Gang Wang

Gang Wang
Northwest Normal University · College of Computer Science and Enigering

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151
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Introduction
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Publications

Publications (151)
Chapter
Alzheimer’s disease (AD) is a significant global medical concern due to the aging population. AD is featured by gradual cognitive impairment, impacting daily functioning and causing behavioral and personality changes, causing disruptive psychiatric symptoms. While pharmacological interventions are the primary clinical approach, their efficacy is va...
Article
Alzheimer’s disease (AD) is a significant global medical concern due to the aging population. AD is featured by gradual cognitive impairment, impacting daily functioning and causing behavioral and personality changes, causing disruptive psychiatric symptoms. While pharmacological interventions are the primary clinical approach, their efficacy is va...
Preprint
Full-text available
Background Cognitive impairment (CI), including Alzheimer’s disease (AD) and mild cognitive impairment (MCI), has been a major research focus for early diagnosis. Both speech assessment and artificial intelligence (AI) have started to be applied in this field, but faces challenges with limited language type assessment and ethical concerns due to th...
Article
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Background The relationship between periodontitis and Alzheimer’s disease (AD) has attracted more attention recently, whereas profiles of subgingival microbiomes and gingival crevicular fluid (GCF) metabolic signatures in AD patients have rarely been characterized; thus, little evidence exists to support the oral-brain axis hypothesis. Therefore, o...
Article
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The clinical application of extracellular vesicles (EVs)‐based therapeutics continues to be challenging due to their rapid clearance, restricted retention, and low yields. Although hydrogel possesses the ability to impede physiological clearance and increase regional retention, it typically fails to effectively release the incorporated EVs, resulti...
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Background There have been no effective treatments for slowing or reversing Alzheimer’s disease (AD) until now. Growing preclinical evidence, including this study, suggests that mesenchymal stem cells-secreted exosomes (MSCs-Exos) have the potential to cure AD. Aims The first three-arm, drug-intervention, phase I/II clinical trial was conducted to...
Article
Background: Recently, Sigma nonopioid intracellular receptor 1 (SIGMAR1) variants have been shown harboring C9orf72 pathogenic repeat expansions in some frontotemporal dementia (FTD) cases. However, no SIGMAR1 genotype analysis has been reported in a cohort absent of C9orf72 pathogenic repeat expansions to date. Objective: The present study inve...
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Identified as the pathogenic genes of Alzheimer's disease (AD), APP, PSEN1, and PSEN2 mainly lead to early-onset AD, whose course is more aggressive, and atypical symptoms are more common than sporadic AD. Here, a novel missense mutation, APP E674Q (also named "Shanghai APP"), was detected in a Chinese index patient with typical late-onset AD (LOAD...
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Introduction Acupuncture is used as an adjuvant therapy for Alzheimer’s disease (AD), but available evidence for efficacy is limited so far. Growing studies suggest that resident gut microbiota contributes to the development and progression of AD. Meanwhile, acupuncture is reported to treat gastrointestinal and neurodegenerative disorders via the g...
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Background Language deficits frequently occur during the prodromal stages of Alzheimer’s disease (AD). However, the characteristics of linguistic impairment and its underlying mechanism(s) remain to be explored for the early diagnosis of AD. Methods The percentage of silence duration (PSD) of 324 subjects was analyzed, including patients with AD,...
Chapter
As an important economy branch dealing with the allocation of health-related resource, health economics mainly covers studies concentrating on issues related to multiple medical actions and disease researches concerning efficiency, effectiveness, value, and behavior in the production and consumption of both health and health care. The focus of this...
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Background The association between sarcopenia and mild cognitive impairment (MCI) among elderly adults in China remains unclear. The present study aimed to examine the association based on a nationally representative large‐scale survey. Methods The study used two waves of data from China Health and Retirement Longitudinal Study (CHARLS) in 2015 an...
Article
Introduction: The increasing prevalence of Alzheimer's disease and related dementias (ADRD) presents both a burden and an opportunity for intervention. This study aims to estimate the impacts of health insurance and resources on the burden attributed to ADRD. Method: Data were mainly collected from global databases for ADRD. Analysis of variance...
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Background There is rare reports about opinions and clinical practice of functional movement disorders (FMD) in China. The present survey aimed to investigate the views of FMD in Chinese clinicians. Methods The Chinese version survey of FMD were conducted in nationwide practitioners by means of an online questionnaire. Results Four hundred and th...
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Different cellular and molecular changes underlie the pathogenesis of Alzheimer's disease (AD). Among these, neuron‐specific dysregulation is a necessary event for accumulation of classic pathologies including amyloid plaques. Here, we show that AD‐associated pathophysiology including neuronal cell death, inflammatory signaling, and endolysosomal d...
Article
Introduction: We investigated the association between Alzheimer's disease (AD) and the risk of cancer in the Chinese population. Methods: In this retrospective cohort study, multivariate Cox proportional hazard regression analysis was used to determine the correlation between AD and the risk of various cancers, as shown by hazard ratios (HRs) wi...
Article
Background: Previous studies revealed that abnormal blood pressure (BP) plays an important role in the pathogenesis of Alzheimer's disease (AD). However, little is known about the ambulatory BP characteristics of AD in the mild or severe stage. Objective: We explored the ambulatory BP characteristics of AD in the mild or severe stage. Methods:...
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Compared with early-onset familial AD (FAD), the heritability of most familial late-onset Alzheimer’s Disease (FLOAD) cases still remains unclear. However, there are few reported genetic profiles of FLOAD to date. In the present study, targeted sequencing of selected candidate genes was conducted for each of 90 probands with FLOAD and 101 unrelated...
Article
Objectives: Cardiovascular dysautonomia can be present at early, late and even prodromal stages of Parkinson's disease. This study aimed to describe the characteristics of 24-h ambulatory blood pressure (BP) monitoring and investigate the frequency of cardiovascular dysautonomia in Parkinson's disease without an abnormal BP history. Methods: Par...
Article
Background: Language dysfunction is a frequently reported symptom in Alzheimer's disease (AD). However, computer-assisted analysis of spontaneous speech in AD and mild cognitive impairment (MCI) is rarely used to date. Objective: To characterize the language impairment in AD and amnestic MCI (aMCI) with computer-based automatic analysis via the...
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Background: Progressive supranuclear palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aimed to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living. Method: All patients recruited fulfilled the movement disorder society (MDS) clinica...
Preprint
Full-text available
Backgrounds: Progressive Supranuclear Palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aims to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living. Method: All patients recruited fulfilled the movement disorder society (MDS) clinical d...
Preprint
Full-text available
Backgrounds: Progressive Supranuclear Palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aims to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living. Method: All patients recruited fulfilled the movement disorder society (MDS) clinical d...
Preprint
Full-text available
Backgrounds: Progressive Supranuclear Palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aims to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living. Method: All patients recruited fulfilled the movement disorder society (MDS) clinical...
Preprint
Full-text available
Introduction: Progressive Supranuclear Palsy (PSP) is a rare movement disorder with poor prognosis. The natural history of PSP has been described in a few studies. This retrospective study aims to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living. Method: All patients r...
Article
Background: Identifying risk factors and mortality of individuals with Alzheimer's disease (AD) could have important implications for the clinical management of AD. Objective: This pilot study aimed to examine the overall mortality of AD patients over a 10-year surveillance period in Shanghai, China. This study is an extension of our previous in...
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A major hallmark of Parkinson’s disease (PD) is the degeneration of dopaminergic neurons in the substantia nigra, and the causative mechanism is thought to be the activation of programmed neuronal death. Necroptosis is a regulated process of cell death triggered by RIPK1. Although the pathophysiology of PD has been studied extensively, the cellular...
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Rho‐associated coiled‐coil kinase 1 (ROCK1) is proposed to be implicated in Aβ suppression; however, the role for ROCK1 in amyloidogenic metabolism of amyloid precursor protein (APP) to produce Aβ was unknown. In the present study, we showed that ROCK1 kinase activity and its APP binding were enhanced in AD brain, resulting in increased β‐secretase...
Article
Background: Repetitive transcranial magnetic stimulation (rTMS) is thought to be effective in alleviating cognitive symptoms in patients with amnestic mild cognitive impairment (aMCI), but the mechanisms related to network modification are poorly understood. Objective: Here we tested rTMS efficacy and explored the effect of rTMS-induced changes...
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Background: Urine samples, which capture an individual’s metabolic profile, are ideal for the exploration of non-invasive biomarkers to confirm the amnestic mild cognitive impairment (aMCI) status of patients vs. unimpaired ones. Objective: We aimed to detect differentially metabolized amino acids, which are important objectives in metabolomics, ga...
Article
Background: In addition to the increasing evidence for a molecular mechanism of rho kinase 1 (ROCK1) in Alzheimer's disease (AD), there are several published studies regarding the relationship between ROCK1 gene polymorphisms and neurological diseases. However, it is unknown whether there is an association between the polymorphisms of ROCK1 and AD...
Article
Objective: Lymphocyte activation gene‐3 (LAG‐3) could mediate pathological α‐synuclein transmission in neurodegeneration and may be involved in the pathogenesis of Parkinson's disease (PD). The aim of the present study was to explore soluble LAG‐3 (sLAG‐3) as a potential diagnostic biomarker for PD. Methods: Serum sLAG‐3 concentrations were measure...
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Background: Chinese guidelines for management of Parkinson's disease (PD) have been issued and updated regularly since 2006. We undertook a cross-sectional survey to evaluate the impact of the latest edition (2014) on current approaches to the management of PD based on previous pilot works. Methods: Seven hundred and seventeen participants, divi...
Article
In this paper, a new method, namely, the dynamic delay partitioning method, is firstly developed to solve the problems of stability analysis and stabilization for a class of unknown nonlinear systems. To study the system stability and facilitate the design of fuzzy controller, Takagi-Sugeno (T-S) fuzzy models are employed to represent the system dy...
Article
Background Standardized mortality ratio (SMR) is the most frequently used index in Parkinson's disease (PD) survival survey. However, there is little SMR data in PD from China. Objective To examine the outcome, including overall and cause-specific mortality, of PD patients subsequent to 10 years of surveillance in Shanghai, China. This is an exten...
Article
As an important multifunctional protein involved in regulation of mitochondrial metabolism, CHCHD2 was identified as a causative gene for Parkinson's disease (PD), yet the relationship between CHCHD2 and neurodegenerative dementia is not well understood. We directly sequenced the entire coding region of CHCHD2 gene in 150 AD patients, 84 FTD patien...
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Background Huntington’s disease (HD) is an autosomal dominant disorder, typically characterized by chorea due to a trinucleotide repeat expansion in the HTT gene, although the clinical manifestations of patients with juvenile HD (JHD) are atypical. Case presentation A 17-year-old boy with initial presentation of tics attended our clinic and his DN...
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Background Disclosing the diagnosis of Alzheimer's disease (AD) to a patient is controversial. There is significant stigma associated with a diagnosis of AD or dementia in China, but the attitude of the society toward disclosure of such a diagnosis had not been formally evaluated prior to our study. Therefore, we aimed to evaluate the attitude towa...
Article
Background: Mutations in microtubule associated protein tau (MAPT), progranulin (GRN), chromosome 9 open-reading frame 72 (C9orf72) and CHCHD10 genes have been reported causing frontotemporal dementia (FTD) in different populations. However, collective analysis of mutations in these four genes in Chinese FTD patients has not been reported yet. Me...
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Wavelet transform is an effective method for removal of noise from image. But traditional wavelet transform cannot improve the smooth effect and reserve image’s precise details simultaneously; even false Gibbs phenomenon can be produced. This paper proposes a new image denoising method based on adaptive multiscale morphological edge detection beyon...
Article
As detecting the pressure signal is the main method in the real-time leak diagnosis of long pipeline, an abnormal pressure diagnosis method is proposed to make the leak diagnosis rapidly and accurately. Firstly, a combination filter algorithm is designed to realize noise reduction. Then, an anomaly detection algorithm is designed to detect abnormal...
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[This corrects the article on p. 13 in vol. 8, PMID: 26903857.].
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Alzheimer's disease (AD) is the most prevalent form of late-life dementia in the population, characterized by amyloid plaque formation and increased tau deposition, which is modulated by Rho-associated coiled-coil kinase 1 (ROCK1). In this study, we further analyze whether ROCK1 regulates the metabolism of amyloid precursor protein (APP). We show t...
Article
The wind Storage Power Generation System can not only smooth output fluctuation and improve the quality of electric energy, but also can be used as standby power of black start, the research direction is a new way to realize power grid black start. During the process of black start, the wind storage system has characteristics of output fluctuation...
Article
This paper investigates the problems of stability analysis and stabilization for a class of fuzzy hyperbolic time-delay systems. A generalization of the fuzzy hyperbolic time-delay model is firstly proposed, which is more effective in representing nonlinear control systems. By means of the delay-partitioning method, a novel basis-dependent Lyapunov...
Article
This paper investigates the consensus stabilization problem of stochastic multi-agent systems with noises, Markovian switching topology, and communication delays. To solve the consensus problem of the group of interacting agents, it is supposed to use the stochastic approximation type algorithm with the step-size non-decreasing to zero. For stochas...
Article
Okara is a byproduct from the process of soybean foods, and is rich in proteins, fatty acids and dietary fibers. Drying of wet okara is essential for long-term storage and its value-added applications. This study applied response surface methodology and synthetic evaluation method to optimize the drying process of okara in an air jet impingement dr...
Article
Background: Previous studies suggested that plasma sex hormones may be implicated in the pathogenesis of Alzheimer's disease (AD). However, the relationship between sex hormones and AD remains unclear. Objective: To systematically review and quantitatively analyze studies observing plasma total testosterone (TT), estradiol (E2), and sex hormone-...
Article
This study investigated the effect of high hydrostatic pressure processing (HHP, at 0.1 [control], 200, 400 or 600MPa) on purine, taurine, cholesterol, antioxidant micronutrients (Mn, Se, Fe, Zn, Cu, vitamin B2, A and E), DPPH, and reducing power of squids during 10-day storage at 4°C. Compared with the control, pressurization did not change the co...
Article
In this paper, we describe a method for removing Gaussian noise from digital images, based on edge detection and prethresholding Wiener filtering of multi-wavelets fusion. First, we decompose the noisy image by using multiple wavelets, then the edge of image is detected via wavelet multi-scale edge detection. On this basis, the wavelet coefficients...
Article
In this paper, we study stochastic consensus stabilization problems for a stochastic high-order multi-agent system with Markovian switching topologies and stochastic communication noise. By using the generalized It formula for the Markovian switching multi-agent system with stochastic communication noise, a state-feedback controller is constructed...
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Objectives To investigate the association between serum C-reactive protein (CRP) concentration and cognitive impairment as well as interactions between CRP and other relevant factors. Methods Patients with cognitive impairment and 1 to 2 age- and sex-matched controls nested from a population-based study among residents aged 60 years and older in S...
Conference Paper
The paper studies the load distribution optimization in microgrid; Exclusive re searches on microgrid operation are required as it is different from traditional power. The accuracy of load model and its parameters have great effect on micro grid system digital simulation results. The paper establishes a load model that can reflect frequency charact...
Conference Paper
This paper presents a new substation auxiliary control system communication scheme based on WIA industrial wireless technology. The structure and operation principle are introduced, and the technical difficulties and solutions of the WIA industrial wireless technology in substation auxiliary control system application are analyzed from the network...
Article
Objective: We conducted a case-control study to investigate whether TREM2 polymorphism (rs75932628-T) was associated with late onset Alzheimer's disease in Chinese Southern Han population. Methods: PCR-restriction fragment length polymorphism assay was performed to genotype rs75932628 in 279 cases with late onset Alzheimer's diseases patients an...
Article
Previous studies have demonstrated altered metabolites in samples of Alzheimer's disease (AD) patients. However, the sample size from many of them is relatively small and the metabolites are relatively limited. Here we applied a comprehensive platforms using ultra performance liquid chromatography-time-of-flight mass spectrometry and gas chromatogr...
Article
Three-dimensional porous scaffolds of a borosilicate bioactive glass (designated 13-93B1), with the composition 6Na2O-8K2O-8MgO-22CaO-18B2O3-36SiO2-2P2O5 (mol%), were prepared using a foam replication technique and evaluated in vitro and in vivo. Immersion of the scaffolds for 30days in a simulated body fluid in vitro resulted in partial conversion...
Article
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Little is known about the clinical features and treatment of Chinese patients with Parkinson disease (PD). A large cross-sectional survey of clinical features, medication use, and motor complications was conducted in 901 consecutive PD patients, from 42 randomly selected university-affiliated hospitals in four urban economic regions of China, betwe...
Article
Background Recent studies highlight the role of DNA methylation in the pathogenesis of Parkinson's disease (PD). However, there is a paucity of studies exploring the role of blood-based DNA methylation in PD. We aimed to explore identifiable epigenetic biomarkers for PD by analyzing the methylation status of α-synuclein (SNCA) and leucine-rich repe...
Article
Background: The prevalence of cognitive impairment (CI) and its associated risk factors among elderly peoples in China has been investigated. However, dynamic studies revealing the risk factors associated with cognitive decline from follow-up observations in China are rarely performed. Objective: The present study aimed to identify factors predi...
Article
The number of elderly in the world is increasing rapidly, especially in China. The prevalence of dementia among elderly was investigated in a community of Sheshan town, located in the Southwest suburb of Shanghai, China. Face-to-face interviews were conducted to collect relevant information with prepared questionnaires. The Chinese version of the M...
Article
Full-text available
Background/aims: As a suitable test to screen for Alzheimer's disease (AD) or mild cognitive impairment (MCI), studies to validate the Chinese version of Addenbrooke's Cognitive Examination-Revised (ACE-R) are rare. Methods: A total of 151 subjects were recruited and the neuropsychological assessments were employed. One-way analysis of variance...
Article
Genome-wide association studies (GWAS) have identified numerous single-nucleotide polymorphisms (SNPs) that can modulate the risk of developing Parkinson's disease (PD). We investigated the association of previously identified loci in a Mainland Chinese population to identify a possible ethnic-specific effect with GWAS analysis. Seventeen SNPs were...
Article
Fuzzy hyperbolic tangent model (FHM) is a global fuzzy model and also a neural network model. The controller based on the FHM can achieve the optimal performance index of the whole system. Compared to the existing fuzzy models, the FHM is more suitable to model a multi-variable nonlinear system, in which the information of plant is insufficient. Th...
Article
Recently, a large genome-wide association study has revealed that polymorphism of alleles and genotypes in rs3,764,650 within ABCA7 gene is associated with Alzheimer disease in whites. We conducted a case-control study to investigate whether these susceptible genetic variants are risk factors for sporadic Alzheimer disease (SAD) in Chinese Han popu...
Article
Tumescent anesthesia makes it feasible to perform liposuction in an office setting. There are often patients who desire extensive liposuction on approximately 30% of total body surface area, which means the lidocaine total dose might be over the dosing recommendation. So the segmental infiltration is applied, although the concentration of lidocaine...
Article
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The variations of SORCS1 gene may play potential key roles in late-onset Alzheimer's disease (LOAD). To evaluate the relationship between the polymorphism of SORCS1 gene and LOAD in the ethnic Han Chinese, we conducted a case-control study to investigate the association between the single-nucleotide polymorphisms (SNPs) in intron 1 of SORCS1 and LO...
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This paper develops the fuzzy hyperbolic model with time-varying delays guaranteed cost controller design via state-feedback for a class of nonlinear continuous-time systems with parameter uncertainties. A nonlinear quadratic cost function is developed as a performance measurement of the closed-loop fuzzy system based on fuzzy hyperbolic model with...
Article
Background The gluteal concave deformity, a complication of repeated intragluteal injections in childhood, is a relatively common complaint of many young women in China. This issue could be addressed by lipofilling, as the method could produce aesthetically acceptable results in correcting soft tissue contour defects. Methods Twelve patients with b...
Article
Full-text available
Background To explore current status and choices regarding diagnosis and treatment of Parkinson’s disease (PD) among physicians, general neurologists and movement disorders specialists in China via a national survey. Methods The cross-sectional questionnaire-based survey was conducted from November, 2010 to July, 2011. Six hundreds and twelve doct.