Gail Mahady

Gail Mahady
University of Illinois at Chicago | UIC · Department of Pharmacy Practice

Doctor of Philosophy

About

194
Publications
76,918
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
5,367
Citations

Publications

Publications (194)
Article
Introduction: In previous work, we have shown the synergistic effects of combinations of vitamins A, D2, and D3 in reducing the proliferation of HCT-116 colon cancer cells. This combination also induced apoptosis and altered gene expression patterns as determined by transcriptomic profiling. Aims: The aims of this study were to investigate the effe...
Chapter
To optimize clinical outcomes and reduce the risk of adverse events, it is important that patients adhere to drug regimens. In general, patients should carefully follow the label instructions for proper administration of all medications. Some medications should be taken with a full glass of water, some must be taken with food, while others should b...
Chapter
Traditional and herbal medicines (THM) are recognized by the World Health Organization to significantly contribute to the goal of ensuring healthcare for all people, when they are proven to be of sufficient quality, safety, and efficacy. Over the past 10 years the publication of Good Manufacturing guidelines by many countries has been a significant...
Article
Experimental and clinical studies suggest a positive impact of anthocyanins on bone health; however, the mechanisms of anthocyanins altering the differentiation and function of osteoblasts and osteoclasts are not fully understood. This work demonstrates that dietary anthocyanins and resveratrol increased proliferation of cultured human hFOB 1.19 os...
Article
Full-text available
Integrated systems biology approaches suggest that combinations of nutrients may be more effective against cancer due to the large number of signaling pathways associated with cancer initiation and promotion. In a previous work, we have reported that combinations of vitamins A (as all trans-retinoic acid, ATRA), D2, and D3 act synergistically to in...
Article
Background Dillenia indica L. (Dilleniaceae) and Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) are used in traditional Nigerian medicine to treat various forms of cancer. This study investigated the cytotoxic effects of these plant extracts using COV434 granulosa tumor and MCF-7 breast cancer cells. Methods Samples of D. indica and A....
Article
Tuberculosis is a highly infectious disease declared a global health emergency by the World Health Organization, with approximately one third of the world's population being latently infected with Mycobacterium tuberculosis. Tuberculosis treatment consists in an intensive phase and a continuation phase. Unfortunately, the appearance of multi drug-r...
Article
Full-text available
Objective: To evaluate the effect LMHFV on body weight gain, NAFLD and muscle strength and explore effect in mitochondrial biogenesis, AMPKα and p38 pathways. Methods: Vibration platform used in this study provides specific whole-body cyclic mechanical stimulation at low magnitude (0.3 g) and high frequency (50 Hz). Diabetic mice (8-9 mice per g...
Article
Sarcopenia is a geriatric syndrome that is characterized by low muscle mass, strength, and function, that increases morbidity and mortality, and the rates of hospitalization and nursing home admissions in geriatric populations. Poor nutritional intake and alterations in the muscle response to anabolic stimuli from meals in aging populations contrib...
Article
Full-text available
The anthocyanin delphinidin is a natural compound found as water‐soluble pigment in coloured fruits and berries. Anthocyanin‐rich diets have earlier been proposed to have bone protective effects in humans and mice, but the underlying mechanisms remain unclear. In this study, we used a medaka (Oryzias latipes) osteoporosis model to test the effects...
Article
Full-text available
Acori Tatarinowii Rhizome (ATR, the dried rhizome of Acorus tatarinowii Schott), a well-recognized traditional Chinese herbal medicine, is prescribed to treat neurological disorders. The essential oil is considered as the active fraction of ATR, and the neuroprotection of ATR essential oil (ATEO) is proven, including the protection against oxidativ...
Article
Full-text available
Oral diseases are considered the most common noncommunicable diseases and are related to serious local and systemic disorders. Oral pathogens can grow and spread in the oral mucosae and frequently in biomaterials (e.g., dentures or prostheses) under polymicrobial biofilms, leading to several disorders such as dental caries and periodontal disease....
Article
Background Leukotrienes are powerful mediators of inflammation and interact with specific receptors in target cell membrane to initiate an inflammatory response. Thus, leukotrienes (LTs) are considered to be potent mediators of inflammatory diseases including allergic rhinitis, inflammatory bowel disease and asthma. Leukotriene B4 and the series of...
Article
Background Purified fractions from a Boswellia serrata Roxb. Ex. Colebr. (Burseraceae) extract (ETOH and DCM) contain biologically active compounds that are well known for having inflammation inhibitory properties. In this work, the purified fractions were tested in-vitro for LTC4, LTA4 and COX-2 activities using ELISA and qPCR was performed to det...
Article
Full-text available
Background: Vitamin D was first hypothesized to play a role in cancer chemoprevention in 1980 when it was observed that there was a higher rate of colon cancer in the Northern USA as compared with populations living in the South. While cholecalciferol (vitamin D3) has been tested in many cancer cell lines, published results for ergocalciferol (vita...
Article
Background: Vitamin D was first hypothesized to play a role in cancer chemoprevention in 1980 when it was observed that there was a higher rate of colon cancer in the Northern USA as compared with populations living in the South. While cholecalciferol (vitamin D3) has been tested in many cancer-cell lines, published results for ergocalciferol (vita...
Article
Osteoporosis and osteopenia impact more than 54 million Americans, resulting in significant morbidity and mortality. Alterations in bone remodeling are the hallmarks for osteoporosis, and thus the development of novel treatments that will prevent or treat bone diseases would be clinically significant, and improve the quality of life for these patie...
Article
Full-text available
Context: Pimenta dioica (L.) Merr. (Myrtaceae) is used in Costa Rican traditional medicine for women’s health. Our previous work showed that P. dioica extracts were oestrogenic. Objectives: This work identifies phytochemicals from P. dioica that are responsible for the plant’s oestrogen-like activities. Materials and methods: P. dioica leaves were...
Article
Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected...
Article
Full-text available
Article
Full-text available
Poster
Full-text available
Best Poster Presentation Award _ Excellent Contribution to the Functional Food Center 22nd Annual Conference at the HARVARD MEDICAL SCHOOL, Boston, MA, USA
Chapter
Over the past 20 years, Central America (CA) has made considerable progress in improving the health status of its populations. However, in some countries, the overall health status remains below average with poor outcomes concentrated geographically among the poor and Indigenous populations. Although Indigenous people make up the second largest pop...
Poster
Full-text available
In serum-starved L6 cells, both extracts prevented L6 cell apoptosis, and in glucose and serum starved cell, the extracts also prevented cell death and apoptosis. Of the anthocyanins present in the extracts, cyanidin-3-glucoside was the most active and enhanced L6 growth by 200%. These data suggest that fruit extracts reduce muscle cell apoptosis a...
Chapter
Full-text available
Sarcopenia is caused by the progressive loss of skeletal muscle mass (myopenia) and strength (dynapenia) over decades, and is a significant cause of frailty and disability in the elderly. However, sarcopenia has also been observed in younger patients, including those with inflammatory diseases, physical disabilities, malnutrition and cachexia. Maln...
Article
Background: Now-a-days, discovery of bioactive compounds of plant origin is playing very important role in treatment of various ailments without any side effect world widely. Since, time immemorial, plants have been utilized as a source of Traditional System of Medicine and in India, one of the well known system is Ayurvedic System of Medicine that...
Chapter
Full-text available
The purpose of this chapter is to review some of the most common drug interactions with food and beverages. By acting on gastric motility, pH, and drug metabolism, food and beverages can have a variety of effects on the absorption and metabolism of prescription drugs, as well as vitamins and minerals. The clinical significance of these interactions...
Article
Full-text available
Tuberculosis is a highly infectious disease declared a global health emergency by the World Health Organization, with approximately one third of the world's population being latently infected with Mycobacterium tuberculosis. Tuberculosis treatment consists in an intensive phase and a continuation phase. Unfortunately, the appearance of multi drug-r...
Article
Similar to their US counterparts, Costa Rican women enter menopause at ∼50 years of age, have similar symptoms, including hot flashes and night sweats, as well as an overall negative attitude toward the menopausal transition. One study of rural women in Monteverde reported that women knew little about the menopausal transition, as the subject was n...
Chapter
Full-text available
In general, for proper administration of medications, patients should follow the label instructions carefully. Some medications should be taken with a full glass of water; some must be taken with food, while others should be taken on an empty stomach. Patients should consult with a physician or pharmacist to determine if there are any foods that sh...
Article
Full-text available
Background: Ganoderma (Ganodermataceae), a genus of medicinal mushrooms, has been employed as an herbal medicine in Traditional Chinese medicine (TCM) for over 2000 years. The fruiting bodies have been used historically in TCM, while the mycelia, and spores are now also used as a tonic, to stimulate the immune system and treat many diseases, includ...
Article
Full-text available
Background: To determine the mechanism by which the flavonoid glycoside astragalin (AST) reduces ovarian failure in an aged rat model of menopause. Methods: The in vivo effect of AST on granulosa cell (GC) apoptosis in aged female rats was determined using flow cytometry. In vitro, the effects of AST on cultured GCs were investigated using the M...
Article
Background—Ginger root (Zingiber officinale) has been used traditionally for the treatment of gastrointestinal ailments such as motion sickness, dyspepsia and hyperemesis gravidarum, and is also reported to have chemopreventative activity in animal models. The gingerols are a group of structurally related polyphenolic compounds isolated from ginger...
Article
Chlamydia pneumoniae (CP) is an intracellular gram-negative pathogen, responsible for 5 – 30% of acute respiratory tract infections worldwide [1, 2]. In this investigation the activity of Curcuma longa L. and Zingiber officinalis L. (Zingiberaceae) methanol extracts were assessed on the proliferation of CP in HEp-2 cells. CP isolates, TW 183 (ATCC...
Article
Gingivitis and periodontial disease are inflammatory disorders that lead to the progressive destruction of gingival tissues and alveolar bone. The mechanisms underlying the destructive processes involve both direct tissue damage, resulting from periodontal pathogens, and indirect damage through host inflammatory reaction. Invasive pathogenic anerob...
Article
Full-text available
The effect of Menoprogen (MPG) on ovarian granulosa cell (GC) apoptosis was investigated in vitro and in vivo in an aged rat model of menopause. Intragastric administration of Menoprogen or estradiol valerate to 14-month-old senile female rats for eight weeks increased plasma E 2 levels, as well as the weight of both ovarian and uterine tissues....
Article
Traditional medicines (TMs) continue to serve the healthcare needs of millions, if not billions, of people worldwide. Herbal medicines (HMs) play a central role in TM and can contribute to the goal of ensuring healthcare for all people, when proven to be of sufficient quality, safety, and efficacy. However, continuing problems that deter the progre...
Chapter
Recent data suggest that the global herbal medicines market continues to increase, with estimates of annual sales as high as $160 B USD. In the United States alone, almost 30 % of U.S. adults use herbal medicines, and of the $11.5 billion spent annually on dietary supplements in the U.S., over half a billion dollars are spent on herbal products. Wo...
Article
Full-text available
Ethnopharmacological relevance: In Central America, most Maya women use ethnomedicines for all aspects of their reproductive cycle including menstruation, pregnancy and menopause. However, very few of these plants have been documented, collected and tested in appropriate pharmacological assays to determine possible safety and efficacy. The aim of...
Article
Icaritin, a prenylflavonoid isolated from Herbal Epimedii, is well known for its osteoplastic and anti-tumour activities. Here, we examined the cardioprotective actions of icaritin on cardiac H9c2 cells under oxidative stress conditions induced by treatment with tert-butylhydroperoxide (t-BHP). Icaritin at a concentration range between 1 and 4 μM e...
Article
Full-text available
Menoprogen (MPG), a TCM herbal formula improves menopausal symptoms in clinical trials, however its mechanism has remained elusive. Previous studies show that MPG is not directly estrogenic, thus the goal of this study was to investigate the effects of MPG on IGF-1 and IGFBP-1 levels in an aged female rat model of menopause. In a six-armed study, 1...
Article
A traditional Chinese medical (TCM) formula, containing five medicinal herbs including Morus alba L. (mulberry; Moraceae), has been shown to be effective in clinical trials for the management of menopausal symptoms. Mulberry has been used in TCM for thousands of years for the treatment of a wide range of women's reproductive disorders including bre...
Article
The effects of Menoprogen (MPG), a traditional Chinese medicine formulation for menopause, were determined on granulosa cell (GC) apoptosis in an aged rat model of menopause. Intragastric administration of MPG or estradiol valerate to 14-month-old female rats for 8 weeks increased plasma estrogen levels and the weight of both ovarian and uterine ti...
Article
Menoprogen (MPG), a traditional Chinese medicine formula for menopause, improves menopausal symptoms; however, its mechanism remains unknown. Previous studies have shown that MPG is not directly estrogenic; thus, the goal of this study was to investigate the effects of MPG on insulin-like growth factor-1 (IGF-1) and insulin-like growth factor bindi...
Chapter
Since the 1930s, natural products have played a significant role in the discovery of new classes and novel antibiotic drugs; and in fact, most antibacterial drugs were derived directly from natural products or discovered using a natural product lead. In addition to bacterial and fungal sources of natural antimicrobial agents, traditional plant-base...
Conference Paper
Human epidermal growth factor 2 (HER2) is a trans-membrane tyrosine kinase that is over expressed in 20% of breast cancers. Overexpression of HER2 has been linked to tumor proliferation and poor prognosis. Numerous studies have focused on targeting HER2 for breast cancer treatment. The leaves of Pimenta dioica (L.) Merr. (Myrtaceae), commonly known...
Article
Aims: To investigate the in vitro and in vivo anti-inflammatory effects of Bacopa monnieri extracts in HL-60 cells and in OVA-induced airway inflammation in BALB/C mice. Materials and Methods: Bacopa monnieri (Brahmi) leaves and stems were collected in Vidisha (M.P.), India, identified and air-dried. The dried plant materials were pulverized to a p...
Conference Paper
Full-text available
Brosimum alicastrum Swingle (Moraceae) is a large, evergreen canopy tree found throughout the Neotropics and is native to Guatemala and Costa Rica. The fruit of the tree is also known as “Mayan bread fruit” or breadnut. The seeds and the fruit of the tree have been used in traditional Mayan medicine for the treatment of menopause and osteoporosis,...
Article
Full-text available
Allium ascalonicum Linn. and Gladiolus psittacinus Hook., are two important plants cultivated across the world for their nutritional as well as medicinal values. In the quest for a more natural bioactive substance to check the rising incidence of antimicrobial resistance amongst pathogens, these two plants were in this study, screened for activity...
Article
Full-text available
High prevalence of multidrug-resistant microorganisms in the etiologic structure of different infectious processes significantly decreases the effectiveness of the treatment and enhances the probability of an unfavorable outcome from the infection. Combinations between antibiotics and other antimicrobial agents represent one of the most promising a...
Article
Full-text available
Background The risks attributed to drug-herb interactions, even when known, are often ignored or underestimated, especially for those involving anti-clotting drugs and Chinese medicines. The aim of this study was to structurally search and evaluate the existing evidence-based data associated with potential drug interactions between anticoagulant/an...
Data
Summary of review articles to retrieve relevant information about interactions between anticoagulants/antiplatelet drugs and natural products/herbs (including CMHs). (DOCX)
Chapter
Key Points Black cohosh is an alternative therapy used for the management of menopausal symptoms by ­perimenopausal and postmenopausal women. Data from the clinical trials are, at best, conflicted with many older clinical trials of poor quality showing beneficial effects in reducing vasomotor symptoms and the Kupperman Index. However, the most rece...
Data
Full-text available
The Central American (CA) isthmus consists of seven countries including Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua and Panama, some of the poorest countries in the world. Over the past twenty years, CA has made good progress in improving the health status of their populations. Analysis of the peer-reviewed literature, as well a...
Article
Full-text available
The botanical status in EU, USA, and Thailand is different owing to the regulatory status, the progress of science, and the influence of culture and society. In the EU, botanicals are positioned as herbal medicinal products and food supplements, in the US they are regulated as dietary supplements but often used as traditional medicines, and in Thai...
Article
Full-text available
The present study was a collaborative research project with the Q'eqchi Maya of Livingston, Izabal, to explore the influence of sociocultural factors on the health and well-being of Q'eqchi women and the role of plant medicines in treating women's health conditions. Data were obtained through participant observation, semi-structured interviews, foc...