Gayathri Devi D

University of Calicut · Department of Life Sciences

Plant derived proteins are receiving ample acceptance as therapeutic agents against oxidative injury throughout the progression of many human diseases. Plant trypsin inhibitors are compounds that help plants to exhibit defense on pests. Extensive investigations are proceeding globally to identify the natural trypsin inhibitors with therapeutic appl...

Natural trypsin inhibitors are increasingly recognised as putative anticancer or antimicrobial therapeutics. In the present study, we isolated a proteinaceous trypsin inhibitor from the seeds of Artocarpus hirsutus to assess its anticancer, antioxidant and microbicidal effects. A trypsin inhibitory protein (AhTI) was isolated from the seeds of A. h...

Background: Photodynamic therapy (PDT) has clinical approval for use as a minimally invasive therapeutic procedure that is able to exert selective cytotoxic activity toward malignant cells. The dye selected for our study, symmetrical diiodinated squaraine, is one of the newly developed photosensitizers. The study is designed to determine the effic...

Saraca asoca (Family Caesalpiniaceae) has been widely used in traditional Indian medicine especially due to its wound-healing property. The present study investigates the chemopreventive property of flavonoids from Saraca asoca (flowers) on 2-stage skin carcinogenesis in mice models. Skin cancer was induced in Swiss albino mice by single topical ap...

Photodynamic Therapy (PDT) using a sensitizing drug is recognized as a promising medical technique for cancer treatment. It is a two step process that requires the administration of a photosensitizer followed by light exposure to treat a disease. Following light exposure the photosensitizer is excited to a higher energy state which generates free r...

This paper deals with two potential modes for the treatment of skin cancer-one a novel approach using a squaraine dye and the other using a natural product- the flavonoid fraction of Saraca asoka. Squaraine dye is a photosensitizing agent, which is preferentially taken up and retained by the tumor cells and when irradiated with high power visible l...

Saraca asoka (Family - Caesalpiniaceae) has been widely used in the Ayurvedic (traditional Indian) system of medicine especially due to its wound healing property. The present study investigated the chemopreventive property of flavonoids from the flowers of Saraca asoka on 7,12 dimethyl benz(a)anthracene (DMBA) induced skin cancer in mice models. A...

Photodynamic therapy (PDT) is based on the light-induced activation of a photosensitizer generating highly reactive oxygen species that induce tissue destruction in malignant tissues. The present study was carried out to assess the photosensitizing potential of bis(3,5-diiodo-2,4,6-trihydroxyphenyl)squaraine in PDT trials in vivo. Male Swiss albino...

Emilia sonchifolia Linn. (DC.) is a traditionally used medicinal plant seen in most tropical and subtropical regions worldwide. Various parts of the plant are used for the treatment of diseases like asthma, intermittent fevers, breast cancer, ophthalmia, nyctalopia etc. We have isolated the flavonoid fraction from E. sonchifolia (whole plant). Fema...

In this study we have looked into a fairly less studied, common edible plant- Emilia sonchifolia Linn (ES), for possible antioxidant and antitumor activity. We have isolated the flavonoid fraction from the whole plant and the antioxidant property was assessed by measuring its capacity to inhibit Cu²⁺ induced lipoprotein oxidation in huma...