: Having previously shown that comorbidity is a major determinant of neurological sequelae in hypoglycaemia, our aim was to describe the neuroimaging patterns of brain damage in different hypoglycaemic situations and to elucidate the factors that determine lesion topography. Method: We reviewed 50 patients (31 females, 19 males) with symptoma...
Article
In the last 50 years, researchers have debated over the lexical or grammatical nature of children's early multiword utterances. Due to methodological limitations, the issue remains controversial. This corpus study explores the effect of grammatical, lexical, and pragmatic categories on mean length of utterances (MLU). A total of 312 speech samples...
Article
Aim To determine risk factors for neurological sequelae following hypoglycemia. Method We analysed the neurological outcome in 164 patients (mean age 10y 10mo, SD 5.9) following hypoglycemia due to three diseases with various metabolic contexts, different ages at onset, and combinations with comorbidity (fever/infection, hypoxia/ischemia): glycogen...
Article
Full-text available
Numerical cognition is based on two components - number processing and calculation. Its development is influenced by biological, cognitive, educational, and cultural factors. The objectives of the present study were to: i) assess number processing and calculation in Brazilian children aged 7-12 years from public schools using the Zareki-R (Battery...
Article
Full-text available
This longitudinal study examined lateral differences between latency time of the two hands during the development of prehension in 12 infants from 20 to 30 weeks. Latency time (LT) is defined as the delay between the visual localisation of a reachable target and the beginning of the movement and could be considered as a phase in the preparation of...
Conference Paper
Full-text available
BACKGROUND: Glutathione S-transferase (GST) enzymes are involved in detoxifying chemotherapy agents and clearing reactive oxygen species formed by radiation. In this study, we explored the relationship between the host GSTP1-105 polymorphism (rs1695), tumor GSTpi protein expression, and clinical outcomes in pediatric medulloblastoma. We hypothesize...
Conference Paper
https://academic.oup.com/nop/article/4/2/111/2631786