Fujun Chen

Fujun Chen
Shanghai Jiao Tong University | SJTU · Bio-X Institute

About

21
Publications
1,947
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806
Citations

Publications

Publications (21)
Article
Full-text available
The substantia nigra pars reticulate (SNr), which plays a pivotal role in motor control, is the key structure in integrating information for cortex, basal ganglia and thalamus. Abnormal gait and posture deficits can be reversed by SNr deep brain stimulation (DBS) in certain Parkinson’s disease cases. However, functional characterization of SNr, whi...
Article
Full-text available
Polymorphisms in the oxytocin receptor ( OXTR ) gene are related to individual differences in negative emotions, such as depressive symptoms and anxiety. However, it remains unclear what the potential roles of OXTR polymorphisms are in subjective well-being (SWB), which is negatively correlated with depressive symptoms. We examined attributional st...
Article
Full-text available
Schwann cells are integral components of vertebrate neuromuscular synapses; in their absence, pre-synaptic nerve terminals withdraw from post-synaptic muscles, leading to muscle denervation and synapse loss at the developing neuromuscular junction (NMJ). Here, we report a rescue of muscle denervation and neuromuscular synapses loss in type III Neur...
Data
Motor neuron staining and motor axon counts in CRD-Nrg1–/–Chat−/−mice (E18.5). A: Cross sections of cervical spinal cords were immune-stained by anti-CHT antibodies, which label motor neurons (arrow) in the ventral horn of the spinal cord (upper panels show low-power images of entire spinal cords, and lower panels show high-power views of ventral h...
Data
Rescue of diaphragm muscle denervation in CRD-Nrg1–/–Chat−/−mice (E16.5). Embryonic diaphragm muscles (E16.5) from the control (CRD-Nrg1+/+Chat +/–) (A), CRD-Nrg1–/–Chat +/–(B), CRD-Nrg1+/–Chat−/−(C) and CRD-Nrg1–/–Chat−/−(D) mice were immuno-stained by a mixture of antibodies (anti-NF150 and anti-synaptotagmin 2) to reveal innervation pattern (gre...
Data
Amplitude distribution of mEPPs. The amplitudes were plotted against either event numbers (upper panels) or percentage of total events (lower panels). In both control and mutant mice, the amplitude distribution patterns exhibited a single peak, with a right-skewed tail. The mEPP frequencies were massively increased in mutants [Cacnb1–/–, 3 mice, 39...
Article
Full-text available
Studies have implied that the circadian oscillation of mitogen-activated protein kinase (MAPK) signal pathways is crucial for hippocampus-dependent memory. NF1 mouse models (Nf1 heterozygous null mutants; Nf1+/−) displayed enhanced MAPK activity in the hippocampus and resulted in memory deficits. We assumed a link between MAPK pathways and hippocam...
Article
The suppression of inappropriate actions is critical for flexible behavior. Cortical-basal ganglia networks provide key gating mechanisms for action suppression, yet the specific roles of neuronal subpopulations are poorly understood. Here, we examine Arkypallidal (“Arky”) and Prototypical (“Proto”) globus pallidus neurons during a Stop task, which...
Article
Many chronic neuroscience studies require neural probes that can reliably record with a large number of electrodes in a densely configured array. Previous works have shown that adverse tissue reaction can be significantly reduced as probe shanks are scaled down toward subcellular dimensions. In addition, flexible probes can mitigate shear stress-in...
Conference Paper
In order to advance the understanding of brain functions, it is critical to manipulate and monitor the neural circuitry in the cellular level. Supporting optogenetics, silicon probes with monolithically integrated waveguides and electrodes were designed and validated with in-vivo recording of photo-induced neural activity. For chronic applications,...
Article
Full-text available
Salient cues can prompt the rapid interruption of planned actions. It has been proposed that fast, reactive behavioral inhibition involves specific basal ganglia pathways, and we tested this by comparing activity in multiple rat basal ganglia structures during performance of a stop-signal task. Subthalamic nucleus (STN) neurons exhibited low-latenc...
Conference Paper
Many chronic brain implants would benefit from a neural probe with many densely configured electrodes with stable recording quality. We present a novel strategy to scale up the number of electrodes with minimized risk of proportionally increasing the adverse foreign body reactions. A flexible parylene probe having 64 electrodes has been designed an...
Article
Emerging evidence suggests that synaptic dysfunction occurs prior to neuronal loss in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). Therefore, monitoring synaptic activity during early stages of neurodegeneration may provide valuable information for the development of diagnostic and/or therapeutic strategies. Here, we des...
Article
Full-text available
Developing skeletal myofibers in vertebrates are intrinsically 'pre-patterned' for motor nerve innervation. However, the intrinsic factors that regulate muscle pre-patterning remain unknown. We found that a functional skeletal muscle dihydropyridine receptor (DHPR, the L-type Ca(2+) channel in muscle) was required for muscle pre-patterning during t...
Article
Full-text available
The enzyme ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) is one of the most abundant proteins in the mammalian nervous system. In humans, UCH-L1 is also found in the ubiquitinated inclusion bodies that characterize neurodegenerative diseases in the brain, suggesting its involvement in neurodegeneration. The physiologic role of UCH-L1 in neurons...
Article
Full-text available
The noradrenergic nucleus locus coeruleus (LC) has a direct projection to the basal lateral amygdala (BLA). Behavioral, lesion and pharmacological studies suggest that this pathway has an important role in mediating responses to emotional stimuli and in the formation of long term memory. The effect of LC activation on the activity of BLA neurons in...

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