Gábor Orgován

Gábor Orgován
Semmelweis University | SOTE · Department of Pharmaceutical Chemistry

Ph.D.

About

27
Publications
17,048
Reads
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260
Citations
Additional affiliations
December 2010 - present
Semmelweis University
Position
  • Professor (Assistant)
December 2010 - present
Semmelweis University
Position
  • Research Assistant
Education
September 2007 - September 2010
Semmelweis University
Field of study
  • Pharmacy
September 2001 - July 2007
Semmelweis University
Field of study
  • Pharmacy

Publications

Publications (27)
Article
The removal of Ni(II), Cu(II) and Zn(II) from aqueous model solutions and real wastewater samples by using pod razor (Ensis siliqua) shell powder has been investigated under several conditions such as heavy metal concentrations, pH, contact time, powder dosage. It was found that the removal of heavy metals was dependent on the dose of the biominera...
Article
Adrenaline, noradrenaline, the biogenic catecholamines of vital importance, and four closely related compounds were studied by 1H NMR-pH titrations, and the resulting acid-base properties are quantified in terms of three macroscopic and twelve microscopic protonation constants for both molecules. The species-specific basicities are interpreted by m...
Article
A novel method was elaborated and a set of 1H NMR-pH indicator molecules was selected to develop an NMR-based pH determination method, which needs neither any glass or other electrodes, nor any separate reference compound, being thus devoid of the usual acid- and base-errors of the glass and combined electrodes. The method utilizes organic compound...
Article
Dopamine and 4 related compounds were studied by 1H NMR-pH titrations and a case-tailored evaluation method. The resulting acid-base properties of dopamine are quantified in terms of 3 macroscopic and 12 microscopic protonation constants and the concomitant 3 interactivity parameters. The species- and site-specific basicities are interpreted by mea...
Article
In the present study, several Cu chelators [2,2'-biquinoline, 8-hydroxiquinoline (oxine), ammonium pyrrolidinedithiocarbamate (APDTC), Dp44mT, dithizone, neocuproine] were used to study Cu uptake, depletion and localization in different cancer cell lines. To better understand the concentration dependent fluctuations in the Cu intracellular metal co...
Article
Full-text available
The aim of this study is to confirm the formation of inclusion complexes between bifonazole (BFZ) and different cyclodextrin (CD) derivatives. Bifonazole, an imidazole antifungal derivative,is a very hydrophobic compound, which is a major drawback in obtaining topical pharmaceutical formulations with optimal bioavailability. Cyclodextrins may incre...
Article
Full-text available
Lapatinib (LAP), the tyrosine kinase inhibitor drug with moderate bioavailability, was characterized in terms of physicochemical properties: acid-base characteristics, lipophilicity, and solubility. The highly lipophilic nature of the drug and its extremely low water solubility ( S0=0.82 nM) limit the development of a parenteral formulation. In ord...
Article
Full-text available
Lapatinib (LAP) the tyrosine kinase inhibitor drug with moderate bioavailability was characterized in terms of physicochemical properties – acid-base characteristics, lipophilicity and solubility. The highly lipophilic nature of the drug and its extremely low water solubility (S0=0.82 nM) limits the development of a parenteral formulation. In order...
Article
Biorelevant, isomer-specific physicochemical parameters of resveratrol, a multifunctional component in red wines, with cardioprotective, anti-Alzheimer and several other pharmacologic activities were determined. The parameters include site-specific basicities, lipophilicities, solubilities and diffusion constants for the two geometric isomers. The...
Article
The hydroxide-catalyzed non-enzymatic, simultaneous and consecutive hydrolyses of diacetylmorphine (DAM, heroin) are quantified in terms of 10 site- and species-specific rate constants in connection with also 10 site- and species-specific acid-base equilibrium constants, comprising all the 12 coexisting species in solution. This characterization in...
Article
Full-text available
Fluconazole, the adequate antifungal agent in Candida infections was studied to quantify its acid–base and cyclodextrin-complex formation equilibria. 1H NMR-pH titrations revealed protonation steps in the highly basic region (log K1 = 11.96) and in the acidic region (log K2 = 1.48). The stability and structure of its complexes with β-cyclodextrin (...
Article
Azole antifungals are a group of compounds that play essential rule in the treatment of surface and deep mycoses. They can be used externally to treat fungal infections of skin, mucous membranes and external genitalia but they are also suitable for oral treatment of systemic mycoses. Structurally they are classified into two groups: imidazoles and...
Article
Ezetimibe belongs to a new class of lipid-lowering agents that selectively inhibit the intestinal absorption of cholesterol and related plant sterols. The molecular target of ezetimibe is the sterol transporter, Niemann-Pick C1-Like 1 (NPC1L1), which is responsible for the intestinal uptake of cholesterol and phytosterols. Its action is localized a...
Article
Erlotinib (ERL), the anticancer drug of poor bioavailability, was quantified in terms of bio-relevant physicochemical parameters, such as acid–base properties, lipophilicity and solubility, and a comprehensive study on its inclusion complexation was carried out. The protonation constant of ERL (log K = 5.32) indicates that it exists mainly in depro...
Article
Spectinomycin, a tricyclic aminoglycoside antibiotic with peculiar chemical structure and pharmacological profile was characterized in terms of microscopic protonation constants. 1H-15N HMBC–pH titrations were carried out to allocate the order of basicities of the two similar methylamino functions of spectinomycin, and 1H NMR–pH titrations were per...
Article
The site-specific acid-base properties of ovothiol A disulfide (OvSSOv), the smallest hexabasic multifunctional biomolecule with complex interdependent moieties, were studied with (1)H NMR-pH and potentiometric titrations. The unprecedented complexity of the protonation microequilibria could be overcome by taking into account the mirror-image molec...
Article
Ovothiol A, a small biomolecule with highly potent antioxidant capacity, and three newly synthesized derivatives were studied by 1H NMR, 15N NMR, UV-pH titrations, and a customized evaluation method. The omni-interactive imidazole, amino, carboxylate, and thiolate moieties of ovothiol A are quantified in terms of 32 microscopic protonation constant...
Article
Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone (Dp44mT) is a potential candidate in chelation therapy as an iron chelator. This study showed that a combined treatment with 2μM easily available Fe(II), Cu(II) and Zn(II) each and 5μM Dp44mT on eight different cancer cell lines resulted in a 10-40-fold increase in the intracellular Cu content co...
Article
Streptomycin, the classical aminoglycoside antibiotic, generally considered the most basic drug compound was characterized in terms of protonation macro- and microconstants. ¹H NMR-pH and ¹H-¹³C HSQC-pH titrations were carried out on streptomycin and streptidine, a symmetrical constituent compound of reduced complexity to monitor the proton-binding...
Article
(1)H NMR-pH titrations of arginine, the most basic natural amino acid and citrulline, its neutral counterpart were carried out. Two other closely related auxiliary compounds were also studied. The 8 macroscopic protonation constants were determined. Combining the four datasets in a deductive method, all the 12 microconstants of arginine, the 4 micr...
Article
A set of indicator molecules was selected and applied to elaborate an NMR-based pH determination method, free of glass electrode errors in highly basic media. Accurate measurement of pH values and protonation constants was achieved by a successive build-up of overlapping, increasingly high pH solutions, using a collection of 8 compounds of appropri...
Article
Drug delivery to the central nervous system (CNS) has long been recognised as an enormous task, due to the physiological gate-keeping function of the blood-brain barrier (BBB). With the development of molecular biology, the function and properties of the BBB are better understood. In this review, transporterization, a promising method for drug deli...
Article
The rate constants of spontaneous and hydroxide-catalyzed decomposition and the tautomer-specific protonation constants of tolperisone, a classical muscle relaxant were determined. A solution NMR method without any separation techniques was elaborated to quantitate the progress of decomposition. All the rate and equilibrium constants were determine...

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