Gayan Adikari Appuhamillage

• Doctor of Philosophy
• Senior Lecturer at University of Sri Jayewardenepura

Tellurite, the most soluble tellurium oxyanion, is extremely harmful for most microorganisms. Part of this toxicity is due to the generation of reactive oxygen species that in turn cause oxidative stress. However, the way in which tellurite interferes with cellular processes is not well understood to date. Looking for new cellular tellurite targets...

A design paradigm is demonstrated that enables new functional 3D printed materials made by fused filament fabrication (FFF) utilizing a thermally-reversible dynamic covalent Diels-Alder reaction to dramatically improve both strength and toughness via self-healing mechanisms. To achieve this, a partially cross-linked terpolymer consisting of furan-m...

div> Herein, we describe a 3D printable hydrogel that is capable of removing toxic metal pollutants from water solutions. To achieve this, shear-thinning hydrogels were prepared by blending chitosan with diacrylated Pluronic F-127 (F127-DA) which allows for UV curing after printing. Several hydrogel compositions were tested for their ability to ab...

Here we report a 3D printable polymer that retains uniform mechanical strength after printing and can be used with a conventional fused filament fabrication (FFF) printer. To achieve this, a synthetic polymer containing dynamic Diels-Alder functionality was blended with commercially available polylactic acid (PLA). This new polymer contains cross-l...

Herein, we communicate that altering the number of carbon atoms on the alkoxyphenyl substituent in naphthalene diimides results in tunable thermo-salient behavior across a variety of temperatures. Additionally, these compounds were found to display reversible thermochromic behavior in the single crystalline state. We analyzed this behavior using di...

Human skin is a physical and biochemical barrier that protects the internal body from the external environment. Throughout a person’s life, the skin undergoes both intrinsic and extrinsic aging, leading to microscopic and macroscopic changes in its morphology. In addition, the repair processes slow with aging, making the older population more susce...

Excessive exposure to ultraviolet (UV) radiation causes premature aging of the skin, known as photoaging. UV radiation induces DNA damage, oxidative stress, inflammatory reactions, and degradation of extracellular matrix (ECM) proteins, contributing to the aged skin phenotype. The skin synthesizes vitamin D upon UVB exposure, which plays a pivotal...

Three-dimensional (3D) and four-dimensional (4D) printing have emerged as the next-generation fabrication technologies, covering a broad spectrum of areas, including construction, medicine, transportation, and textiles. 3D printing, also known as additive manufacturing (AM), allows the fabrication of complex structures with high precision via a lay...

The traditional long-term preservative system of latex has an impact on environmental air pollution by ammonia and leads to the production of carcinogenic nitrosamine substances by tetramethyl thiuram disulfide (TMTD). In this research, ammonia and a novel preservative with a polysulfidic link were compounded and tested as a novel traditional long-...

This commentary discusses current capabilities of vat photopolymerization, an additive manufacturing (AM) technique also known as VP, with recent advances in the literature, current challenges/limitations, and future outlook in novel materials design. Current trends and recent research advances are broadly discussed covering a spectrum of material...

Herein, we describe a 3D printable hydrogel that is capable of removing toxic metal pollutants from aqueous solution. To achieve this, shear‐thinning hydrogels were prepared by blending chitosan with diacrylated Pluronic F‐127 which allows for UV curing after printing. Several hydrogel compositions were tested for their ability to absorb common met...

3D printing, also known as additive manufacturing, is an advancing technology for fabricating three dimensional objects of simple to complex architectures using computer aided design (CAD) models. Fused Filament Fabrication (FFF) is a relatively cost effective, straightforward 3D printing technique which relies upon utilization of relatively cheap,...

The purpose of this research was: (1) to determine the reducing power of two E. coli strains, AG1/pCA24NgshA and AG1/pCA24NgshB, for the toxic oxyanions SeO32-, SeO42-, and TeO32- in comparison to their wild type E. coli strain AG1 in terms of their relative ability to produce intracellular glutathione (GSH); and (2) to produce an E. coli strain ha...