Gaelle HogrelPerha Pharmaceuticals
Dyrk1A in neurologic disorders - Past: Bacterial immune defense systems, DNA repair & protein quality control in Archaea
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After several years of researches on Archaeal proteins and more recently on Bacterial anti-phage defense systems, I work today on Dyrk1A. This kinase is a maestro of cell signaling by phosphorylation - in human cells, Dykr1A dysregulation in disease such as Alzheimer, Down syndrome or Dykr1A syndrome leads to severe cognitive deficiences. More information about my actual and past work here: https://orcid.org/0000-0003-4078-0577
January 2018 - December 2019
- PostDoc Position
- - Research project on homologous recombination in extremophilic archaea. - Reconstitution in vitro of recombination-associated DNA synthesis assays on supercoiled DNA substrate with the recombinase RadA and DNA polymerases.
January 2016 - December 2017
- PostDoc Position
- - Functional and structural analysis of unkown proteins interacting with the archaeal proteasome machinery. - Analysis of interactomic data obtained by pull-down experiment combined with mass spectrometry identification.
September 2012 - September 2015
- PhD Student
- - Characterization of protein/protein interactions by functional and biophysical approaches. - Project focus on DNA recombination and replication
Cyclic nucleotide signalling is a key component of antiviral defence in all domains of life. Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in activation of effector proteins. This is exemplified by the metazoan cGAS–STING innate immunity pathway¹, which originated in bacteria². These defence systems requir...
The proteasome system allows the elimination of functional or structurally impaired proteins. This includes the degradation of nascent peptides. In Archaea, how the proteasome complex interacts with the translational machinery remains to be described. Here, we characterised a small orphan protein, Q9UZY3 (Uniprot ID) conserved in Thermococcales. Th...
Cyclic nucleotide signalling is a key component of anti-viral defence in all domains of life, from bacteria to humans. Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in activation of effector proteins. This is exemplified by the metazoan cGAS-STING innate immunity pathway 1, which originated in bacteria 2....
Among the three domains of life, the process of homologous recombination (HR) plays a central role in the repair of double-strand DNA breaks and the restart of stalled replication forks. Curiously, main protein actors involved in the HR process appear to be essential for hyperthermophilic Archaea raising interesting questions about the role of HR i...
Several archaeal species prevalent in extreme environments are particularly exposed to factors likely to cause DNA damages. These include hyperthermophilic archaea (HA), living at temperatures >70°C, which arguably have efficient strategies and robust genome guardians to repair DNA damage threatening their genome integrity. In contrast to Eukarya a...
Vivant à des températures supérieures à 80°C, les archées hyperthermophiles ont démontré une capacité étonnante à se remettre de dommages dans leur ADN, suggérant la présence de gardiens du génome particulièrement efficaces. Ces gardiens, des protéines relativement similaires entre archées et eucaryotes, agissent et interagissent dans un ballet sav...
In Archaea, the proteins involved in the genetic information processing pathways, including DNA replication, transcription, and translation, share strong similarities with those of eukaryotes. Characterizations of components of the eukaryotic-type replication machinery complex provided many interesting insights into DNA replication in both domains....