Gemini Alam

• Hasanuddin University

Dengue fever remains a major public health threat in Indonesia, exacerbated by rising insecticide resistance in Aedes aegypti. Strategies relying on chemical insecticides, while initially effective, have led to widespread resistance in mosquito populations. This resistance is particularly pronounced in areas such as Java, where the extensive use of...

Background: Gastric ulcers are a significant health issue caused by various factors, including excessive alcohol consumption. Manilkara zapota (M. zapota) has been reported to exhibit anti-inflammatory and antioxidant properties, which may contribute to its gastroprotective effects. Objective: This study aimed to evaluate the differences in the num...

Applying chemometrics in analyzing the chemical data from natural materials is very important for understanding the complex data of herbal raw materials. This study aims to apply chemometric principal component analysis (PCA) and cluster analysis (CA) techniques to know the fingerprint profiling of 20 types of ethanolic extract of Mangosteen obtain...

Laportea decumana (Roxb.) Wedd. is a plant that is traditionally used for its analgesic, antipyretic, antioxidant, anti-inflammatory, and antibacterial purposes. This study aimed to determine the wound-healing effects of fractionated L. decumana ethanol extract ointment on the inflammatory, proliferation, and maturation phases in a rat model of acu...

This study explored the antimicrobial potential of Piper betle L. (PBL) and Piper nigrum L. (PNL) extracts against MRSA. Plant parts including stem, leaf, and fruit were extracted using aquadest, methanol, and hexane, resulting in 18 distinct extracts. FT-IR combined with cluster analysis (CA) categorized the extracts, and anti-MRSA activity was as...

Background: Tuberculosis (TB) is caused by *Mycobacterium tuberculosis*, and Multiple Drug-Resistant Tuberculosis (MDR-TB) arises from resistance to first-line treatments like Rifampicin and Isoniazid. Since current TB medications have been used for over four decades, discovering new drug candidates is critical. This research focuses on herbal comp...

This study explored the antimicrobial potential of Piper betle L. (PBL) and Piper nigrum L. (PNL) extracts against MRSA. Plant parts including stem, leaf, and fruit were extracted using aquadest, methanol, and hexane, resulting in 18 distinct extracts. FT-IR combined with cluster analysis (CA) categorized the extracts, and anti-MRSA activity was as...

Background Microorganisms associated with sea sponges have proven to be good natural product resources that are biologically active and pharmaceutically important. Objective This research aimed to identify actinomycetes related to a sponge from Bar-ranglompo Island Makassar and the antibacterial compounds. Methods Identification of actinomycetes...

The parasitic plant Macrosolen cochinchinensis (Lour.) VAN Tiegh, commonly found parasitizing mango trees, contains flavonoid compounds with potential anticancer properties. This study aims to optimize the extraction of flavonoids from M. cochinchinensis using the Ultrasonic Assisted Extraction (UAE) method. Three extraction parameters were investi...

Polyethylene terephthalate (PET) is utilized in the containment of potable water, nonetheless, it is susceptible to impairment due to temperature and duration of storage. Migration of formaldehyde from PET arises as a consequence of thermal deterioration. This study aims to ascertain the extent of formaldehyde transference in PET-contained drinking...

Remdesivir, a competitive inhibitor of viral RNA-dependent RNA polymerase, is the drug of choice for anti-COVID-19 treatment. However, the instability of these substances in plasma raises doubts about their therapeutic potency. Additionally, SARS-CoV-2-infected cells may exhibit a variety of antiviral behaviors due to intricate activation pathways....

Purpose To prove the effect of Miana (M), Quercetin (Q), and the combination as an anti-inflammatory agent and Cefixime (C) as an antibiotic in Balb/c mice infected with Salmonella enterica serovar Typhi (S. Typhi) and related to the dynamics of NF-κB mRNA expression and NF-κB protein levels. Methods A cohort study on male Balb/c mice with subject...

Background: Miana, also known as Coleus scutellariodes, is a supplement agent frequently used to treat infectious disorders. Its antibacterial and anti-inflammatory mechanisms are not well understood. Nuclear factor-kappa B (NF-kB), which acts as a major regulator in these infectious processes, strongly induces proinflammatory cytokines via I-kB th...

This research aims to investigate the interaction between cynaroside, a natural compound found in Orthosiphon aristatus plant extract, with TNF Alpha as a stimulant in the context of malaria and asthma. The research method involved an in-silico approach using software such as Pymol, PyRx, Protein Plus, and the Lepinski Rule. The results of the stud...

Introduction: Gastric hyperacidity and gastroduodenal ulcers are serious global problems today. A disease found in many people throughout the world and often caused by excessive alcohol consumption. Important factors in the pathogenesis of acute gastric mucosal lesions induced by ethanol. The accumulation of ROS induces oxidative stress and causes...

Paederia foetida L. is a tropical Asian plant containing bioactive compounds and often used as functional foods. The aim of this study was to determine the antioxidant capacity and inhibitory activity of P. foetida leaves extract on tyrosinase activity. In addition, the total phenolic content (TPC) and total flavonoid content (TFC) were determined....

Abstrak Upaya proteksi terhadap infeksi pada kondisi pandemik virus salah satunya adalah dengan cara meningkatkan imunitas tubuh. Upaya tersebut dapat dilakukan dengan memanfaatkan tanaman obat yang diolah dengan baik. Penelitian ini bertujuan untuk mengetahui aktivitas hemaglutinasi dan karakteristik ekstrak dari akar Tapak Dara (Vinca rosea) dan...

This study aimed to compare the effects of simvastatin, rosuvastatin, and fenofibrate therapies on the body weight and lipid profiles of the female rats receiving a combination of oral contraceptives (COC) and a high-fat diet (HFD). Twenty female Wistar rats (130-200 g) were divided equally into four groups. The rats received a standard diet for se...

One of the successful determinants of active compounds extraction from plant material depends mainly on the extraction procedures, including the type of solvents, plant materials, and extraction techniques used in the extraction procedure. This research aimed to optimize Pagoda’s extraction yields (Clerodendrum paniculatum L.) using several types o...

Rante H, Alam G, Usmar, Zahra S, Kurniawati A, Ali A. 2022. Antimicrobial activity of Streptomyces spp. sponge-associated isolated from Samalona Island of South Sulawesi, Indonesia. Biodiversitas 23: 1392-1398. The resistance case of infectious diseases increases annually, while the necessity of antibiotics as a drug choice for therapy most importa...

Sponge is an invertebrate animal in the Porifera phylum, which potentially produces bioactive compounds that are known as potential agents in producing antimicrobial compounds. This research aims to determine the antimicrobial activity of bacteria isolates obtained from the samples of the sponge of Kodingareng Keke Island-Makassar Indonesia. Sample...

Rhizobacteria are a group of bacteria that live saprophytically in the rhizosphere area. Some of them can act as plant growth promoters and as biocontrol agents against diseases to increase crop yields. This study was conducted to find potential of the rhizobacteria consortium in various treatments to increase the area and weight of mulberry (Morus...

Mitragyna is a genus belonging to the Rubiaceae family and is a plant endemic to Asia and Africa. Traditionally, the plants of this genus were used by local people to treat some diseases from generation to generation. Mitragyna speciosa (Korth.) Havil. is a controversial plant from this genus, known under the trading name "kratom", and contains mor...

Mitragyna is a genus belonging to the Rubiaceae family and is a plant endemic to Asia and Africa. Traditionally, the plants of this genus were used by local people to treat some diseases from generation to generation. Mitragyna speciosa (Korth.) Havil. is a controversial plant from this genus, known under the trading name “kratom”, and contains mor...

Introduction: Acne vulgaris is a chronic inflammatory disease that occurs with various factors, both intrinsic and extrinsic. Treatment of choice can vary from topical, systemic or a combination of both depending on the degree of severity. Recently, treatment using products from human blood has been widely studied, including in the field of dermato...

Metabolomic studies in medicinal plants using NMR analytical instruments are useful for plant fingerprinting and exploration of biological effects in drug discovery investigation. Cleome rutidosperma DC is a herbaceous plant that grows wild and is found many in tropical areas and used as a health treatment. This study analyzed metabolite profiles i...

This study aimed to demonstrate optimization extraction and cytotoxicity of variety of Plectranthus scutellariodes, which is known as Miana Hias, as new candidate for anticancer drug. This research is analytic experimental which conduct by optimization of extraction using three solvent and three extraction method, and cytotoxicity assay using brine...

Objective This study was aimed to know the effect of parity, nutritional mother, age of the baby, and smoking status to antioxidant of breast milk. Method This study was an experimental laboratory study aimed at obtaining total antioxidants in breast milk. A sample of 24 people was taken using purposive sampling that met the inclusion criteria, na...

Lime (Citrus aurantifolia) is a traditional plant that is widely used as antibacterial. This study to prove the effect of lime peel extract (LPE) on the growth of bacterial colonization of S. Typhi medited by activity of IL-6. True experimental pre-post test design, mice were divided into; LPE 510 mg/kgbw, LPE 750 mg/kgbw, positive and negative con...

Due to many cases of antibiotic resistance in typhoid fever, efforts have been made to combine antibiotic therapy or active compounds with herbs. Curcumin is an active compound found in herbal plants. Curcumin has an antimicrobial effect; through binding to vitamin D receptors as a ligand, this increases the expression of mRNA CAMP gene and eradica...

Sponges as a residence for microorganisms make it a High Microbial Abundance Sponge (HMAS) where 40-60% of the biomass of the sponge consists of microorganisms. One of the bacteria that originates from the sea and has long been known to be breed is Actinomycetes. Actinomycetes that are symbiotic with sponges are very numerous and rich in the discov...

Objective This study aimed to determine the effectiveness of ginger candy to reduce the frequency of vomiting in trimester pregnant women. Methods It was a quasi-experimental study with non-randomized pre-test post-test with control group. The subject was divided into three groups of interventions, i.e. ginger candy, placebo, administering vitamin...

Introduction: Paederia foetida and Vitis vinifera were reported to have antioxidant activities due to their polyphenolic phytochemical contents. Arbutin may be included as active compounds in the plants. The chemometric analysis is used to identify the similarity of functional groups found in arbutin and that are in Paederia foetida and Vitis vinif...

TB is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Empirically the plants that have long been used in medicine are Curcuma mangga rhizome, which shows pharmacological activity as an anti Mycobacterium tuberculosis drug. The objective of the research is to determine the ability of hexane and methanol extracts of Curcuma...

Periodontitis therapy originating from local natural resources is still lacking so it needs to be researched and developed, one of the natural resources from Soppeng Regency in South Sulawesi, Indonesia is the purple miana leaf. It has not been reported before about the effect of purple miana leaf extract on periodontitis related to IL-10 mRNA expr...

The emergence of antibiotic-resistant Pseudomonas aeruginosa is one of main health issues in global communities. To overcome such threat, the discovery of novel antibacterial agents is indispensable. This study aimed to evaluate the in vivo antipseudomonal activity of Ulva reticulata extract in Drosophila model of infection. Ethanolic extract of Ul...

Aims: The aim of this research was to know the species of plant that is used as anti-hematemesis medicine that has the activity of antituberculosis and antituberculosis-MDR and then investigate the phytochemistry characteristics of the compound from every parts of the plant extract that show the activity of antituberculosis and antituberculosis-MD...

The emergence of drug resistant and multidrug-resistant microbes as well as the lack of any current chemotherapy augmented the necessity to search for new and better anti-infective drug.. This study was aim to screen potential antiinfective extracts of sponges collected from Bunaken, Manado and to report on their antibacterial and antifungal proper...

Wound healing is a complex physiological process consisting of four phases: coagulation, inflammation, proliferation and migration, and remodeling, each with distinct characteristics. Studies have suggested that mangosteen pericarp extract (MPE) may accelerate wound healing. However, the mechanism is not fully understood. This study aims to evaluat...

Tanaman sereh Cymbopogon citrus (DC.) Stapf merupakan salah satu tanaman sereh penghasil minyak atsiri yang digunakan sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui pengaruh ketinggian tempat tumbuh dan aktivitas antibakteri. Masing-masing sampel dari ketinggian 935 m dol, 260 m dpl, dan 10 m dpl didestilasi dengan metode destilasi...

Sterculiapopulifoliaextract contains flavonoid and polyphenol compounds which are the most potential components in reducing ROS (Radical Oxidative Superoxide) to prevent skin damaged caused by UV-B radiation. This study aims to assess the effectiveness of cream extract klikaSterculiapopulifolia to the thickness and density of collagen in albino mic...

Background Endophytic fungi live in plants’ tissue and can produce the same bioactive compounds as its host plant produces. Syzygiumpolyanthum leaves have known to be one of the antibacterial compound producers. Aim and Objective This study aimed to characterize morphologically, microscopically, and molecularly the antibacterial-producing endophyt...

Introduction: Miana is one of the most widely used medicinal plants in Indonesia because its antibacterial activity, but its mechanisms not clear. This study aims to determine mRNA TLR-4 expression in Balb/c Mice induced by Salmonella typhi after miana leaf extract (MLE) treatment. Material and Method: Mice were divided into four groups, antibiotic...

Sterculia populifolia is commonly used as the ingredient of traditional herb in Timor Island, East Nusa Tenggara, Indonesia. It contains flavonoid which roles as antioxidant. This flavonoid can be sunblock due to the existence of chromophore which commonly gives color to plants. This study aimed to determine the activity of antioxidants and sunbloc...

Introduction Dry skin is a problem for millions of people and often causes discomfort and even psychological stress. Curcuma Longa (C. Longa) has been known to have an effect in improving skin texture due to exogenous effects associated with dry skin Objective This study aims to determine the effect of C.Longa 0.5% extract on sebum composition and...

Typhoid fever, an enteric disease caused by Salmonella typhi, plays an important role of global health matter, contributing to the economic encumbrance in most developed countries. Even more, antibiotic resistance has ensued in Salmonella entericainfection. These health problems have proposed a broad struggle towards more study for new source of an...

Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are known to possess anticancer property. Despite its...

West Papua Province of Indonesia has the highest malaria incidence (5.1%) and prevalence (12.5%) and the population is used to Self-medication (2.8%). Incidence of tropical malaria in the district of Manokwari in 2015 based on laboratory results tests registry were 1,672 cases, most cases is from Prafi Health Center (960 cases). The study aims to d...

Introduction: The wood bark of Mezzetia parviflora Becc, has long served as one of the most important traditional herbal medicine sources in Buton Regency, Southeast Sulawesi. M. parviflora extracts were rich in polyphenols. This study was aimed to explore the lipid peroxidation inhibitory activity of polar extract of M. parviflora. Methods: The po...

Turmeric and garlic phytobiotic contain bioactive substances, each of which has a function as an antifungal. The study aims to determined to test the ability turmeric and garlic phytobiotic pressed fungal colonies in the feed with different storage time. The data were analyzed by a factorial experimental design with 5 treatments 4 replications and...

Tuberculosis (TB) remains a major global health problem, responsible for ill health among millions of people each year.One of the main problem of TB treatment is the resistance of Mycobacterium tuberculosis. Continuous efforts to develop new drugs to combat M. Tuberculosisare under way and bioactive compounds of natural origin, particularly from pl...

BACKGROUND: Uric acid is a final result of purine catabolism, the enzymatic reactions in the body cells from amino acids or ribonucleotide dinucleotide. Peperomia pellucida L. (P. pellucida), Acalypha indica L. (A. indica) and Momordica charantia L. (M. charantia) are plants which have efficacy to reduce levels of uric acid excess. The aim of this...

Exposure to ultraviolet B (UVB) has an impact in the form of changes in the dermis collagen fibers and can result in decreasing the thickness and density of collagen. This study aims to assess the effectiveness of mangosteen pericarp extract to the thickness and density of collagen in mice skin after being exposed to UVB. This research was conducte...

Ongkea cortex, the wood bark of Mezzettia Parviflora Becc, is a traditional medicine originated from Southeastern Sulawesi (Indonesia). It has been empirically known to have antitumor property. In this study, we examined the antiproliferative activity and obtained the antimitotic compound of ongkea cortex. Antimitotic activity was ultimately determ...

Cancer is one of the leading causes of death worldwide. Many researchers have attempted to develop new treatments that will improve the prognosis of cancer patients. Indonesian forests, one of the most important world's biodiversity, but little is known about chemical and/or pharmacological potential of these plants. The aim of this study to invest...

Context: The woodbark of Mezzefia parviflora Becc. (Annonaceae) used as traditional herbal remedies in Buton Regency, Southeast Sulawesi, Indonesia, which is traditionally used for tumor, asthma, cholesterol, and diabetes mellitus. The diseases have been linked to cellular damages due to free radical activity. Aims: The present study was aimed to e...

Plantago major L. is a plant of the Plantaginaceae family which has been investigated on diethyl ether extract generate active spot as an antibacterial. The aim of the investigation was to identify the antibacterial compound from diethyl ether extract of daun sendok. as much 500 gram material was extracted maceration method was obtained 50 gram met...

Quantitative Structure-Activity Relationship (QSAR) study have been conducted to antimalarial active compounds of cassane-type diterpenes isolated from seed kernels of Bagore (Caesalpinia crista Linn.), using the atomic net charges data resulted from AM1 method of semi-empirical calculations. The aim of this research is to determine the mathematic...

Daun sendok (Plantago major L.) is one of the Plantaginaceae family plant which have been investigated on diethyl ether extract generate active spot as an antibacterial. The aim of the investigation was identify antibacterial compound from diethyl ether extract of daun sendok. as much 500 gram material was extracted maceration method was obtained 5...

Two alkaloid compounds have been isolated from sponge Petrosia sp collected from Bunaken Bay Menado. These compounds have been found to inhibit several human cancer cell proliferation in vitro. Structure elucidation is needed to further characterize these bioactive compounds. The structure is determined by analyzing Ultra Violet (UV), Infra Red (IR...

In an attempt to increase the productivity of the pharmaceutical compound canthin-6-one from cell suspension culture of Brucea javanica, a high cell density culture and improved culture conditions have been investigated. Various culture conditions and culture stage of growth, especially addition of tryptophan as a stimulant on the production of can...

Majority of the currently available anticancer drugs are designed to have selective toxicity to rapidly dividing cells. Among these agents the focus of many studies are compounds obtained from natural products with high therapeutic index. In this study the cytotoxicity of a marine alkaloid compound isolated from sponges collection number MD-02 on c...

The n-hexane extract that has shown activity in the tracheospasmolytic bioassay was fractionated by solvent extraction and from the major active fraction two compounds were isolated and identified as viteosin-A and vitexicarpin. These compounds blocked spontaneous contraction of isolated male guinea pig trachea induced by histamine; however only vi...

Natural Products are the major source of lead compounds for drugs against cancer. Marine invertebrates are known as rich sources of compounds having unique chemical structures and potential bioactivities. This study was aimed to screen potential anticancer axtracts of sponges collected from Barrang Lompo Island and the result was reported on their...

Recent work from this laboratory demonstrated that apoptosis of pulmonary alveolar epithelial cells (AEC) in response to Fas requires angiotensin II (ANGII) generation de novo and binding to its receptor (Wang et al., 1999b, Am J Physiol Lung Cell Mol Physiol 277:L1245-L1250). These findings led us to hypothesize that a similar mechanism might be i...

Thesis (Ph. D.)--University of Manchester Institute of Science and Technology, 1978.