Gamal Thabet

Gamal Thabet
National Cancer Institute Egypt | NCI · Clinical pathology

MD

About

27
Publications
2,567
Reads
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178
Citations
Additional affiliations
March 2012 - April 2012
St. Jude Children's Research Hospital
Position
  • Researcher
July 2011 - October 2011
Fred Hutchinson Cancer Research Center
Position
  • Researcher
February 2003 - December 2003
King Faisal Specialist Hospital and Research Centre
Position
  • Researcher

Publications

Publications (27)
Article
Full-text available
Objectives: This study aims to investigate hemostatic changes in patients with coronavirus disease (COVID-19) and their relationship to disease severity and survival. Methods: This study included 284 patients with COVID-19 who attended the Security Forces Hospital, Makkah, Saudi Arabia between October 2020 and March 2021, and retrospectively review...
Article
Full-text available
This study was designed to evaluate the effect of Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms on MTX toxicity in pediatric Egyptian ALL patients. Ninety-Four of Pediatric ALL patients aged 3-13 years (7.6 ± 3.6) on oral maintenance dose of 50 mg/m2 weekly of MTX. MTHFR c.677C>T (rs1801133) and c.1298A>C (rs1801131) genotyping wer...
Article
Full-text available
Background Type1 diabetes mellitus (T1DM) has a multi-factorial pathogenesis; the interplay between genetic susceptibility and environmental factors is thought to provide the fundamental element for the disease. Apart from HLA, more than 50 genetic variants are associated with T1DM. INS -23/Hph1 A>T (rs689) is one of the effective loci with inconsi...
Article
Full-text available
Background: Prostate cancer (PC) is considered the fifth most common cancer causing death worldwide. Many studies have pointed to dysregulated microRNA (miRNA) expression in PC and their use in early detection and follow-up of the disease. In addition, the Prostate Health Index (PHI) is the FDA-approved blood test joining total, free, and -2proPSA...
Article
Background: Genotypic mutation of FLT3, NPM1, and DNMT3A has been involved in the leukemogenesis of acute myeloid leukemia, with well-known poor prognostic role of FLT3 and DNMT3A and favourable for NPM1 mutation. Methods: A total of 123 patients with AML treated at NCI, Cairo University were examined for mutations in DNMT3A, FLT3 and NPM1 by poly...
Article
Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic stem cell transplantation (HSCT); cytokines are recognized as important mediators in its pathogenesis. In this study we investigated the role of cytokine gene polymorphisms on HSCT outcome. A total of 106 patient and 98 donors were genotyped by polymerase chain r...
Article
Full-text available
To study the effect of MATE 1, MATE 2 and OCT1 genetic variants on metformin action in recently diagnosed Egyptian Type-2 diabetic patients. Patients & Methods: One hundred type-2 DM patients and forty healthy control were included in the study. All patients were recently diagnosed receiving no treatment before participation in the study. Three sin...
Article
Full-text available
Background and objectives: Detection of chromosomal abnormalities in myeloproliferative disorders is important for proper diagnosis of these disorders. This study has investigated the presence of JAK2 mutation (V617F) in Egyptian patients with myeloproliferative disorders referred to National Cancer institute, Cairo University. Methods: The stud...
Conference Paper
Full-text available
Background and Purpose: The etiology of pediatric Acute lymphoblastic leukima is multifactorial. Several studies reported that genetic polymorphisms are associated with an altered risk of development of ALL. 5,10-Methylenetetrahydofolate reductase (MTHFR), Glutathione S-Transferase gene (GSTM1, GSTT1, GSTP1), NADP(H): quinine oxidoreductase (NQO1),...
Article
Full-text available
N-Acetyltransferases (NAT) have been known to modify the risk to a variety of solid tumors. However, the role of NAT2 polymorphism in risk susceptibility to childhood acute lymphoblastic leukemia (ALL) is still not well known. We performed a case-control study to determine if the common NAT2 polymorphisms play a role in altering susceptibility to p...
Conference Paper
In spite of prophylactic measures GVHD continues to be one of the serious complications that affect transplantation-related morbidity and mortality. We have previously reported a role of cytokines in the prediction of aGVHD (Kamel et al, 54th ASH Annual meeting, December 8-11.2012.Publicaion Number 1956. Nov 2012; 120: 195 and J Leuk 2013, 1:2 http...
Article
Introduction: P-glycoprotein (PGP), encoded by the MDR1 gene is a trans-membrane active efflux pump for a variety of environmental toxins and xenobiotics. Studies have evaluated the association between MDR1 C3435T polymorphism, cancer susceptibility and therapeutic outcome. Methods: In our study we identified the MDR1 C3435T polymorphism in 94 bre...
Article
In spite of prophylactic measures GVHD continues to be one of the serious complications that affect transplantation-related morbidity and mortality. We have previously reported a role of cytokines in the prediction of aGVHD (Kamel et al, 54th ASH Annual meeting, December 8-11.2012.Publicaion Number 1956. Nov 2012; 120: 195 and J Leuk 2013, 1:2 http...
Article
Full-text available
Cytochrome P450 3A4 (CYP3A4) is the most plentiful cytochrome P450 in adult human liver and small intestine and is responsible for detoxification of more than 50% of drugs in addition to the metabolic deactivation and metabolism of many carcinogens. Polymorphism of CYP3A4-A-290G considered the only allele that appears to stimulate CYP3A4 expression...
Article
Full-text available
Background: Type 1 diabetes is one of the most common chronic childhood illnesses. Interplay between genetic susceptibility and environmental factors is thought to provide the fundamental element for the disease. Apart from the Major Histocompatibility locus which is the main contributor to risk susceptibility, more than 40 loci are recognized. One...
Article
Full-text available
Background: The P53 tumor suppressor gene plays a pivotal role in maintaining cellular homeostasis by preventing the propagation of genome mutations. P53 in its transcriptionally active form is capable of activating distinct target genes that contribute to either apoptosis or growth arrest, like P21. However, the MDM2 gene is a major negative regu...
Article
Full-text available
Abstract: Molecular characterization of acute myeloid leukemia (AML) allows prognostic stratification and assessment of the chances of durable treatment response. The presence of FLT3 internal tandem duplication (ITD) mutation as well as the allelic ratio (ITD-AR) and JAK2 V617F mutation may be associated with clinical outcome in patients with AML....
Article
Full-text available
Abstract: Background: Mercaptopurine is one of the most important drugs used in cancer treatment. Its elimination depends mainly on the enzyme Thiopurine S-methyl Transferase (TPMT). A number of known genetic polymorphisms can affect the activity of this enzyme. Aim of the work: to study the pattern of TPMT polymorphisms in a cohort of Egyptian pat...
Article
Full-text available
Acute lymphoblastic leukemia is the major pediatric cancer in developed countries. To date most association studies of acute lymphoblastic leukemia have been based on the candidate gene approach and have evaluated a restricted number of polymorphisms. Such studies have served to highlight difficulties in conducting statistically and methodologicall...
Article
ALL is the most common pediatric cancer. The causes of the majority of pediatric acute leukemia are unknown and are likely to involve an interaction between genetic and environmental factors. Therefore, unfavourable gene-environmental interactions might be involved in the genesis of ALL. The aim of this work was to evaluate, in a case-control study...
Article
Full-text available
Background and Aim: Diagnosis of meningeal local- ization of lymphoid malignancies by means of cytologic examination of the cerebrospinal fluid (CSF) can be difficult. Thus far, no reliable CSF tumor marker has been identified. The aim of this study is to determine prospectively the value of CSF soluble interleukin-2 receptor (sIL-2R) for the diagn...

Questions

Question (1)
Question
if there is some SNPs at introns that showed a higher prevalence more than 1%, is it significant to study such SNPs some diseases without solid scientific correlations.

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Projects

Projects (3)
Archived project
Study Pharmacogenetic of Peripheral Blood Stem Cell Transplantation From An Identical Sibling. including paharmacogenetics of Drugs used as conditioning regimen and Role of Cytokine gene polymorphisms
Archived project
Study the Effect of DNA repair and Drug metabolizing enzymes Gene Polymorphisms as a risk factors in Acute Myeliod Leukemia