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Citations since 2016
26 Research Items
Heart Rate Variability (HRV) is an indicator of the balanced functioning of the brain. When we take a breath and inhale, our heartbeat accelerates, when we exhale, it slows down. Heart Rate Variability (HRV) measures the dynamic change of this process. The more evenly our heart beats, the greater the problem may be with the complex function of reg...
The importance of central proinsulin C peptide in the treatment of COVID-19 The increase of the inflammatory markers CRP and Il-6 predict the unfavorable course of the covid-19 infection. The decrease of HRV by more than 40% precedes a 50% increase in CRP during the next 72 hours according to a small study. The sudden decrease of HRV may signal th...
Possible impact of intranasal proinsulin c-peptide on the course of COVID-19 infection: the role of the cholinergic anti-inflammatory pathway measured by Heart Rate Variability (HRV) and the importance of microglia, the resident immune cells in the brain The increase of the inflammatory markers CRP and Il-6 predict the unfavorable course of the cov...
The first beauty-care product containing proinsulin c-peptide was launched two years ago and it is available in the market since that time. A number of people tried using it off-label, as a nasal spray, similarly to the intranasal insulin. The experiences gathered during the past two years are astonishing and surprising. The present study is alrea...
Consequences of low oxygenation It is among the most severe effects of the coronavirus infection that the high risk patients may have breathing problems. The oxygen supply of their body decreases. Independently of the causes of this problem, the oxygen deficiency, hypoxia may decrease heart rate variability (HRV). (1) HRV or the parasympathetic ner...
In the beginning of 2020 a team of special education teachers, speech-therapists, a psychologist and a health visitor conducted a pilot study in order to evaluate the experiences of clients using the intranasal C-peptide spray. Our study was based on two sources: video-recordings documenting the cases and a questionaire filled in during a conversat...
A woman reports that her husband, who was delivered to the hospital with pulmonary infections and damage and breathing problems recovered within 5 days with the help of intranasal proinsulin c peptide. The CRP decreased from 267 to 83,5 within this short period. The case is form Slovakia. From Hungary we have a few similar case descriptions. The CRP values are attached.
May it be that central/ intranasal proinsulin C-peptide has a favorable effect by its HRV increasing ability on most of the clinical markers of the poor outcome of COVID-19? (Il-6, D-dimer, Lymphocytes)
- IL-6: Heart rate variability (HRV) is in an inverse relationship with IL-6: Relationship between Heart Rate Variability, Interleukin-6, and Soluble Tissue Factor in Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8/
- D-dimer: D-dimer is in an inverse relationship with endothelial progenitor cells and edothelial progenitor cells are positively associated with HRV or parasympathetic tone at least in patients with hypertension. : Lower Levels of Circulating Endothelial Progenitor Cells Are Associated with Increased Recurrence after Unprovoked Venous Thrombosis: https://ashpublications.org/blood/article/128/22/3805/97010/Lower-Levels-of-Circulating-Endothelial-Progenitor Sympathetic Predominance Is Associated With Impaired Endothelial Progenitor Cells and Tunneling Nanotubes in Controlled-Hypertensive Patients: https://pubmed.ncbi.nlm.nih.gov/24858852/
- Lymphopenia: Under certain condition lymphocytes (CD4+, CD8+ etc.) are positively associated with HRV or parasympathetic tone and C-peptide increases parasympathetic tone and HRV: Leukocyte Populations are Associated with Heart Rate Variability After a Triathlon: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187961/ Stress Determined Through Heart Rate Variability Predicts Immune Function: https://pubmed.ncbi.nlm.nih.gov/31408866/
Proinsulin C Peptide Obviates Sympathetically Mediated Suppression of Splenic Lymphocyte Activity in Rats: https://pubmed.ncbi.nlm.nih.gov/11151760/
C-peptide Improves Autonomic Nerve Function in IDDM Patients: https://pubmed.ncbi.nlm.nih.gov/8781764/
Proinsulin C-peptide Activates Vagus Efferent Output in Rats: https://pubmed.ncbi.nlm.nih.gov/16005542/
Intranasal Administration of Proinsulin C-Peptide Enhances the Stimulating Effect of Insulin on Insulin System Activity in the Hypothalamus of Diabetic Rats: https://pubmed.ncbi.nlm.nih.gov/31346872/