Geetha Venkatesh

German Cancer Research Center | DKFZ · Division of Epigenetics

DNA methylation is an important epigenetic modification that has been repeatedly implied in organismal adaptation. However, many previous studies that have linked DNA methylation patterns to environmental parameters have been limited by confounding factors, such as cell-type heterogeneity and genetic variation. In this study, we analyzed DNA methyl...

Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease without clear etiology or effective treatment. Genetic factors contribute to PSC pathogenesis, but so far, no causative mutation has been found. We performed whole-exome sequencing in a family with autosomal dominant inheritance of PSC and identified a heterozygous germlin...

Human longevity is a complex trait influenced by both genetic and environmental factors, whose interaction is mediated by epigenetic mechanisms like DNA methylation. Here, we generated genome-wide whole-blood methylome data from 267 individuals, of which 71 were long-lived (90-104 years), by applying reduced representation bisulfite sequencing. We...

Under conditions reflecting the Western lifestyle, APOE ε4 vs. APOE ε3 may be associated with a lower expression of markers important in innate immune activation. The results encourage further investigations into the role of the APOE genotype in metabolic diseases associated with chronic inflammation.

With this study, we provide a comprehensive reference dataset of detailed miRNA expression profiles from seven types of human peripheral blood cells (NK cells, B lymphocytes, cytotoxic T lymphocytes, T helper cells, monocytes, neutrophils and erythrocytes), serum, exosomes and whole blood. The peripheral blood cells from buffy coats were typed and...

Fig. S3 Cross sectional mRNA regulation of three selected genes. Fig. S4 mRNA expression of genes correlating with age. Table S1 The top 25 up‐ and downregulated genes in LLI. Table S2 All the significantly represented biological processes with respect to the genes upregulated and downregulated in LLI (in the German samples). Table S3 The top 5...

Fig. S1 Comparison of findings to previous transcriptomic studies.

Appendix S2 This file contains FPKM (fragments per kilobase of exon per million fragments mapped) values for all Danish samples.

Fig. S2 Unique and overlapping features compared to previous studies.

Appendix S1 This file contains FPKM (fragments per kilobase of exon per million fragments mapped) values for all German samples.

Human longevity is a complex phenotype influenced by genetic and environmental components. Unraveling the contribution of genetic vs. nongenetic factors to longevity is a challenging task. Here, we conducted a large-scale RNA-sequencing-based expression quantitative trait loci study (eQTL) with subsequent heritability analysis. The investigation wa...