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Geoffrey David Adamson

Geoffrey David Adamson
Stanford University School of Medicine · Obstetrics and Gynecology

BSc MD FRCSC FACOG FACS

About

228
Publications
21,728
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11,533
Citations
Citations since 2016
25 Research Items
7156 Citations
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201620172018201920202021202202004006008001,0001,2001,400
201620172018201920202021202202004006008001,0001,2001,400
201620172018201920202021202202004006008001,0001,2001,400
Introduction
G. David Adamson is Director of Equal3 Fertility, CEO of ARC Fertility, Clinical Professor ACT at Stanford University School of Medicine and Associate Clinical Professor at University of California San Francisco. David does research in assisted reproductive technologies, endometriosis, infertility and access to reproductive care. He currently is focused on research with the International Committee for Monitoring Assisted Reproductive Technologies (ICMART) and the World Endometriosis Research Foundation (WERF) Endometriosis Phenome and Biobanking Harmonisation Project (EPHect).

Publications

Publications (228)
Chapter
The second edition of the essential guide for reproductive professionals is now available in a Clinical Guide and a Case Studies Guide, presenting the most current knowledge on counseling diverse patients amidst rapidly advancing modern technology. Follow an in-depth presentation of clinical concepts in this Clinical Guide for a foundational unders...
Article
STUDY QUESTION What were the utilization, effectiveness and safety of practices in assisted reproductive technologies (ART) globally in 2014 and what global trends could be observed? SUMMARY ANSWER The estimated total number of ART cycles conducted in 76 participating countries in 2014 was 1.93 million representing ∼66% of global activity, with 5-...
Article
Objective To report the utilization, effectiveness, and safety of practices in assisted reproductive technology (ART) globally in 2013 and assess global trends over time. Design Retrospective, cross-sectional survey on the utilization, effectiveness, and safety of ART procedures performed globally during 2013. Setting Seventy-five countries and 2...
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Full-text available
STUDY QUESTION: Can the priorities for future research in infertility be identified? SUMMARY ANSWER: The top 10 research priorities for the four areas of male infertility, female and unexplained infertility, medically assisted reproduction, and ethics, access, and organization of care for people with fertility problems were identified. WHAT IS KNO...
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Full-text available
Study Question Can the priorities for future research in infertility be identified? Summary Answer The top 10 research priorities for the four areas of male infertility, female and unexplained infertility, medically assisted reproduction, and ethics, access, and organization of care for people with fertility problems were identified. What is Known...
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Full-text available
STUDY QUESTION Is electronic digital classification/staging of endometriosis by the EQUSUM application more accurate in calculating the scores/stages and is it easier to use compared to non-digital classification? SUMMARY ANSWER We developed the first digital visual classification system in endometriosis (EQUSUM). This merges the three currently m...
Article
In the early years of in vitro fertilization, overall pregnancy rates were low, and it was considered necessary to transfer more than one embryo to increase the chances of pregnancy. It was not until advances in assisted reproductive technologies resulting in increased pregnancy rates that the concept of transferring just one embryo was considered...
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Study question: What was the utilization, effectiveness and safety of practices in ART globally in 2012 and what global trends could be observed? Summary answer: The total number of ART cycles increased by almost 20% since 2011 and the main trends were an increase in frozen embryo transfers (FET), oocyte donation, preimplantation genetic testing...
Article
This commentary outlines the importance of utilization of assisted reproductive technology as an indicator of access to infertility care and provides a standard way of reporting utilization to facilitate international comparisons. Factors that influence ART utilization as well as underlying inequalities and inequities in access to care are discusse...
Book
For over forty years, assisted reproductive technology (ART) has helped millions of patients around the world to overcome infertility. Careful monitoring of ART treatments and their outcomes is vital to maintain the remarkable pace of change in science and technology, whilst minimizing potential risks to infertility patients, and their children. Wr...
Article
Objective To report the utilization, effectiveness, and safety of practices in assisted reproductive technology (ART) globally in 2011 and assess global trends over time. Design Retrospective, cross-sectional survey on the utilization, effectiveness, and safety of ART procedures performed globally during 2011. Setting Sixty-five countries and 2,5...
Article
Background Clinical management of endometriomas, prior to starting treatment with assisted reproductive technologies (ART), has since long been a matter of debate. Whereas cystectomy has been advocated in the past, recently more evidence has emerged on the potential negative effect of surgery on ovarian reserve. Parallel to this, prolonged downregu...
Article
Challenges intrinsic to the accurate diagnosis of endometriosis contribute to an extended delay between the onset of symptoms and clinical confirmation. Intraoperative visualization, preferably with histologic verification, is considered by many professional organizations to be the gold standard by which endometriosis is diagnosed. Clinical diagnos...
Article
Study question: Can live birth be accurately predicted following surgical resection of moderate-severe (Stage III-IV) endometriosis? Summary answer: Live births can accurately be predicted with the endometriosis fertility index (EFI), with adnexal function being the most important factor to predict non-assisted reproductive technology (non-ART)...
Chapter
Endometriosis is a heterogeneous condition in terms of surgical characterization of the disease and nonsurgical symptomatic and non-symptomatic characteristics of the woman. Many centers across the world conduct research into endometriosis independently from each other, using different standard operating protocols (SOPs) for collection of biologica...
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Full-text available
Study question: Can a consensus and evidence-driven set of terms and definitions be generated to be used globally in order to ensure consistency when reporting on infertility issues and fertility care interventions, as well as to harmonize communication among the medical and scientific communities, policy-makers, and lay public including individua...
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Full-text available
Study question: Can a consensus and evidence-driven set of terms and definitions be generated to be used globally in order to ensure consistency when reporting on infertility issues and fertility care interventions, as well as to harmonize communication among the medical and scientific communities, policy-makers, and lay public including individua...
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Study question: What is the global consensus on the classification of endometriosis that considers the views of women with endometriosis? Summary answer: We have produced an international consensus statement on the classification of endometriosis through systematic appraisal of evidence and a consensus process that included representatives of na...
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The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/progn...
Article
Study question: What were utilization, outcomes and practices in assisted reproductive technology (ART) globally in 2008, 2009 and 2010? Summary answer: Global utilization and effectiveness remained relatively constant despite marked variations among countries, while the rate of single and frozen embryo transfers (FETs) increased with a concomit...
Article
Objective: To develop and test a nonidentifying prospective data collection system for cross-border reproductive care (CBRC) in Canada and the United States (U.S.). Design: Survey and cross-sectional study. Setting: Fertility clinics. Patient(s): Women traveling to and from Canada and the U.S. for reproductive care. Intervention(s): None....
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Objective: To determine if an automated time-lapse test (TL-test) combined with traditional morphology for embryo selection and day 3 transfer results in improved clinical outcomes. Design: Prospective concurrent-controlled pilot study. Setting: IVF clinic and laboratory in the United States. Patient(s): A total of 319 female patients <41 ye...
Article
The high burden of infertility causes patients and physicians to do everything possible to achieve pregnancy. Frequently, this involves transferring more than one embryo, often resulting in multiple pregnancy with increased maternal and neonatal morbidity and mortality and societal costs. As a result, elective single-embryo transfer (eSET) has been...
Chapter
Katie and Paulo are a highly successful, driven couple, who have worked hard in their careers to get established. Katie, 34, and Paulo, 36, met five years ago while in an MBA program, dated for three years as they concentrated on their jobs, and then carefully planned a wedding to be followed a year later by starting a family. They are used to work...
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Objective To harmonize the collection of nonsurgical clinical and epidemiologic data relevant to endometriosis research, allowing large-scale collaboration. Design An international collaboration involving 34 clinical/academic centers and three industry collaborators from 16 countries on five continents. Setting In 2013, two workshops followed by...
Article
Objective To harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, and storage of fluid biospecimens relevant to endometriosis. Design An international collaboration involving 34 clinical/academic centers and 3 industry collaborators from 16 countries on 5 continents. Setting I...
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Objective To harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, and storage of human tissues relevant to endometriosis. Design An international collaboration involving 34 clinical/academic centers and three industry collaborators from 16 countries on five continents. Setting...
Article
Full-text available
Objective: To standardize the recording of surgical phenotypic information on endometriosis and related sample collections obtained at laparoscopy, allowing large-scale collaborative research into the condition. Design: An international collaboration involving 34 clinical/academic centers and three industry collaborators from 16 countries. Setting:...
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STUDY QUESTION Is the ongoing pregnancy rate with a new aqueous formulation of subcutaneous progesterone (Prolutex®) non-inferior to vaginal progesterone (Endometrin®) when used for luteal phase support of in vitro fertilization? SUMMARY ANSWER In the per-protocol (PP) population, the ongoing pregnancy rates per oocyte retrieval at 12 weeks of ges...
Article
To analyze information on assisted reproductive technology (ART) performed worldwide and trends in outcomes over successive years. Cross-sectional survey on access, effectiveness, and safety of ART procedures performed in 53 countries during 2005. A total of 2,973 clinics from national and regional ART registries. Infertile women and men undergoing...
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Full-text available
To evaluate the relationship between frozen-thawed single blastocyst transfer (BT) and maternal and neonatal outcomes of pregnancy. Retrospective analysis. Japanese nationwide registry of assisted reproductive technology (ART) with mandatory reporting for all ART clinics in Japan. Registered from 2008 through 2010 undergoing single embryo transfer...
Article
To systematically quantify the impact of consumer cost on assisted reproduction technology (ART) utilization and numbers of embryos transferred. Ordinary least squared (OLS) regression models were constructed to measure the independent impact of ART affordability-measured as consumer cost relative to average disposable income-on ART utilization and...
Article
Endometriosis is a complex disease commonly encountered by gynecologists. We report the case of an otherwise healthy young nullipara who presented with massive ascites, pleural effusion and shortness of breath and was subsequently diagnosed with endometriosis. This case demonstrates that, with a careful history, physical examination and appropriate...
Article
Many aspects of endometriosis continue to make it an enigmatic medical condition nearly a century after its first description as a specific disease. The Endometriosis Fertility Index (EFI) is the first validated scoring system that is predictive of nonassisted reproductive technologies pregnancy following surgical evaluation when the patient has fu...
Article
Alongside the debate around clinical, scientific, and ethical aspects of assisted reproductive technology (ART), there exists a parallel debate around the economics of ART treatment and what is the most appropriate funding framework for providing safe, equitable, and cost-effective treatment. The cost of ART treatment from a patient perspective exh...
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Introduction: This is the fourteenth report of the European IVF-monitoring (EIM), the ESHRE register on assisted reproductive techniques (ART) organization. This report deals with the results of treatments initiated during 2010. Methods: Data were collected from existing national registries in 30 countries (data sent in at the time of abstract dea...
Article
Objective: To assess the first computer-automated platform for time-lapse image analysis and blastocyst prediction and to determine how the screening information may assist embryologists in day 3 (D3) embryo selection. Design: Prospective, multicenter, cohort study. Setting: Five IVF clinics in the United States. Patient(s): One hundred sixt...
Article
PURPOSE OF REVIEW: Endometriosis is a complex disease, one aspect being the existence of multiple staging systems. The recent Endometriosis Fertility Index (EFI) is compared with other endometriosis infertility staging systems and three new studies assessing the EFI are reported. RECENT FINDINGS: The revised American Fertility Society classificatio...
Article
The initial results of in vitro maturation suggest the potential for clinical application. However, at this time in vitro maturation should be performed only as an experimental procedure evaluating both efficacy and safety in carefully selected patients. (Fertil Steril (R) 2013;99:663-6. (C) 2013 by American Society for Reproductive Medicine.)
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STUDY QUESTION Have changes in assisted reproductive technology (ART) practice and outcomes occurred globally between 2003 and 2004? SUMMARY ANSWER Globally, ART practice has changed with an increasing prevalence of the use of ICSI rather than conventional IVF. In 2004, a small but increasing number of countries are incorporating single embryo tra...
Article
The Supreme Court's decision upholding the constitutionality of the Affordable Care Act (ACA) provides an opportunity to review its impact on fertility care in the United States. After examining the legislation, we identified several core areas that might affect patients struggling with infertility. Although changes to the tax code, elimination of...
Chapter
The rapid expansion of IVF into mainstream medicine has created many medical, scientific, ethical, religious, cultural, and socioeconomic issues. These issues have affected numerous different stakeholders in all countries in which IVF is practiced and caused them to respond with both regulation and guidelines in order to protect or promote their pe...
Article
The purpose of this committee opinion, which replaces the 2006 ASRM Practice Committee document titled Multiple Pregnancy Associated with Infertility Therapy, is to provide physicians with pertinent information that may help to avoid multiple gestations and to aid in patient counseling regarding the associated risks. (Fertil Steril (R) 2012;97:825-...
Article
As in vitro fertilization implantation rates have improved, the practice of transfering multiple embryos must be evaluated. The purpose of this document is to reassess the literature on elective single-embryo transfer, to provide guidance for patient selection, and to discuss barriers to utilization. (Fertil Steril (R) 2012;97:835-42. (C)2012 by Am...
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There is a need to determine the optimal treatment methods for patients with tubal factor infertility. This document reviews the available treatments and discusses factors that must be considered when deciding between surgical repair versus in vitro fertilization. This document replaces the 2008 document of the same name. (Fertil Steril (R) 2012;97...
Article
Endometriosis remains an enigmatic disease for many reasons, not the least being a continued inability to stage its clinical presentation so that prognosis and treatment for both pain and infertility patients can be facilitated. This chapter reviews issues with current staging systems as well as the behavior and presentation of endometriosis. It ad...
Article
Introduction This is the Thirteenth report of the European IVF-monitoring (EIM), the ESHRE register on assisted reproductive techniques (ART) organization. This report deals with the results of treatments initiated during 2009. Methods Data were collected from existing national registries in 30 countries (data sent in at the time of abstract dead...
Article
The modern role of reproductive surgery has changed because of improved capabilities of endoscopic surgery resulting from innovation, instrumentation and experience, the development and increasing applicability of assisted reproductive technologies, and improved knowledge of the optimal application of these and other technologies. Rather than these...
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Full-text available
Introduction This is the twelfth report of the European IVF-monitoring (EIM), the ESHRE register on assisted reproductive techniques (ART) organization. This report deals with the results of treatments initiated during 2008. Methods Data were collected from existing national registries in 36 countries (3 more than in 2007) and directly entered by...
Article
Endometriosis remains an enigmatic disease for many reasons, not the least being a continued inability to stage its clinical presentation so that prognosis and treatment for both pain and infertility patients can be facilitated. This article reviews issues with current staging systems. The revised American Fertility Society (rAFS) classification sy...
Article
To analyze information on assisted reproductive technologies (ART) performed globally. Data on access, efficacy, and safety of ART were collected for the year 2003 from 54 countries. National and regional ART registries globally. Patients undergoing ART globally. Collection and analysis of international ART registry data. Number of cycles performed...
Article
The aim of this report is to describe our experience and results with implementation of a cut standard straw technique for vitrification and warming of day 3 cleavage-stage human embryos. Detailed description of the method and results of 63 frozen embryo transfers performed with this technology are discussed, and it is concluded that this method pr...
Article
Introduction Studies have suggested 30-50% of patients with endometriosis have infertility. While the exact pathophysiological mechanisms causing infertility in women with endometriosis remain unknown, hypotheses include distortion of pelvic anatomy, abnormal peritoneal, hormonal and cellular function, ovulatory and endocrine abnormalities, and imp...
Article
Decisions about method of birth should be evidence based. In Australia, the rising rate of cesarean section has not been limited to births after spontaneous conception. This study aimed to investigate cesarean section among women giving birth after in vitro fertilization (IVF). Retrospective population-based study was conducted using national regis...
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Full-text available
Procedures have evolved for the collection, preparation and use of sperm in assisted reproductive technologies. However, the utilization of these procedures varies widely throughout the world due to economic, social and environmental factors. The numerous issues associated with male gametes receive scant attention in comparison with issues pertaini...
Article
To collect data on the prevalence and reasons for cross-border fertility care (CBFC). Retrospective survey conducted by the International Committee Monitoring Assisted Reproductive Technologies. Forty-nine countries who have previously participated with the International Committee Monitoring Assisted Reproductive Technologies. Number of CBFC patien...
Article
Introduction Endometriosis is estimated to affect 6–10% of reproductive-age women. The prevalence of endometriosis is higher in the infertile population, in which it is estimated to be about 20%. Though endometriosis may not be the sole cause of infertility in such patients, it is now widely believed that endometriosis reduces overall fecundity. Th...
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Full-text available
Endometriosis affects an estimated 176 million women worldwide during the prime years of their lives. Yet many clinical questions remain unanswered, treatment failures are common, and there is little investment in investigating disease mechanisms. The World Endometriosis Research Foundation (WERF) has been created to provide a global platform where...
Article
Building families through adoption of children has been supported by human society throughout history. Building families through reproductive donation of surplus embryos, in contrast, has become an option only since the dawn of assisted reproductive technologies. The ethical appropriateness of patients donating embryos to other patients for family...
Article
Many definitions used in medically assisted reproduction (MAR) vary in different settings, making it difficult to standardize and compare procedures in different countries and regions. With the expansion of infertility interventions worldwide, including lower resource settings, the importance and value of a common nomenclature is critical. The obje...
Article
To develop a clinical tool that predicts pregnancy rates (PRs) in patients with surgically documented endometriosis who attempt non-IVF conception. Prospective data collection on 579 patients and comprehensive statistical analysis to derive a new staging system--the endometriosis fertility index (EFI)--from data rather than a priori assumptions, fo...
Article
• •Single individuals, unmarried heterosexual couples, and gay and lesbian couples have interests in having and rearing children. • •There is no persuasive evidence that children are harmed or disadvantaged solely by being raised by single parents, unmarried parents, or gay and lesbian parents. • •Data do not support restricting access to assisted...
Article
Assisted reproductive technology (ART) is the most successful treatment for the 9% of people at reproductive age who suffer with infertility, but only a small percentage of those needing ART actually access it. Access varies greatly internationally owing to religious, cultural and political factors, probably the most important factor being each soc...
Article
To compare regulatory and economic aspects of assisted reproductive technologies (ART) in developed countries. Comparative policy and economic analysis. Couples undergoing ART treatment in the United States, Canada, United Kingdom, Scandinavia, Japan, and Australia. Description of regulatory and financing arrangements, cycle costs, cost-effectivene...
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Full-text available
The International Committee for Monitoring Assisted Reproductive Technology's (ICMART) Eighth World Report analyzes assisted reproductive technology (ART) practice and results for the year 2002 from 53 countries by type of ART, women's age, number of embryos transferred and multiple births. Over 601 243 initiated cycles resulted in a delivery rate...
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An attitude shift toward ART in developing countries has resulted in attempts exploring low-cost ART suitable to limited resource settings. This is a positive and needed development. Future steps should consider national infertility needs, position of infertility services within comprehensive reproductive health programs, ART surveillance, and equi...
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Introduction Assisted reproductive technology (ART) including in vitro fertilization (IVF) has become increasingly successful in the last 30 years and now is responsible for more than 3,000,000 births worldwide [1, 2]. Despite its global application, ART practice has tremendous regional differences, among them disparate multiple gestation rates [3,...
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Introduction Definition of regulation and self-regulation Regulation is defined as “a rule or order issued by an executive authority or regulatory agency of a government and having the force of law” [1]. Only government or its designated authorities can regulate and impose sanctions. Self-regulation involves guidelines or rules from professional or...
Article
In the reproductive-age female, estimates of the general prevalence of endometriosis range from 6 to 11 percent (1–4). Among infertile women, the prevalence of endometriosis has been estimated to be about 20 percent (5). This is in contrast to asymptomatic women undergoing tubal ligation who have a prevalence of 4 percent. Although endometriosis ma...