Gabriel Vallejos BaccelliereUniversity of Chile · Departamento de Biología
Gabriel Vallejos Baccelliere
Biochemist and philosopher of science
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Citations since 2016
7 Research Items
As a biochemist, my research belongs to the field of biophysical chemistry and the evolution of enzymes. My focus is on phenomena like allosteric regulation, catalytic mechanisms, and the effect of extrinsic factors like ionic strength on substrate binding and catalysis. In the philosophy of science, my research is within the philosophy of biology and scientific practice, specifically on epistemological problems related to laboratory biology, biochemistry, and macromolecular sciences.
Si bien en la filosofía de las ciencias ya se han explorado algunos ejemplos provenientes de la bioquímica como casos de estudio, la filosofía de la bioquímica (i.e. el estudio filosófico sistemático de los problemas metacientíficos de esta ciencia) es una subdisciplina naciente. En este artículo estudiaremos dos problemas filosóficos de relevancia...
Methanogenic archaea have received attention due to their potential use in biotechnological applications such as methane production, so their metabolism and regulation are topics of special interest. When growing in a nutrient‐rich medium, these organisms exhibit gluconeogenic metabolism; however, under starvation conditions, they turn to glycolyti...
One of the foundational problems of biochemistry concerns the conceptualisation of the relationship between the composition, structure and function of macromolecules like proteins. Part of the recent philosophical literature displays a reductionist bias, that is, the endorsement of a form of microstructuralism mirroring an out-dated biochemical con...
The hydroxymethylpyrimidine phosphate kinases (HMPPK) encoded by the thiD gene and involved in the thiamine biosynthesis pathway, can perform two consecutive phosphorylations of 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) and are found in thermophilic and mesophilic bacteria, and only a few characterizations of mesophilic enzymes are availabl...
In his 1995 book, The Mangle of Practice, Andrew Pickering distinguished between representationalist and performative idioms in philosophy of science. While the former describes science as mainly a theoretical enterprise, the latter represents science as a collection of practices. The two perspectives outline two kinds of epistemologies presenting...
Cold shock proteins (Csp) constitute a family of ubiquitous small proteins that act as RNA-chaperones to avoid cold-induced termination of translation. All members contain two subdomains composed of 2 and 3 β-strands, respectively, which are connected by a hinge loop and fold into a β-barrel. Bacillus caldolyticus Csp (BcCsp) is one of the most stu...