Fuad Mosis

King's College London | KCL · Randall Division of Cell and Molecular Biophysics

Cell migration is important for development and its aberrant regulation contributes to many diseases. The Scar/WAVE complex is essential for Arp2/3 mediated lamellipodia formation during mesenchymal cell migration and several coinciding signals activate it. However, so far, no direct negative regulators are known. Here we identify Nance-Horan Syndr...

Cell migration is important for development and its aberrant regulation contributes to many diseases. The Scar/WAVE complex is essential for Arp2/3 mediated lamellipodia formation during mesenchymal cell migration and several coinciding signals activate it. However, so far, no direct negative regulators are known. We have identified Nance-Horan Syn...

Cancer invasion is a hallmark of metastasis. The mesenchymal mode of cancer cell invasion is mediated by elongated membrane protrusions driven by the assembly of branched F-actin networks. How deregulation of actin regulators promotes cancer cell invasion is still enigmatic. We report that increased expression and membrane localization of the actin...

Video S1: Intravital imaging of ZsGreen-Ctrl-shRNA tumor.? Representative 30 minute time lapse movie from multiphoton imaging of a ZsGreen-Ctrl-shRNA tumor. Cyan= Zsgreen-positive cells, red= collagen fibers. Images were taken every 2 min for 30 min. Video is played at 5 frames per second. Video S2: Intravital imaging of ZsGreen-Lpd-shRNA2 tumor.?...

Contact inhibition of locomotion (CIL) is a multifaceted process that causes many cell types to repel each other upon collision. During development, this seemingly uncoordinated reaction is a critical driver of cellular dispersion within embryonic tissues. Here, we show that Drosophila hemocytes require a precisely orchestrated CIL response for the...