George Ainooson

George Ainooson
Kwame Nkrumah University of Science and Technology | KNUST · Department of Pharmacology

PhD (Molecular Biology), MPhil (Pharmacology), BPharm (Pharmacy)

About

31
Publications
15,716
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
634
Citations
Introduction
Skills and Expertise
Additional affiliations
October 2023 - April 2024
Nagasaki University
Position
  • Postdoc
Description
  • Postdoc
October 2013 - November 2017
Karlsruhe Institute of Technology
Position
  • PhD Student
Description
  • PhD Candidate
Education
October 2013 - October 2017
Karlsruhe Institute of Technology
Field of study
  • Molecular Biology

Publications

Publications (31)
Conference Paper
Full-text available
Castration-resistant prostate cancer (CRPC) is an androgen-independent variant of prostate cancer (PCa) associated with significant mortality, with a mean survival time of 16–18 months. This has necessitated the continuous search for novel and effective compounds, including those of natural origin, for the treatment of CRPC. One of such natural sou...
Article
Full-text available
Context Lantana camara Linn. (Verbenaceae) is used for improving memory in certain African societies. Objective This study investigated the effect of prophylactic treatment with hydroethanolic leaf extract of Lantana camara (LCE) on short-term memory deficit and neuroinflammation induced with scopolamine in zebrafish and mice. Materials and metho...
Article
Full-text available
Background: Cordia vignei Hutch and Dalziel (Fam. Boraginaceae) is a woody plant found in west tropical Africa. The aim of this research is to find out if the leaf extract of this plant prevents oedema in animal models. Methods: (a) Inflammation was induced in the animals by injecting 100 µl of 2% lambda carrageenan into the subplantar tissue of...
Article
Full-text available
Airway inflammation in asthma is managed with anti-inflammatory steroids such as dexamethasone (DEX). However, about 20% of asthmatics do not respond to this therapy and are classified as steroid-resistant. Currently, no effective therapy is available for steroid-resistant asthma. This work therefore evaluated the effect of a plant sterol, stigmast...
Article
Full-text available
The study sought to formulate and evaluate suppositories using a locally produced brand of alum (Aw) obtained from bauxite waste generated at Awaso bauxite mine in the Western-North region of Ghana, for use in the treatment of hemorrhoids. The suppositories were formulated using shea butter modified, respectively, with amounts of beeswax and theobr...
Article
Full-text available
Background: Ulcerative colitis (UC) is a recurrent inflammatory bowel disease (IBD) that causes long-lasting inflammation on the innermost lining of the colon and rectum. Leaf decoctions of Cordia vignei have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease. Aim: In this study, w...
Article
Full-text available
Mast cells (MCs), which are best known for their detrimental role in patients with allergic diseases, act in a diverse array of physiologic and pathologic functions made possible by the plurality of MC types. Their various developmental avenues and distinct sensitivity to (micro-) environmental conditions convey extensive heterogeneity, resulting i...
Article
Full-text available
Protein tyrosine phosphatases and glucocorticoids are known to regulate allergic and antiallergic action in activated mast cells. Here we provide RNA sequencing and quantitative real-time PCR data from bone marrow derived mast cells, for wild-type and PEST-domain-enriched tyrosine phosphatase (PEP) null mice, activated by immunoglobulin E sensitiza...
Article
Full-text available
The EU COST Action BM1007 "Mast cells and Basophils - Targets for Innovative Therapies" represents a network of researchers analyzing the physiological and pathological roles of mast cells and basophils in the organism in order to come up with new treatment strategies. In this review the conclusions from a training school organized by the network i...
Article
Full-text available
Background: Ischuria is a health and social problem, having a negative impact on sufferers. This study therefore was a preliminary investigation of the ischuretic property and safety for use of a hydro-ethanolic extract of Amaranthus spinosus used traditionally in managing ischuria. Methods: Phytochemical screening, thin layer chromatography and hi...
Article
Full-text available
Objective: In the present study, we demonstrate the myorelaxant actions of an ethanolic root extract of Sphenocentrum jollyanum (SJE) in isolated smooth muscle preparations-corpus cavernosum and rabbit aortic strip. Materials and Methods: Isolated tissue experiments using tissue/organ bath were conducted to evaluate the myorelaxant effect of Spheno...
Article
Full-text available
Background: The present study examined the possible mechanism(s) of analgesic action of the ethanol extract of the fruits of Xylopia aethiopica (XAE) and its kaurene diterpene constituent, xylopic acid (XA). Methods: Naloxone (2 mg kg-1 i.p.), L-NAME (10 kg-1 i.p.), ondansetron (0.5 mg kg-1 i.p.), theophylline (5 mg kg-1 i.p.), glibenclamide (8 mg...
Article
Full-text available
Various parts of Trichilia monadelpha (Thonn) JJ De Wilde (Fam. Meliaceae) are used in Ghanaian traditional medicine for the treatment of painful and inflammatory conditions. The present study examined the analgesic properties of the petroleum ether (PEE), ethyl acetate (EAE), and the hydro-ethanolic (HAE) extract of the stem bark of the plant in m...
Article
Full-text available
Various parts of the perennial herb Hilleria latifolia (Lam.) H. Walt. (Family: Phytolaccaceae) are used in Ghanaian traditional medicine for the treatment of several inflammatory-related disorders. The present study examined the anti-inflammatory effect of an ethanolic extract of the aerial parts of Hilleria latifolia (HLE) in acute and chronic in...
Article
Full-text available
Various parts of the perennial herb Hilleria latifolia (Lam.) H. Walt. (Family: Phytolaccaceae) are used in Ghanaian traditional medicine for the treatment of several inflammatory-related disorders. The present study examined the anti-inflammatory effect of an ethanolic extract of the aerial parts of Hilleria latifolia (HLE) in acute and chronic in...
Article
Full-text available
Trichilia monadelpha (Thonn) JJ De Wilde (Meliaceae) bark extract is used in African traditional medicine for the management of various disease conditions including inflammatory disorders such as arthritis. The present study was undertaken to evaluate the anti-inflammatory properties of aqueous (TWE), alcoholic (TAE) and petroleum ether extract (TP...
Article
Full-text available
Various parts of the perennial herb Hilleria latifolia (Lam.) H. Walt. (Family: Phytolaccaceae) are used in Ghanaian traditional medicine for the treatment of several inflammatory-related disorders. The present study examined the anti-inflammatory effect of an ethanolic extract of the aerial parts of Hilleria latifolia (HLE) in acute and chronic in...
Article
Full-text available
Background Hilleria latifolia is a perennial herb commonly used in Ghanaian traditional medicine. However, little scientific evidence exists in literature on the safety of this plant. Objectives and Methods The present study evaluated the potential toxicity of the ethanolic extract of the aerial parts of Hilleria latifolia (HLE) in acute and sub-ac...
Article
Full-text available
Background: Leaves of Palisota hirsuta K. Schum. (Commelinaceae) have been used to relieve inflammation and rheumatism in Ghanaian and West African traditional medicine. Nevertheless, scientific information regarding this species is scarce.
Article
Full-text available
Leaf extracts of Ficus exasperata P. Beauv. (Moraceae) are commonly used in Ghanaian traditional medicine for the treatment of several pathological states including inflammatory disorders. The present study was undertaken to evaluate the antiarthritic effect of an ethanolic extract of F. exasperata (FEE) in the Freund's adjuvant-induced arthritis m...
Article
Full-text available
Antinociceptive effect of an ethanolic extract of Capparis erythrocarpos Isert roots (10-300 mg kg-1; p.o.) was evaluated in the mouse formalin test. Morphine (1-10 mg kg-1; i.p.) was used as positive control. The extract dose-dependently reduced pain scores in both phases of formalin-induced nociception with the 100 mg kg-1 dose significantly redu...
Article
Full-text available
The hydro alcoholic leaf extract of Ficus exasperata (Vahl) (family Moraceae) (FEE) was evaluated for its antinociceptive, anti-inflammatory and anti-pyretic properties in animal models. The leaf extract (10-300 mg kg-1) showed a dose-dependent anti-inflammatory activity in carrageenan-induced foot oedema in chicks, with an IC50 of 46.05±12.3 mg kg...
Article
Full-text available
The anti-nociceptive effect of an ethanolic leaf extract of Palisota hirsuta , a plant used locally in Ghana for various painful conditions was assessed, using various pain models. Palisota hirsuta extract (PHE) together with morphine and diclofenac (positive controls), all showed significant dose-dependent anti-nociceptive activity in all the mode...
Article
Full-text available
Various parts of Newbouldia laevis (fam. Bignoniaceae) are used for pain and several inflammatory conditions in Ghana. This study presents the effect of a hydro-alcoholic extract of N. leavis stem bark in formalin-induced pain, a model of neuropathic pain, in rats. Morphine (1-10 mg kg -1 i.p) and stem bark extract of N. laevis (10-300 mg kg -1 p.o...
Article
Full-text available
The effect of Palisota hirsuta root ethanolic extract, a herbal preparation used in Ghana for pain and inflammatory disorders, was assessed in acute inflammation in carrageenan-induced foot oedema in chicks and brewer's yeast-induced pyrexia in rats. Two paradigms were used for the inflammation assessment; effect of the extract on established infla...
Conference Paper
Full-text available
Sphenoccntrum jollyanum is used in Ghanaian folk medicine as an aphrodisiac to overcome impotence and infertility. In this study, with a bioassay-guided identification, we nvestigated the vasorelaxant elfcct of the most potent of four fractions (A1, A2, EA, and PE) of the crude hydroalcohol ic extract of S. jollyanurn root. Rabbit aortic strips wer...
Article
Full-text available
Newbouldia laevis (fam. Bignoniaceae) is used in traditional medicine for the treatment of various conditions. The stem bark is used for pain, ulcer, arthritis, rheumatism and other inflammatory conditions. The purpose of this study is to pharmacologically validate the use of N. laevis stem bark extracts in African traditional medicine for the mana...
Article
Full-text available
Root extracts of Carissa edulis (Forsk.) Vahl (Apocynaceae) are used for the treatment several pathological states including inflammatory disorders. The present study was undertaken to evaluate the effect of an alcoholic extract of C. edulis (CEE) on carrageenan-induced foot oedema in chicks. Also since free radicals and reactive oxygen species are...

Network

Cited By