Gabriele Koller

Gabriele Koller
Ludwig-Maximilians-University of Munich | LMU · Department of Psychiatry

Doctor of Medicine

About

157
Publications
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2,504
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Publications

Publications (157)
Article
Full-text available
Background: The rising number of people using methamphetamine leads to an increasing need for treatment options for this patient group. Evidence-based research on the efficacy of treatment programs for methamphetamine users is limited. Due to specific characteristics of methamphetamine users, the question arises whether established treatment metho...
Article
Full-text available
Translational research on complex, multifactorial mental health disorders, such as bipolar disorder, major depressive disorder, schizophrenia, and substance use disorders requires databases with large-scale, harmonized, and integrated real-world and research data. The Munich Mental Health Biobank (MMHB) is a mental health-specific biobank that was...
Article
Full-text available
Identifying treatment options for patients with alcohol dependence is challenging. This study investigates the application of real-time functional MRI (rtfMRI) neurofeedback (NF) to foster resistance towards craving-related neural activation in alcohol dependence. We report a double-blind, placebo-controlled rtfMRI study with three NF sessions usin...
Article
The status of remission in patients with major depressive disorder treated with selective serotonin reuptake inhibitors (SSRIs) is mostly evaluated with clinical rating scales. Morphological correlates of the remission status remain a rare event. Addressing this challenge, we investigated functional correlates of remission by assessment of serotoni...
Preprint
Translational research on complex, multifactorial mental health disorders, such as bipolar disorder, major depressive disorder, schizophrenia, and substance use disorders requires databases with large-scale, harmonized, and integrated real-world and research data. The Munich Mental Health Biobank (MMHB) is a mental health-specific biobank that was...
Article
Full-text available
Background Alcohol use disorder, a prevalent and disabling mental health problem, is often characterized by a chronic disease course. While effective inpatient and aftercare treatment options exist, the transferal of treatment success into everyday life is challenging and many patients remain without further assistance. App-based interventions with...
Article
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Methamphetamine use disorder is associated with severe psychiatric symptoms and psychosocial problems. Women seem to be more affected than men. Therefore, this study examined psychiatric comorbidities and psychopathology, drug use patterns, and treatment outcomes in women addicted to methamphetamine compared to men. Data on methamphetamine-dependen...
Preprint
Full-text available
Background Cognitive reserve (CR) explains interindividual differences in the impact of neurodegenerative burden on cognitive and daily functioning. A residual model was proposed to estimate CR more accurately compared to static measures, such as years of education. However, the functional brain correlates of residual CR markers (CRM) remain unexpl...
Article
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Background: Pharmacological neuroenhancement (PN) is a common healthcare problem at least among students. PN seems to be associated with stressful situations. There is a lack of data about personal characteristics, comorbidities, and coping strategies regarding stress and factors of resilience in students and medical staff. Methods: A web-based sur...
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Methamphetamine use disorder is often associated with psychopathological symptoms and attention performance deficits. Little is known about the co-incidence of methamphetamine use disorders and attention deficit hyperactivity disorder in childhood. This study examines potential correlations between substance use patterns, psychopathological symptom...
Preprint
Background: There is an increasing demand of treatment options for methamphetamine users. The present study evaluates differences between methamphetamine users and users of other substances with respect to cognitive function and psychopathology and possible correlates of treatment outcome. Method: 110 subjects were recruited for an observational lo...
Article
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This naturalistic study among patients with alcohol dependence examined whether routine blood biomarkers could help to identify patients with high risk for relapse after withdrawal treatment. In a longitudinal study with 6-month follow-up among 133 patients with alcohol dependence who received inpatient alcohol withdrawal treatment, we investigated...
Article
Ethyl chloride spray, which is usually used to relieve pain after injuries, is increasingly being used as a sniffing alternative. The number of people using this is rising due to its easy availability, cost-effectiveness and legality. The high lipid solubility of ethyl chloride leads to a rapid absorption of it in the lungs. However, data on the bi...
Article
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The emergence of e-cigarettes on the consumer market led to a tremendous rise in e-cigarette consumption among adolescents in the United States. The success of JUUL and other pod systems was linked to its high nicotine delivery capacity. In compliance with the European Tobacco Product directive, liquid nicotine contents in the European JUUL variant...
Article
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Introduction: Pharmacological neuroenhancement (PN) is a topic of increasing importance and prevalence among students. However, there is a lack of differentiating PN substances, according to their psychoactive effects. In particular, there is a lack of data about PN by caffeinated drinks, even if coffee is a common and broadly used Neuroenhancer be...
Article
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Background Psychiatry is facing major challenges during the current coronavirus disease 2019 (COVID)-19 pandemic. These challenges involve its actual and perceived role within the medical system, in particular how psychiatric hospitals can maintain their core mission of attending to people with mental illness while at the same time providing relief...
Article
Veröffentlichung in: SuchtAktuell, 27 (2), 43-51. Der Konsum von Methamphetamin (MA) stellt weltweit ein zunehmendes Gesundheitsproblem dar. Es fehlen evidenzbasierte Therapiekonzepte, die auch die komorbiden psychischen Störungen im Fokus haben. 108 MA-Abhängige in zwei Rehabilitationskliniken wurden im Rahmen der „Crystal-Studie“ hinsichtlich ps...
Article
CARE OF PATIENTS WITH MENTAL ILLNESS AND SARS-COV-2 INFECTION AT THE DEPARTMENT OF PSYCHIATRY AND PSYCHOTHERAPY LMU MUNICH, GERMANY : People with mental illness are particularly at risk in the event of a SARS-CoV-2 infection. In order to ensure their care, a 5-stage pandemic plan has been drawn up in the Clinic for Psychiatry and Psychotherapy at L...
Article
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At present, risk assessment for alcohol withdrawal syndrome relies on clinical judgment. Our aim was to develop accurate machine learning tools to predict alcohol withdrawal outcomes at the individual subject level using information easily attainable at patients’ admission. An observational machine learning analysis using nested cross-validation an...
Article
This study investigates the effects of two different residential treatments and of treatment drop-out in a German methamphetamine (MA) dependent sample. 108 subjects from two addiction treatment concepts were recruited at treatment begin and followed-up at 12 (T2) and 18 (T3) months after treatment. Based on follow-up samples (n = 38 at T3, n = 25...
Article
The aim of the study was to explore whether abstinent patients on recent opioid detoxification or on opioid maintenance treatment suffer from sleeping problems. 199 patients on opioid maintenance treatment (methadone, diacetylmorphine and buprenorphine) or recent opioid detoxification were included in this exploratory cross-sectional study. We used...
Article
Background and aims: Withdrawal is a serious and sometimes life-threatening event in alcohol-dependent individuals. It has been suggested that epigenetic processes may play a role in this context. This study aimed to identify genes and pathways involved in such processes which hint to relevant mechanisms underlying withdrawal. Design: Cross-sect...
Article
In psychiatry, routine EEGs are often abnormal and not very specific, raising questions about the clinical relevance and consequences of potential anomalies. One such question is whether the administration of anticonvulsants would be useful if epileptic discharges are detected in patients without any clinical correlates. With regard to this questio...
Article
A continuously rising consumption of methamphetamine (MA) has been suggested to be associated with increasing cognitive dysfunction. The objective of this study was to investigate associations between cognitive functions and gender, drug using patterns and treatment-attending profiles of recently abstinent MA users over the course of six months abs...
Article
Introduction: Opioid addiction is a worldwide disease with a significant impact. A multitude of physical and mental comorbidities are associated with opioid addiction, pain being one of the most relevant. Insufficient pain management may lead to a disruption in medical treatment, self-medication, and subsequent harm to patients. Areas covered: In t...
Article
Background: ADHD in childhood and adolescence is characterized by the symptoms hyperactivity, impulsivity, and inattentiveness; these symptoms may persist into adulthood or may manifest as restlessness, emotional instability, and disorganized behavior. In adults ADHD often occurs with increased substance use and is associated with an early onset o...
Article
In der stationären Drogenreha gewinnt Methamphetamin zunehmend an Bedeutung. Für eine erfolgreiche Behandlung sollten die spezifischen Konsumentenmerkmale berücksichtigt werden. Es mangelt an repräsentativen Studien zur Charakterisierung des typischen Crystal-Abhängigen. Das laufende Forschungsprojekt an der MEDIAN Klinik Mecklenburg in Kooperation...
Article
Background: Stimulant drugs can cause persistent changes in the brain. Imaging studies show that these changes are most apparent in dopamine transporter (DAT) or receptor availability within the striatum. Methods: This work focuses on influences of stimulant use on dopaminergic function assessed using nuclear-medicine imaging (PET/SPECT). Includ...
Article
BACKGROUND: There is an increasing demand of evidence-based treatment options for methamphetamine users, but research in this field is limited. This study therefore evaluates the efficacy of two residential treatment programs for methamphetamine users. METHOD: A total of 108 patients with a history of methamphetamine abuse from two inpatient reh...
Article
Alcohol dependence is a common public health problem and epigenetics may offer new aspects in understanding the biological and genetic underpinnings and improve treatment of this complex disease. Supposedly, methylation and hydroxymethylation are altered in brain tissues and in synapse-related genes due to chronic alcohol intake and during withdraw...
Article
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OBJECTIVE: Preclinical and clinical findings suggest a substantial association of the endogenous opioid system in nicotine dependence. The present study investigates the possible dose-dependent influence of naloxone, an unspecific opioid-receptor-antagonist, combined with cue exposure on the physiological state, locomotor activity, craving and the...
Article
Use of alcohol, cannabis and opioids is highly prevalent and is associated with global disease burden and high economic costs. The exact pathophysiology of abuse or addiction associated with these sedative substances is not completely understood, but previous research implicates the important role of the striatal dopamine system in the addiction pr...
Article
Background and Objectives Numbers of drug‐related deaths have been growing in Europe and the USA, especially those attributable to mixed drug consumption. Overdose deaths account for about one third up to one half of all illicit drug deaths worldwide. In most cases opioids are involved. Opioid maintenance treatment (OMT) is a well‐established thera...
Article
Methamphetamine use has spread in many European countries and the United States. The current review provides a summary and critical analysis of research on cognitive deficits associated with methamphetamine, also known as “crystal meth.” The literature search performed for this review led us to the hypothesis that methamphetamine use is associated...
Article
Background: At the Department of Psychiatry and Psychotherapy of the University of Munich a "day clinic for substance use disorders" was opened in 2014. A multimodal treatment concept for patients with addictions was developed. Employees of the clinic performed a first scientific study to assess the effects of treatment approaches on the course of...
Article
Zusammenfassung Diese Pilotstudie untersucht die Einführung von Praktika mit Psychoedukation für Schüler in der Psychiatrie, um diese über Berufe in der Psychiatrie zu informieren. 29 Jugendliche im Alter von 16–21 Jahren nahmen an einem Praktikum zur beruflichen Orientierung an der Klinik für Psychiatrie und Psychotherapie der Ludwig-Maximilians-U...
Article
Die Verbreitung von Methamphetaminen steigt in Deutschland zunehmend an, sodass inzwischen eine S3 Leitlinie zu Methamphetamin-bezogenen Störungen entwickelt und im Jahr 2017 veröffentlicht wurde. Der Konsum von Methamphetamin kann psychische und körperliche Reaktionen sowie neurologische Schädigungen auslösen. Das vorliegende Review betrachtet unt...
Article
Following a short overview on the epidemiology and clinical correlates of amphetamine abuse and dependence, with special emphasis on metamphetamine ("crystal"), current treatment concepts and recent results of therapy research are discussed. The efficacy of two inpatient treatment models for methamphetamine dependence are currently studied in a stu...
Article
Background: Concomitant opioid misuse is an increasing problem in opioid maintenance treatment as it interferes with treatment success. Objective: Therefore, the rates of concomitant fentanyl misuse in opioid maintained patients were investigated. Methods: We conducted a cross-sectional study which consisted in collecting data via urine sample...
Article
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BPSD (Behavioral and Psychological Symptoms in Dementia) affects virtually all patients with dementia. The aim of this review is to present information on epidemiology, consequences and evidence-based non-pharmacological and pharmacological treatment approaches. The review also covers recent literature derived from a systematic literature Medline s...
Conference Paper
One of the most prominent symptoms in substance use disorders is a strong desire to consume a particular substance or to show a certain behaviour (craving). The aim of the present project was to modify craving-related neuronal responses in patients with alcohol use disorder (AUD) using neurofeedback (real-time fMRI). Patients with AUD and healthy s...
Article
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Literature One prominent symptom in addiction disorders is the strong desire to consume a particular substance or to display a certain behaviour (craving). Especially the strong association between craving and the probability of relapse emphasises the importance of craving in the therapeutic process. Neuroimaging studies have shown that craving is...
Article
In ihrer Tagklinik für Suchterkrankungen bietet die Klinik für Psychiatrie und Psychotherapie der Universität München ein multiprofessionelles Therapiekonzept an, um Patienten eine rasche soziale und berufliche Wiedereingliederung zu ermöglichen. Im ersten Jahr lag die Abbrecherquote bei nur 5%.
Article
We compared personality traits of 27 persons with multiple substance dependence with personality data of 52 alcohol-dependent persons regarding their personality traits and disorders (obtained by using SCID-II, TCI and NEO FFI). Both patient groups were free of any other mental disorder. In SKD-II, we found significant differences in the male group...
Article
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Aggressive and criminal traits have a complex genetic background which interacts with environmental factors. Alcohol intoxication has been related to lower thresholds of aggressive behaviors. In this association study of two independent samples, a number of candidate gene variants (5HT2A T102C, 5-HTTLPR, DRD Ins-141Del, DAT1 VNTR) were related to v...
Article
Zusammenfassung Hintergrund: Im Jahr 2014 wurde das DSM-IV durch die fünfte Version des Diagnostischen und Statistischen Manuals Psychischer Störungen (DSM-5) abgelöst. In der vorliegenden Übersicht soll auf die Darstellung der Abhängigkeitserkrankungen im DSM-5 (Kapitel: Substance Related and Addictive Disorders, in der Übersetzung: Störungen im Z...
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Aims: We have analysed the MAOA-uVNTR polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. The first aim was to examine the association between the MAOA genotype and the alcoholic phenotype. In the second part of the paper we have analysed the association of the MAOA genotype with impulsive and aggressive behavi...
Article
Introduction: Bupropion is an effective and well-tolerated second-generation antidepressant generally assumed to be without abuse potential. In the past years, several case reports about the recreational use of bupropion, mainly via nasal insufflation, have been published. Last year, a first case of intravenous bupropion dependence was reported....
Article
Full-text available
One of the proposed psychobiological pathways of craving attributes the desire for drinking in the context of tension, discomfort or unpleasant emotions, to "negative" (or "relief") craving. The aim of this study was to replicate a previously reported association of the PDYN rs2281285 variant with negative craving using a different phenotyping appr...
Article
Aggression, violence and antisocial behavior are common in alcoholism, but their biological basis is poorly understood. Several studies and recent meta-analyses indicate that in schizophrenia the catecholamine-O-methyltransferase (COMT) Val158Met genotype may be associated with aggression, most often in methionine allele carriers. We tested this hy...
Article
Several previous studies have shown that real-time neurofeedback can be used to willfully regulate neuronal activity in specific brain-regions. The aim of the study was to find out whether patients with alcohol dependency would be able to learn how to regulate their neuronal activity in dependency-associated areas. In addition, neurofeedback-relate...
Article
Full-text available
Abstract Objectives: Animal and clinical studies implicated opioid dysfunction in the pathogenesis of alcohol abuse and dependence. The π-opioid antagonist naltrexone reduces craving, eventually modulated by hypothalamic-pituitary-adrenal axis. Altered cortisol response to opioid receptor blockade not only in alcohol dependent persons, but also in...