Gabino Garrido

Gabino Garrido
Journal of Pharmacy & Pharmacognosy Research

Editor

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208
Publications
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Introduction
Gabino Garrido currently works at the Editor of Journal of Pharmacy & Pharmacognosy Research, under the auspices of the Academic Association of Pharmaceutical Sciences from Antofagasta (ASOCIFA), Chile, which publishes studies in the pharmaceutical and herbal fields concerned with the physical, botanical, chemical, biological, toxicological properties and clinical applications of molecular entities, active pharmaceutical ingredients, devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture, evaluation and marketing. Gabino does research in Pharmacy, Pharmacology and Medicinal Chemistry. Their current project is 'Natural Products and Cancer'.

Publications

Publications (208)
Article
Coronavirus disease 2019 (COVID-19) represents a global healthcare crisis that has led to morbidity and mortality on an unprecedented scale. While studies on COVID-19 vaccines are ongoing, the knowledge about the reactogenic symptoms that can occur after vaccination and its generator mechanisms can be critical for healthcare professionals to improv...
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Context: The COVID-19 outbreak is caused by the transmission and infection of SARS-CoV-2 at the end of 2019. It has led many countries to implement lockdown policies to prevent the viral spreading. Problems arise in a COVID-19 patient because of viral infection that leads to a systemic response in the immune system, specifically due to cytokine sto...
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Context: The decision to perform an intervention on a narrowed coronary artery depends on the ischemia caused by the stenosis. The indication for intervention usually applies to cases with ≥70% stenosis of vascular diameter because of the risk of myocardial ischemia. Aims: To define the efficacy of fractional flow reserve (FFR) measurement in the...
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Context: Inappropriate prescribing of antibiotics can result in serious patient harm. Aims: To investigate the incidence, nature, clinical severity, and causes of antibiotic prescribing errors (APEs) in the emergency department (ED) of a large hospital in Jordan. Methods: A mixed-method approach was used to explore the incidence and types of APEs...
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Context: Ammodaucus leucotrichus commonly known as a ‘Kamune es sufi or akâman’ in Morocco, is used to treat many diseases including diabetes. Aims: To investigate the antihyperglycemic activity of an aqueous extract of fruits A. leucotrichus (AEAL) and its chemical composition. Methods: The antihyperglycemic effect of the AEAL was tested against...
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Context: Diabetes is a dangerous chronic disease with a rapidly increasing rate of hospitalization and death. Patients with uncontrolled diabetes are prone to dangerous acute and chronic complications. Aims: To determine the characteristics of insulin use and factors related to blood glucose control in inpatients with diabetes at the Department of...
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Context: Zanthoxylum rhetsa (Roxb.) DC is a plant rich in essential oils, terpenes, coumarins, and alkaloids, among others, and has traditionally been used by tribal healers for decades. But as yet, there is no systematic and critical review on this plant to document the phytochemistry and pharmacological properties of its isolated compounds. Aims:...
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Context: Piper cubeba L. (family Piperaceae) is used traditionally for the treatment of many diseases, including cancer. Aims: To determine the anticancer activity of P. cubeba crude extracts on cancer cells and identify chemical constituents of the active fraction. Methods: Seeds of P. cubeba were sequentially extracted with dichloromethane foll...
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Context: Medicinal and aromatic plants are used by people for various purposes, whether for health care, beauty, or as a food source. Aims: To valorize the knowledge about their uses, therapeutic, cosmetic, and food. Methods: The ethnobotanical study was conducted from November 1, 2019, to March 1, 2021, in the Moulay Yacoub region. A total of 40...
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Context: The extraction mode plays a key role in extracting a particular type of pharmacologically active compounds that can be isolated as leads to develop novel therapeutic molecules. Aims: To evaluate the impact of extraction mode on extract yield, phytochemicals constituents, and antidiabetic activity of different parts of the Calotropis proce...
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Context: Flaxseed constituents provide to antioxidant, anti-inflammatory, antimicrobial and wound healing benefits. Aims: To systematically review the experimental evidence on the wound healing ability of flaxseed extracts and formulations. Methods: Comprehensive searches in six databases (Scopus, Science Direct, Web of Science, PubMed, Google Scho...
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Context: The beneficial effects of natural polyphenolic compounds are increasingly emerging as powerful antioxidants and digestive boosters. Phoenix dactylifera seeds are recently identified as a healthy functional food with rich amounts of phenolic compounds. Aims: To analyzing the phenolic profile obtained from Moroccan variety of date seeds and...
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Context: Asthma is characterized by hyperresponsiveness and bronchoconstriction, induced by histamine and other noxes, with a prevalence in Peru of 20.7-28.2%, which is why, in traditional medicine, Jatropha macrantha Müll.Arg is used. Aims: To evaluate the in vivo bronchodilator activity of the ethanolic extract of the stems of J. macrantha. Met...
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Context: The standard management of oral ulcer therapy is focused only on symptomatic therapy, such as reducing pain. To date, there is no topical drug that has the pharmacodynamics to intervene in oral ulcer pathogenicity. Liquid smoke is traditionally used as a safe natural preservative. The liquid smoke is highly phenolic and compound rich. It i...
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Context: Spain was at the epicenter of the pandemic. Health centers across Spanish territory were not able to respond to non-emergency enquiries, leaving community pharmacies as the first point of patient’s contact. Aims: To investigate the impact of COVID-19 on the mental and physical health of community pharmacy teams across Spain. Methods: A c...
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Context: Osteoporosis occurs not only in the lumbar bone, femur, and radius but also occurs in the mandibular bone. Therefore, osteoporosis is a disease that required attention from the dentists. Aims: To determine the ratio of Receptor Activator of Nuclear Factor kB-Ligand:Osteoprotegerin (RANKL:OPG) expression and the ratio of osteoclasts:osteob...
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Context: Hyperuricemia is a metabolic syndrome characterized by a high serum uric acid level with an increased risk of gout, diabetes, cardiovascular and renal disease. Allopurinol is a widely known xanthine oxidase inhibitor that lowers serum uric acid production. Documented adverse effects of the drug raise the need for a natural alternative for...
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Context: The development of apoptotic agent from natural plant products may have a beneficial effect as a promising candidate for cancer therapy. The study about the efficacy of Phaleria macrocarpa leaves on breast cancer is still limited. Aims: To elucidate the molecular mechanisms underlying the anti-breast cancer activity of P. macrocarpa leave...
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Context: Health care quality has been widely discussed for over 40 years. However, it is still complex to define, understand, and assess it due to the multiple factors it involves, especially in the emergency services. Aims: To identify the main factors that influence the quality of the medical emergency services provided across the health care ne...
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Context: Caesalpinia sappan and Ochna integerrima are two native plants of Thailand and distributed widely throughout the country. Recently, water extracts from the stem bark of C. sappan and O. integerrima were found to exhibit potently antibacterial property but the antibacterial mechanism of action toward target bacteria has not been investigate...
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Context: In pharmacy products, glutathione and vitamin C are often present together. Both components not only enhance each other’s action but also protect each other from oxidation, forming an antioxidant couple. The work is devoted to the development of an HPLC method for determining the activity of pharmaceutical preparations containing the antio...
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Context: More than 500 Centaurea species compose the Asteraceae family, and most of the recent studies made on the species of this genus proved their pharmacological potential, especially to treat chronic illnesses. Aims: To evaluate for the first time the antioxidant, anti-inflammatory, neuroprotective and anti-microbial properties of the n-butan...
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Context: SARS-CoV-2, a member of family Coronaviridae and the causative agent of COVID-19, is a virus which is transmitted to human and other mammals. Aims: To analyze the B-cell epitope conserved region and viroinformatics-based study of the SARS-CoV-2 lineage from Indonesian B.1.1.7 isolates to invent a vaccine nominee for overcoming COVID-19....
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Context: Clinical Pharmacy services in the United Arab Emirates (UAE) are evolving, mostly with reference to the advancements in the United States of America (USA). American and Swedish healthcare agencies are operating healthcare facilities in the UAE. Benchmarking the advancements from observations of Clinical Pharmacists or Pharmacists in these...
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Context: Human life is contested with the emergence of new infectious diseases and antibiotic-resistant pathogens, cellular deterioration due to oxidative stress, and age-related neurodegenerative disorders. Aims: To evaluate the antibacterial, antioxidant, and acetylcholinesterase inhibitory activities of crude extract from the endophytic fungus F...
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Context: The most common biomaterial used for dental implants is titanium. However, the release of metal ions and the risk of allergic reactions to metals that may occur in some patients cannot be avoided. Hydroxyapatite-polymethylmethacrylate (HA-PMMA) composite biomaterials are proposed to have potential as dental implant biomaterials due to thei...
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Context: COVID-19 pandemic has caused more than 2.7 million mortality worldwide. Although the COVID-19 vaccine has been developed, the amount is still limited, and very few countries have reached ‘herd immunity’ level. In this regard, imported and community infections is still happening in the world. In order to complement the vaccine rollout, the...
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Context: Euphorbia hirta L. is widely distributed in the Indian subcontinent and has many ethnomedicinal uses. Traditionally, the leaves of E. hirta have been used as antidiarrheal agents, for bronchial and respiratory diseases and against conjunctivitis. Aims: To evaluate the antidiarrheal activity of the aqueous extract of leaves of Euphorbia hi...
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Context: Curcuma longa (turmeric) is extensively cultivated as spices and herbal medicines in tropical and sub-tropical countries. Geographical origin is known to significantly determine the quality of the herbs used and, consequently, the safety and efficacy of their products. Aims: To validate and develop TLC-fingerprint combined with chemometri...
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Context: The benefit of early switching from intravenous (IV) to oral (PO) antibiotic therapy has been controversial during the last few decades. Aims: To evaluate the effect of early switching from IV to PO antibiotics on treatment outcomes in surgical patients at one of the largest public hospitals. Methods: Two hundred and nine patients admitt...
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Context: As part of the development of the natural heritage of Morocco, an ethnobotanical and agronomic study was conducted in the regions of Figuig and Draa- Tafilalet. Aims: To collect detailed information about the usage of Brocchia cinerea plant in human therapy and its incorporation into the feed system of livestock. Methods: The survey was...
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Context: Warionia saharae Benthem ex Benth. & Coss has been widely used for gastrointestinal problems in Morocco and Algeria. Aims: To explore the possible mechanism for its use to such ailments in order to rationalize some of these folkloric uses. We investigated the aqueous extract of this plant (AqWs) for antispasmodic activity on isolated rat...
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Context: Cadmium has been considered as one of the most hazardous toxic compounds with harmfully effect on the health of organisms. Aims: To evaluate the effects of gallic acid (GA) on the cadmium-induced liver and renal oxidative stress in Wistar rats. Methods: Twenty Wistar rats were grouped into four (A–D) of five rats. Rats in Group A, B, C a...
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Context: Pediatric brain tumors are the most common solid tumors and the leading cause of death among children worldwide. Although there are some published studies from many countries regarding the pathological model of pediatric brain tumors, comprehensive clinical pathology studies conducted at Vietnam are still lacking. Aims: To explore the cli...
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Context: Pediatric brain tumors are the most common solid tumors and the leading cause of death among children worldwide. Although there are some published studies from many countries regarding the pathological model of pediatric brain tumors, comprehensive clinical pathology studies conducted at Vietnam are still lacking. Aims: To explore the cli...
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Context: Diabetes mellitus is considered one of the scourges of the third millennium in the world for several years. Aims: To evaluate, identify and preserve the experiences gained over the centuries. It is about therapeutic use of medicinal plants exploited for the treatment of diabetes, and to clarify its toxicities, in order to sensitize the po...
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Context: Periodontitis causes pocket formation, gingival recession, and destruction of periodontal ligaments and alveolar bone. Periodontitis disturbs the attachment of periodontal ligaments to the maxillary and mandibular bones. The α-mangostin has shown role-playing in the bone remodeling process. Aims: To evaluate the potential of α-mangostin i...
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Context: Gallic acid and quercetin in sikkam leaves (Bischofia javanica) have scientific potential as antidiabetic agents. Quercetin suppresses hyperglycemia by inhibiting active glucose transport. Meanwhile, gallic acid acts as an antidiabetic is closely related to its antioxidant properties. Antioxidant compounds neutralize cells that experience...
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Context: Magnolia champaca (L.) Baill. ex Pierre has traditionally been used by the culture to prevent and cure the inflammatory disease. Aims: To determine the benefit of M. champaca in the local community, especially in the treatment of tuberculosis, and investigate the potency of the flavonoid content of M. champaca as an anti-inflammatory agen...
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Context: Nanostructured lipid carriers can enhance skin penetration of active substances. Coenzyme Q10 is a lipophilic antioxidant, that has poor skin penetration. This limitation is overcome by nanostructured lipid carriers. Aims: To developed coenzyme Q10 nanostructured lipid carriers using myristic acid with various liquid lipids as lipid matri...
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Context: The poor storage practices in warehouses and pharmacies may lead to drug degradation. Aims: To analyze the Good Storage Practices for medicines in the warehouse and pharmacies of the Hospital Escuela of Tegucigalpa, Honduras. Methods: A mixed research was carried out using a qualitative-quantitative approach, non-experimental design, and...
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Context: Epirubicin (EPI), belonging to the anthracycline family, is one of the most effective chemo-therapeutic agents used in the treatment of a variety of solid and hematologic malignant tumors but Its anti-tumor efficacy is dose-dependent, but its clinical use is limited by the development of cardiac, hepatic and nephrotic toxicities. Aims: To...
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Context: Momordica charantia (Cucurbitaceae) is extensively distributed in tropical areas, and it is traditionally used as antidiabetic. Nevertheless, few studies supporting the metabolic effects of its foliage extracts have been reported elsewhere. Aims: To evaluate the effects of M. charantia foliage extract (MCh) on blood glucose and lipids lev...
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Context: The shark liver of the species Ginglimostoma cirratun, Carcharhinus longimanus, and Carcharhinus falciformis, captured in the north-central coast of Cuba are a source of oil, that when extracted it must be purified due to its bad smell, taste and the amount of impurities it has. Aims: To evaluate the purification of the shark liver oil (S...
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Context: Orthodontic force causes the compression of the periodontal ligament in inhibiting vascularization on the pressure side of orthodontic tooth movement (OTM), while on the opposite side, the periodontal ligament is stretched. Hyperbaric oxygen therapy (HBOT) can increase the dissolved oxygen in the blood, which can affect the tissue regenera...
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Context: Most people believe that goat milk contains high fat; therefore, regular consumption of goat milk will increase body weight. This assumption needs to be proven to be able to utilize the use of milk to improve public health. Aims: To analyze the effects of fresh goat milk on body weight and body mass index (BMI) in women. Methods: The res...
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Context: It was found that flavonoids and frankincense exert anti-cancer effect through their antioxidant and anti-inflammatory activities. Aims: To evaluate the cytotoxic effect against MCF-7 cells of flavonoids isolated from Physalis pubescens L., frankincense ethanol extract and the combined therapy with epirubicin to reduce the resistance and...
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Context: Lung cancer is a type of cancer that causes the most deaths worldwide. The most common type of lung cancer is non-small cell lung cancer (NSCLC). Sea urchin (Arbacia lixula) has high potential as an anti-NSCLC agent. Aims: To analyze the anticancer activity of peptides from A. lixula coelomic fluid in inhibiting the activity of NSCLC-rela...
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Context: Vietnam is one of the countries at the high alert of antibiotic resistance. Aims: To evaluate the compliance rate and changes in physicians’ prescribing patterns in patients with community-acquired pneumonia (CAP) before and after using the antibiotic order form (AOF) in a tertiary hospital. Methods: 120 inpatient medical records having...
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Context: Patients with COVID-19 present different biochemical and metabolic alterations from the acute state of infection until months later with variability of symptoms and increased toxicity of drugs related to oxidative stress according to previous studies. There are various alternatives to modulate oxidative stress, including the use of medical...
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Context: Diabetes is a chronic health condition with insulin disturbance. Hibiscus surattensis L. is a medicinal plant and plays a pivotal role in diabetes. Aims: To evaluate the effect of H. surattensis leaves extract to increase insulin secretion and repair pancreatic tissue damage in streptozotocin (STZ)-induced diabetic mice. Methods: This rese...
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Context: Bifidobacterium bifidum as a beneficial probiotic may regulate the inflammation and induce the bone remodeling by enhancing osteoblasts and basic fibroblast growth factor (bFGF) expression in the tension side of alveolar bone during orthodontic tooth movement (OTM). Aims: To evaluate the expression of bFGF and the number of osteoblasts du...
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Context: Much attention has been given recently to the antioxidant capacity of natural products, with particular interest on those that are frequently consumed by people. Aims: To evaluate the commonly used and frequently consumed edible herbs in Jordan to compare their in vitro and in vivo antioxidant properties. Methods: The in vitro antioxidan...
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Context: Premature aging usually occurred due to free radicals reducing the skins’ physiological functions. Muntingia calabura, a plant containing rich antioxidants, has the potential to overcome this problem. Aims: To evaluate the antioxidant capacity of M. calabura in inhibiting the premature aging process, to be potentially developed into an an...
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Context: Human immunodeficiency virus (HIV) antiretrovirals that target the binding of viral enzyme are chosen as the lead solution in the treatment of HIV-1 infection, such as non-catalytic site integrase inhibitor (NCINI), nevirapine, and darunavir. There are natural compounds from specific plants that can be effective in treating HIV-1 infection...
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Context: Celecoxib (Cele), a nonsteroidal anti-inflammatory drug (NSAID) is linked with a spectrum of hepatotoxic influences, however the underlying mechanism (s) by which this drug induces liver damage is still unexplored. Aims: To demonstrate the hepatotoxic mechanism (s) of Cele in rats and the prophylactic roles of melatonin (Mel) and/or querc...