Geetha Venkatesh

Geetha Venkatesh
German Cancer Research Center | DKFZ · Division of Epigenetics

PhD

About

16
Publications
4,021
Reads
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178
Citations
Citations since 2016
16 Research Items
178 Citations
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
Additional affiliations
November 2018 - present
German Cancer Research Center
Position
  • PostDoc Position
November 2014 - October 2017
Christian-Albrechts-Universität zu Kiel
Position
  • PostDoc Position
May 2010 - October 2014
Christian-Albrechts-Universität zu Kiel
Position
  • PhD Student
Description
  • Next generation sequencing data analysis (Transcriptomics)
Education
May 2010 - August 2014
Christian-Albrechts-Universität zu Kiel
Field of study
  • Bioinformatics
October 2007 - April 2010
University of Bonn
Field of study
  • Life Science Informatics
September 2002 - June 2006
Visvesvaraya Technological University
Field of study
  • Biotechnology

Publications

Publications (16)
Article
Full-text available
DNA methylation is an important epigenetic modification that has been repeatedly implied in organismal adaptation. However, many previous studies that have linked DNA methylation patterns to environmental parameters have been limited by confounding factors, such as cell-type heterogeneity and genetic variation. In this study, we analyzed DNA methyl...
Article
Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease without clear etiology or effective treatment. Genetic factors contribute to PSC pathogenesis, but so far, no causative mutation has been found. We performed whole-exome sequencing in a family with autosomal dominant inheritance of PSC and identified a heterozygous germlin...
Article
Full-text available
Human longevity is a complex trait influenced by both genetic and environmental factors, whose interaction is mediated by epigenetic mechanisms like DNA methylation. Here, we generated genome-wide whole-blood methylome data from 267 individuals, of which 71 were long-lived (90-104 years), by applying reduced representation bisulfite sequencing. We...
Article
Under conditions reflecting the Western lifestyle, APOE ε4 vs. APOE ε3 may be associated with a lower expression of markers important in innate immune activation. The results encourage further investigations into the role of the APOE genotype in metabolic diseases associated with chronic inflammation.
Article
Full-text available
With this study, we provide a comprehensive reference dataset of detailed miRNA expression profiles from seven types of human peripheral blood cells (NK cells, B lymphocytes, cytotoxic T lymphocytes, T helper cells, monocytes, neutrophils and erythrocytes), serum, exosomes and whole blood. The peripheral blood cells from buffy coats were typed and...
Data
Fig. S3 Cross sectional mRNA regulation of three selected genes. Fig. S4 mRNA expression of genes correlating with age. Table S1 The top 25 up‐ and downregulated genes in LLI. Table S2 All the significantly represented biological processes with respect to the genes upregulated and downregulated in LLI (in the German samples). Table S3 The top 5...
Data
Fig. S1 Comparison of findings to previous transcriptomic studies.
Data
Appendix S2 This file contains FPKM (fragments per kilobase of exon per million fragments mapped) values for all Danish samples.
Data
Fig. S2 Unique and overlapping features compared to previous studies.
Data
Appendix S1 This file contains FPKM (fragments per kilobase of exon per million fragments mapped) values for all German samples.
Article
Full-text available
Human longevity is a complex phenotype influenced by genetic and environmental components. Unraveling the contribution of genetic vs. nongenetic factors to longevity is a challenging task. Here, we conducted a large-scale RNA-sequencing-based expression quantitative trait loci study (eQTL) with subsequent heritability analysis. The investigation wa...

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