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Introduction
I am a clinician scientist specializing in dermatology and sexually transmitted diseaes. My clinical interests are dermatooncology, especially cutaneous lymphomas, autoimmune diseaes and sexually transmitted diseases. My research activity focusses on diagnostic tests and classification of diseases and skin conditions.
Current institution
Additional affiliations
October 2012 - present
February 2019 - June 2021
Position
- PostDoc Position
February 2019 - June 2021
Position
- PostDoc Position
Description
- PostDoc, topic: cutaneous lymphomas
Publications
Publications (119)
Zusammenfassung
Mycosis fungoides (MF) und Sézary‐Syndrom (SS) sind die häufigsten Subtypen der heterogenen Gruppe der kutanen T‐Zell‐Lymphome (CTCL). Mit der Erweiterung der Therapielandschaft sind in den letzten Jahren neue Behandlungsoptionen verfügbar geworden, allen voran der gegen den C‐C‐Chemokinrezeptor 4 (CCR4) gerichtete monoklonale Antik...
Background and Objectives
Patients with cutaneous lymphomas (CL) are at an increased risk of developing secondary malignancies. This study aimed to assess the frequency of association between CL and Kaposi sarcoma (KS) and to identify factors that may promote the co‐occurrence of these two diseases.
Patients and Methods
On January 25, 2024, we con...
Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of the heterogeneous group of cutaneous T‐cell lymphomas (CTCL). With the expansion of the biologic treatment landscape, new treatment options have become available in recent years, most notably the C‐C chemokine receptor 4 (CCR4)‐directed monoclonal antibody mogamulizumab...
Zusammenfassung
Hintergrund
Interferon‐α2a ist eine wichtige Therapieoption in der Behandlung kutaner T‐Zell‐Lymphome (CTCL). Seit Januar 2020 wird das zur Therapie zugelassene rekombinante Interferon‐α2a (IFN‐α2a) nicht mehr produziert. Als empfohlene Alternative steht pegyliertes Interferon‐α2a (pegIFN‐α2a) im off‐label use zur Verfügung. Das Zi...
Background
Interferon‐alpha is an important therapeutic option for the treatment of the cutaneous T‐cell lymphomas (CTCL). Since the approved recombinant interferon‐α‐2a (IFN‐α2a) has no longer been produced since January 2020, pegylated interferon‐α2a (pegIFN‐α2a) can be used as an alternative treatment, even though it is not approved for the trea...
In 1997 rituximab, a genetically engineered chimeric monoclonal antibody (mAb) targeting CD20 expressed on B cells was approved for treatment of non-Hodgkin’s lymphoma. Since then, pharmacological improvements combined with increased knowledge on the immunopathogenesis of diseases led to the development of specific mAb targeting different antigens...
Traditionally, Sezary syndrome (SS) has been associated with few therapeutic options and poor prognosis, with 5‐year disease‐specific survival (DSS) less than one‐third in historical cohorts. However, newer therapies and combinations are associated with impressive time‐to‐next‐treatment (TTNT), particularly allogeneic stem‐cell transplantation (All...
Background
Sézary syndrome is an extremely rare and fatal cutaneous T-cell lymphoma (CTCL). Mogamulizumab, an anti-CCR4 monoclonal antibody, has recently been associated with increased progression-free survival in a randomized clinical trial in CTCL. We aimed to evaluate OS and prognostic factors in Sézary syndrome, including treatment with mogamul...
In this perspective we provide BJD readers with an overview on the Horizon project. It illuminates the diverse perspectives of specialists across five prominent European centers of excellence in the CTCL field.
Zusammenfassung
Hintergrund
Primäre kutane Lymphome sind seltene lymphoproliferative Neoplasien und gehören zur heterogenen Gruppe der Non‐Hodgkin‐Lymphome. Sie umfassen ein klinisch und histologisch breites Spektrum an Manifestationsformen, wobei kutane T‐Zell‐Lymphome (CTCL) mit 73% am häufigsten sind. Aufgrund der Seltenheit der Erkrankungen si...
Background
Primary cutaneous lymphomas (PCL) are rare skin tumors of lymphoproliferative neoplasms and belong to the heterogeneous group of non‐Hodgkin's lymphomas. PCL encompass a broad spectrum of clinical and histologic manifestations, with cutaneous T‐cell lymphoma (CTCL) being the most common (73%). Due to the rarity of the diseases, populatio...
Despite increasing availability of therapies, patients with Sezary syndrome (SS) commonly endure multi-line treatment journeys, mostly with partial responses of short duration. Measuring clinical benefit is challenging; time-to-next-treatment (TTNT) provides a robust, objective measurement of efficacy. This international observational study, from t...
Background:
Efficacy and safety of mogamulizumab, a monoclonal antibody directed against C-C chemokine receptor 4, were demonstrated in a previous multinational clinical trial conducted in patients with previously treated cutaneous T-cell lymphoma (CTCL): Sézary syndrome (SS), or Mycosis Fungoides (MF).
Objectives:
The real-world French OMEGA st...
Simple Summary
The surrounding cells of the tumor tissue are called microenvironment, and they may contribute to disease progression and/or antitumor immune response. Much has been learned about the microenvironment of mycosis fungoides and Sézary syndrome over the past decades and how it is affected by treatments. This review summarizes the recent...
Primary cutaneous T‑cell lymphomas are a heterogeneous group of rare diseases. Patients often suffer from visible, severely pruritic skin lesions, infections, relapses, and their life expectancy may be reduced. Under current therapies, long-lasting, complete remission is rare. However, new treatment approaches and combination therapies are changing...
Little is known on the efficacy of systemic or skin-directed therapies (SDT) in CBCL. Time to next treatment (TTNT), a simple and reliable surrogacy for duration of clinical benefit, measured from the start of a therapy to the start of a subsequent treatment line after the prior therapy has ended.
Aim of this retrospective study was to evaluate C...
Background:
Cutaneous T-cell lymphomas (CTCLs) are rare forms of non-Hodgkin's lymphoma of T-cell origin that occur mainly in the skin. The most common form is mycosis fungoides (MF), but Sézary syndrome (SS), a more aggressive form of CTCL, is another relevant subgroup. Due to the rare nature of the disease, population-based studies of the epidem...
Hintergrund: Kutane T-Zell-Lymphome (CTCL) sind seltene Formen von Non-Hodgkin-Lymphomen mit T-Zell-Ursprung, die hauptsächlich in der Haut auftreten. Die häufigste Form ist Mycosis fungoides (MF), aber auch das Sézary-Syndrom (SS), als eine aggressivere verlaufende Form des CTCL, ist eine relevante Untergruppe. Aufgrund des seltenen Krankheitsbild...
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Background
Primary cutaneous lymphomas are a group of T- (CTCL) and B-cell (CBCL) malignancies. These diseases have different clinical presentations and prognosis. Our knowledge on their epidemiology is limited. Aim of this review was to summarise recent findings on the incidence of CTCL and CBCL, how they change over time, and to describe possible...
Cutaneous involvement of chronic graft-versus-host disease (cGVHD) has a wide range of manifestations including a lichenoid form with a currently assumed mixed Th1/Th17 signature and a sclerotic form with Th1 signature. Despite substantial heterogeneity of innate and adaptive immune cells recruited to the skin and of the different clinical manifest...
Cutaneous T-cell lymphoma (CTCL) is a malignancy of skin-homing T-cells. Long-term remissions are rare in CTCL, and the pathophysiology of long-lasting disease control is unknown. Mogamulizumab is a defucosylated anti-human CCR4 antibody that depletes CCR4-expressing CTCL tumor cells and peripheral blood memory regulatory T cells. Prolonged remissi...
Introduction
Le mogamulizumab, anticorps monoclonal humanisé ciblant le récepteur de chimiokines CCR4, a été récemment approuvé pour le traitement des lymphomes T cutanés épidermotropes. Des exanthèmes ont été rapportés comme effet indésirable du mogamulizumab. Nous rapportons six cas originaux d’éruption granulomateuse des zones photoexposées mima...
Introduction
Le mycosis fongoïde (MF) chalazodermique (MFC) est une variante très rare de MF caractérisée cliniquement par des plaques ou tumeurs flasques (par perte de l’élasticité cutanée) et histologiquement par un infiltrat dermique (± hypodermique) de lymphocytes tumoraux, de cellules géantes plurinucléées, une perte du tissu élastique et parf...
Introduction
Le diagnostic précoce de lymphome T cutané n’est pas toujours aisé et repose sur un faisceau d’arguments cliniques, biologiques, histologiques et moléculaires. Le séquençage haut débit du TCR-bêta permet par la reconnaissance de séquences CDR3 spécifiques l’identification et la quantification de chaque clone T présent dans un échantill...
Linked Article: Xiao et al. Br J Dermatol 2022; 186:520–531.
The early diagnosis of MF and SS may be challenging and is based on a combination of clinical, biological, histological, and molecular criteria. Until now, the search for T-cell clones in skin was mostly performed by standard PCR amplification of the T-cell receptor (TCR) genes and capillary electrophoresis (CE) but false positives and negatives wi...
Cutaneous T-cell lymphoma (CTCL) is a malignancy of skin-homing T-cells. Long-term remissions are rare in CTCL, and the pathophysiology of long-lasting disease control is unknown. Mogamulizumab is a defucosylated anti-human CCR4 antibody that depletes CCR4-expressing CTCL tumor cells and peripheral blood memory regulatory T cells. Prolonged remissi...
Background
Despite increasing availability of therapeutic agents, Sézary syndrome (SS) remains associated with a generally poor prognosis. Typically, patients endure multi-line treatment, frequently with disappointingly short durations of clinical benefit. Time to next treatment (TTNT) measures the interval from the date of commencement of one ther...
Introduction
Cancer-associated fibroblasts (CAFs), a component of tumor microenvironment, play a key role in oncogenesis and promote growth, invasion, metastasis and chemo-resistance of tumor cells. Our previous RNAseq results brought evidence of the contribution of dermal fibroblasts obtained from cutaneous T-cell lymphoma (CTCL) lesions to suppor...
Background
Mogamulizumab is a defucosylated monoclonal antibody targeting the C-C chemokine receptor 4 (CCR4) and approved for the treatment of adult patients with mycosis fungoides (MF) and Sézary syndrome (SS) who have received at least one prior systemic therapy. The efficacy of mogamulizumab was demonstrated in the open-label, phase 3 MAVORIC c...
Funding sources: none
Conflicts of interest: the authors declare they have no conflicts of interest.
Dear Editor, The early diagnosis of cutaneous T‐cell lymphoma (CTCL) may be challenging and based on a combination of clinical, biological, histological and molecular criteria.¹ High‐throughput sequencing (HTS) of the T‐cell receptor genes allows id...
Background
Clinical and histological diagnosis of Sézary syndrome (SS) and mycosis fungoides (MF) is challenging in routine. We investigated five blood markers previously described for SS (T‐plastin, Twist, KIR3DL2, NKp46 and Tox) in a prospective validation cohort of patients.
Methods
The markers were analyzed by RT‐q‐PCR on peripheral blood leuc...
Un des enjeux majeurs de ce XXI e siècle est la lutte contre le vieillissement, défini comme un ensemble de mécanismes physiologiques altérant les capacités physiques et intellectuelles de l’organisme. Le vieillissement de la peau n’est qu’un trait visible de ce processus. Il est associé à des défauts de cicatrisation majeurs liés à l’altération de...
Introduction
Le microenvironnement tissulaire joue un rôle clé dans l’oncogenèse et favorise la croissance, l’invasion, les métastases et la résistance à la chimio-prévention des cellules tumorales. Notre objectif est de déterminer quelle est la contribution du microenvironnement cutané mésenchymateux dans les lésions tumorales des lymphomes T cuta...
Introduction
Les lymphomes cutanés primitifs sont un groupe hétérogène de maladies rares. Plusieurs publications ont démontré des motifs épidémiologiques locaux, mais pour l’instant, il n’y avait pas encore de comparaison systématique globale publiée. Le but de cette étude était de comparer les fréquences relatives des lymphomes cutanés entre les d...
Introduction
Les lymphomes cutanés primitifs sont un groupe hétérogène de lymphomes T cutanés (LTC) et de lymphomes B cutanés (LBC). Nous avons peu d́informations sur les caractéristiques des patients atteints de ces maladies et leurs stades initiaux. Malgré plusieurs publications nationales européennes il existe peu de données sur ĺévolution de le...
Actinic cheilitis is a pre‐malignant condition that can progress to squamous cell carcinoma with a higher propensity for metastasis than cutaneous squamous cell carcinoma. Optimal treatment for actinic cheilitis has not been established and evidence‐based estimates of clinical cure in the dermatology literature are limited. Here, we review and synt...
Background
Primary cutaneous lymphomas (PCLs) are a heterogeneous group of T‐cell (CTCL) and B‐cell (CBCL) malignancies. Little is known about their epidemiology at initial presentation in Europe and about potential changes over time.
Objectives
The aim of this retrospective study was to analyse the frequency of PCLs in the French Cutaneous Lympho...
Cutaneous T-cell lymphomas (CTCL) are a heterogenous group of rare diseases. Many studies have reported on local epidemiology or geographic clustering, however we lack information from a global perspective. A systematic review and meta-analysis was conducted in Medline and the Cochrane Library based on a previously registered protocol and according...
Abstract is missing (Short communication)
is missing (Short communication).
Introduction
Le mycosis fongoïde (MF) et son variant leucémique, le syndrome de Sézary (SS), sont les formes les plus fréquentes des lymphomes T cutanés (LTC). Leur diagnostic clinique et histologique peut être difficile. Notre équipe a décrit quatre marqueurs sanguins prometteurs du SS : Twist, T-plastine, NKp46 et KIR3DL2. De plus Tox a été décri...
Introduction
Le lymphome T cutané anaplasique à grandes cellules est un lymphome T cutané (LTC) de bon pronostic avec expression de CD30 par plus de 75 % des cellules. Les lymphomes T cutanés primitifs qui ne correspondent à aucune des catégories définies par la classification Organisation mondiale de la santé/European Organization for Research and...
To the Editor: Primary cutaneous anaplastic large‐cell lymphoma (pcALCL) is a cutaneous Tcell lymphoma (CTCL) generally associated with a good prognosis, composed of large cells, with >75% expressing CD301 . The rare cases of extensive disease can be efficiently treated with chemotherapy and/or brentuximab vedotin, an anti‐CD30 antibody‐drug conjug...
Background
Malignant melanoma is a frequent form of skin cancer with a very high mortality. In Europe approximately 22,000 people die each year due to melanoma, of which 2700 patients in Germany alone. The incidence has shown an increasing tendency for years. Significant risk factors for the emergence of a malignant melanoma are the number of melan...
Background:
Associations between daily amounts of drinking water and skin hydration and skin physiology receive increasingly attention in the daily life and in clinical practice. However, there is a lack of evidence of dermatological benefits from drinking increased amounts of water.
Materials and methods:
Pubmed and Web of Science were searched...
Androgenetic alopecia is the most common hair loss disorder, affecting both men and women. Initial signs of androgenetic alopecia usually develop during teenage years leading to progressive hair loss with a pattern distribution. Moreover, its frequency increases with age and affects up to 80% Caucasian men and 42% of women. Patients afflicted with...
Objectives
The aim of this study was to measure the prevalence of skin diseases in aged nursing home residents and to explore possible associations with demographic and medical characteristics.
Design
Descriptive multicentre prevalence study.
Setting and participants
The study was conducted in a random sample of ten institutional long-term care f...
