Gabriel Aumont-Rodrigue- Bachelor of Science
- McGill University
Gabriel Aumont-Rodrigue
- Bachelor of Science
- McGill University
About
8
Publications
214
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Introduction
Current institution
Publications
Publications (8)
Cognitive dysfunction in Alzheimer’s disease (AD) correlates closely with pathology in the neuronal microtubule-associated protein tau. Tau pathology may spread via neural synapses. In a population of cognitively unimpaired elderly at elevated risk of AD, we investigated four cerebrospinal (CSF) markers of synaptic dysfunction and degeneration. Thr...
Background
Scavenger receptors (SR) are a group of receptors involved in the endocytosis of various ligands, such as modified LDL and soluble β‐amyloid, which connects them to Alzheimer’s disease (AD). SCARF2 (SREC‐II) is part of the SR family, but unlike other scavenger receptors, internalizes a low amount of modified LDL. Its main function revolv...
Apolipoprotein B (APOB), a receptor-binding protein present in cholesterol-rich lipoproteins, has been implicated in Alzheimer's disease (AD). High levels of APOB-containing low-density lipoproteins (LDL) are linked to the pathogenesis of both early-onset familial and late-onset sporadic AD. Rare coding mutations in the APOB gene are associated wit...
Background
Apolipoprotein B (APOB) is well‐known for its role in cholesterol metabolism. We recently showed that APOB protein levels are elevated in the CSF of patients suffering from sporadic Alzheimer’s disease (AD) compared to control individuals (Picard et al, Alzheimers Dement. https://doi.org/10.1002/alz.12442 ). Since rare coding APOB varian...
The macrophage scavenger receptor 1 (MSR1) also known as SCARA1, is a gene that encodes for a macrophage/microglia cell surface receptor. Its primary function is to mediate the endocytosis of modified (acetylated or oxidized) low density lipoproteins (LDLs)(Frenkel, Wilkinson et al. 2013). Interestingly, MSR1 has been found to bind to soluble β‐amy...
Background:
We have recently identified apolipoprotein B (APOB) as a putative CSF indicator of early synaptic and Tau pathology in cognitively unimpaired individuals with a parental history of Alzheimer's disease (AD). The goal of this study is to understand how APOB is regulated under healthy and AD-related neuropathological conditions.
Method:...
