Gabriella Margetts-Smith

Gabriella Margetts-Smith
University of Exeter | UoE · Medical School

Master of Science

About

10
Publications
611
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67
Citations
Introduction
Neurophysiology; synaptic functionality; retrosplenial cortex; prodromal Alzheimer's disease; whole-cell patch clamp electrophysiology; mouse models
Additional affiliations
September 2018 - September 2022
University of Exeter
Position
  • PhD Student

Publications

Publications (10)
Preprint
The connectivity and interplay between the prefrontal cortex and hippocampus underpin a number of key cognitive processes, with changes in these interactions being implicated in both neurodevelopmental as well as neurodegenerative conditions. Understanding the precise cellular connections through which this circuit is organised is, therefore, vital...
Preprint
Full-text available
Thalamic nucleus reuniens (NRe) is located on the midline and acts as a hub to mediate interactions between hippocampal, entorhinal and prefrontal areas although these connections are poorly defined at the cellular and synaptic level. Using electrophysiology and monosynaptic circuit-tracing, we found that pyramidal cells in CA1 receive no direct in...
Preprint
Full-text available
One of the main features of Alzheimer's disease is the progressive loss of memory, likely due to pathological changes within brain regions such as the hippocampus and entorhinal cortex. These structures are embedded within the Papez circuit, an interconnected set of brain regions that are essential for episodic memory. The anterior thalamic nuclei...
Article
Full-text available
Exposure to environmental enrichment can modify the impact of motivationally relevant stimuli. For instance, previous studies in rats have shown that even a brief, acute (~1 day), but not chronic, exposure to environmentally enriched (EE) housing attenuates instrumental lever pressing for sucrose‐associated cues in a conditioned reinforcement setup...
Article
Full-text available
Animals must quickly adapt food‐seeking strategies to locate nutrient sources in dynamically changing environments. Learned associations between food and environmental cues that predict its availability promote food‐seeking behaviors. However, when such cues cease to predict food availability, animals undergo ‘extinction’ learning, resulting in the...
Article
Animals selectively respond to environmental cues associated with food reward to optimize nutrient intake. Such appetitive conditioned stimulus–unconditioned stimulus (CS-US) associations are thought to be encoded in select, stable neuronal populations or neuronal ensembles, which undergo physiological modifications during appetitive conditioning....
Article
Full-text available
Animals must learn relationships between foods and the environmental cues that predict their availability for survival. Such cue-food associations are encoded in sparse sets of neurons or "neuronal ensembles" in the nucleus accumbens (NAc). For these ensemble-encoded, cue-controlled appetitive responses to remain adaptive, they must allow for their...
Article
Full-text available
Learned associations between drugs of abuse and the drug administration environment play an important role in addiction. In rodents, exposure to a drug-associated environment elicits conditioned psychomotor activation, which may be weakened following extinction learning. While widespread drug-induced changes in neuronal excitability have been obser...
Article
Full-text available
Cues that predict the availability of food rewards influence motivational states and elicit food-seeking behaviors. If a cue no longer predicts food availability, then animals may adapt accordingly by inhibiting food-seeking responses. Sparsely activated sets of neurons, coined “neuronal ensembles,” have been shown to encode the strength of reward–...
Article
Learned associations about salient experiences (e.g., drug exposure, stress) and their associated environmental stimuli are mediated by a minority of sparsely distributed, behaviorally activated neurons coined 'neuronal ensembles.' For many years, it was not known whether these neuronal ensembles played causal roles in mediating learned behaviors....

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