George Nikov Chaldakov

George Nikov Chaldakov
Medical University of Varna · Dept of Anatomy and Cell Biology

MD, PhD

About

429
Publications
53,964
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4,495
Citations
Citations since 2017
128 Research Items
1918 Citations
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20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
Additional affiliations
February 2003 - present
Medical University of Varna
Position
  • Professor
Description
  • Teaching medical and dental medicine students in Cell Biology, Adipobiology and Neurobiology.
June 1999 - present
Italian National Research Council (CNR)
Position
  • CNR - Consiglio Nazionale delle Ricerche
Description
  • Visiting Scientist, 1998-now
August 1998 - present
National Research Council - Italy

Publications

Publications (429)
Chapter
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Today, the most widespread disease around the world is not Coronavirus disease 2019 (COVID-19) or any other communicable disease. Indeed, type 2 diabetes mellitus (T2DM) and obesity (hence, diabesity) have been lionized as the main risks for cardiometabolic diseases (CMD) and their morbidity and mortality signature. Recent studies revealed that the...
Conference Paper
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Conference Paper
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Presentation
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Tribute to Great GEORGE E. PALADE....
Conference Paper
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Decalogue for students
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Objective: GDF11 is a member of the TGF-β superfamily that was recently implicated as potential "rejuvenating" factor, which can ameliorate metabolic disorders. The main objective of the presented study was to closely characterize the role of GDF11 signaling in the glucose homeostasis and in the differentiation of white adipose tissue. Methods:...
Book
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This is a stream-of-associations (SOA)– and bench-to-bedside (B2B)–based textbook for students of medicine, dental medicine and cell biology and for all graduates and postgraduates in biological sciences. It may also be of particularly interest for a reader who wishes to change career to biology and its related subdisciplines. The main goal of the...
Article
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How we flew with the fishing flotillas in the bluest - the sea arena - and how the dolphins danced. Hristo Fotev, from "Liturgy for Dolphins" Uncle Iliya and his family were our neighbors. They lived for rent in the house of my friend Peter Raykov on 29 Slivnitsa Street, we-on 27, opposite the back of the Fire Brigade in the city of Burgas. .....
Book
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To view, disseminate, and purchase this textbook, please click here: https://www.amazon.com/PRINCIPLES-CELL-BIOLOGY-George-Chaldakov-ebook/ This is a stream-of-associations (SOA)-and bench-to-bedside (B2B)-based textbook. The main goal of the book is to provide state-of-the-science (SOS) knowledge of cell and (extracellular) matrix biology and its...
Preprint
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“The Miracle of Athens” has been broken again" is an appeal for Peace.
Book
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To view, disseminate, and purchase this textbook, please click here: https://www.amazon.com/PRINCIPLES-CELL-BIOLOGY-George-Chaldakov-ebook/ dp/B09QZ4DQ6F/ref=sr_1_1? crid=1BW34R81M9Y39&keywords=chaldakov&qid=1642936501&sprefix=chaldakov %2Caps%2C139&sr=8-1 This is a stream-of-associations (SOA)-and bench-to-bedside (B2B)-based textbook. The main go...
Book
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This is the link to stream-of-associations (SOA)-, bench-to-bedside (B2B)-based PRINCIPLES OF CELL BIOLOGY textbook by George N. Chaldakov, available on Amazon.com: https://www.amazon.com/PRINCIPLES-CELL-BIOLOGY-George-Chaldakov-ebook/ dp/B09QZ4DQ6F/ref=sr_1_1? crid=1BW34R81M9Y39&keywords=chaldakov&qid=1642936501&sprefix=chaldakov %2Caps%2C139&sr=8...
Book
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The main goal of the present textbook is to provide – in a stream of associations (SOA) fashion – state-of-the-science(SOS)-based knowledge of cell biology and its translation into the pathogenesis, prevention and therapy of diseases, being away from any descriptive details. The major concepts of the book are (i) cell-extracellular matrix unity, (i...
Book
Full-text available
The main goal of the present textbook is to provide – in a stream of associations fashion – state-of-the-science-based knowledge of cell biology and its translation into the pathogenesis, prevention and therapy of diseases, being away from any descriptive details. The major concepts of the book are (i) cell-extracellular matrix unity, (ii) triarchi...
Book
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Principles of Cell Biology textbook available in Amazon....
Presentation
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Healthy and Creative 2022 Year!!!!
Article
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Currently, obesity has been recognized as a prime risk in the development of car-diometabolic diseases (CMD) and neurodegenerative diseases (NDD). The patho-genesis and therapy of CMD are immensely complex at the cellular and molecular levels. This scenario raises the question of how such a complexity may be grappled in a more tangible manner. Sinc...
Article
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All articles of ADIPOBIOLOGY 11, 2021
Article
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Today, the most widespread disease around the world is not COVID-19 or any other communicable disease. Indeed, obesity and type 2 diabetes mellitus (T2DM) have been recognized as the main risks for cardiometabolic diseases (CMD) and their morbidity and mortality signature. Recent studies revealed that the adipose tissue and the skeletal muscles may...
Article
Full-text available
Currently, obesity has been recognized as a prime risk in the development of car-diometabolic diseases (CMD) and neurodegenerative diseases (NDD). The patho-genesis and therapy of CMD are immensely complex at the cellular and molecular levels. This scenario raises the question of how such a complexity may be grappled in a more tangible manner. Sinc...
Article
Full-text available
To view, disseminate, and purchase this textbook, please use the link: https://www.amazon.com/PRINCIPLES-CELL-BIOLOGY-George-Chaldakov-ebook/dp/B09QZ4DQ6F/ref=sr_1_1?crid=1BW34R81M9Y39&keywords=chaldakov&qid=1642936501&sprefix=chaldakov%2Caps%2C139&sr=8-1 PRINCIPLES OF CELL BIOLOGY textbook is an intellectual entertainment that may enjoy your love...
Chapter
Currently, the most widespread global ailment is not COVID-19 or any other such devastating infectious diseases. In fact, obesity has been recognized as a prime risk in the development of cardiometabolic diseases (CMD), neurodegenerative diseases (NDD) and cancer and their morbidity and mortality signature. The pathobiology and therapy of obesity a...
Book
Full-text available
Currently, the most widespread global ailment is not COVID-19 or any other such devastating infectious diseases. In fact, obesity has been recognized as a prime risk in the development of cardiometabolic diseases (CMD), neurode-generative diseases (NDD) and cancer and their morbidity and mortality signature. The pathobiology and therapy of obesity...
Chapter
Full-text available
Currently, the most widespread global ailment is not COVID-19 or any 2 other such devastating infectious diseases. In fact, obesity has been recognized 3 as a prime risk in the development of cardiometabolic diseases (CMD), neurode-4 generative diseases (NDD) and cancer and their morbidity and mortality signa-5 ture. The pathobiology and therapy of...
Preprint
Full-text available
Еudaimonia В Ta Ethika Аристотел описва еudaimonia (eu – хубаво, daimon – дух) – да живееш добре, да си щастлив. Да постигнеш еudaimonia трябва равнопоставено да прилагаш logos (разум), pathos (емоция) и ethos (морал – рефлекси за емпатия и алтруизъм). И filia (приятелство), базирано на интелект-и-емоции – Приятелство с мозък-и-сърце (Brain-and-hea...
Article
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This short overview and updates expresses our brain-and-heart homage to George Emil Palade, "the most influential cell biologist ever". In his 1971 paper Palade wrote for Albert Claude, the founder of biological electron microscopic method: "Seldom has a field owed so much to a single man". Herein, we articulate the same words for George Palade, th...
Article
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Studies over the past 30 years have revealed that adipose tissue is the major endocrine and paracrine organ of the human body. Arguably, adiopobiology has taken its reasonable place in studying obesity and related cardiometabolic diseases (CMDs), including Alzheimer’s disease (AD), which is viewed herein as a neurometabolic disorder. The pathogenes...
Article
Full-text available
Studies over the past 30 years have revealed that adipose tissue is the major endocrine and paracrine organ of the human body. Arguably, adiopobiology has taken its reasonable place in studying obesity and related cardiometabolic diseases (CMDs), including Alzheimer's disease (AD), which is viewed herein as a neurometabolic disorder. The pathogenes...
Article
Lipoprotein disorders are a major risk factor for atherosclerotic neuro-cardiovascular disease (ACVD) and are heavily influenced by lifestyle, including alcohol drinking. Moderate drinkers have a lower ACVD risk than abstainers because of their higher levels of high-density lipoprotein (HDL) cholesterol, an important protective factor against ACVD....
Chapter
Alcohol addiction represents a chronic condition characterized by behavioral, physical, and mental alterations, caused by compulsive consumption of high quantities of alcohol. The effects of alcoholism heavily interfere with physical health and with relational and social life. Scientific research has constantly focused on finding solutions not only...
Article
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E d i t o r ' s f o r e w o r d BMR Biomedical Reviews Biomed Rev 31, 2020 III Picture by Todor Krastev, Prof. of Architecture Dear Colleagues, We are pleading Clotho* to give Healthy and Creative Longevity to all the BHFs and their families worldwide! *In ancient Greek mythology, Clotho (Spinner) is one of the three Fates or Moirai. She is respons...
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Reviews, Research articles etc published in this volume of Biomedical Reviews (BMR).......
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BMR 31, 2020 Editor's foreword, Spotlight, In Memoriam
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Spotlight: Professor WALE SULAIMAN....
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The world is facing the pandemic of a new coronavirus (SARS-CoV-2) leading to the development of coronavirus disease (COVID-19). In effect, the scientific potential in the field becoming the cutting-edge of biomedical research. It is in a big race to test the available pharmacologic resource of registered antiviral drugs and to discover of novel ph...
Article
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Atherosclerosis and its complications, erosion and rupture of the plaque fibrous cap, lead to myocardial infarction and stroke, the main causes of mortality worldwide. In this setting, arterial smooth muscle cells (SMC) of the innermost media undergo phenotypic changes, a switch towards a secretory phenotype engaged in matrix proteins production. I...
Article
Full-text available
Atherosclerosis and its complications, erosion and rupture of the plaque fibrous cap, lead to myocardial infarction and stroke, the main causes of mortality worldwide. In this setting, arterial smooth muscle cells (SMC) of the innermost media undergo phenotypic changes, a switch towards a secretory phenotype engaged in matrix proteins production. I...
Article
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Tribute to one the best opera singer RAINA KABAIVANSKA, EVVIVA!!!
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Stress is a constant threat for homeostasis and is represented by different extrinsic and intrinsic stimuli (stressors, Hans Selye's "noxious agents"), such as aggressive behavior, fear, diseases, physical activity, drugs, surgical injury, and environmental and physiological changes. Our organism responds to stress activating the adaptive stress sy...
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In the spring of 1891 the ship „Oceanien” sailed from France to Tahiti. One of the passengers was Paul Gauguin. Having fallen in love with estrogenic young ladies of the island, he transformed his love and melancholy into an amazing spectrum of colors of post-impressionism. He completed one of his conceptual paintings in 1897-1898. In one corner of...
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The nerve growth factor (NGF) belongs to a family of proteins named neurotrophins, consisting of NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5 and NT-6. NGF regulates a large number of physiological mechanisms that result in neurotrophic, metabotrophic and/or immunotrophic effects. Neurodegenerative diseases, includin...
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This is an essay calling for reciprocal empathy, kindness and fairness in the world of greed, aggression, arrogance and anomie? – the deadly quartet of the present civilization.
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1 Лаборатория по лекарствена токсикология, Институт по невроби-ология, Българска академия на науките, София; YanevSG@gmail.com 2 Катедра по анатомия и клетъчна биология, Медицински универси-тет, Варна; chaldakov@yahoo.com Научният потенциал на водещите страни в света е в надпревара за тестиране на наличния фармакологи-чен ресурс от регистрирани а...
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Je est un autre (аз е другият в мен)-написано от Артюр Рембо на 13 май 1871 в писмо до негов учител. Емпатията и алтруизмът са профил на духовно бога-тите личности, апатията и егоизмът-на бездушните. "Емпатията е сила, която поддържа обществото ця-лостно и ние трябва да се научим да я прилагаме". VERSUS Metanoia-от гръцки, означава позитивна промян...
Article
The nerve growth factor (NGF) belongs to the family of neurotrophic factors. Initially discovered as a signaling molecule involved in the survival, protection, differentiation and proliferation of sympathetic and peripheral sensory neurons, it also participates in the regulation of the immune system and endocrine system. NGF biological activity is...
Article
Full-text available
The nerve growth factor (NGF) belongs to a family of proteins named neurotrophins, consisting of NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5 and NT-6. NGF regulates a large number of physiological mechanisms that result in neurotrophic, metabotrophic and/or immunotrophic effects. Neurodegenerative diseases, includin...
Book
Full-text available
Biomedical Reviews is an official journal of the Bulgarian Society for Cell Biology published by the Medical University Press, Varna, Bulgaria. The Journal is published annually, and includes state-of-the-science (SOS) Reviews, Research Articles and Dance Round (a form of position papers) focused on disease-oriented molecular cell biology presented...
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Introduced are five novel Biomorphogenetic Principles in teaching Cell Biology.
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Recent advances have shed light on the relationship between smooth muscle cell (SMC) phenotypic modulation, resolution of inflammation and atherosclerotic plaque stability. The thick fibrous cap covering the lipid core of plaques is composed of bundles of SMC and collagen fibers and few macrophages and lymphocytes, all of which make the plaque resi...
Presentation
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Rethinking Adipose Tissue lecture for medical and dental students, also for teachers and MD
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Tissue Biology (Histology) Lecture for medical and dental students, also for teachers and MD.
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Cell Biology. Cytoskeleton lecture for medical and dental students, also for teachers and MD
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Cell Biology Lecture for medical and dental students, also for teachers and MD.
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Part 1. Tissue biology: Introduction Part 2. Epithelial tissue
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To teach medical students how information becomes knowledge and way of thinking in biomedicine… and life. To feel the knowledge like they feel their mother tongue. To transform knowledge of cellular Molecules-Structures-Functions (MSF) into knowledge of of Diseases-Prevention-Therapy (DPT).
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Some of my lecture presented in YouTube...
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According to data from the Bulgarian National Statistical Institute from these and other diseases, 108 526 Bulgarians - a big Bulgarian city - died in 2018. Of these, 70 546 were from strokes and myocardial infarctions, and 17 462 from malignant tumors.
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.... to keep students-to-teacher communicating junctions alive and kicking (Fig. 1) Figure 1. Schematic view of cell-to-cell interactions via nexuses (gap junctions, channel junctions, communicating junctions , macula communicans) between the neibouring Cell A and Cell B, intercellular space of 2-4 nm. One channel of nexus is composed of two conne...
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Many papers, also abstracts of 5th ISAA, published in volume 10 of Adipobiology...
Presentation
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Abstracts of the Merida Yucatan, Mexico 5th Int Symp Adipobiol Adipopharmacol (ISAA), 1 - 4 May 2019...
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Cognitive adipobiology lecture focuses on adipose tissue communication with the brain in the pathogenesis of Alzhemer''s disease...
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Abstracts of the lectures and posters presented at 5th ISAA....
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Dedicated to the great RITA LEVI-MONTALCINI...
Conference Paper
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Dear Colleagues , You are WELCOME to contribute to the excellence of the Mexico 5th International Symposium on Adipobiology and Adipopharmacology (ISAA) presenting your state-of-the-science (SOS) lectures, at, for example, the Session "From cognitive neuroscience to cognitive adiposcience". Please find attached the announcement for 5th ISAA. Cordi...
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Laryngeal squamous cell carcinoma (LSCC) is the second most common neoplasm of the upper aerodigestive tract after cancer of the oral cavity. Over the past two decades, even though patients have benefited greatly from the latest advances in surgical techniques, chemotherapy and radiation therapy, the survival rate of LSCC has not improved significa...
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BMR 29, 2018, several Review articles....
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In 1990, one of us (GNC) for the first time reported a hypothesis of receptor-mediated endocytosis (RME)-based pharmacology relevant to the possible antiviral therapy including in acquired immunodeficiency syndrome (AIDS). Then, RME using clathrin-coated pits/vesicles was the best-characterized endocytic pathway. Since then now, intensive research...
Article
Full-text available
In 1990, one of us (GNC) for the first time reported a hypothesis of receptor-mediated endocytosis (RME)-based pharmacology relevant to the possible antiviral therapy including in acquired immunodeficiency syndrome (AIDS). Then, RME using clathrin-coated pits/vesicles was the best-characterized endocytic pathway. Since then now, intensive research...
Presentation
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The lecture presents a new conception designated COGNITIVE ADIPOSCIENCE...
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Abstract This work highlights recent studies in epigenetic mechanisms that play a role in alcoholism, a complex multifactorial disorder. A large body of evidence has shown that alcohol can modify gene expression through epigenetic processes, namely DNA methylation and nucleosomal remodeling via histone modifications. In that vein, chronic ethanol e...
Presentation
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Lectures: (i) Homage to George Palade, and (ii) SOS (state-of-the-science) of Cell Biology
Book
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HOMO JANUS. Psychology and Psychopathology (not only) of Bulgarians. 3rd revised and enlarged edition. August 2018. 140 essays, 23 of them bilingual - in Bulgarian and English, indicated in bold in Contents at the end of the book.
Presentation
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Homage to great GEP....
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Homo Janus contains 140 essays (publissays), 23 of them bilingual - in Bulgarian and English, the titles of latter indicated BOLD in the Contents at the end of the book. You may enjoy reading Homo Janus...
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Over the past decades, advances in the knowledge of colchicine about its mechanisms of cellular actions have led to potential new uses for this very old drug. Here, I present briefly the Bulgarian contribution to possible potential of microtubule-disassembling agents (antitubulins), such as colchicine, in the therapy of various cardiovascular disea...
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Colchicum autumnale, from which colchicine has been isolated more than 100 years ago, has been used as a treatment for pain and swelling for thousands of years. It is one of the few drugs known from that time period whose use has survived to modernity. Over the past decades, advances in the knowledge of (i) cytoskeletal microtubules (МТ), and (ii)...

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