Gebremedhin B. Gebretekle

Gebremedhin B. Gebretekle
University of Toronto | U of T

PhD, MSc, BPharm

About

69
Publications
34,186
Reads
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508
Citations
Introduction
Dr. Gebretekle is a postdoc fellow in health economics and outcomes research at the University of Toronto, Canada. He completed his PhD in Public Health and received a master’s and bachelor’s degree in Pharmacy. His areas of expertise encompass several methodological domains including economic evaluations, decision modeling, quality of life, costing, and epidemiological studies with a focus on infectious diseases.
Additional affiliations
November 2016 - January 2020
Addis Ababa University
Position
  • Assistant Professor
July 2011 - October 2016
Addis Ababa University
Position
  • Lecturer
September 2007 - June 2011
Addis Ababa University
Position
  • Assiatnt Lecturer
Education
January 2015 - January 2020
Addis Ababa University
Field of study
  • Public Health

Publications

Publications (69)
Article
There has been an increased interest in health technology assessment and economic evaluations for health policy in Ethiopia over the last few years. In this systematic review, we examined the scope and quality of healthcare economic evaluation studies in Ethiopia. We searched seven electronic databases (PubMed/MEDLINE, EMBASE, PsycINFO, CINHAL, Eco...
Article
Full-text available
Background Type 2 diabetes mellitus (T2DM) and its treatment impact patients’ physical health as well as emotional and social wellbeing. This study aimed to assess health-related quality of life (HRQoL) and associated factors among patients with T2DM at a tertiary care hospital in Ethiopia. Methods A face-to-face cross-sectional survey was conduct...
Article
Full-text available
Objective Effective antimicrobial containment strategies such as Antimicrobial Stewardship Programs (ASPs) require comprehensive data on antibiotics use which are scarce in Ethiopia. This study sought to assess antibiotics use and healthcare-associated infections (HCAIs) in Ethiopian public hospitals. Design We conducted a cross-sectional study us...
Article
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Background The EQ-5D is a validated and widely used generic measure of health-related quality of life (HRQoL) in both healthy individuals and those with various medical conditions. The objective of this study was to test whether EQ-5D-5L is reliable and valid for use among school sample adolescents and those with major mental health disorders in Et...
Article
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Introduction: Evidence on authorship trends of health research conducted about or in Africa shows that there is a lack of local researchers in the first and last authorship positions, with high income country collaborations taking up these positions. The differences in authorship calls into question power imbalances in global health research and wh...
Preprint
Full-text available
Background: Caspofungin was shown to be more effective than fluconazole in treating patients with invasive candidiasis and/or candidaemia (IC/C). However, cost-effectiveness of caspofungin for treating IC/C in Ethiopia remains unknown. We aimed to assess the cost-effectiveness of caspofungin compared to fluconazole as primary treatment of IC/C in E...
Article
Full-text available
Objective Antimicrobial stewardship (AMS) significantly reduces inappropriate antibiotic use and improves patient outcomes. In low-resource settings, AMS implementation may require concurrent strengthening of clinical microbiology capacity therefore additional investments. We assessed the cost-effectiveness of implementing AMS at Tikur Anbessa Spec...
Article
Full-text available
IntroductionCOVID-19 poses significant health and economic threat prompting international firms to rapidly develop vaccines and secure quick regulatory approval. Although COVID-19 vaccination priority is given for high-risk individuals including healthcare workers (HCWs), the success of the immunization efforts hinges on peoples' willingness to emb...
Article
Background and Objective Understanding the preferred choice of healthcare service attributes for women is important, particularly in sub-Saharan Africa where resources are constrained and improving reproductive and maternal healthcare services is of high importance. The aim of this systematic review was to identify attributes of reproductive and ma...
Preprint
In March 2020, the Your COVID-19 Risk tool was developed in response to the global spread of SARS-CoV-2. The tool is an online resource based on key behavioural evidence-based risk factors related to contracting and spreading SARS-CoV-2. This article describes the development of the tool, the produced resources, the associated open repository, and...
Article
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Background In several countries, the dolutegravir (DTG)-based regimen is generally preferred as first-line antiretroviral therapy (ART) over the efavirenz (EFV)-based regimen, but the evidence in low-income countries is limited.Objective Our study aimed to evaluate the cost effectiveness of DTG- versus EFV-based first-line human immunodeficiency vi...
Article
Introduction Poor adherence to medication and healthy lifestyle managements, such as diet and regular exercise, remains to be a challenge for patients with type 2 diabetes mellitus. The objective of this study was to assess the pattern of adherence to common recommendations, reasons, and factors associated with poor overall adherence among outpatie...
Article
Full-text available
Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) is a major public health, social, and economic problem in Ethiopia. Even though the government is working to scale up Anti-Retroviral Therapy (ART) services, patient loss to follow-up and ensuring adherence to ART regimens remain major challenges of the ART program in the c...
Article
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Background: Patients' health-related quality of life (HRQoL) and health state utility values are critical inputs in the clinical and economic evaluation of treatments for human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). However, information on health state utility values is lacking in the context of Ethiopia. Here, we...
Article
Full-text available
Background Novel Coronavirus is a global pandemic affecting all walks of life and it significantly changed the health system practices. Pharmacists are at the front line and have long been involved in combating this public health emergency. Therefore, the study was aimed to explore pharmacy preparedness and response to prevent and control coronavir...
Article
Full-text available
Background: Cervical cancer is the second most common cancer in Ethiopia next to breast cancer. Despite the high burden of the disease and availability of free screening services in Ethiopia, uptake is still trivial. This study aims to identify factors associated with cervical cancer screening uptake, VIA (visual inspection with acetic acid) posit...
Article
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Background Hospital-associated infection (HAI) and antimicrobial resistance (AMR) are major health threats in low- and middle-income countries (LMICs). Because diagnostic capacity is lacking throughout most of Africa, patients are commonly managed with prolonged empirical antibiotic therapy. Our goal was to assess mortality in relation to HAI and e...
Article
Full-text available
Objectives: In this systematic review, we synthesize the current evidence on health-related quality of life (HRQoL) for the two of the most relevant outcomes of Zika virus infection in humans, microcephaly and Guillain-Barré Syndrome (GBS). Methods: We searched the following databases: MEDLINE, Embase, CINAHL, LILACS, WHO's ICTRP clinical trials...
Article
Full-text available
Background: With the rapid increase in magnitude and mortality of cancer, which is costly disease to manage, several patients particularly in developing countries are facing a huge financial burden. The study aimed to examine the incidence of catastrophic health expenditure (CHE), identify associated factors and coping strategies among patients at...
Article
Full-text available
Introduction. The majority of the population in developing countries including Ethiopia still relies on traditional medicines (TMs). Patients with chronic illness like diabetes mellitus (DM) are dissatisfied with conventional medicines and thus are more likely to simultaneously use herbal medicines (HMs). However, such practice could result in pote...
Article
Full-text available
Background. Multidrug-resistant tuberculosis (MDR-TB) is becoming a major challenge of tuberculosis (TB) control program globally but more serious in developing countries like Ethiopia. In 2013, a survey result showed that in Ethiopia, tuberculosis patients from new cases and retreatment cases had resistance to at least isoniazid and rifampicin wit...
Preprint
Full-text available
Background Novel Coronavirus is a global pandemic affecting all walks of life and it significantly changed the health system practices. Pharmacists are at the front line and have long been involved in combating this public health emergency. Therefore, the study was aimed to explore pharmacy preparedness and response to prevent and control coronavir...
Preprint
Full-text available
Background: With the rapid increase in magnitude and mortality of cancer, which is costly disease to manage, several patients particularly in developing countries are facing a huge financial burden. The aim of the study was to examine the incidence of catastrophic health expenditure (CHE), identify associated factors and coping strategies among pat...
Article
Full-text available
Intense antibiotic consumption in Low- and Middle-Income Countries (LMICs) is fueled by critical gaps in laboratory infrastructure and entrenched syndromic management of infectious syndromes. Few data inform the achievability and impact of antimicrobial stewardship interventions, particularly in Sub-Saharan Africa. Our goal was to demonstrate the f...
Article
Full-text available
Background: Cancer of the cervix is the most frequent cancer among women in Ethiopia. The disease burden and its treatment adversely affects patients’ health-related quality of life (HRQoL). We aimed to investigate the HRQoL and its predictors among cervical cancer patients in Ethiopia. Methods: A hospital-based cross-sectional study was conducted...
Preprint
Full-text available
Background: With the rapid increase in magnitude and mortality of cancer, which is costly disease to manage, several patients particularly in developing countries are facing a huge financial burden. Objective: The purpose of the study was to examine the level of catastrophic health expenditure (CHE), identify associated factors and coping strategie...
Article
Full-text available
Background: Breast cancer is the second most prevalent malignancy in Ethiopia and severely affects patients' health-related quality of life (HRQOL). We aimed to assess HRQoL, factors influencing HRQoL, and utilities among breast cancer patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Methods: A hospital-based cross-sectiona...
Article
Full-text available
Objectives: There is a growing interest in health technology assessment and economic evaluations in developing countries such as Ethiopia. The objective of this study was to derive an EQ-5D-5L value set from the Ethiopian general population to facilitate cost utility analysis. Methods: A nationally representative sample (N = 1050) was recruited...
Preprint
Background: With the rapid increase in magnitude and mortality of cancer, which is costly disease to manage, several patients particularly in developing countries are facing a huge financial burden. Objective: The purpose of the study was to examine the level of catastrophic health expenditure (CHE), identify associated factors and coping strategi...
Article
Full-text available
Background: Dispensary and use of antibiotics without prescriptions from qualified providers is a common practice in countries with poor pharmaceutical regulations and where due focus is not given to rational use. This practice is a main factor for the spread of antimicrobial resistance due to its non-reliance on pre-treatment microbiologic work-up...
Article
Full-text available
Background: Seeking healthcare in children is unique since parents decide upon the type and frequency of healthcare services accessed. Mothers/caregivers lower healthcare seeking behavior is one of the major reason for increased morbidity and mortality from childhood illness in developing countries. Hence, this study aimed to assess healthcare see...
Article
Full-text available
Background Owing to lack of adequate healthcare financing, access to at least the basic health services is still a problem in Ethiopia. With the intention of raising funds and ensuring universal health coverage, a mandatory health insurance scheme has been introduced. The Community Based Health Insurance has been implemented in all regions of the c...
Article
Full-text available
Background Cervical cancer is among the leading gynecological cancers affecting women worldwide. Maintenance and improvement of cervical cancer patients‘health related quality of life (HRQoL) is an important issue. The cervical cancer specific quality of life module of the European Organization for Research and Treatment of Cancer (EORTC QLQ-CX24)...
Article
Full-text available
Background: Global action plans to tackle antimicrobial resistance (AMR) include implementation of antimicrobial stewardship (AMS), but few studies have directly addressed the challenges faced by low and middle-income countries (LMICs). Our aim was to explore healthcare providers' knowledge and perceptions on AMR, and barriers/facilitators to succ...
Article
Full-text available
Objective: The study aims to the assess prescription completeness and drug use pattern of the hospital using the World Health Organization/ International Network for Rational Use Drugs (WHO/ INRUD) core drug use indicators. Methods: The study was carried out at Tikur Anbessa Specialized Hospital (TASH). Three hundred eight four prescriptions were c...
Conference Paper
Full-text available
Background: With the rapid increase in magnitude and mortality of cancer, which is costly disease to manage, several patients particularly in developing countries are facing a huge financial burden. Objectives: The purpose of the study was to examine the level of catastrophic healthcare expenditure (CHE), identify associated factors and coping stra...
Poster
Full-text available
Objectives: There is a growing interest in health technology assessment and economic evaluations in developing countries such as Ethiopia. The objective of this study was to derive an EQ-5D-5L value set from the Ethiopian general population to facilitate cost utility analysis. Methods: A nationally representative sample (N = 1050) was recruited usi...
Article
Full-text available
Abstract Background: Negative perception of consumers towards domestically manufactured medicines is one of the major challenging barriers to use these products. In Ethiopia, all pharmaceutical industries are producing generic medicines and thus customers’ acceptance of domestic medicines is essential as they are the end users. Hence, the study ai...
Article
Full-text available
Fluoroquinolones are widely used globally and there is a growing trend of resistance to these agents. However, there is scanty information in Ethiopia and this study aimed to assess the level of bacterial resistance to fluoroquinolones and identify contributing factors in Addis Ababa, Ethiopia. Concurrent mixed methods study design was used. Record...
Article
Full-text available
Background Prevalence of tuberculosis in vulnerable groups such as prisoners is usually high, and the problem is worsened by poor treatment outcomes. In spite of this, there is limited information regarding tuberculosis in prisons of Ethiopia. Hence, this study was aimed to assess the prevalence of tuberculosis and treatment outcomes of patients wi...
Article
Full-text available
Background: A lot has been done globally, continentally and at national level to improve health status of the community. Despite the increasing scope and sophistication of healthcare, the huge resources devoted to it and the focus on improvement; it is still failing at a fundamental level. Caring and compassion, the basics of care delivery, and the...
Article
Full-text available
Back ground- A lot has been done globally, continentally and at national level to improve health status of thecommunity. Despite the increasing scope and sophistication of healthcare, the huge resources devoted to it andthe focus on improvement; it is still failing at a fundamental level. Caring and compassion, the basics of caredelivery, and the h...
Article
Full-text available
Background Clinical pharmacy service has evolved steadily over the past few decades and is now contributing to the ‘patient care journey’ at all stages. It is improving the safety and effectiveness of medicines and has made a significant contribution to the avoidance of medication errors. In Ethiopia, clinical pharmacy service is in its initial pha...
Conference Paper
Full-text available
ABSTRACT Background: Multi-drug resistant tuberculosis is a growing challenge of the tuberculosis control program globally, with the highest rates of incident cases and deaths in developing countries. In Ethiopia, tuberculosis patients from new cases and re-treatment cases had resistance to at least isoniazid and rifampicin with significant increas...
Article
Full-text available
The objective of the study was to assess the magnitude and predictors of first‐line antiretroviral treatment failure among HIV‐infected children. A retrospective cohort study was conducted between January 2006 and December 2015. All pediatric patients of <15 years old and who took at least 6 months of ART in Fiche and Kuyu hospitals of Oromia regio...
Article
Full-text available
Background Clinical pharmacy service has evolved steadily over the past few decades and is contributing to the ‘patient care journey’ at all stages. The service improves safety and effectiveness of medicines, thereby avoiding medication errors. As part of this global shift in pharmacy education and practice, Ethiopian Universities revamped the unde...
Article
Full-text available
A wide range of pharmaceutical products are needed for diagnosis, treatment, and prevention of HIV/AIDS. However, interrupted supplies and stock-outs are the major challenges in the supply chain of ARV medicines and related commodities. The aim of this study was to assess the supply chain management of HIV/AIDS related commodities in public health...