Gabriel Perli

• Doctor of Philosophy
• Marie Skłodowska-Curie Individual Fellow in Sardon Lab at University of the Basque Country

Plastics play a vital role in modern society, but their accumulation in landfills and the environment presents significant risks to ecosystems and human health. In addition, the discarding of plastic waste constitutes to a loss of valuable material. While the usual mechanical recycling method often results in reduced material quality, chemical recy...

Escalating environmental concerns driven by continuous demand for fossil-based materials have sparked a growing interest in designing biobased polymeric materials for high-added-value applications. A novel series of self-blowing polycarbonate foams...

Natural Fiber Composites (NFCs) offer significant environmental benefits. However, the use of thermoset matrices presents major challenges since they are oil-based, non-recyclable, and require energy-intensive curing processes, which diminishes their sustainability. Various proposed alternatives, particularly sustainable, dynamic matrices, have lim...

Switchable adhesives are materials of utmost importance due to their capability of having their adhesion/cohesion properties reversibly triggered upon stimuli, allowing on‐demand surface attaching/detaching. Still, several challenges mainly associated with complex uncontrolled chemical processes hinders their production. In this study, it is found...

Dendrimers and supramolecular chemistry continue to fascinate researchers due to the endless unrevealed potential of their combination. This study investigates the self‐assembly process of a series of hydrophobic triazolylferrocenyl dendrimers in aqueous medium. Deep investigation through NMR spectroscopy, absorption UV–vis spectroscopy along with...

A circular economy for chemicals and materials must revaluate the technologies, policies, and economics of the entire value chain, from supplying raw materials to managing waste. At the center of this new paradigm, biomass, CO2, and recycled or upcycled wastes replace traditional fossil-based feedstocks, aiming to create a sustainable and closed-lo...

To protect crops as well as human and animal health, the development of novel repellents based on biopolymers is critical for a growing world population. Here, novel aphid-repellent electrospun mats containing epoxidized ionic liquids (ILs) covalently bonded to the carboxyl or hydroxyl groups of poly(lactic acid) (PLA) were designed to produce nonw...

Aircraft, automotive industries and the increasing numbers of wind turbine blade lead to a huge amount of carbon fiber reinforced polymers requiring to be recycled and/or reused in a closed loop supply chain or circularity of materials. Herein, we have designed and synthesized a tetra-epoxidized imidazolium ionic liquid (Tetra-IL) monomer containin...

In this study, we set out to modify poly(lactic acid) (PLA) by incorporating epoxidized ionic liquids (ILs) that were specifically designed with imidazolium-NTf2 moieties. First, we synthesized di-, tri- and tetra-epoxidized ILs, which were incorporated into a PLA matrix at 3, 5, and 10 wt% through a melt extrusion process. We investigated the rela...

Infections caused by multi-drug resistant (MDR) microorganisms are one of the most critical issues in global health. The emergence of new resistant strains stresses the need for the discovery of novel antimicrobial agents. To address this issue, this work aimed to develop nanostructured materials with antimicrobial potential. In the first part of t...

The efficient capture of CO2 from flue gas or directly from the atmosphere is a key subject to mitigate global warming, with several chemical and physical absorption methods previously reported. Through polarizable molecular dynamics (MD) simulations and high-level quantum chemical (QC) calculations, the physical and chemical absorption of CO2 by i...

The design and development of multifunctional epoxy thermosets have recently stimulated continuous research on new degradable epoxy monomers. Herein, tri- and tetra-epoxidized imidazolium monomers were rationally designed with cleavable ester groups and synthesized on a multigram scale (up to 100 g), yielding room-temperature ionic liquids. These m...

Carbon nanodots (CNDs) are interesting materials due to their intrinsic fluorescence, electron-transfer properties, and low toxicity. Here, we report a sustainable, cheap, and scalable methodology to obtain CNDs from sugarcane syrup using a domestic microwave oven. The CNDs were characterized by infrared spectroscopy, dynamic light scattering, atom...

Dendronized gold nanoparticles (AuNPs) were synthesized bearing charged peripheral groups. Two novel AB3-type dendrons were synthesized with a thiol group at the focal point followed by their attachment to AuNPs. Dendrons were designed to have nine charged peripheral groups (carboxyl or amine), glycol solubilizing, units and one thiol moiety at the...

Combination of advantages of ferrocenyl compounds and multifunctional dendrimer scaffold afforded a water‐soluble well‐defined bifunctional dendrimer with polyamide backbone and thirty two termini: eighteen carboxylic acid groups and eighteen triazolylferrocenyl moieties. The structure of the new dendrimer was thoroughly characterized by nuclear ma...

Nontraditional intrinsic luminescence emerges upon hierarchical organization of hydrophobic triazolylferrocenyl dendrimers in aqueous medium, resulting in green fluorescent vesosomes that act as nanotheranostic systems.

The promising field of nanomedicine stimulates a continuous search for multifunctional nanotheranostic systems for imaging and drug delivery. Herein, we demonstrate that application of supramolecular chemistry's concepts in dendritic assemblies can enable the formation of advanced dendrimer-based nanotheranostic devices. A dendrimer bearing 81 tria...

This paper presents a practical laboratory approach on polymer melt flow rate and stress-strain testing to teach undergraduate students how to measure important properties of molten and solid plastics. They may learn how to obtain parameters that are important for: quality control; processing; engineering design on polymer and petrochemical industr...

Presentation in: https://youtu.be/0dq7ITmV_Uo. This paper presents a practical laboratory approach on polymer melt flow rate and stress-strain testing to teach undergraduate students how to measure important properties of molten and solid plastics. They may learn how to obtain parameters that are important for: quality control; processing; engineer...

Recently, a new generation of polymerised ionic liquids with high thermal stability and good mechanical performances has been designed through novel and versatile cycloaliphatic epoxy-functionalised ionic liquids (CEILs). From these first promising results and unexplored chemical structures in terms of final properties of the PILs, a computational...

This chapter describes the synthesis of stealth and cationic liposomes and their complexation with plasmid DNA to generate lipoplexes for gene delivery applications. Two techniques are presented: a top-down approach which requires a second step of processing for downsizing the liposomes (i.e., ethanol injection method) and a microfluidic technique...

A presente invenção trata-se um processo de obtenção de nanocápsulas antimicrobianas e nanocápsulas antimicrobianas assim obtidas aplicáveis na área médica, especialmente no uso tópico de tratamento de infecções microbianas da pele. A presente invenção apresenta uma rota química direta para a síntese e estabilização de nanopartículas de prata encap...

A process for producing fluorescent Carbon Nanodots from sugarcane syrup is reported. The syrup is processed in a domestic microwave oven for 1.5 min, filtered and centrifuged, resulting in an orange stable suspension of nanoparticles capable of emitting visible (green) fluorescence when irradiated by ultraviolet (254 nm). The particles present dim...

Fluorescent carbon nanodots with excitation-dependent emission (blue-green, UV irradiation) were obtained from widely available green sources (orange juice and milk) by microwave-assisted synthesis, a scalable and energetically-efficient approach. Presentation in: https://youtu.be/MuUxDCXP1Z0

Presentation of the paper: One-Step Synthesis of Fluorescent Carbon Nanodots from Two Widely Available Natural Sources. In: OSA Advanced Photonics Congress (AP) 2020 (IPR, NP, NOMA, Networks, PVLED, PSC, SPPCom, SOF), 13-16 July. L. Caspani, A. Tauke-Pedretti, F. Leo, and B. Yang, eds., OSA Technical Digest (Optical Society of America, 2020), paper...

Amorphous silica can be synthesized with controlled dimensions and morphologies by the Vapor-phase Axial Deposition (VAD) method, so we performed an exploratory study for verifying the possibility of using this technique for the obtention of a sponge-shaped ramified nanostructure with high superficial area. We were successful in synthesizing SiO2 a...

This work presents an optical fiber dynamic light scattering sensor capable of simultaneously assessing concentration and flow speed of nanofluids. Silica nanoparticles (189 nm) in water were tested, yielding a sensitivity of 0.78288 10³ s−1 for static conditions. Then, the sensor was submitted to situations that simulate spatial concentration chan...

The quest for alternative therapeutic agents with safety and effective profiles is one of the biggest challenges in oncology. The folate-targeted therapy can deliver drugs selectively into malignant cells via the Fr receptor, whereas the bioorganometallic chemistry offers potential new drug candidates. Herein, novel folate -ferrocene (-Fc) conju...

A process for producing fluorescent Carbon Nanodots from sugarcane syrup is reported. The syrup is processed in a domestic microwave oven for 1.5 min, filtered and centrifuged, resulting in an orange stable suspension of nanoparticles capable of emitting visible (green) fluorescence when irradiated by ultraviolet (254 nm). The particles present dim...

Acetalated Dextran (Ac-Dex) is a promising pH-sensitive biocompatible and biodegradable polymer for nanomedicine applications. In this work, Ac-Dex nanoparticles were synthesized by two different solvent evaporation methods, the single nanoemulsion and the double nanoemulsion. The Ac-Dex particles were characterized by Scanning Electron Microscopy...

Colloids are metastable suspensions of particles dispersed in a base fluid, with high scientific and industrial importance, but the monitoring of these systems still demands expensive and large instrumentation. In this research, the measurement of concentration gradients in colloidal silica samples using an optical fiber sensor is reported. (189 nm...

A presente invenção se refere a um processo de produção de nanopartículas fluorescentes de carbono a partir de derivados da cana-de-açúcar, particularmente xarope da cana-de-açúcar. Mais especificamente, se refere a produção de nanopartículas fluorescentes de carbono por meio de um processo assistido por micro-ondas, esse processo sendo facilmente...

The utilization of an optical fiber reflectometer on the evaluation of filtration capability by SiO2 membranes is reported. Quartz powder obtained by milling of natural quartz was pressed under 30 MPa and sintered under ~1000°C for producing 4.35 mm thickness ceramic membranes. The SEM analysis revealed a high porosity material and the XRD measurem...

Nanoparticles (NPs) based on the biodegradable acetalated dextran polymer (Ac-Dex) were used for near-infrared (NIR) imaging and controlled delivery of a Pt IV prodrug into cancer cells. The Ac-Dex NPs loaded with the hydrophobic Pt IV prodrug 3 (Pt IV /Ac-Dex NPs) and with the novel hydrophobic NIR-fluorescent dye 9 (NIR-dye 9/Ac-Dex NPs), as well...

In this work, we describe a hydrodynamic flow-focusing microfluidic process to produce stealth cationic liposomes (SCL), stabilized with poly(ethylene glycol) (PEG), with uniform and reproducible features. Through cryogenic transmission electron microscopy (cryo-TEM) characterization and real-time monitoring, we verified the formation of multi-size...

Processo microfluídico de obtenção de lipossomas stealth catiônicos com características físico-químicas em processos reprodutíveis, incluindo tamanho controlado e baixo índice de polidispersidade, no qual é utilizado a alteração da força iônica. Tais lipossomas possuem aplicação em várias áreas, desde a agrícola, alimentícia, cosmética, até a área...