Gabriel Krasovec

Gabriel Krasovec
National University of Ireland, Galway | NUI Galway · Centre for Chromosome Biology

PhD

About

13
Publications
1,267
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31
Citations
Introduction
I am currently working at the NUI Galway in the Frank's lab on the development of Hydractinia, mainly the metamorphosis and cells aggregates. I did my PhD at the Sorbonne University, France. My research focused on the morphegenetic functions of apoptosis and the evolution of apoptotic regulatory network by working on a tunicate (Ciona) and a cnidarian (Clytia). Then, I did a post-doc at the Sasakura's lab (Shimoda, Japan) to explore the tail regression process during ascidian metamorphosis.
Additional affiliations
March 2018 - March 2018
Sorbonne Université
Position
  • PhD
Description
  • Schmid Training Course "Established and emerging model organisms for Marine Science"
Education
October 2015 - October 2018
Sorbonne University, Paris, France
Field of study
  • Evolutionary and Developmental Biology
September 2014 - July 2015
Claude Bernard University Lyon 1
Field of study
  • Ecology, Evolution, Biometry
September 2013 - July 2014
Université de Montpellier
Field of study
  • Paleontology

Publications

Publications (13)
Preprint
Full-text available
Cell fate stability is essential to maintaining 'law and order' in complex animals. However, high stability comes at the cost of reduced plasticity and, by extension, poor regenerative ability. This evolutionary trade-off has resulted in most modern animals being rather simple and regenerative or complex and non-regenerative. The mechanisms mediati...
Article
Full-text available
d -Serine, a free amino acid synthesized by serine racemase, is a coagonist of N -methyl- d -aspartate–type glutamate receptor (NMDAR). d -Serine in the mammalian central nervous system modulates glutamatergic transmission. Functions of d -serine in mammalian peripheral tissues such as skin have also been described. However, d -serine’s functions i...
Preprint
Apoptosis is characterised by an analogous set of morphological features1 that depend on a proteolytic multigenic family, the caspases. Each apoptotic signalling pathway involves a specific initiator caspase, upstream of the pathway regulation, which finally converges to common executioner caspases. Intrinsic apoptosis, previously known as the mito...
Chapter
Full-text available
Solitary ascidians belong to the tunicate phyla and were the first animals used by experimental embryologists. This chapter, dedicated to these organisms, points out the several advantages offered by the solitary ascidians in modern biology, especially through the combined knowledge of 13solitary ascidians species genomes, of large amount of transc...
Article
A feeding polyp from the sessile stage of the cnidarian Clytia hemisphaerica, labelled by TUNEL (red) and counterstained with DAPI (green). The polyp, connected to the colony by the stolon, is formed by a stalk topped by a head bearing tentacles. A few apoptotic cells are detected at the extremity of tentacles, while the other part of the animal is...
Article
Full-text available
Background Apoptosis is a caspase regulated cell death present in all metazoans defined by a conserved set of morphological features. A well-described function of apoptosis is the removal of excessive cells during development and homeostasis. Recent studies have shown an unexpected signalling property of apoptotic cells, affecting cell fate and/or...
Article
Full-text available
Background: Metamorphosis in marine species is characterised by profound changes at the eco-physiological, morphological, and cellular levels. The cnidarian Clytia hemisphaerica exhibits a triphasic life cycle that includes a planula larva, a colonial polyp, and a sexually reproductive medusa. Most studies so far have focused on embryogenesis of t...
Article
At the onset of the Ciona intestinalis metamorphosis, the first event is tail regression characterized, by a contraction, an apoptotic wave and Primordial Germ Cells (PGC) movement. All these cell behaviors originate from the posterior tail tip and progress to the anterior. Interestingly, earlier in Ciona development, the antero-posterior (A/P) pat...
Thesis
L'apoptose est une mort cellulaire très bien caractérisée d’un point de vue morphologique et biochimique mais dont le rôle morphogénétique a longtemps été restreint à une destruction des structures transitoires ou surnuméraires (Fonction Destructrice de l’Apoptose, FDA). Plus récemment une capacité des cellules apoptotiques à modifier le comporteme...
Article
Full-text available
A new Propalaeotherium species, clearly distinct from the genus Eurohippus, is described. It is characterized by having a similar size as P. voigti from the German Geiseltal localities (MP 11 to MP 13 reference-level), but differs in several features suggesting a slighty more derived morphology. It presents indeed less brachyodont crowns with less...

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