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Gabriel Alfonso Gutiérrez

Gabriel Alfonso Gutiérrez
Escuela Nacional de Ciencias Biológicas Insituto Politécnico Nacional · Pharmacy

PhD

About

30
Publications
15,449
Reads
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354
Citations
Introduction
Throughout my training in the field of research of natural products, the development of various interdisciplinary projects has allowed me to acquire the necessary knowledge for my personal and work growth. My objectives are among others to apply all this knowledge for the development of strategies and verification of them with an important social impact in the fields of pharmaceutical and preclinical research, which are also the basis for the establishment of future drugs or alternative treatment options based mainly in medicinal plants.
Additional affiliations
November 2019 - present
Instituto Politécnico Nacional
Position
  • Professor (Associate)
Description
  • Professor in the subjects of General Toxicology and General Biochemistry, in Bachelor level
October 2016 - September 2018
Metropolitan Autonomous University
Position
  • PostDoc Position
August 2012 - July 2016
Mexican Institute of Social Security
Position
  • PhD
Education
August 2012 - June 2016
Instituto Politécnico Nacional
Field of study
  • Inflammation and oxidative stress
August 2010 - June 2012
Instituto Politécnico Nacional
Field of study
  • Inflammation and Oxidative Stress
August 2005 - February 2010
Universidad Veracruzana
Field of study
  • Chemistry and Inflammation

Publications

Publications (30)
Article
Objective: To estimate to what extent the mixture of ursolic acid and oleanolic acid, in addition to the antitubercular standard regime, affects the hepatotoxicity profile. Methods: Liver injury was induced in male BALB/c mice by administering, per os and daily for 11 weeks, a combination of anti-Tubercular (anti-TB) agents Rifampicin (10 mg/kg)...
Article
One of the major mechanisms in the pathogenesis of chronic inflammation is the excessive production of reactive oxygen and reactive nitrogen species, and therefore, oxidative stress. Spirulina (Arthrospira) maxima has marked antioxidant activity in vivo and in vitro, as well as anti-inflammatory activity in certain experimental models, the latter a...
Article
Full-text available
Moussonia deppeana is known as tlachichinole, clachichinole, etc. In Mexican traditional medicine is used to treat gastrointestinal disorders, cough, stomach and duodenal ulcers, kidney and vaginal infections. The organic extracts prepared by maceration were evaluated against 11 mycobacterial strains and three protozoal. The AcOEt extract was activ...
Article
Full-text available
Arnica montana cell suspension culture could be a sustainable source of a vegetal material producer of secondary metabolites (SMs) possessing biological effects. Different plant growth regulator concentrations (0-5 mg/L) were tested in foliar explants to induce a callus that was used to establish a cell suspension culture. Growth kinetics was carri...
Chapter
Cnidoscolus chayamansa, commonly known as Chaya, belongs to the Euphorbiaceae family, and the Cnidoscolus genus is composed of approximately 50–75 species, of which 20 are endemic to Mexico. C. chayamansa is used as a food supplement in southeastern Mexico and has been used medicinally to treat diabetes, rheumatism, and gastrointestinal, diuretic,...
Chapter
Alzheimer is a chronic-generative neurological syndrome which affects mainly the central nervous system, however late experimental, epidemiological and clinical data had shown that the illness also affects nerve endings beyond the brain and cerebellum. The current panorama of the fight against Alzheimer’s disease, although it has made great advance...
Chapter
B. americana, B. cordata, B. parviflora, B. perfoliata, B. scordioides and B. sessiliflora, belonging to Buddleja Genus, are species distributed in Mexico reported in folk medicine to treat ills related to inflammatory processes. For some of them, this ethnopharmacological uses have been validated by scientific studies. Their phytochemistry has bee...
Book
ABSTRACT Aim: Testing Local diatomaceous earth (Silica nano-particles) and commercial pesticide (Challenger 36% SC) formulation against alfalfa grasshopper, Heteracris littoralis (Rambur, 1838) (Orthopetra: Acrididae) under laboratory conditions. Study Design: Histological study for alimentary tract using light microscope. Place and Duration of Stu...
Article
Since NSAIDs are commonly used anti-inflammatory agents that produce adverse effects, there have been on going efforts to develop more effective and less toxic compounds. Based on the structure of the anti-inflammatory pyrrolizines licofelone and ketorolac, a series of 1-arylpyrrolizin-3-ones was synthesized. Also prepared was a series of substitut...
Article
Cnidoscolus chayamansa ('Tree spinach' or Chaya) produces lupeol acetate (LUAC) naturally. Cell culture may represent a viable alternative production method to sustainably use of natural resources. No studies have reported LUAC production in vitro or in Chaya cell culture. The aim of the study was to establish a C. chayamansa cell suspension cultur...
Article
Journal of Immunology Research and Therapy (ISSN: 2472-727X) Introduction: In recent years, the use of food supplements like co-adjuvants in the treatment of various diseases has increased; being one of the most studied and consumed the algae Spirulina maxima, which possesses important demonstrated biological effects including antioxidant and anti...
Experiment Findings
Both extracts were evaluated in CD1 male mice first in a toxicity test of repeated dose administrations (1 g/kg) for 28 days, after which pharmacological activity of both extracts was measure during experimental induced arthritis where three doses were tested, at the end of the study edema formation, body weight gain and antioxidant activity were m...
Experiment Findings
Both extracts were evaluated in CD1 male mice first in a toxicity test of repeated dose administrations (1 g/kg) for 28 days, after which pharmacological activity of both extracts was measure during experimental induced arthritis where three doses were tested, at the end of the study edema formation, body weight gain and antioxidant activity were m...
Article
Ethnopharmacological relevance: Buddleja cordata Humb. Bonpl. & Kunth, known by the population as Tepozán blanco, is a shrub plant used in traditional herbal medicine in Mexico for the treatment of tumors, cancer, sores, skin burns, rheumatic pains and diseases related to inflammatory processes such as arthritis; authors adjudicate this etno-medici...
Article
Buddleja cordata is a species used by Mexican folk medicine for treating illnesses related to inflammation such as skin wounds and arthritis. It bio-synthesizes metabolites such as verbascoside that contributes to its ethno-therapeutic properties as anti-inflammatory remedy. HPLC analysis showed that the methanolic extract from cell suspension cult...
Article
Moussonia deppeana (Schltdl. & Cham.) Klotzsch ex Hanst., Gesneriaceae, known as tlachichinole, is a Mexican medicinal plant used for treatment of chronic inflammation-related diseases such as arthritis. In this paper, the main metabolite verbascoside was quantified in ethanolic extract; anti-arthritic and antioxidant activities were also evaluated...
Presentation
En la actualidad el uso de plantas medicinales como una alternativa para el tratamiento de enfermedades se ha incrementado. La OMS estima que para el 2011 aproximadamente cerca del 80% de la población mundial hace uso de las terapias alternativas sobretodo de remedios herbolarios, debido a que las terapias alopáticas convencionales provocan un gran...
Article
Leishmaniasis is considered as an emerging, uncontrolled disease and is endemic in 98 countries. Annually, about 2 million cases of cutaneous and 500000 cases of visceral-type leishmaniasis are recorded and 60000 persons died from the disease. In Mexico, cutaneous leishmaniasis is known as chiclero's ulcer and is reported in 22 states, it is consid...
Article
Cnidoscolus chayamansa is a medicinal and edible plant known as Chaya, is commonly used as an anti-inflammatory, antiprotozoal, antibacterial agent and as a remedy for respiratory illness, gastrointestinal disorders, and vaginal infections related with the inflammation process. In this paper, we describe the plant’s phytochemical analysis and biolo...
Article
Aim: To identify the anti-inflammatory activity through two murine models and the median Lethal Dose (LD50) of three dietary supplements that contain Moussonia deppeana. Methods:The anti-inflammatory activity of three dietary supplements (Cicatrisan/Gastricus®, Gastinol®, and Gastrovita®) EtOH extracts was evaluated by TPA and by carrageenan murine...
Book
Actualmente y debido al alto costo de los fármacos aunado a los efectos adversos que provocan, las plantas medicinales constituyen un recurso valioso para obtener principios activos y/o fitomedicamentos que permiten complementar los tratamientos alopáticos y mejorar la calidad de vida de la población. Cnidoscolus chayamansa y C. aconitifolius, cono...
Article
Drug-induced liver injury encompasses a spectrum of diseases ranging from mild biochemical abnormalities to acute liver failure; example of this scenery is hepatotoxicity caused by the first-line antituberculous drugs isoniazid, rifampin and pyrazinamide, which are basic for treatment of drugsensible and drug-resistant tuberculosis. In the search f...
Article
Currently, the high cost of drugs and the adverse side effects that they produce have led to the use of medicinal plants as a complement to allopathic treatment in order to improve quality of life. Cnidoscolus chayamansa, known as chaya, is used as food in the southeast of Mexico for its high nutritional value and as an alternative medicine to trea...
Article
Context: Spirulina (Arthrospira) exerts a wide spectrum of pharmacological activities that are largely attributed to its phycobiliprotein content, mainly to C-phycocyanin. The extraction, isolation and purification of C-phycocyanin have been studied for many years, resulting in diverse methodologies with a range of yields and grades of purity. Obj...
Patent
Detalla el uso del extracto etanólico de las partes aéreas de Moussonia deppeana en el tratamiento de la artritis reumatoide, principalmente en la disminución del cuadro edematoso crónico y el restablecimiento del ambiente óxido reducción de las articulaciones.
Article
Tuberculosis is treated with rifampicin, isoniazid and pyrazinamide; however, these drugs generated hepatotoxicity, which Ieads to non-adherence to treatment, contributes to treatment failure and favors the appearance of drugresistant. The hepatoxicity incidence depends on population studied, treatment time, age, malnutrition, HIV/AIDS, etc. and is...
Article
Background: Tuberculosis is a global and serious Public Health problem due to the increase of multidrugresistant and extensively drug-resistant cases; as a result, diverse research groups worldwide are focusing their efforts on finding novel antituberculous agents that can provide greater effectiveness, less toxicity and having a specific mechanism...
Article
Leishmaniasis is considered as an uncontrolled emerging disease and is endemic in 98 countries. Anually, is registered about 2 million cases of cutaneous, 500,000 cases of visceral-type and 60,000 persons die. In Mexico it is known as Chiclero´s ulcer and is reported in 22 states. For its treatment, pentavalent antimonial drugs are administered, th...

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Projects

Projects (2)
Archived project
Goals: 1. To evaluate the possible toxic effect of repeated administration for 28 days of methanolic extracts from wild Buddleja cordata Kunth and its cell suspension cultures 2. To evaluate the anti-arthritic activity of methanolic extracts in a murine model of experimental arthritis in mouse 3. To determine oxidative stress biomarkers in tissue obtained from arthritic mice
Archived project
1. To determine if the cell culture of medicinal plants generates an increase in the synthesis of certain metabolites 2. To evaluate if there is a relation between the anti-inflammatory effect and the increase in the concentration of the secondary metabolites 3. To determine the toxicity of these cell cultures of medicinal plants