George Cotsarelis

George Cotsarelis
University of Pennsylvania | UP · Department of Dermatology

42.21

About

120
Publications
22,676
Reads
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15,926
Citations
Introduction
Skills and Expertise
Skin Biology
Hair Follicle
Research Experience
January 1996 - present
University of Pennsylvania
  • Department of Dermatology
  • Philadelphia, United States
Position
  • Professor and Chair

Publications

Publications (120)
The Alopecia Areata Consensus of Experts (ACE) Study: Results of an International Expert Opinion on Treatments for Alopecia Areata
Article
  • Mar 2020
Cutaneous epithelial stem cells
Chapter
  • Jan 2020
Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
Article
Full-text available
  • Dec 2019
Supplementary Material 3
Data
  • Feb 2019
Supplementary Material 1
Data
  • Feb 2019
Supplementary Material 2
Data
  • Feb 2019
Supplementary Material 4
Data
  • Feb 2019
Supplementary Material 5
Data
  • Feb 2019
Supplementary Material 6
Data
  • Feb 2019
Supplementary Material 7
Data
  • Feb 2019
Supplementary Material 8
Data
  • Feb 2019
Supplementary Material 9
Data
  • Feb 2019
Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing
Article
Full-text available
  • Dec 2018
Supplementary Material
Data
  • Nov 2018
Proceedings of the Ninth World Congress for Hair Research (2015)
Article
Full-text available
  • Dec 2017
JID Aug 2017 World Congress for Hair Research 2015
Data
  • Dec 2017
Objective Outcome Measures: Collecting Meaningful Data on Alopecia Areata
Article
  • Nov 2017
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation
Article
  • May 2017
A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers
Article
Full-text available
  • Jan 2017
Regeneration of fat cells from myofibroblasts during wound healing
Article
  • Jan 2017
Isolation of Mouse Hair Follicle Bulge Stem Cells and Their Functional Analysis in a Reconstitution Assay
Chapter
  • Jul 2016
Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease
Article
Full-text available
  • Jun 2016
TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles
Article
Full-text available
  • Nov 2015
Vismodegib Resistance in Basal Cell Carcinoma: Not a Smooth Fit
Article
  • Mar 2015
Cutaneous Epithelial Stem Cells
Chapter
  • Dec 2014
Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors
Article
Full-text available
  • Dec 2014
CD133 Expression Correlates with Membrane Beta-Catenin and E-Cadherin Loss from Human Hair Follicle Placodes during Morphogenesis
Article
  • Jul 2014
Hypoxia-Inducible Factors Regulate Filaggrin Expression and Epidermal Barrier Function
Article
  • Jul 2014
Supplementary Material
Data
  • Jul 2014
Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells
Article
Full-text available
  • Jan 2014
Distinct Functions for Wnt/β-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis
Article
  • Dec 2013
Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal-Epidermal Composites
Article
Full-text available
  • Aug 2013
Supplementary Material
Data
  • Aug 2013
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding
Article
Full-text available
  • Jun 2013
Retinoids Putting the “A” in Alopecia
Article
  • Feb 2013
Epithelial Stem Cells and Implications for Wound Repair
Article
  • Oct 2012
Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia
Article
Full-text available
  • Mar 2012
A Keratin 15 Containing Stem Cell Population From the Hair Follicle Contributes to Squamous Papilloma Development in the Mouse
Article
  • Jan 2012
Fox-Fordyce Disease Following Axillary Laser Hair Removal
Article
  • May 2011
Characterization and quantification of wound-induced hair follicle neogenesis using in vivo confocal scanning laser microscopy
Article
  • Apr 2011
The Autoimmune Regulator (AIRE), Which Is Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17
Article
  • Mar 2011
Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells
Article
Full-text available
  • Feb 2011
Keratin 15-Positive Stem Cells Give Rise to Basal Cell Carcinomas in Irradiated Ptch1(+/-) Mice
Article
  • Jan 2011
Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice
Article
Full-text available
  • Feb 2010
Review of hair follicle dermal cells
Article
  • Dec 2009
Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation
Article
  • Sep 2009
Epidermal cells rev up reprogramming
Article
Full-text available
  • Dec 2008
Role of bulge cells in wound healing: possible implications for hidradenitis suppurativa: HSF Abstracts
Article
  • Jun 2008
Is the Hair Follicle Necessary for Normal Wound Healing?
Article
  • Jun 2008
The longest telomeres: A general signature of adult stem cell compartments
Article
Full-text available
  • Apr 2008
Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter
Article
Full-text available
  • Feb 2008
Comprehensive microarray transcriptome profiling of CD34-enriched mouse keratinocyte stem cells [2]
Article
Full-text available
  • Jan 2008
How Hair Gets Its Pigment
Article
  • Oct 2007
Defining Hair Follicles in the Age of Stem Cell Bioengineering
Article
Full-text available
  • Oct 2007
Turning skin into embryonic stem cells
Article
  • Aug 2007
Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss
Article
  • Jul 2007
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
Article
Full-text available
  • Jun 2007
CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice
Article
Full-text available
  • Jun 2007
Stem Cells of Pelage, Vibrissae, and Eyelash Follicles: The Hair Cycle and Tumor Formationa
Article
  • Dec 2006
Telogen effluvium associated with the dopamine agonist pramipexole in a 55-year-old woman with Parkinson's disease
Article
  • Dec 2006
Epithelial Stem Cells: A Folliculocentric View
Article
  • Aug 2006
456. Gene Transfer to Skin Stem Cells by Early Gestational Intra-Amniotic Injection of Lentiviral Vector
Article
Full-text available
  • May 2006
Report from the Cicatricial Alopecia Colloquium
Article
Full-text available
  • Apr 2006
Gene expression profiling gets to the root of human hair follicle stem cells
Article
  • Feb 2006
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis
Article
Full-text available
  • Jan 2006
Stenn KS, Cotsarelis GBioengineering the hair follicle: fringe benefits of stem cell technology. Curr Opin Biotechnol 16:493-497
Article
  • Nov 2005
Sox9 Is Essential for Outer Root Sheath Differentiation and the Formation of the Hair Stem Cell Compartment
Article
  • Sep 2005
Developmental biology - Rac1 up for epidermal stem cells
Article
  • Sep 2005
Vitiligo-like hypopigmentation associated with imiquimod treatment of genital warts
Article
  • May 2005
Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen
Article
  • Jan 2005
Desmogleins 1 and 3 in the Companion Layer Anchor Mouse Anagen Hair to the Follicle
Article
  • Dec 2004
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epide
Article
  • Nov 2004
Capturing and profiling adult hair follicle stem cells
Article
Full-text available
  • May 2004
Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge
Article
  • Dec 2003
Decreased Serum Ferritin is Associated With Alopecia in Women
Article
  • Dec 2003
CD34 in human hair follicle - Response
Article
  • Nov 2003
Scarring alopecia associated with mastocytosis
Article
  • Nov 2003
Differential Expression of Cyclin D1 in the Human Hair Follicle
Article
  • Oct 2003
Multiply Recurrent Trichilemmal Carcinoma With Perineural Invasion and Cytokeratin 17 Positivity
Article
  • Sep 2003
Multiply Recurrent Trichilemmal Carcinoma With Perineural Invasion and Cytokeratin 17 Positivity
Article
  • Aug 2003
Update on Cicatricial Alopecia
Article
Full-text available
  • Jul 2003
Desmoglein Isotype Expression in the Hair Follicle and its Cysts Correlates with Type of Keratinization and Degree of Differentiation
Article
  • Jul 2003
Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34
Article
  • Apr 2003
Summary of North American Hair Research Society (NAHRS)-sponsored Workshop on Cicatricial Alopecia, Duke University Medical Center, February 10 and 11, 2001
Article
  • Feb 2003
Acrodermatitis enteropathica associated with anorexia nervosa
Article
  • Jan 2003
The hair follicle as a target for gene therapy
Article
  • Jun 2002
The hair follicle as a target for gene therapy
Article
  • Jan 2002
Atrichia Caused by Mutations in the Vitamin D Receptor Gene is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene
Article
  • Oct 2001
Cotsarelis G, Millar SETowards a molecular understanding of hair loss and its treatment. Trend Mol Med 7:293-301
Article
  • Aug 2001
??-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Article
  • May 2001
The human hair follicle immune system: cellular composition and immune privilege
Article
  • Jun 2000
Efficient delivery of transgenes to human hair follicle progenitor cells using topical lipoplex
Article
  • May 2000
Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide
Article
  • Feb 2000
Human Hair Follicle Bulge Cells are Biochemically Distinct and Possess an Epithelial Stem Cell Phenotype
Article
Full-text available
  • Jan 2000
The Biology of Hair Follicles
Article
Full-text available
  • Sep 1999
Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells
Article
  • Apr 1999
Desmoglein (Dsg) compensation hypothesis explains telogen hair loss in Dsg3 mutant mice and lack of pathology in neonatal pemphigus foliaceus
Article
  • Apr 1999
Transfection of human hair follicles using topical liposomes is optimal at the onset of anagen
Article
  • Apr 1999
Protease Nexin-1 expression during development and throughout the hair cycle correlates with migration of the dermal papilla
Article
  • Apr 1999
Cotsarelis G, Kaur P, Dhouailly D, Hengge U & Bickenbach J. Epithelial stem cells in the skin: Definition, markers, localization, and functions. Exp Dermatol8: 80-88
Article
  • Mar 1999

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Projects

Projects (2)
Changes in female hair with aging and menopause.
Project
World Congress Hair Research - WCHR
Project