Gaelle Hogrel

Gaelle Hogrel
Perha Pharmaceuticals

PhD in protein Science
Dyrk1A in neurologic disorders - Past: Bacterial immune defense systems, DNA repair & protein quality control in Archaea

About

9
Publications
852
Reads
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57
Citations
Citations since 2016
7 Research Items
50 Citations
20162017201820192020202120220246810
20162017201820192020202120220246810
20162017201820192020202120220246810
20162017201820192020202120220246810
Additional affiliations
January 2018 - December 2019
Institut Français de Recherche pour l'Exploitation de la Mer
Position
  • PostDoc Position
Description
  • - Research project on homologous recombination in extremophilic archaea. - Reconstitution in vitro of recombination-associated DNA synthesis assays on supercoiled DNA substrate with the recombinase RadA and DNA polymerases.
January 2016 - December 2017
Institut de Biologie Structurale (IBS)
Position
  • PostDoc Position
Description
  • - Functional and structural analysis of unkown proteins interacting with the archaeal proteasome machinery. - Analysis of interactomic data obtained by pull-down experiment combined with mass spectrometry identification.
September 2012 - September 2015
Université de Bretagne Occidentale
Position
  • PhD Student
Description
  • - Characterization of protein/protein interactions by functional and biophysical approaches. - Project focus on DNA recombination and replication
Education
September 2012 - December 2015
Université de Bretagne Occidentale
Field of study
  • Protein sciences
September 2007 - June 2012
Institut National des Sciences Appliquées de Toulouse
Field of study
  • Engineering school - Biochemistry

Publications

Publications (9)
Article
Full-text available
Cyclic nucleotide signalling is a key component of antiviral defence in all domains of life. Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in activation of effector proteins. This is exemplified by the metazoan cGAS–STING innate immunity pathway¹, which originated in bacteria². These defence systems requir...
Article
Full-text available
The proteasome system allows the elimination of functional or structurally impaired proteins. This includes the degradation of nascent peptides. In Archaea, how the proteasome complex interacts with the translational machinery remains to be described. Here, we characterised a small orphan protein, Q9UZY3 (Uniprot ID) conserved in Thermococcales. Th...
Preprint
Full-text available
Cyclic nucleotide signalling is a key component of anti-viral defence in all domains of life, from bacteria to humans. Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in activation of effector proteins. This is exemplified by the metazoan cGAS-STING innate immunity pathway 1, which originated in bacteria 2....
Article
Full-text available
Among the three domains of life, the process of homologous recombination (HR) plays a central role in the repair of double-strand DNA breaks and the restart of stalled replication forks. Curiously, main protein actors involved in the HR process appear to be essential for hyperthermophilic Archaea raising interesting questions about the role of HR i...
Article
Full-text available
Several archaeal species prevalent in extreme environments are particularly exposed to factors likely to cause DNA damages. These include hyperthermophilic archaea (HA), living at temperatures >70°C, which arguably have efficient strategies and robust genome guardians to repair DNA damage threatening their genome integrity. In contrast to Eukarya a...
Thesis
Full-text available
Vivant à des températures supérieures à 80°C, les archées hyperthermophiles ont démontré une capacité étonnante à se remettre de dommages dans leur ADN, suggérant la présence de gardiens du génome particulièrement efficaces. Ces gardiens, des protéines relativement similaires entre archées et eucaryotes, agissent et interagissent dans un ballet sav...
Article
Full-text available
In Archaea, the proteins involved in the genetic information processing pathways, including DNA replication, transcription, and translation, share strong similarities with those of eukaryotes. Characterizations of components of the eukaryotic-type replication machinery complex provided many interesting insights into DNA replication in both domains....

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