Geison Costa

Geison Costa
Pontificia Universidad Javeriana · Department of Chemistry

PhD

About

32
Publications
10,858
Reads
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610
Citations
Additional affiliations
May 2014 - April 2015
National University of Colombia
Position
  • Researcher
August 2008 - December 2009
Federal University of Santa Catarina
Position
  • Substitute teacher
Description
  • Substitute teacher of Pharmaceutical Chemistry and Pharmacognosy.

Publications

Publications (32)
Article
Full-text available
Due to the increased incidence of fungal infections and the emergence of antifungal resistance mainly by Candida species, the need for safe and effective novel therapies is imperative. Consequently, plants and herbs are a powerful source to combat infections. Here, we evaluated the anti-Candida potential of an ethanolic extract from Piper nigrum. T...
Poster
Full-text available
Nowadays, natural products have played an important role in drug discovery and development, especially as anticancer agents1,2. In this way, the search for new therapeutic agents that can be used as potential drugs or as base compounds for the development of anticancer agents is still relevantand can be carried out by using modern phytochemical and...
Article
Objectives: The objective of this work was to evaluate the anti-inflammatory activity of the aqueous extract, fractions and major compounds, which are isolated and identified from Passiflora edulis f. edulis (purple passion fruit) leaves extract. Methods: For the isolation of the major compounds, reversed-phase chromatography and normal phase co...
Article
Full-text available
The need for new therapeutic approaches to improve the response in acute leukemia (AL), either by directing therapy or with new therapeutic alternatives, has been a research and clinical interest topic. We evaluated whether blasts from AL patients were sensitive ex vivo to the induction chemotherapy and whether the extracts of Petiveria alliacea (A...
Article
Full-text available
Among the different metabolites found in the Passiflora species, flavonoids have been related to some of the therapeutic effects of these plants. In the case of Passiflora ligularis, the presence of these metabolites has been related to a promising hypoglycemic effect. This study aimed to optimize the total flavonoid content of P. ligularis leaf ex...
Article
Quercetin 3-O-beta-d-glucopyranoside (isoquercetin) is one of the most frequent metabolites of the Passiflora ligularis Juss. The purpose of this study was to investigate the effect of the aqueous extract and ethanol fraction from P. ligularis Juss leaves on glycaemia and the mechanism of action of isoquercetin on glucose uptake. In the glucose tol...
Article
Astragalin is a flavonol glycoside with several biological activities, including antidiabetic properties. The objective of this study was to investigate the effects of astragalin on glycaemia and insulin secretion, in vivo, and on calcium influx and insulin secretion in isolated rat pancreatic islets, ex vivo. Astragalin (1 and 10 mg / kg) was admi...
Article
Plants of the Passiflora genus are extensively cultivated in South America, as their edible fruits are widely commercialized. They are also recognized worldwide for their ethnopharmacological uses. Different Pharmacopoeias indicate vitexin as the chemical marker for P. incarnata, the most widely studied Passiflora species worldwide. In the present...
Article
Passiflora species have been widely used in folk medicine as tranquilizers, and previous pharmacological studies have reported sedative activity for P. quadrangularis L., Passifloraceae, leaf extracts. The aim of this work was to contribute to the standardization of P. quadrangularis leaf extract with sedative activity. For this purpose, the extrac...
Article
Full-text available
Physalis peruviana L. (Cape gooseberry) is a plant widely cultivated in the Andean mountain in South America and its calyces are the main by-product of the harvest and commercialization of the fruits. Hypoglycemic activity was evaluated to the hydroethanolic extract and its fractions by glucose tolerance test. Since butanolic fraction exhibited hyp...
Article
The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated and consumed in South America, and to identify its main constituents and elucidate the involvement of the GABAergic pathway in its mechanism of action. The bioguided fractionation of the crude...
Article
The genus Passiflora is popularly used to treat anxiety. Recent studies showed antidepressant-like effects of two varieties of P. edulis (edulis and flavicarpa) in mice. However, the mechanisms of antidepressant actions are still unknown. Here, the effects of P. edulis fo. edulis aqueous extract (AE, 100-300mg/kg, po), and ethyl acetate (AcOEt, 25-...
Article
Full-text available
Physalis peruviana is an exotic fruit highly valued for its bioactive compounds. This work evaluates the effect of some variables of the extraction process of P. peruviana calyces extract (considered waste material) on total phenolic content, rutin content, and in vitro antioxidant activity of the extracts obtained. First, the influence of certain...
Article
Background: Botanical drugs contain plant extracts, which are complex mixtures of compounds. As with conventional drugs, it is necessary to validate their efficacy and safety through preclinical and clinical studies. However, pharmacokinetic studies for active constituents or characteristic markers in botanical drugs are rare. Objective: The obj...
Article
Full-text available
6-Methylcoumarin (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity. In order to continue the pre-clinical characterization of this molecule, in vitro intestinal permeability, plasma profile and tissue distribution after oral administration in rats were studied. The permeability of 6MC was evaluated by...
Article
Full-text available
Ilex guayusa Loes (Aquifoliaceae) is native to the Andean Amazon (Colombia, Ecuador, and Perù) commonly known as guayusa. From ancestral times up to today Guayusa has been employed by indigenous and urban communities as a herbal infusion, for the treatment of diabetes, infertility, or venereal diseases. As an antiinflammatory, diuretic or energizin...
Article
Full-text available
Several species of the genus Passiflora are distributed all over South America, and many of these species are used in popular medicine, mainly as sedatives and tranquilizers. This study analyzes the chemical profile of extracts of four Passiflora species used in folk medicine, focusing on the flavonoids, alkaloids and saponins. We employed simple a...
Article
Full-text available
Passiflora edulis Sims, Passifloraceae, has been used in Brazilian traditional folk medicine to the treatment of anxiety and insomnia. P. edulis is commonly known for its economic interests in Brazil. This species exhibits significant variability in the fruit rind color, then two subpopulations has been described (P. edulis fo. flavicarpa O. Deg. (...
Article
Full-text available
In this study, 39 extracts from marine organisms were evaluated as quorum sensing inhibitors, collected in the Colombian Caribbean Sea and the Brazilian Coast including 26 sponges, seven soft corals, five algae and one zooanthid. The results showed that crude extracts from the soft coral Eunicea laciniata, and the sponges Svenzea tubulosa, Ircinia...
Article
Full-text available
In the current study we showed that oral administration of an aqueous extract of Passiflora quadrangularis L., Passifloraceae, pericarp results in a significant prolongation of the sleep duration in mice evaluated in the ethyl ether-induced hypnosis test which indicates sedative effects. Apigenin, the main flavonoid of the extract, induced a simila...
Article
In this study, we applied a gradient High-Speed Counter-Current Chromatography (HSCCC) method that allowed, by direct injection of an aqueous crude extract of the leaves of Passiflora bogotensis, the successful isolation of six flavonoids in a single run, with purity of each compound higher than 81%. This separation enabled the isolation of two new...
Article
Full-text available
Resumen Cecropia glaziovii Sneth (Urticaceae) is a common tree from Southeast and South of Brazil, being widely used in traditional medicine to treat heart and respiratory conditions. C-glycosylflavonoids have being described as the major compounds for this genus, however, no seasonality studies of individual flavonoids was conducted for any Cecro...
Article
Full-text available
The present study investigated inhibition of pancreatic lipase and metabolic effects of high caloric diet in rats. The Passiflora nitida hydroethanol leaf extract (PNE) was used in in vitro assays or administered to rats to study dyslipidemia. Inhibition of lipase in vitro was studied by a spectrophotometric assay using orlistat as the positive con...
Article
Passiflora alata Curtis is a Passiflora species occurring predominantly in South America popularly known as sweet passion fruit. Some species of this genus are used in folk medicine due to their tranquilizing properties. Previous studies showed the importance of flavonoid compounds to the CNS activities of several species from this genus. Hence, th...
Article
The species of Passiflora are widely used in folk medicine as mild sedatives and tranquilizers. P. alata and P. quadrangularis are distributed throughout South America, with widespread occurrence in Brazil and Colombia. Due to the difficulty in making a botanical distinction between these species, especially in the absence of flowers and fruits, th...
Article
Cecropia glaziovii Snethl. (Cecropiaceae), commonly known as "embaúba-vermelha", is widely distributed throughout Latin America and has been reported in Brazilian folk medicine to treat cough, asthma, high blood pressure and inflammation. Objective: Investigate the hepatoprotective properties of crude hydroethanolic extract of C. glaziovii as well...
Article
Full-text available
An efficient and reproducible HPLC-DAD method was developed and validated for the simultaneous quantification of major compounds (chlorogenic acid, isoorientin, orientin and isovitexin) present in the leaves of two Cecropia species, C. glaziovii and C. pachystachya. From the leaves of C. glaziovii and C. pachystachya were isolated the C-glycosylfla...
Article
Full-text available
The Cecropia genus consists of about 60 species distributed throughout Latin America, mostly in Brazil. These species are widely used in traditional medicine to treat cough, asthma, bronchitis, high blood pressure, inflammation, heart disease, and as a diuretic. In recent years, there has been an increase in research on Cecropia species, with sever...
Article
To investigate the in vitro antiherpes effects of the crude aqueous extract obtained from Cecropia glaziovii leaves and their related fractions, the n-butanol fraction (n-BuOH) and the C-glycosylflavonoid-enriched fraction (MeOH(AMB)), and to determine the viral multiplication step(s) upon which this C-glycosylflavonoid-enriched fraction acts. The...
Article
Full-text available
The phenolic content, antioxidant potential, and antimicrobial activity of extracts of different parts of the fruit from Capsicum baccatum L. var. pendulum were investigated. The analysis of phenolic content was performed by the Folin-Ciocalteu method and reversed-phase high-performance liquid chromatography. The in vitro antioxidant activity was a...

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