
George KroumpouzosGK Dermatology PC
George Kroumpouzos
MD, PhD, FAAD
Assoc Professor Clin of Dermatology, Alpert Medical School at Brown University; Founder/Medical Director, GK Dermatology
About
247
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Introduction
I perform clinical research in my private practice, GK Dermatology, PC, in Weymouth, Massachusetts. Also, I am on clinical faculty at Brown University. I am Associate Editor of the International Journal of Women's Dermatology, Frontiers in Medicine, and Dermatologic Therapy, and Editor of Clinics in Dermatology. My research interests include aesthetic/procedural dermatology, obstetric/gynecologic dermatology, psychocutaneous disease, COVID-19 and the skin, and pigmentation disorders.
Additional affiliations
August 2016 - August 2020
April 2005 - present
July 2003 - present
Publications
Publications (247)
Background: Transcutaneous temperature-controlled radiofrequency (TTCRF) is an emerging modality for vulvovaginal rejuvenation. Still, the clinical experience with this modality is limited.
Objectives: The aim of this study was to examine the efficacy of TTCRF in improving female genital appearance, sexual function, and stress urinary incontinence...
Background
In aesthetic practice, delayed onset (late) inflammatory reactions (DIRs) to dermal fillers are encountered. The treatment of DIRS can be challenging, with a response to established therapies, including oral antibiotics, intralesional and oral steroids, and hyaluronidase injection, occasionally reported as unsatisfactory.
Objectives
Eva...
Nonsurgical rhinoplasty (NSR) utilizing hyaluronic acid (HA) filler injections is increasingly used to address nose shape issues. While refinements have been proposed, the technique lacks standardization.
Our study aimed to evaluate the aesthetic outcome, longevity of results, safety, and patient satisfaction with the novel Rino-4-Puntos (R4P) NSR...
Background: Vaginismus is a common sexual dysfunction. A few studies have indicated that botulinum neurotoxin type A (BoNTA) can help treat refractory vaginismus by alleviating muscle tension. However, such studies did not use standardized methodology and BoNTA dosage.
Objective: The aim is to evaluate the efficacy of intravaginal BoNTA injection...
Importance:
Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory skin condition that develops on sun-damaged skin in older individuals. Patients with EPDS present a therapeutic challenge because medical treatments and surgical modalities have met with limited success. Methyl aminolevulinate photodynamic therapy has been effective in...
BACKGROUND
Nonresponse to botulinum toxin (BoNT) type A (BoNT-A) has been reported in medical and aesthetic applications. Secondary nonresponse (SNR) occurs when BoNT-A is initially successful before failure commences at a later point. Most reported cases involve SNR in aesthetics. Several aspects of this complication remain elusive or controversia...
Botulinum neurotoxin type A (BoNTA) and filler injection procedures usually provide predicted outcomes with a low incidence of complications. Most of the complications following these procedures have been extensively discussed. In this study, we report on these injectables' less well-known, recently reported, and novel complications and attempt to...
Frontal fibrosing alopecia (FFA) is characterized by a receding hairline in the frontotemporal region due to the gradual loss of hair follicles and then follicular stem cells and follicular fibrosis. Follicular stem cells are crucial in skin healing after chemical peeling and other resurfacing procedures. Although there is a possible association of...
Hyaluronic acid (H.A.) filler injections have been associated with early, temporary, and delayed-onset onset complications. High-resolution ultrasound (HRUS) with Doppler analysis has been increasingly used to detect and identify such complications. We describe comprehensively the most common ultrasonographic findings of non-vascular complications...
Zoom dysmorphia (ZD) is a facial dysmorphia that is triggered or aggravated by frequent virtual meetings. The frequent use of videoconferencing platforms has been linked to a distorted perception of facial images as individuals have an increased awareness of their appearance, given constant video feedback. As a result, dysmorphic concerns can devel...
BACKGROUND
Hyaluronidase (Hyal) can reverse complications of hyaluronic acid (HA) fillers which has contributed substantially to the popularity of such procedures. Still, there are differing opinions regarding Hyal treatment, including dosage recommendations, in filler complication management.
OBJECTIVE
To address unanswered questions regarding Hy...
Background
Hyaluronidase (Hyal) can reverse complications of hyaluronic acid (HA) fillers, which has contributed substantially to the popularity of such procedures. Still, there are differing opinions regarding Hyal treatment, including dosage recommendations in filler complication management.
Objective
We aimed to address unanswered questions reg...
Zoom dysmorphia (ZD) is a facial dysmorphia triggered or aggravated by frequent virtual meetings. The frequent use of videoconferencing platforms has been linked to a distorted perception of facial images as individuals have an increased awareness of their appearance, given constant video feedback. As a result, dysmorphic concerns can develop. It i...
COVID-19 can have detrimental effects on immunosuppressed patients. Here, we evaluate the evidence regarding continuing immunomodulatory/ biologic (IMBI) therapy in pregnant dermatology patients during the COVID-19 pandemic. Also, we discuss the risks of COVID-19 vaccination in pregnant dermatology patients on IMBI therapy. As indicated in this rev...
Acroosteolysis (AO) is a rare condition characterized by resorption of the distal phalanges of the fingers and/or toes. It can be familial, idiopathic (IAO), occupational, or secondary. Other authors suggest a classification into primary (genetic disorders, lysosomal storage disorders) or secondary AO. Various skin and nail changes have been report...
A case of annular basal cell carcinoma (BCC) with central atrophic scarring that developed secondary to spontaneous regression has been reported. We present a novel case of a large, expanding nodular and micronodular BCC with annular morphology with central hypertrophic scarring. A 61-year-old woman presented with a two-year history of a mildly itc...
The power of beauty influences many aspects of modern society and daily life—perceptions surrounding beauty date to ancient philosophers and have evolved significantly throughout history. Still, there appear to be universally accepted physical characteristics of beauty that span different cultures. Human beings have an inherent ability to distingui...
The pathogenesis of vitiligo and schizophrenia has not been adequately clarified. This article explores the role of lipids in these diseases. Both conditions have been associated with stress in several observations and studies. Research data indicate complex interactions between oxidative stress and metabolic syndrome–with lipid abnormalities being...
Eating disorders (EDs) such as anorexia nervosa and bulimia nervosa have a plethora of skin manifestations. They can be categorized into skin signs of self-purging, skin signs of starvation, skin signs related to drug abuse, skin signs of psychiatric comorbidity, and miscellaneous signs. “Guiding signs” are valuable, because they are pointers to th...
The perception of beauty is fluid within society and can morph based on cultural practices and societal interaction, such as social media exposure. The exposure to digital conference platforms has increased significantly, leading users to check their appearance constantly and find flaws in their perceived virtual appearance. Studies have shown that...
Body dysmorphic disorder (BDD) is a psychiatric condition characterized by profound concern about a minor or imagined defect in the appearance of individuals and increased preoccupation with the imagined/perceived defect. Individuals with BDD often undergo cosmetic intervention for the perceived imperfection but rarely experience improvement in the...
An ever-increasing interest in perioral rejuvenation with dermal fillers reflects the aesthetic importance of this region. However, filler injections in the lips and perioral area have been associated with various complications. Such complications are classified according to severity (mild, moderate, severe) or by the time of onset: immediate (with...
KEY POINTS
• Energy-based devices (EBDs) induce thermal-dependent neocollagenesis, increased epithelial thickness, and neovascularization that enhance mucosal tightening and restoration of pre-menopausal vaginal epithelial milieu and flora
• High-quality evidence (level II) supports the use of EBDs such as fractional carbon dioxide laser and radiof...
Erosive pustular dermatosis (EPD) is a chronic inflammatory skin disorder that usually affects mature individuals. It predominantly affects the scalp and can lead to scarring alopecia. Risk factors include actinic damage and androgenetic alopecia. A traumatic insult to the skin is considered a vital trigger of the condition. EPD is a diagnosis of e...
A 43-year-old male presented to dermatology with a chief complaint of stabbing pain and grouped vesicles on the right side of the chest for 3 days. Discrete fluid-filled lesions had developed on the face, neck, back and chest one day prior to the onset of the eruption. Skin examination showed multiple grouped tense vesicles and a few bullae on an e...
An otherwise healthy man presented with alopecia, plantar keratoderma, and abnormal fingernails and toenails since childhood. He was diagnosed with hidrotic ectodermal dysplasia, or Clouston syndrome. Clouston syndrome is an autosomal dominant disorder caused by mutations in GJB6, which encodes the connexin 30 protein. Clinical features that are hi...
This chapter reviews the complications associated with dermal
filler or botulinum toxin A injection to the lips and perioral area and discusses best practices for management of these
complications.
Carboxytherapy is a medical technique during which a sterile gas – carbon dioxide (CO2) - is injected into the subdermal tissue. The utility of CO2 injections has enhanced the practical relevance of carboxytherapy as a method for the management of multiple disorders. We have evaluated its use in the treatment of dermatologic conditions by searching...
Acne vulgaris is a multifactorial chronic disorder of the pilosebaceous unit. Established treatments include topical retinoids, antibiotics in mild cases, and oral antibiotics and isotretinoin in moderate to severe cases. Anti-androgens and other hormonal therapies constitute another group of drugs in the armamentarium of acne management. These can...
Background:
Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory cutaneous disorder typically affecting sun-damaged skin of mature individuals. Clinical features of EPDS include sterile pustules and chronic crusted erosions that can be hyperkeratotic and lead to scarring alopecia, atrophy, and telangiectasia. While the condition occu...
Skin resurfacing for cutaneous rejuvenation has evolved with the development of a plethora of nonsurgical and minimally invasive modalities. We have highlighted the advances in laser therapy, chemical peels, radiofrequency, microneedling, and platelet-rich plasma therapy. We have also included studies providing head-to-head comparisons between proc...
Treatment of erosive pustular dermatosis of the scalp (EPDS) is challenging. Topical and systemic medications have achieved limited success, and destructive modalities have been associated with EPDS recurrence because of the tendency of the condition to recur after any treatment that induces trauma to the skin. Our group has have recently reported...
Malignant melanoma is one of the most aggressive solid tumors but has low morbidity if treated at an early stage. Over the past decade, the advent of targeted therapy and immunotherapy have productively enriched the treatment options for advanced melanomas and further improved the prognosis. The treatment of melanoma is a rapidly evolving field. In...
Because of the increasing emergence of cutaneous reactions from COVID-19 vaccines worldwide, we investigated the published reports of these complications. We searched the PubMed, Google Scholar, and Scopus databases and the preprint server bioRxiv for articles on cutaneous complications linked to mRNA-1273 (Moderna), BNT162b2 (Pfizer–BioNTech), and...
Tattoos are commonly employed for cosmetic reasons such as make-up and body art. Tattoo pigments, especially red, can trigger a variety of delayed immune responses manifesting as lichenoid, eczematous, and granulomatous reactions. Also, the development of granulomatous lesions within tattoos is a well-recognized manifestation in patients with sarco...
Three siblings aged 16, 20 and 22 years presented to dermatology with multiple, non-pruritic, light brown or whitish lesions of various sizes on the face, neck, trunk and arms since early childhood. On examination, numerous well defined, non-pruritic, hypopigmented macules and slightly verrucous papules were symmetrically distributed over the foreh...
A 12-year-old girl presented with well-defined asymptomatic lesions on cheeks and upper extremities for 6 months. Lesions on the extremities were ulcerated plaques with areas of scarring and atrophy. Laboratory investigations showed anaemia and positive Mantoux test. Cartridge-based nucleic acid amplification test (CBNAAT) of cutaneous tissue and s...
Angioma serpiginosum is a rare nevoid vascular disorder. It is usually a sporadic condition; however, familial cases have been reported. It occurs due to congenital hyperplasia or ectasia of superficial dermal capillaries. There is a female predominance. The onset is usually in childhood, with 80% of cases presenting before 20 years of age. It is c...
An 8-year-old boy presented to dermatology with erythematous plaques over his elbows and knees, and thickening of palms and soles since early childhood. His developmental milestones were normal. Skin examination revealed well-defined, erythematous, hyperkeratotic plaques distributed symmetrically over the dorsal aspect of the fingers and feet, knuc...
Rosacea is a chronic cutaneous disorder affecting primarily the face, characterized by erythema, transient or persistent, telangiectasia, and inflammatory lesions including papulo‐pustules and swelling. The essential component of the disease is the persistent erythema of facial skin. Episodes of flushing (acute‐subacute intermittent vasodilation) a...
Hidradenitis suppurativa (HS) is a chronic inflammatory disorder of the apocrine glands characterized by recurrent episodes. Although several therapies exist, none is completely curative. Several immunosuppressives have been studied with encouraging results and targeted approaches. In this review, we highlight the various immunosuppressives used in...
Optoacoustic imaging (OAI) is a hybrid imaging modality that integrates the benefits of optical contrast and ultrasound detection. Raster-scan optoacoustic mesoscopy (RSOM) is an emerging OAI method that provides information about several dermatological conditions' structural, functional, and molecular features. We searched PubMed and Google Schola...
Excess, unwanted fat in submental and other body areas has been a focus of new modalities in aesthetics. Invasive and, more recently, non-invasive modalities for removal of unwanted fat have been on an increase. ATX-101 (deoxycholic acid injection) is the only injectable drug approved in the United States and Canada for reduction of moderate or sev...
Background: Transcutaneous temperature-controlled radiofrequency (TTCRF) is an emerging modality for vulvovaginal rejuvenation. Still, the clinical experience with this modality is limited.
Objectives: The aim of this study was to examine the efficacy of TTCRF in improving female genital appearance, sexual function, and stress urinary incontinence...
Treatment of striae distensae or stretch marks can present a therapeutic challenge as many modalities are partially effective. The present report indicates that pneumatic injection of hyaluronic acid with a jet volumetric remodeling (JVR) system is a well-tolerated and effective therapy for striae. In this series, three sites (left and right breast...
Facial erythema is one of the most common outpatient complaints in dermatology. There are various causes of facial erythema and several devices are available for its treatment. Pulsed dye laser (PDL) and intense pulsed light (IPL) are the two common light devices used for these conditions. In this review, we evaluated the literature to assess effic...
Coronavirus disease 2019 (COVID-19) care requires a team approach, and dermatologists may collaborate with other specialties, especially infectious disease (ID) medicine and obstetrics and gynecology (ObGyn) at every stage of the infection process. A broad spectrum of cutaneous manifestations may occur early in COVID-19, making appropriate dermatol...
Idiopathic guttate hypomelanosis (IGH) is a benign, typically asymptomatic, acquired leukoderma characteristically affecting mature individuals. Although the etiopathogenesis is unclear, chronic sun exposure and senile degeneration are important triggers. Researchers have been engaged in a continuous effort to unveil the gray areas encompassing dif...
The third outbreak of coronavirus in the form of the COVID-19 infection started in Wuhan, China, in December 2019. The early and rapid spread of this infection across borders can be largely attributed to international air travel that has become a part of modern globalization. In this article, we analyze the spread of the novel coronavirus (SARS-CoV...
Genitourinary syndrome of menopause (GSM) causes significant symptomatic aggravation that affects the quality of life (QoL). Vulvovaginal atrophy (VVA), the hallmark of GSM, is managed
with topical non-hormonal therapy, including moisturizers and lubricants, and topical estrogen application. Patients not responding/being unsatisfied with previous l...
Cosmetic surgery procedures have increased manifolds all over the world owing to the ever‐increasing demand of people to look beautiful and young. Injectable treatments like botulinum toxin are becoming more popular owing to their rapid, well defined and lasting results for the reduction of facial fine lines, wrinkles and facial rejuvenation. These...
Angioma serpiginosum is a rare nevoid vascular disorder. It is usually a sporadic condition; however, familial cases have been reported. It occurs due to congenital hyperplasia or ectasia of superficial dermal capillaries. There is a female predominance. The onset is usually in childhood, with 80% of cases presenting before 20 years of age. It is c...
A 63-year-old Caucasian male developed an intensely pruritic eruption 7 hous after percutaneous coronary intervention (stent placement) that took place soon after he sustained myocardial infarct. He had been on metoprolol and alprazolam for several months before the surgery. He had no history of skin condition. The eruption started from the arms, g...
Port‐wine stain (PWS) is a benign capillary malformation that most commonly occurs in the head and neck. It is present at birth and progresses over time. It is formed by progressive dilatation of post‐capillary venules and is associated with hypertrophy and nodularity with increasing age, leading to cosmetic disfigurement and psychological aggravat...
Peeling skin syndrome (PSS) is a group of rare autosomal recessive conditions characterized by continuual shedding of the skin due to separation of the stratum corneum from the granular layer. PSS can be localized or generalized. The patient we present developed asymptomatic, non-inflammatory, non-pruritic shedding of the skin involving the trunk a...
Tattoos are commonly employed for cosmetic reasons such as make-up and body art. Tattoo pigments, especially red, can trigger a variety of delayed immune responses manifesting as lichenoid, eczematous, and granulomatous reactions. Also, the development of granulomatous lesions within tattoos is a well-recognized manifestation in patients with sarco...
An otherwise healthy man presented with alopecia, plantar keratoderma, and abnormal fingernails and toenails since childhood. He was diagnosed with hidrotic ectodermal dysplasia, or Clouston syndrome. Clouston syndrome is an autosomal dominant disorder caused by mutations in GJB6, which encodes the connexin 30 protein. Clinical features that are hi...
Three siblings aged 16, 20 and 22 years presented to dermatology with multiple, non-pruritic, light brown or whitish lesions of various sizes on the face, neck, trunk and arms since early childhood. On examination, numerous well defined, non-pruritic, hypopigmented macules and slightly verrucous papules were symmetrically distributed over the foreh...
A 12-year-old girl presented with well-defined asymptomatic lesions on cheeks and upper extremities for 6 months. Lesions on the extremities were ulcerated plaques with areas of scarring and atrophy. Laboratory investigations showed anaemia and positive Mantoux test. Cartridge-based nucleic acid amplification test (CBNAAT) of cutaneous tissue and s...
A 43-year-old male presented to dermatology with a chief complaint of stabbing pain and grouped vesicles on the right side of the chest for 3 days. Discrete fluid-filled lesions had developed on the face, neck, back and chest one day prior to the rash. Skin examination showed multiple grouped tense vesicles and a few bullae on an erythematous base...
An 8-year-old boy presented to dermatology with erythematous plaques over his elbows and knees, and thickening of palms and soles since early childhood. His developmental milestones were normal. Skin examination revealed well-defined, erythematous, hyper- keratotic, plaques distributed symmetrically over the dorsal aspect of fingers and feet, knuck...
Nocturnal pruritus (NP) is a relatively common reason for dermatologic consultation. Its pathophysiology is partially understood. Skin conditions such as atopic dermatitis, psoriasis, urticaria, and prurigo nodularis are well-described causes of NP. The most distressing sequela of NP is sleep deficit which can lead to physical and mental disturbanc...
BACKGROUND During the pandemic virtual conferences became the norm.
OBJECTIVES To assess dermatologists’ responses to whether they attend virtual conferences and e-learning programs, and discuss the status of such events during the pandemic.
METHODS This web-based, global survey included 733 dermatologists. Primary outcomes are percentages of re...
A 40-year-old Arab female presented at 37 weeks' gestation with an intensely pruritic generalized, desquamating rash of 2 weeks' duration. Skin examination showed a
Treatment of erosive pustular dermatosis of the scalp (EPDS) is challenging. Topical and systemic medications have achieved limited success, and destructive modalities have been associated with EPDS recurrence because of the tendency of the condition to recur after any treatment that induces trauma to the skin. Kroumpouzos and colleagues have recen...
The availability of personal protective equipment (PPE) among dermatologists in COVID-19 pandemic has not previously been studied. We have assessed PPE availability among dermatologists and relevant aspects of hospital service by surveying 733 dermatologists. Considerable percentages of responders had to purchase own PPE and were not provided with...
This contribution focuses on the effects of Coronavirus disease 2019 (COVID-19) on dermatology practice. We discuss the impact on practice volume and procedures, and considerable increase in teledermatology use. We also describe the important roles that dermatologists have played in enhancing infection prevention and on the frontline. During the cr...
This article focuses on the effects of Coronavirus disease 2019 (COVID-19) on dermatology practice. We discuss the impact on practice volume and procedures, and considerable increase in teledermatology use. Also, we describe the important roles that dermatologists played in enhancing infection prevention and on the frontline. During the crisis, der...
Background:
The spectrum and magnitude of changes in dermatology practice induced by the COVID-19 pandemic have not been adequately studied.
Objectives:
To assess immediate and long-term effects of the pandemic on dermatology practice on a large scale, including the clinical activity of participant, frequency and types of procedures used, and te...
The use of dermal fillers has increased manifold over the past decade, which has been attributed to the ever-increasing need of the population for being young. Fillers have become quite popular both among patients and treating physicians due to their quick and quite predictable results. Filler injection is a safe procedure in the hands of an experi...
Background
There is a sparsity of data regarding the mental health status of dermatologists during COVID‐19 pandemic.
Objectives
Evaluate the effects of pandemic on mental health of dermatologists on a large scale and identify risk factors for mental distress.
Methods
733 dermatologists were included in this cross‐sectional, web‐based survey.
Re...
Hand washing is a known method of maintenance of effective hand hygiene. Currently due to COVID 19 pandemic Centre for Disease Control and Prevention (CDC) is recommending scrubbing the hands frequently for at least 20 seconds to prevent spread of virus.1 COVID 19 has become nightmare for everyone in the world. With no certain effective drug and va...
Acne is one of the commonest problems of adolescence with almost half of the patients experiencing persistence into adulthood. Pulsed dye lasers (PDL) with wavelengths of 585 and 595 nm targeting hemoglobin have been used for the treatment of this condition and its sequelae. Recent introduction of PDL with a higher wavelength of 1319 nm has been re...
Background
Prurigo of pregnancy (PP), a specific pregnancy dermatosis, has been associated with atopic background in the patient and/or family. However, this association was not validated in some studies, and cases without atopic background have been reported.
Objectives
To evaluate the clinical features of PP not related to atopic background and...