Ganesh Acharya

Ganesh Acharya
Karolinska Institutet | KI · Department of Clinical Science, Intervention and Technology - CLINTEC

MD, PhD, FRCOG

About

359
Publications
76,398
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
6,377
Citations
Additional affiliations
January 2016 - present
Karolinska Institutet
Position
  • Professor (Full)
February 2008 - present
UiT The Arctic University of Norway
Position
  • Professor
February 2008 - present
UiT-The Arctic University of Norway
Position
  • Professor

Publications

Publications (359)
Article
Full-text available
The natural polyphenol resveratrol (RES) has shown great potential as an antimicrobial, including against microbes associated with vaginal infections. To fully exploit the activities of RES, an all-natural ingredients formulation for RES delivery at vaginal site has been developed, namely liposomes loaded with RES, incorporated into a chitosan hydr...
Article
Objective: To systematically identify and critically assess the quality of clinical practice guidelines (CPGs) for the management of SARS-CoV-2 infection in pregnancy.
Article
Full-text available
Background: The COVID-19 pandemic has contributed to unprecedented worries and challenges for pregnant women due to social restrictions and changes in maternity care provision. We aimed to investigate the mental health impact of COVID-19 pandemic on pregnant women in Sweden and explore factors associated with poor perinatal mental health in this s...
Article
Full-text available
Objectives The relationship between smoking and ovarian reserve markers is inconclusive. The primary objective of our study was to assess the effect of cigarette smoking on the quantitative ovarian reserve parameters, serum anti-Mullerian hormone (AMH) and antral follicle count (AFC) as relevant to prediction of fertility outcomes in women seeking...
Article
Full-text available
Histology involves the observation of structural features in tissues using a microscope. While diffraction-limited optical microscopes are commonly used in histological investigations, their resolving capabilities are insufficient to visualize details at subcellular level. Although a novel set of super-resolution optical microscopy techniques can f...
Article
Full-text available
Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are associated with preeclampsia and fetal growth restriction (FGR). Oxidative stress is counteracted by antioxidants and oxidative rep...
Preprint
Neuronal differentiation of pluripotent stem cells is an established method to study physiology, disease and medication safety. However, the sequence of events in human neuronal differentiation and the ability of in vitro models to recapitulate early brain development are poorly understood. We developed a protocol optimized for the study of early h...
Preprint
Neuronal differentiation from pluripotent cells is commonly used to recapitulate events in early brain development. Neuronal precursors and developing neurons cultured in vivo, rely on attachment, density and cell-to-cell communication, and cell-passaging steps should be minimised to avert disruption of network cross-connectivity. This is crucial b...
Article
Full-text available
Background: Normal mature sperm have a considerably reduced number of mitochondria which provide the energy required for progressive sperm motility. Literature suggests that disorders of sperm motility may be linked to abnormal sperm mitochondrial number and function. Objectives: To summarize the evidence from literature regarding the associatio...
Article
Choorna is a type of formulation in which plant products are mixed in a definite proportion and pulverized before its use. These are given in various disorders with good outcome. Triphala Choorna, Talisadi Choorna, Sitopaladi Choorna, Laghu Gangadhara Choorna, Gangadhara Choorna, Trikatu Choorna, Lavana Bhaskara Choorna, Hingwashtaka Choorna And Hi...
Article
A drop in arterial oxygen content activates fetal chemoreflex including an increase in sympathetic activity leading to peripheral vasoconstriction and redistribution of blood flow to protect the brain, myocardium, and adrenal glands. By using a chronically instrumented fetal sheep model with intact placental circulation at near-term gestation, we i...
Article
Objectives Umbilical artery (UA) Doppler indices are surrogate measures of placental function, most commonly used to assess fetal wellbeing in pregnancies with fetal growth restriction. Fetuses with trisomy 21 (t21) are reported to have elevated UA Doppler indices, but reference percentiles are currently lacking for this population. We hypothesized...
Article
Full-text available
Background The Norwegian Board of Health Supervision aims to contribute to the improvement of quality and patient safety in the healthcare services. Planned audits were performed to investigate how 12 selected Norwegian obstetric units reported and analyzed adverse events as the part of their quality assurance and patient safety work. Methods Seri...
Article
Full-text available
Hormonal changes associated with pregnancy promote oral bacterial growth, which may affect salivary nitric oxide (NO) levels, oxidative stress (OS), and antioxidant capacity (AC). We hypothesized that caries-related bacterial load, NO level, and OS in the saliva change with advancing gestation. The aim of this study was to investigate longitudinal...
Preprint
Full-text available
Background: The COVID-19 pandemic has contributed to unprecedented worries and challenges for pregnant women due to social restrictions and changes in maternity care provision. We aimed to investigate the mental health impact of COVID-19 pandemic on pregnant women in Sweden and explore factors associated with poor perinatal mental health in this sp...
Article
Full-text available
Background: Cytomegalovirus seroconversion during pregnancy is common and has a substantial risk of congenital infection with longterm sequale. Screening during pregnancy or vaccination have not been shown to be effective for eliminating congenital infections. Preconception screening policy has not been evaluated adequately in a large scale. This n...
Article
Full-text available
High space-bandwidth product with high spatial phase sensitivity is indispensable for a single-shot quantitative phase microscopy (QPM) system. It opens avenue for widespread applications of QPM in the field of biomedical imaging. Temporally low coherence light sources are implemented to achieve high spatial phase sensitivity in QPM at the cost of...
Article
BACKGROUND With the help of ART, an advanced parental age is not considered to be a serious obstacle for reproduction anymore. However, significant health risks for future offspring hide behind the success of reproductive medicine for the treatment of reduced fertility associated with late parenthood. Although an advanced maternal age is a well-kno...
Article
Full-text available
Introduction: In the fetus, a large proportion of the superior vena cava blood flow (Q SVC ) comes from the brain. To provide the possibility of using this blood flow as a representation of fetal brain circulation, we aimed to determine the fetal Q SVC and its fraction of cardiac output during the second half of physiological pregnancies. Materials...
Article
(Acta Obstet Gynecol Scand. 2020;99:815–816) While some countries have reported no increased risk of COVID-19 infection or severity, a report from Sweden analyzing 108 cases of COVID-19 in pregnancy suggests otherwise. The study found pregnant and early postpartum women with COVID-19, compared to non-pregnant women, had a relative risk (RR) to rece...
Article
Objectives: The primary aim of this study was to evaluate the feasibility of measuring fetal atrioventricular plane displacement (AVPD) using an automated analysis software. The secondary objectives were to establish reference ranges for AVPD during the second half of normal pregnancy, assess fetal AVPD in prolonged pregnancies in relation to adve...
Preprint
Histopathological assessment involves the identification of anatomical variations in tissues that are associated with diseases. While diffraction-limited optical microscopes assist in the diagnosis of a wide variety of pathologies, their resolving capabilities are insufficient to visualize some anomalies at subcellular level. Although a novel set o...
Preprint
Full-text available
Histopathological assessment involves the identification of anatomical variations in tissues that are associated with diseases. While diffraction-limited optical microscopes assist in the diagnosis of a wide variety of pathologies, their resolving capabilities are insufficient to visualize some anomalies at subcellular level. Although a novel set o...
Article
Full-text available
Background: Physiological adaptation in pregnancy is characterized by remodeling of endocrine, cardiovascular and renal functions leading to fluid retention, volume expansion, altered cardiac loading conditions and hyperdynamic circulation. Natriuretic peptides have been used as biomarkers of cardiovascular function, but their associations with ge...
Article
Industrial chemicals such as persistent organic pollutants (POPs) have been associated with reduced fertility in women, including longer time-to-pregnancy (TTP), higher odds for infertility, and earlier reproductive senescence. Fertility is highly dependent on the ovarian reserve, which is composed of a prenatally determined stock of non-growing fo...
Preprint
Background: Normal mature sperm have a considerably reduced number of mitochondria which provide the energy required for progressive sperm motility. Literature suggests that disorders of sperm motility may be linked to abnormal sperm mitochondrial number and function. Objectives: To summarise the evidence from literature regarding the association o...
Research
To investigate the impact of a web-based psychosocial intervention on EPDS among urban pregnant women living in Hong Kong and Shanghai.
Article
Full-text available
Background Nifedipine is widely used drug in pregnancies complicated by maternal hypertensive disorders that can be associated with placental insufficiency and fetal hypoxemia. The evidence regarding fetal myocardial responses to nifedipine in hypoxemia is limited. Objective We hypothesized that nifedipine would not impair fetal sheep cardiac func...
Article
Full-text available
(Acta Obstet Gynecol Scand. 2020;99:565–568) The vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from mother-to-fetus has been highly debated, and there are varied recommendations for testing and classifying parturients suspected of COVID-19 infection. Newborns with a coronavirus disease 2019 (COVID-19) infecti...
Article
Full-text available
Background Fetal superior vena cava (SVC) is essentially the single vessel returning blood from the upper body to the heart. With approximately 80-85% of SVC blood flow representing cerebral venous return, its interrogation may provide clinically relevant information about fetal brain circulation. However, normal reference values for fetal SVC Dopp...
Article
Background Most retractions of ob-gyn manuscripts are due to scientific misconduct. It would be preferable to prevent randomized controlled trials (RCTs) with scientific misconduct from ever appearing in the peer-reviewed scientific literature, rather than to have to retract them later. Objective To evaluate the policies of ob-gyn and top medical...
Article
Asavarishtapreparations are popularly used by Ayurveda physicians in the management of various disorders in modern India . Asavarishtas like Balarishta, Ashokarishta, Ashwagandharishta, Abhayarishta, Chandanasava, Chavikasava, Dashamoolarishta , Chitrakasava, Dantyarishta, Eladyarishta , Jeerakarishta , Kutajarishta , Kanakasava , Kankushthasava, L...
Preprint
High space-bandwidth product with high spatial phase sensitivity is indispensable for a single-shot quantitative phase microscopy (QPM) system. It opens avenue for widespread applications of QPM in the field of biomedical imaging. Temporally low coherence length light sources are generally implemented to achieve high spatial phase sensitivity in QP...
Article
Full-text available
Chlamydia trachomatis is the most common cause of bacterial sexually transmitted infections and causes serious reproductive tract complications among women. The limitations of existing oral antibiotics and treatment of antimicrobial resistance require alternative treatment options. We are proposing, for the first time, the natural polyphenol resver...
Article
Full-text available
Introduction Mental health disorders are common during pregnancy and the postnatal period and can have serious adverse effects on women and their children. The consequences for global mental health due to COVID-19 are likely to be significant and may have a long-term impact on the global burden of disease. Besides physical vulnerability, pregnant w...
Article
Full-text available
Background: Saliva plays a significant role in maintaining oral health and oral bacterial milieu. Difference in oxidative stress (OS) levels in saliva in conjunction with bacterial load between pregnant and non-pregnant women has not been studied previously. We hypothesized that the physiological changes in pregnancy alter oral bacterial milieu by...
Article
Full-text available
Background: Fetal anemia is associated with a hyperdynamic circulation and cardiac remodeling. Rapid intrauterine transfusion (IUT) of blood with high hematocrit and viscosity into the umbilical vein used to treat this condition can temporarily further affect fetal heart function. The aim of this study was to evaluate the short-term changes in fet...
Article
Full-text available
Sperm cell motility and morphology observed under the bright field microscopy are the only criteria for selecting a particular sperm cell during Intracytoplasmic Sperm Injection (ICSI) procedure of Assisted Reproductive Technology (ART). Several factors such as oxidative stress, cryopreservation, heat, smoking and alcohol consumption, are negativel...
Article
Objective This study was aimed to report the incidence of neonatal morbidity in monochorionic monoamniotic (MCMA) twin pregnancies according to gestational age at birth and type of management adopted (inpatient or outpatient). Study Design Medline and Embase databases were searched. Inclusion criteria were nonanomalous MCMA twins. The primary outco...
Article
Full-text available
Introduction: Cerebroplacental ratio (CPR) and umbilicocerebral ratio (UCR) are clinically used as a measure of fetal brain sparing. These are calculated as the ratios between the pulsatility indices (PIs) of middle cerebral (MCA) and umbilical (UA) arteries, and are an indirect representation of the balance between cerebral and placental perfusio...
Article
Full-text available
Introduction: The Norwegian Board of Health Supervision inspects healthcare institutions to ensure safety and quality of health and welfare services. A planned inspection of 12 maternity units aimed to investigate the practice of obstetric care in the events of birth asphyxia, shoulder dystocia and severe postpartum hemorrhage. Material and metho...
Article
Full-text available
Those who are infected with Severe Acute Respiratory Syndrome‐related CoronaVirus‐2 are theoretically at increased risk of venous thromboembolism during self‐isolation, if they have reduced mobility or are dehydrated. Should patients develop coronavirus disease (COVID‐19) pneumonia requiring hospital admission for treatment of hypoxia, the risk for...
Article
Full-text available
Super-resolution fluorescence microscopy is a widely employed technique in cell biology research, yet remains relatively unexplored in the field of histopathology. Here, we describe the sample preparation steps and acquisition parameters necessary to obtain fluorescent multicolor super-resolution structured illumination microscopy (SIM) images of b...
Article
In pregnancy during an inflammatory condition, macrophages present at the feto-maternal junction release an increased amount of nitric oxide (NO) and pro-inflammatory cytokines such as TNF-α and INF-γ, which can disturb the trophoblast functions and pregnancy outcome. Measurement of the cellular and sub-cellular morphological modifications associat...
Article
Full-text available
With the pandemic of Coronavirus disease‐19 (COVID‐19) spiraling out of control, the world is desperately frazzled at the moment. A few empirical studies related to this pandemic have reported higher prevalence of mental health problems among women compared to men.1 In this context, pregnant women and new mothers could certainly be more vulnerable....
Article
Nordic countries have a long tradition of collecting health related population data meticulously and reporting them transparently. Such data provide firm grounds for making good decisions and as a result the public health institutions in Scandinavia enjoy the trust of society. The Covid‐19 pandemic has, however, resulted in a completely new situati...
Article
First, we want to thank Dr Bijoy Balakrishnan, Department of Fetal Medicine, Cimar Fertility Center, Cochin, India for recently making us aware of a typographical error in our article published in AOGS.1 When discussing ventricular rhythms with a shorter time interval between two consecutive ventricular contractions (VV‐interval) that systematicall...
Article
The possibility of mother‐to‐fetus transmission of SARS‐CoV‐2, the cause of coronavirus disease 2019 (COVID‐19), is currently a highly debated concept in perinatal medicine. It has implications for the mother, fetus, and neonate, as well as for healthcare providers present at the time of birth and caring for the child during the neonatal period, in...
Article
Full-text available
The Karolinska Institutet Human Embryonic Stem Cell Bank (KI Stem Cell Bank) was established at KI, Stockholm, Sweden, when the first human embryonic stem cell (hESC) line was derived by Professor Hovatta and colleagues in 2002. Since then, the bank has grown to include 60 hESC lines. From the very beginning the aim of the bank has been derivation...
Preprint
Full-text available
Super-resolution fluorescence microscopy is a widely employed technique in cell biology research, yet remains relatively unexplored in the field of histo-pathology. Here, we describe the sample preparation steps and acquisition parameters necessary to obtain fluorescent multicolor super-resolution structured illumination microscopy (SIM) images of...
Article
Full-text available
China's healthcare is improving together with rapid economic growth. Yet, mental healthcare is lagging behind. Prevalence of perinatal depression is high among women of the one-child generation, but access to qualified care is limited. Chinese healthcare professionals, policy makers and patients alike express concerns about insufficient knowledge a...
Preprint
Full-text available
Sperm cell motility and morphology observed under the bright field microscopy are the only criteria for selecting particular sperm cell during Intracytoplasmic Sperm Injection (ICSI) procedure of Assisted Reproductive Technology (ART). Several factors such as, oxidative stress, cryopreservation, heat, smoking and alcohol consumption, are negatively...
Article
Purpose of the article. To explore the role of fetal echocardiography in predicting the risk of urgent balloon atrial septostomy (BAS) at birth in fetuses diagnosed with transposition of the great arteries (TGA). Material and methods: Medline, Embase, and Cochrane databases were searched. The primary aim was to explore the differences in prenatal e...
Preprint
Full-text available
During inflammatory condition in pregnancy, the macrophages present at the feto-maternal junction release an increased amount of NO and pro-inflammatory cytokines such as TNF-α and INF-γ, which can disturb the trophoblast functions and thereby the pregnancy outcome. Measurement of the cellular and sub-cellular morphological modifications associated...