Ganesh Panzade

Ganesh Panzade
University of Missouri | Mizzou · Department of Health Management and Informatics

Doctor of Philosophy

About

21
Publications
2,528
Reads
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108
Citations
Introduction
I am working in the field of Bioinformatics, especially concentrated on high-throughput data handling, management, and analysis in genomics. Besides these, I have established researcher in biological databases development. Other functional areas like epigenetics and non-coding RNAs and Big-data management and analysis.
Additional affiliations
February 2019 - present
Kansas State University
Position
  • PostDoc Position
Description
  • miRNA Biology in C. elegans
January 2014 - November 2018
CSIR - Institute of Himalayan Bioresource Technology
Position
  • PhD Student
Description
  • High-throughput data handling, management and analysis in genomic studies
October 2012 - December 2013
CSIR - Institute of Himalayan Bioresource Technology
Position
  • Researcher
Description
  • Epigenetic and transcription regulation by small RNAs: A computational approach
Education
August 2010 - August 2012
Shri Shivaji Science College
Field of study
  • Bioinformatics

Publications

Publications (21)
Article
Full-text available
microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through translational repression and mRNA destabilization. During canonical miRNA biogenesis, several miRNA isoforms, or isomiRs, are produced from a single precursor miRNA. Templated isomiRs are generated through Drosha or Dicer cleavage at alternate positions on either the...
Preprint
microRNAs (miRNAs) are small non-coding RNAs that play crucial roles in development and in disease. miRNAs associate with Argonaute proteins to form miRNA Induced Silencing Complexes (miRISCs), which post-transcriptionally repress gene expression. miRNA-mediated gene repression itself is subject to regulation by factors that can affect miRNA biogen...
Preprint
Full-text available
Animal development is a complex yet robust process that can withstand lengthy and variable interruptions. In Caenorhabditis elegans, adverse conditions can trigger entry into dauer, a stress-resistant, developmentally arrested diapause stage that occurs midway through larval development. Favorable conditions promote recovery from dauer, and post-da...
Article
Full-text available
microRNAs (miRNAs) are crucial for normal development and physiology. To identify factors that might coordinate with miRNAs to regulate gene expression, we used 2′O-methylated oligonucleotides to precipitate Caenorhabditis elegans let-7, miR-58, and miR-2 miRNAs and the associated proteins. A total of 211 proteins were identified through mass-spect...
Preprint
Full-text available
microRNAs (miRNAs) are crucial for normal development and physiology. To identify factors that might coordinate with miRNAs to regulate gene expression, we used 2’-O methylated oligonucleotides to precipitate Caenorhabditis elegans let-7, miR-58, and miR-2 miRNAs and the associated proteins. A total of 211 proteins were identified through mass-spec...
Article
Full-text available
Picrorhiza kurrooa is an endangered medicinal herb which is distributed across the Himalayan region at an altitude between 3000–5000 m above mean sea level. The medicinal properties of P. kurrooa are attributed to monoterpenoid picrosides present in leaf, rhizome and root of the plant. However, no genomic information is currently available for P. k...
Article
The cover image is based on the Advanced Review microRNA strand selection: Unwinding the rules by Jeffrey C. Medley et al., https://doi.org/10.1002/wrna.1627.
Article
Full-text available
microRNAs (miRNAs) play a central role in the regulation of gene expression by targeting specific mRNAs for degradation or translational repression. Each miRNA is post-transcriptionally processed into a duplex comprising two strands. One of the two miRNA strands is selectively loaded into an Argonaute protein to form the miRNA-Induced Silencing Com...
Article
Full-text available
Gene regulation is a highly complex and networked phenomenon where multiple tiers of control determine the cell state in a spatio-temporal manner. Among these, the transcription factors, DNA and histone modifications, and post-transcriptional control by small RNAs like miRNAs serve as major regulators. An understanding of the integrative and spatio...
Article
Full-text available
miRNA have been known to regulate diverse cellular and molecular functions. In the earlier study, we have reported that adipocytes differentiated from human mesenchymal stem cells (hMSC) on 72hr chronic insulin (CI) treatment exhibit insulin resistance (IR). Present study has further explored above model to investigate the role of early expressed m...
Article
Full-text available
Idiopathic Pulmonary Fibrosis (IPF) is an incurable progressive fibrotic disease of the lungs. We currently lack a systematic understanding of IPF biology and a systems approach may offer new therapeutic insights. Here, for the first time, a large volume of high throughput genomics data has been unified to derive the most common molecular signature...
Article
Full-text available
Plants have highly interacted with the environment through phenotypically. The phenotype of plants controls via epigenome by DNA methylation, histone modification, small RNAs like (miRNAs/siRNAs), transcription factors and repetitive elements. These all regulatory factors work together in various stress conditions of plants for the protection or su...
Article
Full-text available
Inspired by the availability of de novo transcriptome of horsegram (Macrotyloma uniflorum) and recent developments in systems biology studies, first ever global protein-protein interactome (PPI) map was constructed for this highly drought tolerant legume. Large-scale studies of PPIs and the constructed database would provide rationale behind the in...
Article
Full-text available
Post ENCODE, regulatory sRNAs (rsRNAs) like miRNAs have established their status as one of the core regulatory elements of cell systems. However, large number of rsRNAs are compromised due to traditional approaches to identify miRNAs, limiting the otherwise vast world of rsRNAs mainly to hair-pin loop bred typical miRNAs. The present study has anal...

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