Gabriel Nasri Marzuca-Nassr

Gabriel Nasri Marzuca-Nassr
Universidad de La Frontera · Departamento de Ciencias de la Rehabilitación

PhD

About

73
Publications
44,272
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
518
Citations
Citations since 2017
56 Research Items
506 Citations
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150

Publications

Publications (73)
Article
Full-text available
Coronavirus disease 2019 (COVID-19) is triggered by the SARS-CoV-2, which is able to infect and cause dysfunction not only in lungs, but also in multiple organs, including central nervous system, skeletal muscle, kidneys, heart, liver, and intestine. Several metabolic disturbances are associated with cell damage or tissue injury, but the mechan...
Article
Full-text available
Coronary heart disease is the most common cause of death worldwide. Standard cardiac rehabilitation (face-to-face sessions) has shown benefits in increasing muscle strength and functional exercise capacity in adults and older people. However, it is unknown whether hybrid cardiac rehabilitation (a first face-to-face phase + a second remote monitorin...
Article
Full-text available
To describe the physical therapy protocols used in critically ill patients to attenuate skeletal muscle atrophy. We conducted a search in PubMed and Embase from inception to November 2020. Observational or experimental studies published in English or Spanish that evaluated the effect of physical therapy protocols on the attenuation of skeletal musc...
Article
Full-text available
The 2-Minute Step Test (2MST) has been presented as an alternative to the 6-Minute Walk Test (6MWT) based on the association between the two tests in older adults; however, some authors propose that it should not be a substitute but rather a complement to the latter in the fitness evaluation. Specifically, in coronary disease, despite the potential...
Article
Full-text available
Background and Objectives: Patients who survive severe COVID-19 require significant pulmonary rehabilitation. Heart rate (HR) has been used as a safety variable in the evaluation of the results of interventions in patients undergoing pulmonary rehabilitation. The aim of this research was to analyse HR during a pulmonary rehabilitation program in po...
Article
Full-text available
Postural balance and gait are important factors in the functional status of older people; however, few studies have addressed differences by sex. The objective of this study was to analyze the postural balance and temporal–spatial parameters of gait in independent older adults by sex. A cross-sectional study was conducted. Thirty-eight independent...
Article
Full-text available
The aim of this study was to determine the effects of High-intensity interval training (HIIT) on the quality of life in healthy young people (YNG) and older adults (OLD)and its correlation with physical health status (anthropometric parameters and lower limb functionality) YNG (21 ± 2 years, BMI 26.37 ± 2.69 n = 12) and OLD (67 ± 5 years, BMI 27.16...
Article
Brown adipose tissue (BAT) is a potential target to treat obesity and diabetes, dissipating energy as heat. Type 2 diabetes (T2D) has been associated with obesogenic diets; however, T2D was also reported in lean individuals to be associated with genetic factors. We aimed to investigate the differences between obese and lean models of insulin resist...
Article
Full-text available
Objective To determine if there are differences in functional capacity and work ability between older and younger active workers in public institutions, and to relate functional capacity to work ability.Methods This cross-sectional study evaluated 360 subjects from two public institutions, a university and a high-complexity regional hospital. The p...
Article
Full-text available
The aim of this study was to determine the influence of the implementation and application of the learning stations teaching methodology on active learning of the physiology and morphology of the cell. We worked with 90 high school students, distributed in a control group and an experimental group, who received traditional classes and the applicati...
Article
Full-text available
Endoplasmic reticulum stress (ERS) and autophagy pathways are implicated in disuse muscle atrophy. The effects of high eicosapentaenoic (EPA) or high docosahexaenoic (DHA) fish oils on soleus muscle ERS and autophagy markers were investigated in a rat hindlimb suspension (HS) atrophy model. Adult Wistar male rats received daily by gavage supplement...
Article
Full-text available
The coronavirus disease 2019 (COVID-19) pandemic, produced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly throughout the world. Latin American and the Caribbean countries have been harshly affected by the pandemic mainly due to less prepared healthcare systems and fragmented social safety nets. In the region, he...
Article
Background Skeletal muscle atrophy is a relevant and common problem in patients admitted to intensive care units (ICU). It is an imbalance between the muscle protein synthesis/degradation pathways and its onset is due to situations to which these patients are exposed, such as: disuse, corticoids, inflammatory cytokines, and others. Neuromuscular el...
Article
Full-text available
Objective: The purpose of this article was to summarize the available evidence from systematic reviews on telerehabilitation in physical therapy. Methods: Medline/Pubmed, EMBASE and Cochrane Library databases. In addition, the records in PROSPERO and Epistemonikos and PEDro were consulted. Systematic reviews of different conditions, populations...
Article
Background: The maintenance of good work ability has proven to have a positive effect on health, quality of work and productivity. There is little evidence regarding the association between musculoskeletal complaints, individual and work-related factors, and work ability in blue- and white-collar workers. Methods: Cross-sectional study on hospital...
Article
Glutamine levels directly associate with total protein content in cultured skeletal muscle cells, whereas glutamine supplementation enhances skeletal muscle mass in catabolic experimental conditions. We compared the effect of glutamine administration on Extensor Digitorum Longus muscle (EDL) weight, fiber cross-sectional area (CSA), contractile act...
Research Proposal
Full-text available
Review question / Objective: What risk factors are associated with loss of physical functioning in critical care patients? Condition being studied: Several studies that have described various risk factors or predisposing factors that would enhance or influence the patient to develop a greater degree of muscle weakness or further functional impairme...
Article
Full-text available
It is increasingly important to have validated instruments to assess the ability to work. Thus, the aim of this study was to evaluate the psychometric properties of the Spanish version of the Work Ability Index (WAI) in working individuals. A cross-sectional study was conducted on 360 workers (men and women) in a high-complexity public hospital and...
Article
Background Resistance exercise training (RET) has proven effective at reducing the risk of chronic disease in older populations, and it appears to regulate redox homeostasis. Aims To determine the effects of RET on redox homeostasis in older people. Study design A systematic review and meta-analysis of randomized clinical trials identified by sea...
Article
Full-text available
Introducción. El cáncer de mama (CM) es la enfermedad crónica no transmisible más frecuente y letal en mujeres. La información disponible sobre el impacto de sus diversos tratamientos en el sistema respiratorio es controversial. Objetivo. Determinar el efecto del tratamiento con quimioterapia y radioterapia concomitante en los volúmenes pulmonares...
Chapter
In the ordinary course of aging, individuals change their body composition, mainly reducing their skeletal muscle mass and increasing their fat mass. In association, muscle strength and functionality also decrease. The geriatric assessment allows knowing the baseline situation of the patients, determines the impact of diseases, and defines specific...
Article
Full-text available
Psoriasis is a chronic inflammatory disease that presents skin rashes which can arise through plaques. The aim of this work was to compare the effectiveness of short-term physical agents treatment on macroscopic morphology (area and erythema) in patients with plaque psoriasis. This prospective randomized experimental study included fourteen subject...
Article
Full-text available
Introduction: Cardiac rehabilitation (CR) programmes are well established, and their effectiveness and cost-effectiveness are proven. In spite of this, CR remains underused, especially in lower-resource settings such as Latin America. There is an urgent need to create more accessible CR delivery models to reach all patients in need. This trial aim...
Article
Full-text available
The effect of a short-term creatine supplementation on hindlimb suspension (HS)-induced muscle atrophy was investigated. Creatine monohydrate (5 g/kg b.w. per day) or placebo, divided in 2 daily doses, was given by oral gavage for 5 days. Rats were maintained in HS with dietary supplementation concomitantly for 5 days. Body weight, soleus and EDL m...
Preprint
Full-text available
Background and Objective: Type 2 diabetes mellitus (DM2) and breast cancer (BC) are diseases of high prevalence worldwide. Both alter lung function separately. So suffering both tables would increase this decrease in lung function. The objetive was to determine the effects of DM2 and BC on ventilation volumes and pressures in adult women. Material...
Article
Full-text available
Introduction: Ankle instability often seen in people who have suffered repeated ankle sprains. Kinesio Tape is a technique widely applied in recent years, despite not having enough evidence to support its application. Objetive: To determine the functional effectiveness of Kinesio Tape in individuals with ankle instability. Design: Systematic r...
Article
Full-text available
Skeletal muscle atrophy occurs due to a decrease in the synthesis pathways and/or an increase in protein degradation pathways. The current recommendation for the patients with skeletal muscle atrophy are to consume adequate amounts of proteins/amino acids, perform early stimulation using mechanical loading (through electrical stimulation, therapeut...
Article
Full-text available
Background A few days of bed rest or immobilization following injury, disease, or surgery can lead to considerable loss of skeletal muscle mass and strength. It has been speculated that such short, successive periods of muscle disuse may be largely responsible for the age-related loss of muscle mass throughout the lifespan. Objective To assess whe...
Article
Short periods of bed rest lead to the loss of muscle mass and quality. It has been speculated that dietary feeding pattern may have an impact upon muscle protein synthesis rates and, therefore, modulate the loss of muscle mass and quality. We subjected 20 healthy men (age: 25 ± 1 yr, body mass index: 23.8 ± 0.8 kg/m2) to 1 wk of strict bed rest wit...
Chapter
Full-text available
Due to the difficulty of performing research protocols that reproduce human skeletal muscle disuse conditions, an experimental animal model of “hindlimb suspension” (or hindlimb unloading) was developed. This method was created in the 1970s and utilizes rats and mice to mimic space flight and bed rest in humans. It provides an alternative to invest...
Article
Full-text available
The aim of the present investigation was to determine the reliability level of the anthropometric measurements related to the thorax performed by an undergraduate student in kinesiology (ELK) comparing them with those of an expert anthropometrist (AE). The process consisted of the staging of competencies divided into three stages: i) development of...
Article
Full-text available
Introduction: Introduction: obesity and breast cancer (BC) are two diseases with known symptoms; however, the association of both and its impact on the respiratory system is poorly investigated. Objective: to describe the effects of overweight and obesity on the pulmonary volumes of patients with breast cancer from the city of Talca. Method: forty...
Article
Full-text available
Knowing the ultrastructure of skeletal muscle is critical to understand how it works under normal situation and the disorders caused by extreme or pathological conditions. Sarcomere is the basic structural unit of striated muscle tissue. An important element of sarcomere architecture are the intermediate filaments, including the desmin protein. Des...
Article
Full-text available
Background: Short successive periods of physical inactivity occur throughout life and contribute considerably to the age-related loss of skeletal muscle mass. The maintenance of muscle mass during brief periods of disuse is required to prevent functional decline and maintain metabolic health. Objective: To assess whether daily leucine supplement...
Chapter
Full-text available
Skeletal muscle electrical stimulation is commonly used for clinical purposes, assisting recovery, preservation, or even improvement of muscle mass and function in healthy and pathological conditions. Additionally, it is a useful research tool for evaluation of skeletal muscle contractile function. It may be applied in vitro, using cell culture or...
Chapter
Full-text available
This is a modified experimental model previously developed in mouse to study skeletal muscle laceration in rats. All experimental procedures are performed during the light period, including anesthesia and surgery. The animals are randomly distributed into control and injured groups prior to the procedure. This experimental model can be used to inve...
Article
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve insulin sensitivity and glucose homeostasis in animal models of insulin resistance, but the involved mechanisms still remain unresolved. In this study, we evaluated the effects of fish oil (FO), a source of n-3 PUFAs, on obesity, insulin resistance and muscle mitochondria...
Article
Full-text available
The consequences of two-week hindlimb suspension (HS) on skeletal muscle atrophy were investigated in balanced diet-fed Fat-1 transgenic and C57BL/6 wild-type mice. Body composition and gastrocnemius fatty acid composition were measured. Skeletal muscle force, crosssectional area (CSA), and signaling pathways associated with protein synthesis (prot...
Article
Full-text available
Diabetes mellitus induces a reduction in skeletal muscle mass and strength. Strength training is prescribed as part of treatment since it improves glycemic control and promotes increase of skeletal muscle mass. The mechanisms involved in overload-induced muscle hypertrophy elicited at the establishment of the type I diabetic state was investigated...
Article
Full-text available
The aim was to determine the acute effects of high-frequency electrical stimulation (HFES) on the morphohistology and desmin content of the soleus, tibialis anterior (TA) and extensor digitorum longus (EDL) muscles in old rats submitted to hindlimb suspension (HS). Male Sprague-Dawley rats (23 months-old) were submitted to HS for 14 days. After thi...
Article
Full-text available
Introducción El aumento de la población mayor de 60 años es una tendencia demográfica mundial. Para el 2050, la proporción de personas mayores de 60 años pasará del 11 al 22%. Estas cifras han generado la preocupación de los países y hacen indispensable el diseño y ejecución de políticas y programas que brinden atención especial a esta población....
Data
Oleic and linoleic acids modulate fibroblast proliferation and myogenic differentiation in vitro. However, their in vivo effects on muscle regeneration have not yet been examined. We investigated the effects of either oleic or linoleic acid on a well-established model of muscle regeneration after severe laceration. What is the main finding and its...
Article
Full-text available
The effects of either eicosapentaenoic (EPA)- or docosahexaenoic (DHA)-rich fish oils on hindlimb suspension (HS)-induced muscle disuse atrophy were compared. Daily oral supplementations (0.3 mL/100 g b.w.) with mineral oil (MO) or high EPA or high DHA fish oils were performed in adult rats. After 2 weeks, the animals were subjected to HS for furth...
Article
Full-text available
Oleic and linoleic acids control fibroblast proliferation and myogenic differentiation in vitro, however, there was no study in skeletal muscle in vivo. The aim of this study was then to evaluate the effects of either oleic or linoleic acid on muscle content of fibrous tissue (collagen deposition) and contractile function recovery in rat gastrocnem...
Article
Full-text available
The importance of metabolic pathways for life and the nature of participating reactions have challenged physiologists and biochemists for over a hundred years. Eric Arthur Newsholme contributed many original hypotheses and concepts to the field of metabolic regulation, demonstrating that metabolic pathways have a fundamental thermodynamic structure...
Article
Full-text available
The use of hot pack is a common superficial thermotherapy strategy and one of its benefits is the increase of muscle flexibility. However, there is a lack of information about the effects of the heat pack alone, without being used in association with other therapeutic interventions, in the flexibility of the lumbar region. The aim of this study was...
Conference Paper
Full-text available
Background Skeletal muscle atrophy occurs in several conditions, including aging, muscle disuse, and severe catabolic states. The present study aimed to examine the effects of the treatment with high EPA or high DHA fish oils on signaling pathways of protein synthesis and degradation in skeletal muscle atrophy induced by hindlimb suspension (HS) in...
Article
Full-text available
The functional assessment of moderately or severely dependent older people encompasses social, psychological and biological aspects that may influence their quality of life and their degree of independence. This paper reviews the global geriatric assessment that should be performed in primary health care (PHC) for moderately or severely dependent o...
Article
Full-text available
The functional assessment of moderately or severely dependent older people encompasses social, psychological and biological aspects that may influence their quality of life and their degree of independence. This paper reviews the global geriatric assessment that should be performed in primary health care (PHC) for moderately or severely dependent o...
Article
Full-text available
The purpose of this study was to assess the functional status of older adults with moderate and severe dependence from a family health center, applying scales to evaluate activities of daily living, cognitive level, educational level and caregiver burden. We evaluated 55 older adults with moderate and severe dependence. The Katz Index was used to d...

Network

Cited By

Projects

Projects (2)
Project
TITLE: ADQUISICIÓN DE UN EQUIPO DE ABSORCIOMETRÍA DE RAYOS X PARA INVESTIGAR LOS EFECTOS DE LA INACTIVIDAD FÍSICA CAUSADA POR ESTILO DE VIDA Y PANDEMIA COVID-19 SOBRE LA COMPOSICIÓN CORPORAL DE ESCOLARES, ADULTOS CON OBESIDAD, PERSONAS MAYORES Y DEPORTISTAS Introducción: La falta de actividad física (en adelante inactividad física) ha sido considerada por la Organización Mundial de la Salud como el 4to factor de riego para mortalidad en el mundo, relacionándose con una elevada grasa corporal. Un ejemplo común, es la elevada cantidad de grasa corporal (obesidad), la baja cantidad de masa muscular (sarcopenia) y la disminuída masa ósea (osteopenia), han sido todos fenómenos relacionados a enfermedades cardiometabólicas como diabetes tipo 2, hipertensión arterial, y síndrome metabólico. En tanto, junto con la inactividad física por estilo de vida (inactividad física voluntaria), también catástrofes naturales (presuntamente), como la pandemia COVID-19 han demostrado que conllevan a un obligatorio estado de inactividad física, o “confinamiento”, de la cual Chile es también afectado, exacerbando con ello las consecuencias de la inactividad física de la población. Sin embargo, durante esta pandemia por COVID-19, los desmedros en la salud, particularmente en la composición corporal lo sufren grupos de todo el curso de la vida, y más aún aquellos grupos con exceso de peso como pacientes con obesidad mórbida, pero también lo sufren escolares, deportistas de nivel competitivo, y personas mayores. Objetivo: Incrementar la calidad y productividad de la investigación inter-universitaria a nivel de pre y post grado entre entidades nacionales y extranjeras en el área de deporte y acondicionamiento físico mediante la adquisición de un Equipamiento iDEXA para evaluar los efectos de la inactividad física obligatoria (por pandemia COVID-19) y la inactividad física voluntaria por estilo de vida sedentario, sobre temas relacionados a la composición corporal en diferentes tipos de poblaciones (niños, adultos, adultos mayores, en la obesidad mórbida y deportistas) de la macrozona sur de Chile, mediante nuevas líneas de investigación derivadas. Metodología: Mediante la adquisición de un Equipamiento iDEXA relacionado al análisis de la composición corporal de la población, se pretende durante y posterior a la pandemia COVID-19, estudiar los efectos de la inactividad física derivada del estilo de vida y del confinamiento obligatorio. En este sentido, es fundamental la adquisición del Equipamiento iDEXA, pues permitirá también mejorar la calidad y productividad científica de las líneas de investigación relacionadas a esta área entre a nivel inter-universitario, permitirá incrementar el número de líneas de investigación derivadas, así como coadyuvar a los procesos de formación de capital humano avanzado en pre y post grado del área (Educación física, kinesiología, nutrición, enfermería, fonoaudiología) y aquellas relacionadas de 3 universidades de la macrozona sur, y con la participación de universidades extranjeras. Información de mayor calidad por medio del Equipamiento iDEXA permitirá posicionar a Chile en un lugar más destacado en la elaboración de productividad científica del área de deporte y acondicionamiento físico y su implicancia en la medicina y salud. En suma, la adquisición del equipo permitirá obtener valiosa información para la investigación científica, y tecnológica, que en su conjunto con la creación de un BIOBANCO permitirá obtener una mayor claridad sanitarias de estrategias predictivas, así como planear, desarrollar y aplicar estrategias de mitigación para los procesos de inactividad física obligatoria como COVID-19, y la inactividad física voluntaria de los diferentes grupos de la población.