George Koulaouzidis

George Koulaouzidis
Pomeranian Medical University in Szczecin · Department of Biochemical Sciences

MD PhD
Telemedicine, Artificial intelligence, Heart Failure, Coronary Artery Calcification and Long QT

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70
Publications
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276
Citations

Publications

Publications (70)
Article
Full-text available
Artificial intelligence (AI) is an integral part of clinical decision support systems (CDSS), offering methods to approximate human reasoning and computationally infer decisions. Such methods are generally based on medical knowledge, either directly encoded with rules or automatically extracted from medical data using machine learning (ML). ML tech...
Article
Full-text available
Background: Recent echocardiography studies in inherited long QT syndrome (LQTS) have shown left ventricular (LV) myocardial relaxation disturbances to follow markedly prolonged and dispersed mechanical contraction. Aim: We used speckle-tracking echocardiography to assess disturbances in LV myocardial relaxation sequence during exercise and thei...
Chapter
This chapter focuses on the calcification of heart valves. The extent of valve calcification may vary from mild sclerosis with no effects on valve function to the development of leaflets calcification which causes valve dysfunction. It is well known that valve calcification is associated with conventional atherosclerosis risk factors. The valve cal...
Article
Background Speckle-tracking echocardiography studies in inherited long QT syndrome (LQTS) have recently shown myocardial relaxation disturbances at rest in the form of delayed onset of relaxation as a result of prolonged and dispersed mechanical contraction. The aim of this study was to assess disturbances in left ventricular regional myocardial re...
Article
Full-text available
Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, which is estimated to affect 20-30% of the adult population in Europe. Several studies have shown an association of NAFLD with multiple cardiovascular risk factors such as abdominal obesity, atherogenic dyslipidaemia, hypertension, insulin resistance,...
Preprint
Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, which is estimated to affect 20–30% of the adult population in Europe. Several studies have shown an association of NAFLD with multiple cardiovascular risk factors such as abdominal obesity, atherogenic dyslipidaemia, hypertension, insulin resistance,...
Article
Funding Acknowledgements Type of funding sources: None. Background Coronary atherosclerosis is a continuous process beginning early in life, with a long and clinically asymptomatic phase, before manifestations appear in middle and/or late adulthood. Coronary artery calcification (CAC) is a well-established marker of atherosclerosis; but the clinic...
Article
Funding Acknowledgements Type of funding sources: None. Background Although individuals of South Asian (S. Asian) origin represent 20% of the world population, they are under-represented in studies investigating the presence of coronary artery calcification (CAC). Aim We compared the prevalence of CAC in Caucasians and Asians who underwent electr...
Article
Full-text available
Gastrointestinal (GI) cancers remain high on the list of the leading causes of death worldwide; however, the recent emergence of new and ongoing global healthcare threats, such as the COVID-19 pandemic, has led to a temporary reduction in elective endoscopic procedures [...]
Chapter
Full-text available
The early detection of Heart Disease (HD) and the prediction of Heart Failure (HF) via telemonitoring and can contribute to the reduction of patients’ mortality and morbidity as well as to the reduction of respective treatment costs. In this study we propose a novel classification model based on fuzzy logic applied in the context of HD detection an...
Article
Funding Acknowledgements Type of funding sources: None. Background Telemonitoring was introduced with the potential to improve the medical care, quality of life and prognosis of patients with heart failure (HF). The aim of the study was to assess the effect of home telemedicine (HTM) in long-term mortality in patients with heart failure with reduc...
Article
Funding Acknowledgements Type of funding sources: None. Background Trastuzumab has had a major impact on the treatment of human epidermal growth factor receptor 2(HER-2) positive breast cancer patients. However, it is associated with cardiotoxicity, expressed as an asymptomatic decrease in LVEF and less often as clinical HF. Published studies have...
Article
Funding Acknowledgements Type of funding sources: None. Background Several studies have demonstrated the association of coronary artery calcification (CAC) with non alcoholic fatty liver disease(NAFLD). The aim of this systematic review is to assess the association of NAFLD with the progression of subclinical atherosclerosis, reflected as the dyna...
Article
Funding Acknowledgements Type of funding sources: None. Background Controversy exists regarding the association of family history(FH) of premature coronary artery disease (CAD) with coronary artery calcification (CAC). The purpose of this study was to assess the potential association between family history of premature CAD (<55 years in first-degr...
Article
Background: Trastuzumab has had a major impact on the treatment of human epidermal growth factor receptor 2 (HER2) positive breast cancer patients. However, it is associated with cardiotoxicity, expressed as an asymptomatic decrease in left ventricular ejection fraction (LVEF) and less often as clinical HF. The aim of this meta-analysis is to iden...
Article
Full-text available
Funding Acknowledgements Type of funding sources: None. Background Left ventricular (LV) mechanical dispersion and prolonged myocardial contraction are associated with symptoms in long QT syndrome (LQTS) mutation carriers. Sub-clinical LV diastolic impairment has also been reported in this group. Purpose To investigate at rest and during exercise...
Article
Full-text available
Background: Electromechanical heterogeneities due to marked dispersion of ventricular repolarisation and mechanical function have been associated with symptoms in long QT syndrome (LQTS) patients; Aim: To examine the exercise response of longitudinal LV systolic and diastolic myocardial function and synchronicity in LQTS patients and its relations...
Article
Full-text available
The surge of artificial intelligence (AI) in medicine stands on a lengthy, and frequently reticent, buildout [...]
Article
Background Electromechanical (EM) coupling heterogeneity is significant in long QT syndrome (LQTS), particularly in symptomatic patients; EM window (EMW) has been proposed as an indicator of interaction and a better predictor of arrhythmia than QTc. AIM To investigate the dynamic response of EMW to exercise in LQTS and its predictive value of arrh...
Article
Background Long QT syndrome (LQTS) carriers are characterized by abnormal ventricular repolarization, prolonged systole, and mechanical dispersion. Prolonged left ventricular (LV) systole has been shown to result in disproportionate shortening of LV filling in other conditions. The aim of this study was to assess LV filling, diastolic function, and...
Article
Introduction: Heart failure is increasingly common, and characterised by frequent admissions to hospital. To try and reduce the risk of hospitalisation, techniques such as telemonitoring (TM) may have a role. We wanted to determine if TM in patients with newly diagnosed heart failure and ejection fraction <40% reduces the risk of readmission or de...
Article
Background: Heart failure (HF) is increasingly common and characterised by frequent admissions to hospital. To reduce the risk of HF hospitalisation (HFH), approaches as telemonitoring (TM) have been introduced. This study aimed to develop an algorithm for detecting patients at high risk of HFH, using daily collected physiological data (blood pres...
Article
Full-text available
The letter corresponding to the study by Yepuri et al on the effects of proton pump inhibitors (PPIs) on endothelial cells. Extract: The investigators exposed human microvascular endothelial cells to PPIs and observed reduced cell proliferation, a decrease in NO, and impaired proteostasis. Moreover, numerous genes involved in cell senescence expres...
Article
Background Heart failure (HF) is a complex clinical syndrome associated with high mortality and high rate of hospital readmissions. Telehealth (TH) is a promising strategy for improving HF outcomes but there is an urgent need to properly identify those patients in whom a TH approach would provide benefit. The purpose of this study was to determine...
Article
Heart failure (HF) is commonly a chronic condition associated with frequent hospital admissions. Early knowledge about a possible deterioration of this condition would enable early treatment for the prevention of adverse events and related hospital admissions. In this paper we present a computational method for predictive information extraction fro...
Article
Aim: To develop a statistical index based on the phase space reconstruction (PSR) of the electrocardiogram (ECG) for the accurate and timely diagnosis of ventricular tachycardia (VT) and ventricular fibrillation (VF). Methods: Thirty-two ECGs with sinus rhythm (SR) and 32 ECGs with VT/VF were analyzed using the PSR technique. Firstly, the method...
Article
Full-text available
In this paper, we propose a novel statistical index for the early diagnosis of ventricular arrhythmia (VA) using the time delay phase-space reconstruction (PSR) technique, from the electrocardiogram (ECG) signal. Patients with two classes of fatal VA-with preceding ventricular premature beats (VPBs) and with no VPBs-have been analysed using extensi...
Article
Ventricular arrhythmias comprise a group of disorders which manifest clinically in a variety of ways from ventricular premature beats (VPB) and no sustained ventricular tachycardia (in healthy subjects) to sudden cardiac death due to ventricular tachyarrhythmia in patients with and/or without structural heart disease. Ventricular fibrillation (VF)...
Article
To investigate the prevalence of coronary artery calcification (CAC) in symptomatic individuals with CT evidence for left heart valve calcification, aortic valve (AVC), mitral valve (MAC) or both. This is a retrospective study of 282 consecutive patients with calcification in either the aortic valve or mitral annulus. Calcium scoring of the coronar...
Article
Coronary artery calcium score (CACs) is an established quantitative tool for assessing subclinical atherosclerosis. The aim of this study was to assess in a meta-analysis model the natural history and reproducibility of CACs measurements obtained from St Francis and EBEAT trials. We analysed data from 649 individuals: 443 on placebo with 2year foll...
Article
Aim: Coronary artery calcification (CAC) has been introduced as a reliable, non-invasive marker of atherosclerosis. In this retrospective study, we investigated the progression of CAC using electron beam computed tomography. Methods: The study enrolled 598 individuals (521 males; mean age: 59.3±8.3 years) with initial CAC score (CACS) ≥10. The m...
Article
The aim of this study is to determine the progression of coronary artery calcification (CAC) using electron beam computed tomography (CT) when the initial CAC score (CACS) is zero and to determine the best interval to repeat a CAC scan. We studied 388 individuals with zero CACS (308 males; mean age: 48.8 ± 8.26 years) who underwent 2 consecutive CT...
Article
Although several studies have demonstrated the association between coronary artery calcification (CAC) and coronary artery disease events, the underlying mechanism has not been fully elucidated. Furthermore, extensive CAC still remains a poorly understood phenomenon. The objective of this study is to determine the clinical characteristics and diffe...
Article
Background: Ethnic differences in prevalence and severity of coronary artery disease are well established and are usually attributed to risk factors variation. This study investigates the differences in coronary artery narrowing and coronary calcification between two age- and gender-matched cohorts of South Asian and Caucasian symptomatic angina p...
Article
Introduction Atheromatous plaque rupture is the most common cause of coronary artery thrombosis. Non-calcified plaques, with thin fibrous cap and large thrombogenic lipid core, are predominantly the most susceptible to rupture. Aims To investigate, with a 640-slice, 320-row CT scanner, the non-calcified coronary artery plaques (NCAP) prevalence and...
Article
Computed Tomography Coronary Angiography (CTCA) is a rapid, non-invasive diagnostic tool for coronary artery disease (CAD). Rapid Access Chest Pain Clinics (RACPC) were introduced in UK in 2000, in order to assess rapidly patients with chest pain. To evaluate the use of CTCA as initial work-up for unstable angina pectoris in a primary care-based RA...
Article
Full-text available
Noncalcified coronary artery plaques (NCAPs) are susceptible to rupture, resulting in coronary artery thrombosis. Using computer tomography coronary angiography (CTCA), we evaluated the prevalence and degree of stenosis caused by NCAP in patients without coronary artery calcification (CAC). A retrospective analysis of 447 symptomatic patients with...
Article
The pathogenesis of coronary artery calcification and its role in atherogenesis has not been completely understood but is a new focus of interest in experimental and clinical research. Various bioactive substances, including hormones, have been implicated in the process of arterial calcification. This review considers the relationship between coron...

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