Ganiyat Oloyede

University of Ibadan · Department of Chemistry

Anogeissus leiocarpus and Sansiviera liberica are plants used in traditional medicine as antiviral agents. A preliminary study of the bioactive constituents was carried out using Liquid Chromatography – Mass Spectrometry (LC-MS) technique. Free radical scavenging activity of the crude extracts were determined using 2,2-diphenyl picrylhydrazyl radic...

Pericopsis laxiflora (Fabaceae) is a savannah shrub used traditionally to treat headache, stomach ulcers, heart pain and abdominal pain. Air-dried leaves and stem of the plant were extracted by hydrodistillation and the oils obtained were characterized using gas chromatography-mass spectrometry. Antimicrobial assay was carried out by agar well diff...

Social media provides a sense of community, where people share beliefs, ideas and knowledge. It has become increasingly popular in different countries across the globe since their invention because of its benefit in the passage of critical and vital information especially during times of emergencies but the disadvantages almost outweighs the benefi...

Herbal Formulations in Nigeria: A Survey of Three Major Tribes

This study explores the relevance-merits and demerits of digital productivity tools in education, research and career in the 21st century. Education, research and career are like a tripod leading to the socio economic advancement of a nation. Review of different literatures, observation and survey were the exploratory research design adopted to gat...

Online Teaching and Learning as a Paradigm for Gender –Inclusiveness in African Higher Education

Effects of Social Media on Morality of Youths in Nigeria and the role of Religion

Best Practises for the Inclusion of Women in Science and Technology: The South Western Nigeria Experience

Insects in the Production of Dyes: Presentation to commemorate Wprld Earth Day Celebration 2022

Insects in the Production of Dyes. A poster presentation at a one day virtual seminar of American Chemical Society Nigeria International Chapter

The phytochemical screening, and in vitro antifungal activity of the inflorescence, leaf, stem and rhizome crude extracts of Costus lucanusianus J. Braun & K. Schum at concentrations 12.5-100 µg/mL were determined against 4 fungal strains; Penicillium notatum, Candida albicans, Aspergillus niger and Rhizopus stolonifer by Agar well diffusion method...

Agelaea obliqua and Usteria guineensis are plants used extensively in ethno-medicine for the treatment of convulsion and parasitic infections. Air-dried leaves and stem of both plants were subjected to hydro-distillation and chemical components of the volatile oils obtained were identified by Gas Chromatography-Mass Spectrometer (GC-MS). Toxicity,...

Celebrating 2022 UNESCO International Day of Women and Girls in Science by Organization for Women in Science for the Developing World (OWSD) Celebrating 2022 Global Women’s Breakfast by International Union of Pure and Applied Chemistry (IUPAC) and Royal Society of Chemistry (RSC)

Time and Resources Optimization for Career Advencement of Women in Science from Developing Countries

The essential oil of different organs of Costus lucanusianus J. Braun & K. Schum (Family Costaceae) obtained by hydrodistillation were analysed by Gas chromatography-mass spectrometry and its antimicrobial activity evaluated. Thirty-eight constituents were identified, representing an average of 73.64-99.95% of the total oil composition. The main co...

Air dried and pulverized leaves and stem of Dichapetalum bateri (Engl.) Bret. used in ethnomedicine for the treatment of rheumatism and cough were subjected to hydro-distillation which yielded colourless essential oil that was analyzed by gas chromatography-mass spectrometry (GC-MS). The leaves yielded 0.60% essential oil component and is dominated...

Strophanthus hispidus (Apocynaceae), Byrsocarpus coccineus (Connaraceae) and Morus mesozygia (Moraceae) with common usage in ethnomedicine were investigated for their chemical composition and free radical scavenging activity. Hydro-distillation method was used to extract the essential oils of the air-dried plant parts and characterized by Gas Chrom...

Introduction: The study of medicinal plants in different parts of the world has led to major breakthroughs in drug chemistry. The increased interest in discovering drugs from natural source led to our investigation of the chemical composition, antioxidant and antimicrobial activities of the essential oil of Mariscus alternifolius Vahl, used in the...

This study examined the composition of the essential oils long with corresponding antioxidant and antimicrobial properties of the leaves and stems of Leptoderris brachyptera and Leptoderris micrantha. Essential oils were obtained by hydrodistillation method using Clevenger-type apparatus, while identification and characterization were done by gas c...

This research was aimed at synthesizing Mannich bases of piperidine and p-chloroaniline derivatives and investigating their antioxidant and antimicrobial activities since report has it that Mannich bases possessing electron withdrawing group show good anti-oxidant, antimicrobial, anti-cancer and anti-tumor properties. The synthesized compounds were...

Hydro-distillation of the air dried and pulverized whole plant of Euphorbia graminea yielded colourless volatile oil which was analysed by gas chromatography-mass spectrometry. Isopropyl palmitate (45.81%), Oleic acid (14.09%), Palmitic acid (6.65%) and Trans-2-Pentenal (5.68%) were the major constituents in the oil. The volatile oil revealed good...

Herbal formulations (HFs) have been employed all over the world due to its diagnostic and therapeutic applications. It is particularly common in developing countries like Nigeria. Herbal formulations are mixtures consisting of one or more herbs in specified quantities to provide specific nutritional, cosmetic and therapeutic benefits in an attempt...

A phytochemical investigation of the leaf extract of Costus lucanusianus J. Braun & K. Schum (Family Costaceae) a tropical African medicinal plant known for curing several infectious diseases such as venereal disease, cough and urinary tract infection led to the isolation of two new steroids. The identification of these isolates was achieved by mod...

Acalypha hispida (family Euphorbiaceae) is widely known for its medicinal applications in ethno-medicine. The most active antioxidant fraction of the leaf methanol extract was investigated with the aim of isolating and elucidating the active constituents. Bioassay guided isolation and purification was achieved using standard chromatographic techniq...

The African locust bean (Parkia biglobosa) seed is one of the major sources of plant protein in African diet. Effect of fermentation on the chemical composition and physicochemical properties of P. biglobosa seed oil was determined. The chemical composition of the unfermented and fermented seed oil was determined using Gas-Chromatography-Mass Spect...

Hydro-distillation of the air dried and pulverized whole plant of Euphorbia graminea yielded colourless volatile oil which was analysed by gas chromatography-mass spectrometry. Isopropyl palmitate (45.81%), Oleic acid (14.09%), Palmitic acid (6.65%) and Trans-2-Pentenal (5.68%) were the major constituents in the oil. The volatile oil revealed good...

Lignin is a polymer derived from the phenylpropanoid compounds, coniferyl alcohol and related alcohols. It is the second abundant (next to cellulose) and important organic substance in the plant world. Researches on lignin has been in the area of adsorption properties, but this present study is aimed at synthesizing Mannich bases by amination react...

Laportea aestuans (Gaud) belonging to the family Urticaceae is an herbaceous weed consumed as vegetable and used in traditional medicine. In continuation of our work on this plant, bioactive constituents were isolated using chromatographic technique and the structures of all isolated constituents were determined by spectroscopic techniques and comp...

Albizia zygia (Leguminosae) is a gum producing tree and wide spread in tropical Africa. It has secondary metabolites of medicinal importance. This study investigates the enzyme (urease and α-glucosidase) inhibition, antioxidant and insecticidal activities of the crude extract and isolates. Terpenoids (lupeol and betulin) and flavonoids (4',7-dihydr...

Citrullus lanatus L. (Cucurbitaceae) known as Water melon is an edible fruit in many countries especially Nigeria. Chemical composition, phytochemical, physicochemical and antioxidant properties of the dried seeds of C. lanatus were determined to understand its potential health benefits since oil extract from a number of fruits, nuts and seeds...

In continuation of our synthesis and investigation of bioactivities of Mannich bases, synthesized N-Mannich bases were evaluated for their urease inhibition and antioxidant properties. Characterization was achieved by Ultraviolet/visible (UV), Infrared (IR), Nuclear magnetic resonance (1 HNMR) and Mass spectrophotometries. Elemental analysis, optic...

Parquetina nigrescens (Asclepiadaceae) is a flowering plant used in traditional medicine as antioxidant and antimicrobial agent. Isolates were obtained and characterized using chromatographic and spectroscopic techniques. The lipid component was characterized using Gas chromatography (GC) and gas-chromatography mass spectrometry (GC-MS). β-sitoster...

In continuation of our synthesis and investigation of bioactivities of Mannich bases, synthesized N-Mannich bases were evaluated for their urease inhibition and antioxidant properties. Characterization was achieved by Ultraviolet/visible (UV), Infrared (IR), Nuclear magnetic resonance (1 HNMR) and Mass spectrophotometries. Elemental analysis, optic...

Citrullus lanatus L. (Cucurbitaceae) known as Water melon is an edible fruit in many countries especially Nigeria. Chemical composition, phytochemical, physicochemical and antioxidant properties of the dried seeds of C. lanatus were determined to understand its potential health benefits since oil extract from a number of fruits, nuts and seeds are...

Dieffenbachia picta (Lodd.) Schott, mostly used as ornamental plant, has not been thoroughly investigated for its medicinal properties due largely to the presence of oxalic acid deposited as crystals of calcium oxalate on parts of the plant especially the leaves. The present study however was aimed at providing an in-vitro evidence for the potentia...

This research was designed to investigate the effect of media usage, religiosity and gender on performance in chemistry subject. This study employed survey research design. Two hundred participants (66 males and 134 females) drawn from public Senior Secondary Schools in Ibadan North Local Government Area, Oyo State constituted the study's sample. T...

The plant Marisus alternifolious Vahl is a weed used in ethno medicine for the treatment of wounds, bacterial and gonorrheal infections. The dried whole plant was extracted with methanol (MMA) and partitioned using hexane (HMA), ethylacetate (EMA) and butanol (BMA). The fractions were subjected to phytochemical screening, antioxidant assay by the f...

Plants possess bioactive substances that can be utilised to serve health needs as emerging health problems continue to rampage our environment. Node weed Synedrella nodiflora used traditionally in Nigeria for treating various diseases such as arthritis, rheumatism, dropsy, swellings, oedema, gout and leprosy is one of such plant. Methanol, n-hexane...

The chemical composition and free radical scavenging activities of leaf and stem essential oils of two Asclepiadaceae species, Secamone afzelii and Pergularia daemia were investigated. They are claimed to be used in ethno-medicine for the treatment of stomach problems, diabetes, colic, dysentery and kidney problems. Essential oils of the air-dried...

Plants possess bioactive substances that can be utilised to serve health needs as emerging health problems continue to rampage our environment. Node weed Synedrella nodiflora used traditionally in Nigeria for treating various diseases such as arthritis, rheumatism, dropsy, swellings, oedema, gout and leprosy is one of such plant. Methanol, n-hexane...

This research was designed to investigate the effect of media usage, religiosity and gender on performance in chemistry subject. This study employed survey research design. Two hundred participants (66 males and 134 females) drawn from public Senior Secondary Schools in Ibadan North Local Government Area, Oyo State constituted the study's sample. T...

The plant Marisus alternifolious Vahl is a weed used in ethno medicine for the treatment of wounds, bacterial and gonorrheal infections. The dried whole plant was extracted with methanol (MMA) and partitioned using hexane (HMA), ethylacetate (EMA) and butanol (BMA). The fractions were subjected to phytochemical screening, antioxidant assay by the f...

Diseases, infections and unhealthy diet serve as threat to human existence. Bases obtained from Mannich reaction have been found to have pharmacological application as antioxidant, antimicrobial, anti-cancer, anti-hypertensive, antiviral and anti-inflammatory in drugs and as food additives. Biologically active 4-(3-oxo-1,3-diphenyl propylamino) ben...

Plants contain natural products which have been recognized as building blocks for primary health care. Sterculiar tragacantha Lindl, used traditionally in Nigeria for the treatment of boils, diarrhea, gonorrhea, edema, gout, whitlow, fevers and malaria is one of such plants. The prevalence of drug resistant pathogenic microbes as well as the oxidat...

Albizia zygia (DC) J.F. Macbr. (Leguminoseae) has variety of ethno-medicinal applications but little is known of the essential oil component. This research work was aimed at determining the chemical composition of A. zygia leaves and stem-bark essential oils by gas chromatography and gas chromatography-mass spectrometry; to subject the oils to in-v...

Albizia zygia (DC) J.F. Macbr. (Leguminoseae) has variety of ethno-medicinal applications but little is known of the essential oil component. This research work was aimed at determining the chemical composition of A. zygia leaves and stem-bark essential oils by gas chromatography and gas chromatography-mass spectrometry; to subject the oils to in-v...

Diseases, infections and unhealthy diet serve as threat to human existence. Bases obtained from Mannich reaction have been found to have pharmacological application as antioxidant, antimicrobial, anti-cancer, anti-hypertensive, antiviral and anti-inflammatory in drugs and as food additives. Biologically active 4-(3-oxo-1,3-diphenyl propylamino) ben...

Combretum hispidum (Combretaceae) is used for the treatment of microbial infections in traditional medicine. The leaf essential oil was obtained by hydro-distillation and subjected to GC-MS analysis and screened for antimicrobial activity by agar well diffusion method. GC and GC/MS analysis of the colourless essential oil showed the presence of thi...

Phytochemicals responsible for toxicity, antimicrobial and antioxidant activities of extracts obtained from Larpotea aestuans (Gaud) were investigated. Secondary metabolites detected were alkaloids, tannins, resins, saponins and carbohydrate. Flavonois, sterols, cardiac glycosides, phenols glycosides were however beyond detectable limit. Brine shri...

Substituted benzenes were used in the synthesis of Mannich bases 1-Phenylaminomethyl-naphthalen-2-ol (MB1) and (2-{[2-hydroxy ethyl) amino] methyl}phenyl) phenyl peroxyanhydride (MB2) and were characterised by ultraviolet/visible and infra-red spectroscopies. Peaks due to functional groups OH, CO and NH were prominent. Sharp melting points at 134°C...

Phytochemicals responsible for toxicity and antioxidant activities of extracts obtained from Cyperus esculentus were investigated. Toxicity test was carried out using Brine shrimp lethality test while in vitro antioxidant activity was detetermined by three methods; scavenging effect on 2,2-diphenyl-1-picryhydrazyl radical (DPPH), inhibition of hydr...

Numerous studies have highlighted the nutritional and pharmacological importance of cocoa. In this current study, three in vitro assay methods were used to investigate the antioxidant activity of cocoa oil and cake: scavenging effect on 2,2diphenyl-1-picryhydrazyl radical (DPPH), hydroxyl radical generated from hydrogen peroxide and peroxide oxidat...

Abstract: Phytochemicals responsible for toxicity and antioxidant activities of extracts obtained from Cyperus esculentus were investigated. Toxicity test was carried out using Brine shrimp lethality test while in vitro antioxidant activity was detetermined by three methods; scavenging effect on 2,2-diphenyl-1-picryhydrazyl radical (DPPH), inhibiti...

Substituted benzenes were used in the synthesis of Mannich bases 1-Phenylaminomethylnaphthalen-2-ol (MB1) and (2-{[2-hydroxylethyl)amino]methyl}phenyl)phenyl )peroxyanhydride (MB2) and were characterized by ultraviolet/visible and infra-red spectroscopies. Peaks due to functional groups OH, CO and NH were prominent.Sharp melting points at 1340C (MB...

Different fractions of Quassia amara and its bioactive compound quassin have been implicated in male reproductive toxicology. Toxicity results obtained from brine shrimp lethality test on chloroform, methanol and hexane fractions of Quassia amara gave LC 50 value of 93.4569µg/ml, 172.0463µg/ml, and 46.1941µg/ml respectively. LC 50 of quassin was 0....

Export Date: 18 October 2014

Abstract: Free radicals and reactive oxygen species (ROS) are associated with various physiological and pathological situations. They are capable of damaging DNA, proteins, carbohydrates and lipids which are generally in aerobic organisms. Therefore, this study was aimed at determining the lethal dose (LC 50) and investigating the effect of solvent...

Synthesis of 1-Phenyl-3-(phenylamino) propan-1-one (BO1) and Phenyl (2-[phenyl amino) methyl] phenyl) peroxyanhydride (BO2) both of which are Mannich bases were achieved in this study. Analysis and characterisation of the Mannich Bases were also achieved by UV, IR, and NMR Spectroscopy. The ionization constant (pKa) of the products is also reported...

Numerous studies have highlighted the nutritional and pharmacological importance of cocoa. In this current study, three in vitro assay methods were used to investigate the antioxidant activity of cocoa oil and cake: scavenging effect on 2,2-diphenyl-1-picryhydrazyl radical (DPPH), hydroxyl radical generated from hydrogen peroxide and peroxide oxida...

Abstract: The crude methanol extract of Hura crepitans was obtained and screened for the presence of secondary plant metabolites. The leaf essential oil was also obtained by hydro-distillation and GC and GC/MS analysis of the colourless essential oil showed the presence of seven compounds with ethyl propionate (39.6%) and isopentyl alcohol (10.6%)...

Bio-active compounds present in West Indian Wood Nettle Laportea aestuans (L.) Chew (Urticaceae), used in ethno medicine as antioxidant and antimicrobial were studied. The aim of this research work was to isolate and characterize the bio-active compounds in the n-hexane fraction of L. aestuans, determine the toxicity and subject it to in-vitro anti...

Bio-active compounds present in West Indian Wood Nettle Laportea aestuans (L.) Chew (Ur-ticaceae), used in ethno medicine as antioxidant and antimicrobial were studied. The aim of this research work was to isolate and characterize the bio-active compounds in the n-hexane fraction of L. aestuans, determine the toxicity and subject it to in-vitro ant...

Aims: To determine the secondary plant metabolites present in Albizia zygia (DC) stem-bark and investigate its antioxidant, antimicrobial and toxicity activities. Study Design: Methanol (polar) and hexane (non-polar) were used to extract the dried stem bark of A. zygia and biological activities were carried out. Place and Duration of Study: Natural...

Adansonia digitata (Bombacaceae) leaves are used in the treatment of kidney and bladder diseases in ethno- medicine. This research was aimed at justifying its use by isolating the secondary plant metabolites responsible for the observed hepatoprotective activity. Coumarin, terpenoids and steroids were the phytochemicals found in hexane, ethyl aceta...

This study was designed to evaluate the effect of moderate ethanol administration on the biochemical indices in streptozotocin (STZ)-diabetic rats. Twenty-four male Wistar rats were divided into four groups of six animals each. Groups one and two contained non-diabetic normal rats and normal rats treated with ethanol, respectively. Group three was...

The antioxidant activity of two methanolic fractions (CI, C2) of R. communis was determined by three methods: Lipid peroxidation by ferric thiocyanate method and free radical scavenging effect on 2, 2-diphenyl-l-picrylhydrazyl radical (DPPH) and hydroxyl radical generated from hydrogen peroxide. CI and C2 at various concentration possessed signific...

The antioxidant activity of different extracts, aqueous, methanol, hexane, ethylacetate and butanol extracts of Vernonia amygdalina as detetermined by three methods: scavenging effect on 2,2-diphenyl-1-picryhydrazyl radical (DPPH), hydroxyl radical and peroxide oxidation by ferric thiocynate method revealed that the fractions possessed significant...

The antioxidant activity of two methanolic fractions (C1, C2) of R. communis was determined by three methods: Lipid Peroxidation by Ferric thiocyanate method and free radical scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and hydroxyl radical generated from hydrogen peroxide. C1 and C2 at various concentrations possessed signific...

Dieffenbachia picta Schott (Dumb cane) is phytochemically investigated for toxicity, antimicrobial and antioxidant activities. The result of phytochemical screening revealed that alkaloids, saponins, phenol, flavonoids and resins were present in the extracts of leaves and stem of D. picta while tannins, steroids and terpenoids were absent. The brin...

Objective: This study was designed to evaluate the effect of moderate ethanol administration on the biochemical indices in streptozotocin (STZ)-diabetic rats. Methods: Twenty-four male Wistar rats were divided into four groups of six animals each. Groups one and two contained non-diabetic normal rats and normal rats treated with ethanol, respective...

The effects of Quassia amara extract (Q. amara) and its bioactive principles-quassin and 2-methoxycanthin-6-one on gastric ulceration were studied in albino rats. Q. amara (200-800 mg/kg p.o.; 5-20 mg/kg i.p) and 2-methoxycanthin-6-one (12.5, 25.0 and 50.0 mg/kg p.o; 1, 2 and 4 mg/kg i.p) but not quassin (12.5, 25.0 and 50 mg/kg p.o; 1, 2 and 4 mg/...

Anaemia is one of the clinical conditions that constitute serious health problems in many tropical countries as a result of the prevalence of different forms of parasitic infections, including malaria. Methanolic extract of Psidium guajava Linn. bark (Myrtaceae) was investigated for haematinic activity using male Albino Swiss rats. A total of 30 ra...

Ab stra ct Dieffenbachia picta Schott (Dumb cane) is phytochemically investigated for toxicity, antimicrobial and antioxidant activities. The result of phytochemical screening revealed that alkaloids, saponins, phenol, flavonoids and resins were present in the extracts of leaves and stem of D. picta while tannins, steroids and terpenoids were beyon...

Peperomia pellucida (Piperaceae), known as Shiny bush is a herbaceous plant with ethno medical uses which include anti-inflammatory and analgesic properties. Air dried leaves of the plant was extracted using Soxhlet extractor to give the methanol extract which was then partitioned successively in n-hexane, ethyl acetate, butanol and water. Alkaloid...

The colourless essential oils obtained by hydro-distillation from the whole plant of Laportea aestuans (Gaud) were analysed by GC and GC/MS. The major constituents in the oil were methyl salicylate (54.50%), fenchol (10.59%), 1, 2-cyclohexanedione dioxime (9.40%), 1, 4-octadiene (8.86%) and linalool (3.26%). The toxicity results obtained from brine...

Chemical Composition And Free Radical Scavenging Activity Of Leaf Essential Oils Of Acalypha torta. ABS T RACT The colourless essential oil obtained by hydro-distillation from the leaves of Acalypha torta was analysed using GC and GC/MS. It indicated the presence of thirty-four compounds. The major constituents of the oil were (E,E,Z)-1,5,9-Cyclodo...

UV-Visible analysis of Free radical scavenging activities of Leaf Extracts of Dacryodes edulis G. Don Lam (Burseraceae): A comparison of three assay methods ABSTRACT This research reports the in vitro free radical scavenging activity of Dacryodes edulis (Burseraceae) using three different assay methods. Scavenging effect on 2, 2-diphenylpicrylhydra...

The leaves of Alchornea laxiflora have antihistamine, anti-infectious and anti-inflammatory applications in ethno medicine. This study was aimed at investigating the hepatoprotective activity, isolation and structural elucidation of the phytochemical constituents of the leaf ethanolic extract. Hepatoprotective assay was carried out against carbonte...

Essential oil from the stem bark of Nigerian species of Psidium guajava of the family Myrtaceae was obtained by hydro-distillation using an all-glass Clavenger apparatus. GC and GC/MS analysis were carried out on the essential oil and was found to contain 62 compounds constituting 99.98 % of the total oil composition. The principal constituents are...

The cytotoxicity using Brine shrimp lethality assay and free-radical scavenging activities of fractions obtained from chromatographic separation of Dacryodes edulis (G.Don) H.J. Lam (African Pear) were investigated. The hexane extract was separated into smaller fractions by using a mixture of hexane, ethylacetate and methanol and silica gel 70-230...

The crude leaf methanolic extract of Acalypha hispida (Burn. F) was partitioned into hexane and chloroform. The percentage yields of the resulting extracts were 54.8, 2.97 and 41.8% (residue) respectively. The methanolic extract (residue) on column chromatographic separation afforded 236 fractions by gradient elution. The bulked fractions (B1-B14)...

Free radicals are involved in the process of lipid peroxidation and play a cardinal role in numerous chronic diseases like cancer, coronary heart disease and ageing. Thus the ability to scavenge free radicals in order to minimize oxidative damage to living cells is very important. The hexane extract of Acalypha hispida (Burn F.) was screened for ph...