Frowin Ellermann

Frowin Ellermann
Universitätsklinikum Schleswig - Holstein | UKSH · Institut für Neuroradiologie (Kiel)

Master of Science
PhD candidate in Hyperpolarization (parahydrogen/mri/nmr)

About

21
Publications
2,438
Reads
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264
Citations
Additional affiliations
April 2019 - present
Universitätsklinikum Schleswig - Holstein
Position
  • PhD candidate
Description
  • PhD candidate in the research training group "materials4brain" (GRK 2154, DFG)
Education
October 2015 - April 2018
Kiel University
Field of study
  • Materials Science and Engineering

Publications

Publications (21)
Article
Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic resonance imaging by more than 10,000 times, enabling in vivo metabolic imaging to be performed noninvasively in real time. Here, we are developing a group of dDNP polarized tracers based on nicotinamide (NAM). We synthesized 1-15N-NAM and 1-15N nicotinic acid and...
Article
Full-text available
Nuclear spin hyperpolarization is a quantum effect that enhances the nuclear magnetic resonance signal by several orders of magnitude and has enabled real-time metabolic imaging in humans. However, the translation of hyperpolarization technology into routine use in laboratories and medical centers is hampered by the lack of portable, cost-effective...
Article
Full-text available
The recognition of the role of microglia cells in neurodegenerative diseases has steadily increased over the past few years. There is growing evidence that the uncontrolled and persisting activation of microglial cells is involved in the progression of diseases such as Alzheimer’s or Parkinson’s disease. The inflammatory activation of microglia cel...
Article
Benchtop NMR (btNMR) spectrometers are revolutionizing the way we use NMR and lowering the cost drastically. Magnetic field cycling (MFC) experiments with precise timing and control over the magnetic field, however, were hitherto not available on btNMRs, although some systems exist for high-field, high-resolution NMR spectrometers. Still, the need...
Article
Full-text available
Nuclear magnetic resonance has experienced great advances in developing and translating hyperpolarization methods into procedures for fundamental and clinical studies. Here, we propose the use of a wide-bore NMR for large-scale (volume- and concentration-wise) production of hyperpolarized media using parahydrogen-induced polarization. We discuss th...
Article
Full-text available
The setup, operational procedures and performance of a cryogen-free device for producing hyperpolarized contrast agents using dissolution dynamic nuclear polarization (dDNP) in a preclinical imaging center is described. The polarization was optimized using the solid-state, DNP-enhanced NMR signal to calibrate the sample position, microwave and NMR...
Article
Full-text available
The hyperpolarization of nuclear spins has enabled unique applications in chemistry, biophysics, and particularly metabolic imaging. Parahydrogen‐induced polarization (PHIP) offers a fast and cost‐efficient way of hyperpolarization. Nevertheless, PHIP lags behind dynamic nuclear polarization (DNP), which is already being evaluated in clinical studi...
Preprint
Full-text available
Nuclear magnetic resonance has experienced great advances with the development and translation of hyperpolarization methods into routine procedures for fundamental and clinical studies. Here, we propose the use of a wide bore NMR for the large-scale (volume- and concentration-wise) production of hyperpolarized media using parahydrogen-induced polar...
Article
Full-text available
Clinical issueDespite being one of the main pillars of modern diagnostics, magnetic resonance imaging (MRI) uses only a tiny fraction of its potential: no more than a millionth of all nuclear spins contribute to the MRI signal. In order to increase this fraction, called polarization, MRI scanners with stronger magnetic fields are being developed. H...
Preprint
Full-text available
The hyperpolarization of nuclear spins has enabled unique applications in chemistry, biophysics, and particularly in metabolic imaging. Parahydrogen-induced polarization (PHIP) offers a fast and cost-efficient way of hyperpolarization. Nevertheless, PHIP lags behind dynamic nuclear polarization (DNP), which is already being evaluated in clinical st...
Preprint
Full-text available
The setup, operational procedures and performance of a cryogen-free device for producing hyperpolarized contrast agents using dissolution dynamic nuclear polarization (dDNP) in a preclinical imaging center is described. The polarization was optimized using the solid-state, DNP-enhanced NMR signal to calibrate the sample position, microwave and NMR...
Article
he unique properties of the entangled, antisymmetric nuclear spin state of dihydrogen, parahydrogen (pH2), has intrigued physicists, chemists, and other scientists for almost a century. pH2 was used as a model system in the early days of quantum mechanics1 and is used for fueling rockets as well as combustion-free cars today. In the 1980s, pH2 was...
Article
Full-text available
We describe a new method for pulsed spin order transfer of parahydrogen-induced polarization (PHIP) that enables high polarization in incompletely 2H-labeled molecules by exciting only the desired protons in a...
Preprint
Full-text available
We describe a new method for pulsed spin order transfer (SOT) of parahydrogen induced polarization (PHIP) that enables close to 100 % polarization in incompletely 2H-labeled molecules by exciting only the desired protons in a frequency-selective manner. While a selective pulse (SP) on 1H at the beginning of pulsed SOT had been considered before, us...
Article
Full-text available
The hyperpolarization of nuclear spins is a game-changing technology that enables hitherto inaccessible applications for magnetic resonance in chemistry and biomedicine. Despite significant advances and discoveries in the past, however, the quest to establish efficient and effective hyperpolarization methods continues. Here, we describe a new metho...
Article
In this work, we present a new pulse sequence to transform the spin order added to a molecule after the pairwise addition of parahydrogen into 13C polarization. Using a selective 90° preparation instead of a non-selective 45° excitation, the new variant performed twice as well as previous implementations in both simulations and experiments, exempli...
Article
Full-text available
The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used dynamic nuclear polarization (DNP) technique that is already used in clinical trials, the parahydrogen (pH2)-based hyperpolarization approaches are less cost-intensive, are scalable, and offer high t...
Article
The signal enhancement provided by the hyperpolarization of nuclear spins of metabolites is a promising technique for diagnostic magnetic resonance imaging (MRI). To date, most ¹³C-contrast agents are hyperpolarized utilizing a complex or cost-intensive polarizer. Recently, the in situ parahydrogen-induced ¹³C hyperpolarization was demonstrated. Hy...
Preprint
Full-text available
The sensitivity of NMR and MRI can be boosted via hyperpolarization of nuclear spins. However, current methods are costly, polarization is relatively low, or applicability is limited. Here, we report a new hyperpolarization method combining the low-cost, high polarization of hydrogenative parahydrogen-induced polarization (PHIP) with the flexibilit...
Preprint
Full-text available
The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used Dynamic Nuclear Polarization (DNP) technique that is already used in clinical trials, the para-hydrogen (pH2) based hyperpolarization approaches are less cost-intensive, scalable and offer high throu...

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