Gabriel Vallejos Baccelliere

Gabriel Vallejos Baccelliere
University of Chile · Departamento de Biología

Biochemist, PhD in Biological Sciences
Biochemist and philosopher of science

About

7
Publications
1,333
Reads
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21
Citations
Citations since 2016
7 Research Items
21 Citations
201620172018201920202021202202468
201620172018201920202021202202468
201620172018201920202021202202468
201620172018201920202021202202468
Introduction
As a biochemist, my research belongs to the field of biophysical chemistry and the evolution of enzymes. My focus is on phenomena like allosteric regulation, catalytic mechanisms, and the effect of extrinsic factors like ionic strength on substrate binding and catalysis. In the philosophy of science, my research is within the philosophy of biology and scientific practice, specifically on epistemological problems related to laboratory biology, biochemistry, and macromolecular sciences.

Publications

Publications (7)
Article
Full-text available
Si bien en la filosofía de las ciencias ya se han explorado algunos ejemplos provenientes de la bioquímica como casos de estudio, la filosofía de la bioquímica (i.e. el estudio filosófico sistemático de los problemas metacientíficos de esta ciencia) es una subdisciplina naciente. En este artículo estudiaremos dos problemas filosóficos de relevancia...
Article
Methanogenic archaea have received attention due to their potential use in biotechnological applications such as methane production, so their metabolism and regulation are topics of special interest. When growing in a nutrient‐rich medium, these organisms exhibit gluconeogenic metabolism; however, under starvation conditions, they turn to glycolyti...
Article
Full-text available
One of the foundational problems of biochemistry concerns the conceptualisation of the relationship between the composition, structure and function of macromolecules like proteins. Part of the recent philosophical literature displays a reductionist bias, that is, the endorsement of a form of microstructuralism mirroring an out-dated biochemical con...
Article
The hydroxymethylpyrimidine phosphate kinases (HMPPK) encoded by the thiD gene and involved in the thiamine biosynthesis pathway, can perform two consecutive phosphorylations of 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) and are found in thermophilic and mesophilic bacteria, and only a few characterizations of mesophilic enzymes are availabl...
Chapter
In his 1995 book, The Mangle of Practice, Andrew Pickering distinguished between representationalist and performative idioms in philosophy of science. While the former describes science as mainly a theoretical enterprise, the latter represents science as a collection of practices. The two perspectives outline two kinds of epistemologies presenting...
Article
Cold shock proteins (Csp) constitute a family of ubiquitous small proteins that act as RNA-chaperones to avoid cold-induced termination of translation. All members contain two subdomains composed of 2 and 3 β-strands, respectively, which are connected by a hinge loop and fold into a β-barrel. Bacillus caldolyticus Csp (BcCsp) is one of the most stu...

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Projects

Projects (2)
Project
Enzyme kinetics, mathematical models for enzyme action, biochemical experimentation.