Gabriel Famulari

Gabriel Famulari
Jewish General Hospital · Department of Radiation Oncology

Doctor of Philosophy

About

39
Publications
5,267
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179
Citations
Citations since 2017
32 Research Items
176 Citations
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Introduction
Gabriel Famulari is currently a medical physicist at the Jewish General Hospital (JGH) and postdoctoral researcher at Université de Montréal. Current research topics: FLASH-RT electron dosimetry, scintillation dosimetry, intensity modulated brachytherapy
Additional affiliations
September 2020 - July 2022
Centre hospitalier de l'Université de Montréal (CHUM)
Position
  • Medical Physics Resident
Education
September 2016 - July 2020
McGill University
Field of study
  • Medical Physics
September 2014 - August 2016
McGill University
Field of study
  • Medical Physics
September 2011 - June 2014
McGill University
Field of study
  • Physics and Physiology

Publications

Publications (39)
Article
Full-text available
Background: Intensity modulated brachytherapy (IMBT) is an emerging technology for cancer treatment, in which radiation sources are shielded to shape the dose distribution. The rotatable shields provide an additional degree of freedom, but also introduce an additional, directional, type of uncertainty, compared to conventional high dose-rate brach...
Article
Full-text available
Fully coupled photon-electron-positron computational schemes are needed in a broad range of domains, from radiotherapy and radiosurgery treatment planning to nuclear-reactor safety analysis. Industrial deployment of such schemes remains problematic because of the prohibitively time-consuming charged-particle-transport aspects of both Monte Carlo al...
Article
Purpose Intensity-modulated brachytherapy (IMBT) is a developing application of brachytherapy where high-density metallic shields located inside the catheters are used to modulate radiations allowing the production of anisotropic dose distributions at each source dwell position. By rotating the shields during the treatment, the radiation is directe...
Article
Full-text available
A prototype Yb source was developed in combination with a dynamic rotating platinum shield system (AIM‐Brachy) to deliver intensity modulated brachytherapy (IMBT). The purpose of this study was to evaluate the dosimetric characteristics of the bare/shielded Yb source using Monte Carlo (MC) simulations and perform an independent dose verification us...
Article
Nuclear reactions induced during high-energy radiotherapy produce secondary neutrons that, due to their carcinogenic potential, constitute an important risk for the development of iatrogenic cancer. Experimental and epidemiological findings indicate a marked energy dependence of neutron relative biological effectiveness (RBE) for carcinogenesis, bu...
Article
Full-text available
Purpose: Several radionuclides with high (60Co, 75Se) and intermediate (169Yb, 153Gd) energies have been investigated as alternatives to 192Ir for high-dose-rate brachytherapy. The purpose of this study was to evaluate the impact of tissue heterogeneities for these five high- to intermediate-energy sources in prostate and head & neck brachytherapy....
Article
Full-text available
Purpose: Intensity modulated brachytherapy (IMBT) is a novel high dose rate brachytherapy (HDR BT) technique which incorporates static or dynamic shielding to increase tumor coverage and/or spare healthy tissues. The purpose of this study is to present a novel delivery system (AIM-Brachy) design that can enable dynamic-shield IMBT for prostate can...
Article
To analyse the mechanical adaptations in the cardiovascular system that must occur to reach the high cardiac outputs seen at peak aerobic performance, we adapted a computational model of the circulation by adding a second parallel venous compartment as proposed by August Krogh in 1912. One venous compartment has a large compliance and slow time con...
Article
Purpose: To evaluate the TG-43 parameters for a new 169Yb source design for high dose rate brachytherapy. 169Yb has an average energy of 93 keV and a half-life of 32.0 days. The 169Yb source has physical dimensions and dosimetric characteristics that make it suitable as an intermediate energy source for intensity modulated brachytherapy (IMBT). Mat...
Article
Purpose: Intensity modulated brachytherapy (IMBT) is a novel high dose rate brachytherapy (HDR-BT) technique which incorporates rotating metallic shields inside brachytherapy catheters to dynamically direct the radiation towards the tumor and away from healthy tissues. A delivery system that can enable IMBT for prostate cancer was proposed in a pre...
Article
Despite being considered the gold standard for brachytherapy dosimetry, Monte Carlo (MC) has yet to be implemented into a software for brachytherapy treatment planning. The purpose of this work is to present RapidBrachyMCTPS, a novel treatment planning system (TPS) for brachytherapy applications equipped with a graphical user interface (GUI), optim...
Article
Full-text available
Purpose: Clinical standards of brachytherapy (BT) dose calculation have traditionally been based on report number 43 issued in 1995 by the American Association of Physicists in Medicine (AAPM) termed TG-43. In the TG-43 based dose calculation process the affected malignant tissue, the surrounding radiation sensitive healthy organs, BT seeds, needle...
Article
Purpose: Several gamma emitting radionuclides with high (60Co, 75Se) and intermediate (169Yb, 153Gd) energies have been investigated as alternatives to 192Ir for high dose rate (HDR) brachytherapy. The purpose of this study was to evaluate the effect of tissue heterogeneities for 60Co, 192Ir, 75Se, 169Yb and 153Gd for prostate and oral tongue HDR b...
Article
Full-text available
The original version of the Supplementary Information associated with this Article contained an error in Supplementary Figure 3 in which all panels, with the exception of the bottom-left 'Ti' panel, were blank. The HTML has been updated to include a corrected version of the Supplementary Information.
Article
Purpose: Conventional brachytherapy often results in less than ideal tumor dose conformity due to the non-symmetrical shape of the tumors, resulting in dose spillage to radiation sensitive organs at risk (OARs). Intensity modulated brachytherapy (IMBT) can dynamically direct the radiation towards the tumor and away from OARs by incorporating metall...
Article
Full-text available
Laser-driven particle acceleration, obtained by irradiation of a solid target using an ultra-intense (I > 1018 W/cm2) short-pulse (duration <1 ps) laser, is a growing field of interest, in particular for its manifold potential applications in different domains. Here, we provide experimental evidence that laser-generated particles, in particular pro...
Article
Full-text available
Purpose/Objectives: Conventional brachytherapy often results in less than ideal tumor dose conformity due to the non-symmetrical shape of the tumors, resulting in dose spillage to radiation sensitive healthy tissues. Intensity modulated brachytherapy (IMBT) can dynamically direct the radiation towards the tumor and away from healthy tissues by inco...
Article
Purpose Recent studies have identified and proposed gamma emitting radionuclides (⁷⁵Se, ¹⁶⁹Yb, ¹⁵³Gd) with intermediate energy (50 keV < E < 200 keV) as an alternative to ¹⁹²Ir for HDR brachytherapy. The impact of tissue composition and density on the treatment plan quality was studied in a retrospective evaluation for a prostate cancer patient usi...
Article
Purpose The aim of this study was to calculate microdosimetric distributions for low energy electrons simulated using the Monte Carlo track structure code Geant4-DNA. Materials and Methods Tracks for monoenergetic electrons with kinetic energies ranging from 100 eV to 1 MeV were simulated in an infinite spherical water phantom using the Geant4-DNA...
Article
The goal of this study was to investigate the production, purification and immobilization techniques for a (153)Gd brachytherapy source. We have investigated the maximum attainable specific activity of (153)Gd through the irradiation of Gd2O3 enriched to 30.6% (152)Gd at McMaster Nuclear Reactor. The advantage of producing (153)Gd through this prod...
Article
Purpose: Radioisotopes such as (75)Se, (169)Yb, and (153)Gd have photon energy spectra and half-lives that make them excellent candidates as alternatives to (192)Ir for high-dose-rate brachytherapy. The aim of the present study was to evaluate the relative biological effectiveness (RBE) of current ((192)Ir, (125)I, (103)Pd) and alternative ((75)Se...
Article
The aim of this study was to calculate microdosimetric distributions for low energy electrons simulated using the Monte Carlo track structure code Geant4-DNA. Tracks for monoenergetic electrons with kinetic energies ranging from 100 eV to 1 MeV were simulated in an infinite spherical water phantom using the Geant4-DNA extension included in Geant4 t...
Article
Purpose: Conventional brachytherapy often results in less than ideal tumor dose conformity due to the non-symmetrical shape of the tumors resulting in dose spillage to radiation sensitive healthy tissues. Intensity modulated Brachytherapy (IMBT) gives a possibility to dynamically direct the radiation towards the tumor and away from healthy tissues...
Article
Purpose: Recent studies have identified and proposed gamma emitting radionuclides in the intermediate energy region that can provide optimal depth dose distributions while reducing shielding requirements compared to 192Ir. The impact of source energy on the treatment plan quality was studied in a retrospective evaluation for a prostate cancer patie...
Article
Purpose or Objective: Recent interest in alternative radionuclides for use in high dose rate brachytherapy (Se-75, Yb-169, Gd-153) with average energies lower than Ir-192 has triggered the investigation of the microdosimetric properties of these radionuclides. A combination of Monte Carlo Track Structure (MCTS) simulations and track sampling algori...
Article
Purpose: Brachytherapy (BT) can be administrated by low (E < 50 keV), intermediate (50 keV < E < 200 keV) or high (E > 200 keV) energy sources. For the lower energy sources, the photoelectric effect dominates the energy deposition and the dose distribution decreases rapidly as the inverse of the distance from the source. For the intermediate and hi...

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Projects

Projects (6)
Project
Dosimetric characterization of Mobetron electron beam at ultra-high dose rate (UHDR)
Project
We investigate radiobiological differences between different brachytherapy radiation sources. Low energy photons used in brachytherapy have a higher linear energy transfer (LET), associated with higher relative biological effectiveness (RBE = dose of reference radiation (photons)/dose of test radiation). The greater radiobiological effect is the outcome of greater energy delivered per photon that the cell traverses. The RBE of photons increases with decreasing photon energy. RBE is dependent of radiation quality, i.e. LET, biological system or endpoint, i.e. cell type, cell cycle, survival level, radiation dose, dose rate and dose per fraction. When changing one radionuclide with another, it is important to understand the difference in RBE between the two radiation sources for the same end point.
Project
The motivation behind design and development of novel brachytherapy radiation sources is to enable patient specific dose delivery and be able to maximise the dose to the tumour and spare healthy tissues. Currently my group is developing new radiation sources in collaboration with McMaster Nuclear Reactor with energies much lower than the currently used brachytherapy radiation source, 192Ir.